KEGG   ORTHOLOGY: K04721
Entry
K04721                      KO                                     
Symbol
TNFSF10, TRAIL, CD253
Name
tumor necrosis factor ligand superfamily member 10
Pathway
map04060  Cytokine-cytokine receptor interaction
map04061  Viral protein interaction with cytokine and cytokine receptor
map04068  FoxO signaling pathway
map04210  Apoptosis
map04217  Necroptosis
map04650  Natural killer cell mediated cytotoxicity
map05130  Pathogenic Escherichia coli infection
map05132  Salmonella infection
map05164  Influenza A
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
   04061 Viral protein interaction with cytokine and cytokine receptor
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
   04217 Necroptosis
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
   05132 Salmonella infection
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
   04052 Cytokines and neuropeptides
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
   04090 CD molecules
    K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Tumor necrosis fators
   K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
CD molecules [BR:ko04090]
 Proteins
  K04721  CD253, TNFSF10; tumor necrosis factor (ligand) superfamily, member 10
Other DBs
GO: 0005164
Genes
HSA: 8743(TNFSF10)
PTR: 460852(TNFSF10)
PPS: 100986991(TNFSF10)
GGO: 101130096(TNFSF10)
PON: 100441526(TNFSF10)
PPYG: 129033824(TNFSF10)
HMH: 116481248(TNFSF10)
SSYN: 134733082(TNFSF10)
MCC: 694451(TNFSF10)
MCF: 101864918(TNFSF10)
MTHB: 126948360
MNI: 105465646(TNFSF10)
CSAB: 103221246(TNFSF10)
CATY: 105586081(TNFSF10)
PANU: 101016626(TNFSF10)
TGE: 112618898(TNFSF10)
MLEU: 105530892(TNFSF10)
RRO: 104657165(TNFSF10)
RBB: 108540415(TNFSF10)
TFN: 117083738(TNFSF10)
PTEH: 111543475(TNFSF10)
CANG: 105510995(TNFSF10)
CJC: 100396000(TNFSF10)
SBQ: 101030281(TNFSF10)
CIMI: 108305297(TNFSF10)
ANAN: 105727029(TNFSF10)
MMUR: 105855430(TNFSF10)
LCAT: 123630266(TNFSF10)
PCOQ: 105806953(TNFSF10)
OGA: 100958512(TNFSF10)
MMU: 22035(Tnfsf10)
MCAL: 110291484(Tnfsf10)
MPAH: 110320972(Tnfsf10)
RNO: 246775(Tnfsf10)
MCOC: 116095017(Tnfsf10)
ANU: 117707211(Tnfsf10)
MUN: 110557487(Tnfsf10)
CGE: 100754968(Tnfsf10)
MAUA: 101826873(Tnfsf10)
PROB: 127223363(Tnfsf10)
PLEU: 114697551(Tnfsf10)
MORG: 121452941(Tnfsf10)
MFOT: 126501403
AAMP: 119826387(Tnfsf10)
NGI: 103739879(Tnfsf10)
HGL: 101702439(Tnfsf10)
CPOC: 100734497(Tnfsf10)
CCAN: 109683456
DORD: 105985592(Tnfsf10)
DSP: 122107277(Tnfsf10)
PLOP: 125351974(Tnfsf10)
NCAR: 124993468
MMMA: 107149480(Tnfsf10)
OCU: 100355808(TNFSF10)
OPI: 101522735(TNFSF10)
TUP: 102501703(TNFSF10)
GVR: 103585789(TNFSF10)
