KEGG   ORTHOLOGY: K04851Help
Entry
K04851                      KO                                     

Name
CACNA1D, CAV1.3
Definition
voltage-dependent calcium channel L type alpha-1D
Pathway
ko04010  MAPK signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04218  Cellular senescence
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04361  Axon regeneration
ko04530  Tight junction
ko04713  Circadian entrainment
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04921  Oxytocin signaling pathway
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04927  Cortisol synthesis and secretion
ko04929  GnRH secretion
ko04930  Type II diabetes mellitus
ko04934  Cushing syndrome
ko04973  Carbohydrate digestion and absorption
ko05010  Alzheimer disease
ko05031  Amphetamine addiction
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ko05414  Dilated cardiomyopathy (DCM)
Disease
H01603  Primary aldosteronism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04020 Calcium signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04024 cAMP signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04022 cGMP-PKG signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04929 GnRH secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04912 GnRH signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04921 Oxytocin signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04924 Renin secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04925 Aldosterone synthesis and secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04927 Cortisol synthesis and secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04261 Adrenergic signaling in cardiomyocytes
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04270 Vascular smooth muscle contraction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09156 Nervous system
   04724 Glutamatergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04727 GABAergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04725 Cholinergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04728 Dopaminergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04726 Serotonergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04723 Retrograde endocannabinoid signaling
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09158 Development and regeneration
   04361 Axon regeneration
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09165 Substance dependence
   05031 Amphetamine addiction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy (HCM)
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05414 Dilated cardiomyopathy (DCM)
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04934 Cushing syndrome
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
BRITE hierarchy
Other DBs
GO: 0005245
TC: 1.A.1.11.1 1.A.1.11.20 1.A.1.11.21
Genes
HSA: 776(CACNA1D)
PTR: 460447(CACNA1D)
PPS: 100975108(CACNA1D)
GGO: 101140987(CACNA1D)
PON: 100453904(CACNA1D)
NLE: 100600997(CACNA1D)
MCC: 693924(CACNA1D)
MCF: 102138213(CACNA1D)
CSAB: 103227762(CACNA1D)
RRO: 104672388(CACNA1D)
RBB: 108515198(CACNA1D)
CJC: 100397940(CACNA1D)
SBQ: 101043152(CACNA1D)
MMU: 12289(Cacna1d)
MCAL: 110309492(Cacna1d)
MPAH: 110325961(Cacna1d)
RNO: 29716(Cacna1d)
MUN: 110547567(Cacna1d)
CGE: 100772497(Cacna1d)
NGI: 103749025(Cacna1d)
HGL: 101714832(Cacna1d)
CCAN: 109674812(Cacna1d)
OCU: 100327259(CACNA1D)
TUP: 102484770(CACNA1D)
CFA: 484724(CACNA1D)
VVP: 112910069(CACNA1D)
AML: 100467700(CACNA1D)
UMR: 103674739(CACNA1D)
UAH: 113256986(CACNA1D)
ORO: 101383514(CACNA1D)
FCA: 101088394(CACNA1D)
PTG: 102958456(CACNA1D)
AJU: 106986998(CACNA1D)
BTA: 408013(CACNA1D)
BOM: 102271623(CACNA1D)
BIU: 109576190(CACNA1D)
