K04734                      KO                                     
NF-kappa-B inhibitor alpha
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04210  Apoptosis
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04624  Toll and Imd signaling pathway
map04625  C-type lectin receptor signaling pathway
map04657  IL-17 signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04668  TNF signaling pathway
map04722  Neurotrophin signaling pathway
map04920  Adipocytokine signaling pathway
map04926  Relaxin signaling pathway
map04931  Insulin resistance
map04936  Alcoholic liver disease
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05134  Legionellosis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05145  Toxoplasmosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05208  Chemical carcinogenesis - reactive oxygen species
map05215  Prostate cancer
map05220  Chronic myeloid leukemia
map05222  Small cell lung cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05417  Lipid and atherosclerosis
H00007  Hodgkin lymphoma
H00095  Ectodermal dysplasia associated immunodeficiency
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04668 TNF signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04024 cAMP signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04624 Toll and Imd signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04621 NOD-like receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04622 RIG-I-like receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04623 Cytosolic DNA-sensing pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04625 C-type lectin receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04660 T cell receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04658 Th1 and Th2 cell differentiation
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04659 Th17 cell differentiation
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04657 IL-17 signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04662 B cell receptor signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04062 Chemokine signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04926 Relaxin signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05208 Chemical carcinogenesis - reactive oxygen species
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05203 Viral carcinogenesis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05215 Prostate cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05222 Small cell lung cancer
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05170 Human immunodeficiency virus 1 infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05161 Hepatitis B
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05160 Hepatitis C
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05171 Coronavirus disease - COVID-19
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05164 Influenza A
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05162 Measles
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05168 Herpes simplex virus 1 infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05163 Human cytomegalovirus infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05169 Epstein-Barr virus infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05130 Pathogenic Escherichia coli infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05132 Salmonella infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05131 Shigellosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05135 Yersinia infection