CFA: 100174780(TNFSF10)
CLUD: 112645969(TNFSF10)
VVP: 112926677(TNFSF10)
VLG: 121477409(TNFSF10)
NPO: 129498619(TNFSF10)
AML: 100463573(TNFSF10)
UMR: 103676141(TNFSF10)
UAH: 113255024(TNFSF10)
UAR: 123786394(TNFSF10)
ELK: 111152154
LLV: 125100439
MPUF: 101675328(TNFSF10)
MNP: 132012046(TNFSF10)
MLK: 131824863(TNFSF10)
NVS: 122908700(TNFSF10)
ORO: 101371152(TNFSF10)
EJU: 114207003(TNFSF10)
ZCA: 113916957(TNFSF10)
MLX: 118006404(TNFSF10)
NSU: 110591656(TNFSF10)
LWW: 102744830(TNFSF10)
FCA: 100174789(TNFSF10)
PYU: 121033998(TNFSF10)
PCOO: 112849569(TNFSF10)
PBG: 122491727(TNFSF10)
PVIV: 125174978(TNFSF10)
LRUF: 124526454
PTG: 102963342(TNFSF10)
PPAD: 109275136(TNFSF10)
PUC: 125921880
AJU: 106990055
HHV: 120234588(TNFSF10)
BTA: 507215(TNFSF10)
BOM: 102287110(TNFSF10)
BIU: 109558018(TNFSF10)
BBIS: 104985206(TNFSF10)
CHX: 102173335(TNFSF10)
OAS: 101114153(TNFSF10)
BTAX: 128055119(TNFSF10)
ODA: 120869589(TNFSF10)
CCAD: 122444929(TNFSF10)
MBEZ: 129545548(TNFSF10)
SSC: 406191(TNFSF10)
CFR: 102506160(TNFSF10)
CBAI: 105063300(TNFSF10)
CDK: 105085942(TNFSF10)
VPC: 102537869(TNFSF10)
BACU: 102997406(TNFSF10)
BMUS: 118894664(TNFSF10)
LVE: 103083521(TNFSF10)
OOR: 101282902(TNFSF10)
DLE: 111173963(TNFSF10)
PCAD: 102992913(TNFSF10)
PSIU: 116753080(TNFSF10)
NASI: 112396901(TNFSF10)
ECB: 100064377(TNFSF10)
EPZ: 103546356(TNFSF10)
EAI: 106847522(TNFSF10)
MYB: 102262545(TNFSF10)
MYD: 102751425(TNFSF10)
MMYO: 118676101(TNFSF10)
MLF: 102441820(TNFSF10)
MDT: 132230112(TNFSF10)
PKL: 118722395(TNFSF10)
EFUS: 103286737(TNFSF10)
MNA: 107533523(TNFSF10)
DRO: 112307528(TNFSF10)
SHON: 118987393(TNFSF10)
AJM: 119043451(TNFSF10)
PDIC: 114490557(TNFSF10)
PHAS: 123827114(TNFSF10)
MMF: 118617099(TNFSF10)
PPAM: 129076417(TNFSF10)
HAI: 109371673(TNFSF10)
RFQ: 117012422(TNFSF10)
PALE: 102885663(TNFSF10)
PGIG: 120604392(TNFSF10)
PVP: 105305707(TNFSF10)
RAY: 107516234(TNFSF10)
MJV: 108383372(TNFSF10)
TOD: 119257290(TNFSF10)
SARA: 101536897(TNFSF10)
SETR: 126011432(TNFSF10)
LAV: 100659733(TNFSF10)
TMU: 101359129
ETF: 101655233(TNFSF10)
DNM: 101435481(TNFSF10)
MDO: 100010299(TNFSF10)
SHR: 105750042(TNFSF10)
AFZ: 127552879
PCW: 110204161(TNFSF10)
TVP: 118846220(TNFSF10)
OAA: 100074849(TNFSF10)
GGA: 378894(TNFSF10)
PCOC: 116243372(TNFSF10)
MGP: 100550143(TNFSF10)
CJO: 107318308(TNFSF10)
TPAI: 128081922(TNFSF10)
LMUT: 125697632(TNFSF10)
NMEL: 110398962(TNFSF10)
APLA: 101797713(TNFSF10)
ACYG: 106031999(TNFSF10)
CATA: 118253207(TNFSF10)
AFUL: 116492693(TNFSF10)
TGU: 100227931(TNFSF10)
LSR: 110480362(TNFSF10)
SCAN: 103815595(TNFSF10)
PMOA: 120504333(TNFSF10)
OTC: 121336644(TNFSF10)
PRUF: 121353789(TNFSF10)