BBUB: 102405249(CACNA1D)
PHD: 102335896(CACNA1D)
CHX: 102174706(CACNA1D)
OAS: 101106371(CACNA1D)
SSC: 100511102(CACNA1D)
CFR: 102504854(CACNA1D) 106729659
CDK: 105093176(CACNA1D) 105093797
BACU: 103001906(CACNA1D)
LVE: 103074544(CACNA1D)
OOR: 101276749(CACNA1D)
DLE: 111174277(CACNA1D)
PCAD: 102976068(CACNA1D)
ECB: 100051186(CACNA1D)
EAI: 106822066(CACNA1D)
MYB: 102259218(CACNA1D)
MYD: 102761441(CACNA1D)
MNA: 107534931(CACNA1D)
HAI: 109395944(CACNA1D)
RSS: 109443619(CACNA1D)
DRO: 112301160(CACNA1D)
PALE: 102888351(CACNA1D)
RAY: 107513736 107516535(CACNA1D)
LAV: 100659992(CACNA1D)
MDO: 100014450(CACNA1D)
SHR: 100919750(CACNA1D)
PCW: 110197022(CACNA1D)
OAA: 100077296(CACNA1D)
GGA: 395895(CACNA1D)
MGP: 100545748(CACNA1D)
CJO: 107319871(CACNA1D)
NMEL: 110404743(CACNA1D)
APLA: 101803307(CACNA1D)
ACYG: 106048937(CACNA1D)
TGU: 100226925(CACNA1D)
LSR: 110471933(CACNA1D)
SCAN: 103816992(CACNA1D)
GFR: 102035179(CACNA1D)
FAB: 101819434(CACNA1D)
PHI: 102103301(CACNA1D)
PMAJ: 107210294(CACNA1D)
CCAE: 111935128(CACNA1D)
CCW: 104683258(CACNA1D)
ETL: 114058704(CACNA1D)
FPG: 101912795(CACNA1D)
FCH: 102054190(CACNA1D)
CLV: 102091108(CACNA1D)
EGZ: 104126731(CACNA1D)
NNI: 104010825(CACNA1D)
ACUN: 113484825(CACNA1D)
PADL: 103925489(CACNA1D)
AAM: 106488627(CACNA1D)
ASN: 102373960(CACNA1D)
AMJ: 102576817(CACNA1D)
PSS: 102447276(CACNA1D)
CMY: 102934282(CACNA1D)
CPIC: 101951786(CACNA1D)
ACS: 100554865(cacna1d)
PVT: 110084495(CACNA1D)
PBI: 103056075(CACNA1D)
PMUR: 107287678(CACNA1D)
GJA: 107116832(CACNA1D)
XLA: 100462912(cacna1d.L) 108704388
NPR: 108786047(CACNA1D)
DRE: 403310(cacna1da)
IPU: 108265454(cacna1d) 108281043
PHYP: 113533266(cacna1d) 113539515
AMEX: 103033357(cacna1d) 103043956
TRU: 101066777(cacna1d) 101070235
MZE: 101474865(cacna1d) 101485620
OLA: 101157531 101171831(cacna1d)
XMA: 102234425(cacna1d)
XCO: 114135515 114148180(cacna1d)
PRET: 103465120 103468016(cacna1d)
KMR: 108236775(cacna1d) 108247381
LCF: 108886531 108891636(cacna1d)
HCQ: 109517788(cacna1d) 109522320
BPEC: 110168588 110174734(cacna1d)
MALB: 109951925 109970859(cacna1d)
ELS: 105006991 105007355(cacna1d)
SFM: 108925619(cacna1d) 108933838
PKI: 111833375(cacna1d) 111852542
LCM: 102360815(CACNA1D)
CMK: 103185068(cacna1d)
CIN: 100184376
SPU: 578128
APLC: 110974142
SKO: 100371433
DME: Dmel_CG4894(Ca-alpha1D)
DER: 6543266
DPE: 6598125
DSI: Dsimw501_GD24041(Dsim_GD24041)
DWI: 6643675
DAZ: 108611419
DHE: 111594149
MDE: 101899996
AAG: 5574639
AME: 100578899
BIM: 100746891
BTER: 100649439
SOC: 105195131
MPHA: 105827888
AEC: 105144165
PBAR: 105427526
VEM: 105568891
HST: 105183370
DQU: 106749620
CFO: 105255351
LHU: 105672748
PGC: 109853346
OBO: 105280692
PCF: 106788672
NVI: 100119154
MDL: 103575476
TCA: 659557
DPA: 109541068
NVL: 108568734
PXY: 105386242
API: 100160955
DNX: 107169074
AGS: 114121007
BTAB: 109041122
CLEC: 106672043
ZNE: 110839478
TUT: 107359653
CEL: CELE_C48A7.1(egl-19)
CBR: CBG05858(Cbr-egl-19)
BMY: Bm1_39550
PCAN: 112571409
CRG: 105345994
MYI: 110461243
OBI: 106872359
LAK: 106176729
PDAM: 113686524
SPIS: 111341163
SMIN: v1.2.021642.t1(symbB.v1.2.021642.t1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nurnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nurnberg P, Striessnig J, Bolz HJ
  Title
Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness.
  Journal
Nat Neurosci 14:77-84 (2011)
DOI:10.1038/nn.2694
Reference
PMID:1309948
  Authors
Seino S, Chen L, Seino M, Blondel O, Takeda J, Johnson JH, Bell GI
  Title
Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.
  Journal
Proc Natl Acad Sci U S A 89:584-8 (1992)
DOI:10.1073/pnas.89.2.584
  Sequence
[hsa:776]
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