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05134 Legionellosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05140 Leishmaniasis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   05142 Chagas disease
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04931 Insulin resistance
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
   04131 Membrane trafficking
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Ankyrin only
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
Membrane trafficking [BR:ko04131]
  Chaperone mediated autophagy (CMA)
   Selective cargos
    K04734  NFKBIA; NF-kappa-B inhibitor alpha
Other DBs
GO: 0051059
PTR: 467426(NFKBIA)
PPS: 100972867(NFKBIA)
GGO: 101128204(NFKBIA)
PON: 100459445
NLE: 100599351(NFKBIA)
MCC: 695335(NFKBIA)
MCF: 101867458(NFKBIA)
MTHB: 126959170
CSAB: 103228823(NFKBIA)
CATY: 105589068(NFKBIA)
PANU: 101023751(NFKBIA)
TGE: 112628601(NFKBIA)
RRO: 104679802(NFKBIA)
RBB: 108519636(NFKBIA)
TFN: 117069810(NFKBIA)
PTEH: 111524454(NFKBIA)
CJC: 100402266(NFKBIA)
SBQ: 101048714(NFKBIA)
CSYR: 103273993(NFKBIA)
MMUR: 105855502(NFKBIA)
LCAT: 123650127(NFKBIA)
OGA: 100947991(NFKBIA)
MMU: 18035(Nfkbia)
MCAL: 110306864(Nfkbia)
MPAH: 110324484(Nfkbia)
RNO: 25493(Nfkbia)
MCOC: 116080443(Nfkbia)
MUN: 110562401(Nfkbia)
CGE: 100754153(Nfkbia)
MAUA: 101835014(Nfkbia)
PLEU: 114693378(Nfkbia)
MORG: 121452602(Nfkbia)
MFOT: 126499590
AAMP: 119818958(Nfkbia)
NGI: 103734016(Nfkbia)
HGL: 101709256(Nfkbia)
CPOC: 100723189(Nfkbia)
CCAN: 109697260(Nfkbia)
DORD: 105982592(Nfkbia)
DSP: 122106511(Nfkbia)
NCAR: 124978214
OCU: 100357341(NFKBIA)
OPI: 101536420(NFKBIA)
TUP: 102494635(NFKBIA)
CFA: 480291(NFKBIA)
CLUD: 112657364(NFKBIA)
VVP: 112935347(NFKBIA)
VLG: 121493914(NFKBIA)
AML: 100466997(NFKBIA)
UMR: 103666055(NFKBIA)
UAH: 113266131(NFKBIA)
UAR: 123793902(NFKBIA)
ELK: 111140276
LLV: 125105211
MPUF: 101693829(NFKBIA)
ORO: 101384149(NFKBIA)
EJU: 114217931(NFKBIA)
ZCA: 113910226(NFKBIA)
NSU: 110585142(NFKBIA)
FCA: 101090622(NFKBIA)
PYU: 121031656(NFKBIA)
PBG: 122469008(NFKBIA)
LRUF: 124508912
PTG: 102956127(NFKBIA)
PPAD: 109253320(NFKBIA)
AJU: 106965509(NFKBIA)
HHV: 120248609(NFKBIA)
BTA: 282291(NFKBIA)
BOM: 102275402(NFKBIA)
BIU: 109575581(NFKBIA)
BBUB: 102412626(NFKBIA)
CHX: 102169137(NFKBIA)
OAS: 780520(NFKBIA)
ODA: 120875083(NFKBIA)
CCAD: 122455294(NFKBIA)
SSC: 406188(NFKBIA)
CFR: 102519409(NFKBIA)
CBAI: 105079152(NFKBIA)
CDK: 105092140(NFKBIA)
VPC: 102524630(NFKBIA)
BACU: 103002206(NFKBIA)
LVE: 103069029(NFKBIA)
OOR: 101289477(NFKBIA)
DLE: 111173225(NFKBIA)
PCAD: 102973672(NFKBIA)
PSIU: 116749797(NFKBIA)
ECB: 100058000(NFKBIA)
EPZ: 103546400(NFKBIA)
EAI: 106838803(NFKBIA)
MYB: 102256580(NFKBIA)
MYD: 102763089(NFKBIA)
MMYO: 118677878(NFKBIA)
MLF: 102422347(NFKBIA)
MNA: 107526117(NFKBIA)
PKL: 118726764(NFKBIA)
HAI: 109383860(NFKBIA)
DRO: 112296519(NFKBIA)
SHON: 118993928(NFKBIA)
AJM: 119062929(NFKBIA)
PDIC: 114492937(NFKBIA)
PHAS: 123825207(NFKBIA)
MMF: 118617230(NFKBIA)
RFQ: 117024116(NFKBIA)
PALE: 102891056(NFKBIA)
PGIG: 120620765(NFKBIA)
PVP: 105303182(NFKBIA)
RAY: 107514416(NFKBIA)
MJV: 108402523(NFKBIA)
TOD: 119239019(NFKBIA)
SARA: 101556810(NFKBIA)
LAV: 100675651(NFKBIA)
TMU: 101355353
DNM: 101412730(NFKBIA)
MDO: 100011769(NFKBIA)
GAS: 123235754(NFKBIA)