GFR: 102042782(TNFSF10)
FAB: 101806118(TNFSF10)
OMA: 130256712(TNFSF10)
PHI: 102100672(TNFSF10)
PMAJ: 107208991(TNFSF10)
CCAE: 111933337(TNFSF10)
CCW: 104688035(TNFSF10)
CBRC: 103625089(TNFSF10)
ETL: 114061190(TNFSF10)
ZAB: 102067007(TNFSF10)
ZLE: 135451551(TNFSF10)
ACHL: 103806153
SVG: 106859651(TNFSF10)
MMEA: 130575478(TNFSF10)
HRT: 120757292(TNFSF10)
SATI: 136365365(TNFSF10)
FPG: 101922846(TNFSF10)
FCH: 102047699(TNFSF10)
CCRI: 104156104(TNFSF10)
NNT: 104408595
SHAB: 115611740(TNFSF10)
ACUN: 113483422(TNFSF10)
TALA: 104365368(TNFSF10)
ACHC: 115347472(TNFSF10)
HALD: 104318504(TNFSF10)
HLE: 104835094(TNFSF10)
AGEN: 126039139
GCL: 127019986
CSTI: 104554359(TNFSF10)
LDI: 104353138(TNFSF10)
MNB: 103771632(TNFSF10)
DPUB: 104301945(TNFSF10)
AVIT: 104267576(TNFSF10)
BRHI: 104488403(TNFSF10)
EGZ: 104132497(TNFSF10)
NNI: 104022070(TNFSF10)
PCRI: 104030813
PCAO: 104053749(TNFSF10)
PADL: 103924981(TNFSF10)
AFOR: 103906251(TNFSF10)
FGA: 104071065
GSTE: 104261974(TNFSF10)
CLV: 102093335(TNFSF10)
MUI: 104533814(TNFSF10)
PGUU: 104463262(TNFSF10)
PLET: 104618310(TNFSF10)
EHS: 104514136
CMAC: 104476689(TNFSF10)
CUCA: 104063347(TNFSF10)
TEO: 104370091
BREG: 104635047(TNFSF10)
OHA: 104334459(TNFSF10)
ACAR: 104519149
CPEA: 104394568(TNFSF10)
CVF: 104285927(TNFSF10)
RTD: 128911179(TNFSF10)
AAM: 106486566(TNFSF10)
AROW: 112964213(TNFSF10)
NPD: 112952453(TNFSF10)
TGT: 104571811(TNFSF10)
DNE: 112986480(TNFSF10)
SCAM: 104143325(TNFSF10)
ASN: 102371031(TNFSF10)
AMJ: 102576971(TNFSF10)
CPOO: 109308442(TNFSF10)
GGN: 109287988(TNFSF10)
PSS: 102460636(TNFSF10)
CMY: 102945208(TNFSF10)
CCAY: 125642690(TNFSF10)
DCC: 119861691(TNFSF10)
CPIC: 101952595(TNFSF10)
TST: 117882806(TNFSF10)
CABI: 116826739(TNFSF10)
MRV: 120372443(TNFSF10)
ACS: 100566541(tnfsf10)
ASAO: 132770503(TNFSF10)
PVT: 110079056(TNFSF10)
SUND: 121925445(TNFSF10)
PBI: 103056379(TNFSF10)
PMUR: 107286546(TNFSF10)
CTIG: 120305867(TNFSF10)
TSR: 106547753(TNFSF10)
PGUT: 117678186(TNFSF10)
APRI: 131200471(TNFSF10)
PTEX: 113439764(TNFSF10)
NSS: 113411425(TNFSF10)
VKO: 123025632(TNFSF10)
PMUA: 114597986(TNFSF10)
PRAF: 128414776(TNFSF10)
ZVI: 118093614(TNFSF10)
HCG: 128351259(TNFSF10)
GJA: 107113859(TNFSF10)
STOW: 125438099(TNFSF10)
EMC: 129332909(TNFSF10)
XLA: 100316914(tnfsf10.S) 108717006(tnfsf10.L)
XTR: 100493578(tnfsf10)
NPR: 108784823(TNFSF10)
RTEM: 120936756(TNFSF10)
BBUF: 120997891(TNFSF10)
BGAR: 122934073(TNFSF10)
MUO: 115478655(TNFSF10)
GSH: 117367026(TNFSF10)
DRE: 436866(tnfsf10)
PTET: 122329584(tnfsf10)
LROH: 127155372(tnfsf10)
OMC: 131533294(tnfsf10)
PPRM: 120470090(tnfsf10l4) 120488411(tnfsf10)
RKG: 130084007(tnfsf10)
MAMB: 125258532(tnfsf10) 125266562(tnfsf10l4)
