KEGG   ORTHOLOGY: K04724Help
Entry
K04724                      KO                                     

Name
CFLAR, FLIP
Definition
CASP8 and FADD-like apoptosis regulator
Pathway
ko04064  NF-kappa B signaling pathway
ko04140  Autophagy - animal
ko04210  Apoptosis
ko04217  Necroptosis
ko04668  TNF signaling pathway
ko05142  Chagas disease (American trypanosomiasis)
ko05160  Hepatitis C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
   04668 TNF signaling pathway
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
  09143 Cell growth and death
   04210 Apoptosis
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
   04217 Necroptosis
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
  09174 Infectious disease: parasitic
   05142 Chagas disease (American trypanosomiasis)
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C14: caspase family
   K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
BRITE hierarchy
Genes
HSA: 8837(CFLAR)
PTR: 459872(CFLAR)
PPS: 100972044(CFLAR)
GGO: 101130329(CFLAR)
PON: 100172025(CFLAR)
NLE: 100589650(CFLAR)
MCC: 574234(CFLAR)
MCF: 101867183(CFLAR)
CSAB: 103217632(CFLAR)
RRO: 104671861(CFLAR)
RBB: 108532119(CFLAR)
CJC: 100393782(CFLAR)
SBQ: 101028366(CFLAR)
MMU: 12633(Cflar)
MCAL: 110293482(Cflar)
MPAH: 110321922(Cflar)
RNO: 117279(Cflar)
MUN: 110557663(Cflar)
CGE: 100757136(Cflar)
NGI: 103738673(Cflar)
HGL: 101713835(Cflar)
CCAN: 109688488(Cflar)
OCU: 100346964(CFLAR)
TUP: 102494501(CFLAR)
CFA: 488471(CFLAR)
VVP: 112922876(CFLAR)
AML: 100474872(CFLAR)
UMR: 103659740(CFLAR)
UAH: 113250596(CFLAR)
ORO: 101366831(CFLAR)
FCA: 100142680(CFLAR)
PTG: 102963219(CFLAR)
AJU: 106987988(CFLAR)
BTA: 497199(CFLAR)
BOM: 102283650(CFLAR)
BIU: 109569493(CFLAR)
BBUB: 102412372(CFLAR)
PHD: 102325911(CFLAR)
CHX: 100860786(CFLAR)
OAS: 101106914(CFLAR)
SSC: 414381(CFLAR)
CFR: 102508474(CFLAR)
CDK: 105099179(CFLAR)
BACU: 103002342(CFLAR)
LVE: 103076340(CFLAR)
OOR: 101282267(CFLAR)
DLE: 111171724(CFLAR)
ECB: 100068181(CFLAR)
EPZ: 103565999(CFLAR)
EAI: 106823485(CFLAR)
MYB: 102244844(CFLAR)
MYD: 102763362(CFLAR)
MNA: 107533941(CFLAR)
HAI: 109379239(CFLAR)
RSS: 109444981(CFLAR)
DRO: 112307654(CFLAR)
PALE: 102898217(CFLAR)
LAV: 100660836(CFLAR)
TMU: 101343780
MDO: 100617513(CFLAR)
SHR: 100927927(CFLAR)
PCW: 110197210(CFLAR)
OAA: 100076553(CFLAR)
GGA: 424080(CFLAR)
MGP: 100549881(CFLAR)
CJO: 107316522(CFLAR)
APLA: 101799915(CFLAR)
ACYG: 106040001(CFLAR)
TGU: 100230013(CFLAR)
LSR: 110484600(CFLAR)
SCAN: 103814508(CFLAR)
GFR: 102045043(CFLAR)
FAB: 101816960(CFLAR)
PHI: 102104024(CFLAR)
PMAJ: 107207333(CFLAR)
CCAE: 111931986(CFLAR)
CCW: 104693776(CFLAR)
ETL: 114055712(CFLAR)
FPG: 101916800(CFLAR)
FCH: 102056426(CFLAR)
CLV: 102084239(CFLAR)
EGZ: 104130513(CFLAR)
NNI: 104010193(CFLAR)
ACUN: 113482557(CFLAR)
AAM: 106492411(CFLAR)
ASN: 102381131(CFLAR)
AMJ: 102574231(CFLAR)
PSS: 102455949(CFLAR)
CMY: 102931806(CFLAR)
CPIC: 101941100 101954145(CFLAR)
ACS: 100564476(cflar)
PVT: 110089016(CFLAR)
PBI: 103051805(CFLAR)
GJA: 107122428
XLA: 108701437(cflar.L) 780745(cflar.S)
XTR: 779578(cflar)
NPR: 108798399(CFLAR)
DRE: 373114(cflara)
IPU: 108259510 108266354(cflar)
PHYP: 113525356 113547094(cflar)
EEE: 113577703 113584644(cflar)
TRU: 101063858(cflar)
LCO: 104928804(cflar)
NCC: 104963314(cflar)
MZE: 101464799(cflar)
OLA: 100529185(cflar)
XMA: 102228359(cflar)
XCO: 114147948(cflar)
PRET: 103461648(cflar)
NFU: 107390131(cflar)
KMR: 108240700(cflar)
CSEM: 103392053(cflar)
LCF: 108880451(cflar)
SDU: 111218114(cflar)
HCQ: 109523284(cflar)
BPEC: 110168798
MALB: 109957132(cflar)
OTW: 112224883(cflar)
SALP: 112075049(cflar)
ELS: 105007210(cflar)
SFM: 108942112(cflar)
PKI: 111858290(cflar)
LCM: 102349725 102359774(CFLAR)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9326610
  Authors
Han DK, Chaudhary PM, Wright ME, Friedman C, Trask BJ, Riedel RT, Baskin DG, Schwartz SM, Hood L
  Title
MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.
  Journal
Proc Natl Acad Sci U S A 94:11333-8 (1997)
DOI:10.1073/pnas.94.21.11333
  Sequence
[hsa:8837]
Reference
  Authors
Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel DV, Mak TW
  Title
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
  Journal
Immunity 12:633-42 (2000)
DOI:10.1016/S1074-7613(00)80214-9
  Sequence
[mmu:12633]
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