SHR: 100919027(NFKBIA)
PCW: 110211795(NFKBIA)
OAA: 100090081(NFKBIA)
GGA: 396093(NFKBIA)
PCOC: 116229367(NFKBIA)
MGP: 100549878(NFKBIA)
CJO: 107315054(NFKBIA)
NMEL: 110401359(NFKBIA)
APLA: 101791396(NFKBIA)
ACYG: 106038777(NFKBIA)
AFUL: 116489838(NFKBIA)
TGU: 100220015(NFKBIA)
LSR: 110477285(NFKBIA)
SCAN: 103826549(NFKBIA)
PMOA: 120500453(NFKBIA)
OTC: 121334017(NFKBIA)
PRUF: 121356025(NFKBIA)
GFR: 102042109(NFKBIA)
FAB: 101816754(NFKBIA)
PHI: 102109715(NFKBIA)
PMAJ: 107205249(NFKBIA)
CCAE: 111930016(NFKBIA)
CCW: 104688451(NFKBIA)
CBRC: 103621011(NFKBIA)
ETL: 114065291(NFKBIA)
ZAB: 102060600(NFKBIA)
ACHL: 103799024(NFKBIA)
FPG: 101923842(NFKBIA)
FCH: 102051665(NFKBIA)
CLV: 102094222(NFKBIA)
EGZ: 104133251(NFKBIA)
NNI: 104011799(NFKBIA)
PLET: 104623329(NFKBIA)
PCRI: 104025795(NFKBIA)
PCAO: 104040479(NFKBIA)
ACUN: 113480478(NFKBIA)
TALA: 104367877(NFKBIA)
PADL: 103912947(NFKBIA)
ACHC: 115337413(NFKBIA)
HALD: 104323625(NFKBIA)
CCRI: 104166462(NFKBIA)
CSTI: 104556319(NFKBIA)
EHS: 104512375(ANKRD7)
CMAC: 104479711(NFKBIA)
MUI: 104538960(NFKBIA)
FGA: 104079425(NFKBIA)
GSTE: 104258165(NFKBIA)
LDI: 104348772(NFKBIA)
MNB: 103781159(NFKBIA)
OHA: 104338140(NFKBIA)
NNT: 104404537(NFKBIA)
DPUB: 104302476(NFKBIA)
PGUU: 104463563(NFKBIA)
ACAR: 104519341(NFKBIA)
AVIT: 104274118(NFKBIA)
CVF: 104288240(NFKBIA)
CUCA: 104061683(NFKBIA)
AAM: 106483033(NFKBIA)
AROW: 112977918(NFKBIA)
NPD: 112958044(NFKBIA)
TGT: 104574504(NFKBIA)
DNE: 112980324(NFKBIA)
SCAM: 104141593(NFKBIA)
ASN: 102381268(NFKBIA)
AMJ: 102559903(NFKBIA)
CPOO: 109321546(NFKBIA)
GGN: 109298664(NFKBIA)
PSS: 102460666(NFKBIA)
CMY: 102937973(NFKBIA)
CPIC: 101937790(NFKBIA)
TST: 117876433(NFKBIA)
CABI: 116814874(NFKBIA)
MRV: 120405241(NFKBIA)
ACS: 100554664(nfkbia)
PVT: 110083506(NFKBIA)
SUND: 121919325(NFKBIA)
PBI: 103057929(NFKBIA)
PMUR: 107290218(NFKBIA)
CTIG: 120311819(NFKBIA)
TSR: 106551236(NFKBIA)
PGUT: 117665785(NFKBIA)
VKO: 123026853(NFKBIA)
PMUA: 114592509(NFKBIA)
ZVI: 118082229(NFKBIA)
GJA: 107119990(NFKBIA)
STOW: 125427472(NFKBIA)
XLA: 446833(nfkbia.L) 734297(nfkbia.S)
XTR: 448138(nfkbia)
NPR: 108795750(NFKBIA)
RTEM: 120921162(NFKBIA)
BBUF: 120982425(NFKBIA)
BGAR: 122921678(NFKBIA)
DRE: 323099(nfkbiab) 406463(nfkbiaa)
PPRM: 120480064(nfkbiab) 120494118(nfkbiaa)
MAMB: 125268577(nfkbiab) 125279050(nfkbiaa)
IPU: 108258222(nfkbiaa) 108269796(nfkbiab)
PHYP: 113524771 113534059(nfkbia)
SMEO: 124376623(nfkbiaa) 124390474(nfkbiab)
TFD: 113635381(nfkbiab) 113647937(nfkbiaa)
AMEX: 103038271 103043190(nfkbia)
EEE: 113571141(nfkbia) 113571703
LCO: 104928653(nfkbia) 104931204
CGOB: 115003431 115027172(nfkbia)
ELY: 117267593(nfkbiab) 117270437(nfkbiaa)
EFO: 125897111(nfkbiaa) 125900516(nfkbiab)
PLEP: 121953828(nfkbiab) 121955348
SLUC: 116041969 116065706(nfkbiab)
ECRA: 117935665(nfkbiab) 117961674
ESP: 116670651(nfkbia) 116706183
PFLV: 114546563(nfkbia) 114573114
GAT: 120808140 120832907(nfkbiab)
PPUG: 119195336(nfkbiaa) 119228052(nfkbiab)
MSAM: 119908908(nfkbiaa) 119910732(nfkbiab)
CUD: 121521488 121526528(nfkbiab)
ALAT: 119013032 119034409(nfkbiab)
MZE: 101464752 101484153(nfkbia)
ONL: 100691089(nfkbia) 100691708
OAU: 116315547 116325293(nfkbiab)
OLA: 101162015 101168165(nfkbia)
OML: 112149154(nfkbiab) 112158034
XMA: 102217801 102228531(nfkbia)
XCO: 114134154(nfkbia) 114158792
XHE: 116708961(nfkbia) 116734358
PRET: 103457805 103458779(nfkbia)
PFOR: 103149669 103154601(nfkbia)