CIDE: 127506009
CERY: 137014020(tnfsf10)
TROS: 130547155(tnfsf10)
TDW: 130413175(tnfsf10)
MANU: 129426327(tnfsf10)
IPU: 108259907(tnfsf10l4) 108261837(tnfsf10)
IFU: 128599563(tnfsf10)
SMEO: 124375641(tnfsf10)
TFD: 113660344(tnfsf10) 113662866(tnfsf10l4)
TVC: 132840340(tnfsf10)
TRN: 134300955(tnfsf10)
AMEX: 103022098(tnfsf10l4) 103023521(tnfsf10)
CMAO: 118798701(tnfsf10)
CHAR: 122130328(tnfsf10) 122131789
TRU: 100653422(tnfsf10) 101061420
TFS: 130512938 130514030(tnfsf10)
TBEN: 117493858 117496233(tnfsf10)
PGEO: 117466096(tnfsf10) 117467829
EMAC: 134881187 134883756(tnfsf10)
EFO: 125881938(tnfsf10) 125901463
PLEP: 121953865 121960904(tnfsf10)
SLUC: 116040032(tnfsf10) 116057709
GAT: 120832843(tnfsf10)
CLUM: 117749953(tnfsf10) 117751134
SCHU: 122861996 122866216(tnfsf10)
CUD: 121525816 121527724(tnfsf10)
ALAT: 119004309 119008473(tnfsf10)
OLA: 101156131(tnfsf10) 101172365
CSAI: 133423432(tnfsf10) 133462896
XHE: 116711469
PMEI: 106912519(tnfsf10) 106933885
GAF: 122824455(tnfsf10)
PPRL: 129365275 129378922(tnfsf10)
CVG: 107085098(tnfsf10) 107103203
NFU: 107383107 107392066(tnfsf10)
KMR: 108234661(tnfsf10) 108247980
ALIM: 106522312 106525539(tnfsf10) 106534382
NWH: 119426805
CSEM: 103377512 103378994(tnfsf10)
SSEN: 122769486(tnfsf10) 122783147
HHIP: 117753842(tnfsf10) 117756449
HSP: 118098522(tnfsf10) 118116455
SMAU: 118285738 118291530(tnfsf10)
SLAL: 111651407 111665906(tnfsf10)
XGL: 120790035(tnfsf10) 120795438
SBIA: 133492438(tnfsf10) 133513079
PEE: 133396336(tnfsf10) 133412819
BSPL: 114848365 114853377(tnfsf10)
OTW: 112227478(tnfsf10) 112236919
OGO: 123991275(tnfsf10) 124039514
ELS: 105022065
LOC: 102695414(tnfsf10) 107077552
PSEX: 120534156(tnfsf10)
LCM: 102345421(TNFSF10)
CMK: 103177380 103190454(tnfsf10)
RTP: 109938453
HOC: 132821806
LERI: 129703412(tnfsf10)
PMRN: 116937479
SCLV: 120328846
SPU: 100891737
BGT: 106071704
CRG: 105341146
DPOL: 127834493
OBI: 106873185
OSN: 115209299
LJP: 135479392
ATEN: 116302515
AMIL: 114952948
DGT: 114535243
XEN: 124447276
HSY: 130636257
 » show all
Reference
PMID:8777713
  Authors
Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA, et al.
  Title
Identification and characterization of a new member of the TNF family that induces apoptosis.
  Journal
Immunity 3:673-82 (1995)
DOI:10.1016/1074-7613(95)90057-8
  Sequence
[hsa:8743]
Reference
  Authors
McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH, Whyte MK
  Title
TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.
  Journal
J Leukoc Biol 90:855-65 (2011)
DOI:10.1189/jlb.0211062
  Sequence
[mmu:22035]
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