KEGG ORTHOLOGY: K04838

ORTHOLOGY: K04838

Entry

K04838 KO

Name

SCN5A, NAV1.5

Definition

voltage-gated sodium channel type V alpha

Pathway

ko04261

Adrenergic signaling in cardiomyocytes

Disease

H00294

Dilated cardiomyopathy

H00720

Long QT syndrome

H00728

Brugada syndrome

H00729

Sick sinus syndrome

H00730

Familial idiopathic ventricular fibrillation

H00731

Atrial fibrillation

H01263

Progressive cardiac conduction defect (PCCD)

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04838  SCN5A, NAV1.5; voltage-gated sodium channel type V alpha
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04838  SCN5A, NAV1.5; voltage-gated sodium channel type V alpha
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Sodium channel, voltage-gated (Nav)
   K04838  SCN5A, NAV1.5; voltage-gated sodium channel type V alpha

Other DBs

GO:

0005248

TC:	1.A.1.10.3

Genes

HSA:	6331(SCN5A)

PTR:	747523(SCN5A)

PPS:	100992941(SCN5A)

GGO:	101149930(SCN5A)

PON:	100459117(SCN5A)

NLE:	100598395(SCN5A)

MCC:	695085(SCN5A)

MCF:	102120184(SCN5A)

CSAB:

103221052(SCN5A)

RRO:	104668732(SCN5A)

RBB:	108513787(SCN5A)

CJC:	100414601(SCN5A)

SBQ:	101049906(SCN5A)

MMU:	20271(Scn5a)

MCAL:

110301251(Scn5a)

MPAH:

110327174(Scn5a)

RNO:	25665(Scn5a)

MUN:	110555054(Scn5a)

CGE:	100751166(Scn5a)

NGI:	103736659(Scn5a)

HGL:	101710111(Scn5a)

CCAN:

109695727(Scn5a)

OCU:	100009516(SCN5A)

TUP:	102496922(SCN5A)

CFA:	403497(SCN5A)

VVP:	112921648(SCN5A)

AML:	100474866(SCN5A)

UMR:	103680654(SCN5A)

UAH:	113253790(SCN5A)

ORO:	101385643(SCN5A)

ELK:

111159034

FCA:	101100994(SCN5A)

PTG:	102950274(SCN5A)

PPAD:

109248762(SCN5A)

AJU:	106966698(SCN5A)

BTA:	282061(SCN5A)

BOM:	102278540(SCN5A)

BIU:	109576489(SCN5A)

BBUB:

102391734(SCN5A)

CHX:	102176565(SCN5A)

OAS:	101111582(SCN5A)

SSC:	100152567(SCN5A)

CFR:	102515216(SCN5A)

CDK:	105084646(SCN5A)

BACU:

103007817(SCN5A)

LVE:	103071162(SCN5A)

OOR:	101283432(SCN5A)

DLE:	111169457(SCN5A)

PCAD:

102989289(SCN5A)

ECB:	100034027(SCN5A)

EPZ:	103561075(SCN5A)

EAI:	106842860(SCN5A)

MYB:	102240070(SCN5A)

MYD:	102759220(SCN5A)

MNA:	107524300(SCN5A)

HAI:	109393494(SCN5A)

DRO:	112309499(SCN5A)

PALE:

102891452(SCN5A)

RAY:	107499591(SCN5A)

MJV:

108386093

TMU:

101343697

MDO:	100653514(SCN5A)

SHR:

100925158

PCW:

110197030

OAA:

100087403

GGA:	395947(SCN5A)

MGP:	100543469 100543777

CJO:

NMEL:

APLA:

ACYG:

TGU:	100221337 100223270

LSR:	110484531 110484562

SCAN:

103812707 103813057

GFR:	102041347 102045246(SCN5A)

FAB:

101819537

PHI:	102107374(SCN5A)

PMAJ:

107200857 107200876

CCAE:

111925517 111925519

CCW:	104686420(SCN5A)

ETL:	114062267 114062271 114069650 114069651

FPG:	101918751(SCN5A) 101922203

FCH:	102048607 102049132

CLV:	102083872(SCN5A)

EGZ:	104130965 104130992

NNI:	104014886 104014897

ACUN:

113476226 113476396

PADL:

103915628(SCN5A) 103915646

AAM:	106490283(SCN5A)

ASN:	102373313 102380629

AMJ:

PSS:

CMY:

CPIC:

ACS:	100565207(scn5a)

PVT:	110071930 110071940

PMUR:

107303298 107303320

PMUA:

114607605 114607606

GJA:

107111187

XLA:	108718723 108719816

XTR:	100485924(scn5a)

NPR:

108784628

DRE:	566868(scn5lab) 795688(scn12aa)

SRX:	107713684 107714271 107729959 107742187

SANH:

107655859 107687137

SGH:	107558292 107560363 107600242

CCAR:

109112823

IPU:	100304599 100305061(Scn5a)

PHYP:

113526553 113533320

AMEX:

103035061 103037861

EEE:

113583377

TRU:	101080087 115251225

TNG:	GSTEN00015107G001

LCO:	104932209 104934211

NCC:

104962026

MZE:	101467375 101474809

ONL:	100699433 100703031

OLA:	101159774 101167997

XMA:	102230440 102233709

XCO:	114136410 114147123

PRET:

103456963 103478857

CVG:

107097019

NFU:	107384272 107396589

KMR:

ALIM:

AOCE:

CSEM:

POV:

LCF:	108883904 108884986

SDU:	111228889 111237388

SLAL:

111666512 111671160

HCQ:	109512821 109515232

BPEC:

110167658 110170382

MALB:

109962644 109972753

SASA:

106569797 106579582 106590371

OTW:

112227769

SALP:

111953617 112068568

ELS:	105022927 105030614

SFM:	108927986 108931972

PKI:	111849749 111850087

LCM:	102348434 102361559

CMK:

103188289

» show all

Reference

PMID:25422141

Authors

Zhang H, Zou B, Du F, Xu K, Li M

Title

Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.

Journal

Mol Pharmacol 87:207-17 (2015)
DOI:10.1124/mol.114.094789

Sequence

[hsa:6331]

LinkDB

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