PLAI: 106935622 106954015(nfkbia)
PMEI: 106904394 106922947(nfkbia)
GAF: 122825334 122846650(nfkbiab)
CVG: 107094345(nfkbia) 107095483
CTUL: 119774728(nfkbiab) 119783503
GMU: 124855522(nfkbiab) 124882098
NFU: 107396025 107396129(nfkbia)
KMR: 108231757(nfkbiaa) 108241774(nfkbiab)
NWH: 119418055(nfkbiaa) 119427491(nfkbiab)
AOCE: 111577551 111581711(nfkbia)
MCEP: 124999499 125024054(nfkbiab)
CSEM: 103377625(nfkbia) 103380734
SSEN: 122783035(nfkbiab) 122784494
HHIP: 117755644(nfkbiab) 117758841
HSP: 118099823 118116236(nfkbiab)
LCF: 108895835
SDU: 111225264(nfkbia) 111238330
SLAL: 111672507 111673714(nfkbia)
XGL: 120787843 120795821(nfkbiab)
BPEC: 110155259(nfkbia) 110162763
MALB: 109969835 109972831(nfkbia)
BSPL: 114848588(nfkbiab) 114849518
SASA: 106571222(IKBA) 106601178(IKBA) 106607598(IKBA) 106611175(IKBA)
ELS: 105015312 105015478(nfkbia)
SFM: 108919418(nfkbia) 108923979
PKI: 111841750 111852632(nfkbia)
AANG: 118208283(nfkbiab) 118228785
LOC: 102689470(nfkbia)
ARUT: 117404215(nfkbiab) 117421916
LCM: 102347685(NFKBIA)
DME: Dmel_CG5848(cact)
DER: 6541508
DSE: 6613688
DSI: Dsimw501_GD21920(Dsim_cact)
DYA: Dyak_GE19366(Dyak_cact)
DAN: 6498137
DSR: 110181207
DPO: 4817779
DPE: 6595565
DMN: 108161888
DWI: 6641720
DGR: 6561875
DAZ: 108610290
DNV: 115563171
DHE: 111602535
DVI: 6627730
MDE: 101889324
LCQ: 111690732
HIS: 119647312
AGA: AgaP_AGAP007938(CACT)
ACOZ: 120955925
AARA: 120905010
ASTE: 118514049
AAG: 5565922
CNS: 116344516
BCOO: 119066773
AME: 411012 725124(cact1)
BIM: 100743215
BBIF: 117212345
BVK: 117238112
BVAN: 117164883
BTER: 100631059
BPYO: 122567028
CCAL: 108623776
OBB: 114877652
MGEN: 117226543
NMEA: 116432602
CGIG: 122397864
SOC: 105201775
HST: 105190318
DQU: 106741205
CFO: 105252756
PCF: 106787186
PFUC: 122516828
VPS: 122631393
MDL: 103575229
FAS: 105267637
DAM: 107044825
AGIF: 122851834
CCIN: 107268118
TCA: 657221(Cact)
DPA: 109538735
SOY: 115887424
ATD: 109594517
NVL: 108561090
APLN: 108743408
OTU: 111415171
BMOR: 100379185(cact)
BMAN: 114247299
MSEX: 115440475
BANY: 112043665
PMAC: 106712709
PPOT: 106106715
PXU: 106126477
PRAP: 111003662
HAW: 110376896
HZE: 124629681
TNL: 113497565
SLIU: 111348099
OFU: 114349973
PXY: 105384975
API: 100165906(Cact)
RMD: 113553728
BTAB: 109032736
DCI: 103524536
CLEC: 106667081
HHAL: 106680363
NLU: 111044271
FOC: 113204144
TPAL: 117654524
ZNE: 110829682
CSEC: 111862695
FCD: 110843006
DMK: 116924360
PVM: 113823636
PJA: 122245911
PCHN: 125026585
HAME: 121873160
PCLA: 123771684
PTRU: 123509076
HAZT: 108679557
EAF: 111711252
LSM: 121131883
DSV: 119463368
RSAN: 119401458
RMP: 119164101
TUT: 107365267
DPTE: 113791661
CSCU: 111620617
PTEP: 107445253
PCAN: 112570145
MYI: 110461481
PMAX: 117323637
OBI: 106873926
LAK: 106165565
NVE: 116612001
ADF: 107347858
AMIL: 114962641
PDAM: 113684444
SPIS: 111336823
DGT: 114530301
 » show all
Spencer E, Jiang J, Chen ZJ
Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.
Genes Dev 13:284-94 (1999)
Hatakeyama S, Kitagawa M, Nakayama K, Shirane M, Matsumoto M, Hattori K, Higashi H, Nakano H, Okumura K, Onoe K, Good RA, Nakayama K
Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
Proc Natl Acad Sci U S A 96:3859-63 (1999)
Haskill S, Beg AA, Tompkins SM, Morris JS, Yurochko AD, Sampson-Johannes A, Mondal K, Ralph P, Baldwin AS Jr
Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.
Cell 65:1281-9 (1991)

DBGET integrated database retrieval system