KEGG   ORTHOLOGY: K04857
Entry
K04857                      KO                                     

Name
CACNA1S, CAV1.1
Definition
voltage-dependent calcium channel L type alpha-1S
Pathway
ko04010  MAPK signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04723  Retrograde endocannabinoid signaling
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04921  Oxytocin signaling pathway
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04927  Cortisol synthesis and secretion
ko04929  GnRH secretion
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko05010  Alzheimer disease
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05410  Hypertrophic cardiomyopathy
ko05412  Arrhythmogenic right ventricular cardiomyopathy
ko05414  Dilated cardiomyopathy
Disease
H00215  Periodic paralysis
H00746  Hypokalemic periodic paralysis (HypoPP)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04020 Calcium signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04024 cAMP signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04022 cGMP-PKG signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04929 GnRH secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04912 GnRH signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04921 Oxytocin signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04935 Growth hormone synthesis, secretion and action
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04924 Renin secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04925 Aldosterone synthesis and secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04927 Cortisol synthesis and secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04261 Adrenergic signaling in cardiomyocytes
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04270 Vascular smooth muscle contraction
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09156 Nervous system
   04727 GABAergic synapse
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04725 Cholinergic synapse
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04726 Serotonergic synapse
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04723 Retrograde endocannabinoid signaling
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05020 Prion disease
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05022 Pathways of neurodegeneration - multiple diseases
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05414 Dilated cardiomyopathy
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
Other DBs
GO: 0005245
TC: 1.A.1.11.2
Genes
HSA: 779(CACNA1S)
PTR: 469635(CACNA1S)
PPS: 100982136(CACNA1S)
GGO: 101150507(CACNA1S)
PON: 100433948(CACNA1S)
NLE: 100589614(CACNA1S)
MCC: 708706(CACNA1S)
MCF: 102131553(CACNA1S)
CSAB: 103230339(CACNA1S)
RRO: 104661868(CACNA1S)
RBB: 108545075(CACNA1S)
CJC: 100390112(CACNA1S)
SBQ: 101042219(CACNA1S)
MMU: 12292(Cacna1s)
MCAL: 110296075(Cacna1s)
MPAH: 110322010(Cacna1s)
RNO: 682930(Cacna1s)
MUN: 110548425(Cacna1s)
CGE: 100765508(Cacna1s)
NGI: 103731814(Cacna1s)
HGL: 101726232(Cacna1s)
CCAN: 109696593
OCU: 100009585(CACNA1S)
TUP: 102481015(CACNA1S)
CFA: 490244(CACNA1S)
VVP: 112934538(CACNA1S)
AML: 100472835(CACNA1S)
UMR: 103657769(CACNA1S)
UAH: 113242563(CACNA1S)
ORO: 101385947(CACNA1S)
ELK: 111150995
FCA: 654399(CACNA1S)
PTG: 102949808(CACNA1S)
PPAD: 109256096(CACNA1S)
AJU: 106974264(CACNA1S)
BTA: 100337204(CACNA1S)
BOM: 102272241(CACNA1S)
BBUB: 102397191(CACNA1S)
CHX: 102176151(CACNA1S)
OAS: 101108767(CACNA1S)
SSC: 100622149(CACNA1S)
CFR: 102507309(CACNA1S)
CDK: 105090835(CACNA1S)
BACU: 103014409(CACNA1S)
LVE: 103090575(CACNA1S)
OOR: 101275416(CACNA1S)
DLE: 111168340(CACNA1S)
PCAD: 102987099(CACNA1S)
ECB: 100034092(CACNA1S)
EPZ: 103565109(CACNA1S)
EAI: 106823553(CACNA1S)
MYB: 102243265(CACNA1S)
MYD: 102760374(CACNA1S)
MNA: 107536018(CACNA1S)
HAI: 109380439(CACNA1S)
DRO: 112318756(CACNA1S)
PALE: 102896136(CACNA1S)
RAY: 107513628(CACNA1S)
MJV: 108396001(CACNA1S)
LAV: 100673089(CACNA1S)
TMU: 101343945
MDO: 100013684(CACNA1S)
SHR: 100917433(CACNA1S)
PCW: 110219570(CACNA1S)
OAA: 100093447(CACNA1S)
GGA: 395985(CATSPER2)
MGP: 100547445(CACNA1S)
CJO: 107324611(CACNA1S)
NMEL: 110388201(CACNA1S)
APLA: 101801311(CACNA1S)
ACYG: 106046137(CACNA1S)
TGU: 100220193(CACNA1S)
LSR: 110469152(CACNA1S)
SCAN: 103822432(CACNA1S)
GFR: 102037957(CACNA1S)
FAB: 101821759(CACNA1S)
PHI: 102111358(CACNA1S)
PMAJ: 107214754(CACNA1S)
CCAE: 111939717(CACNA1S)
CCW: 104692446(CACNA1S)
ETL: 114064775(CACNA1S)
FPG: 101914764(CACNA1S)
FCH: 102058184(CACNA1S)
CLV: 102092229(CACNA1S)
EGZ: 104122032(CACNA1S)
NNI: 104011070(CACNA1S)
ACUN: 113488965(CACNA1S)
PADL: 103913818(CACNA1S)
AAM: 106500235(CACNA1S)
ASN: 102377229(CACNA1S)
AMJ: 102563699(CACNA1S)
PSS: 102453880
CPIC: 101932307(CACNA1S)
ACS: 100551605(cacna1s)
PVT: 110085291(CACNA1S)
PBI: 103055781(CACNA1S)
PMUR: 107289042(CACNA1S)
TSR: 106549619(CACNA1S)
PMUA: 114599194(CACNA1S)
GJA: 107110972(CACNA1S)
XLA: 100381134(cacna1s.S) 108707491
XTR: 100485035(cacna1s)
NPR: 108804869(CACNA1S)
DRE: 405791(cacna1sb) 570683(cacna1sa)
SRX: 107707674 107711920
SANH: 107667627 107669632 107679379
SGH: 107550462 107572552 107591792
CCAR: 109068176
IPU: 108254927 108266034(CAC1S)
PHYP: 113526802(cacna1s)
AMEX: 103022292 103036105
EEE: 113581084 113586976(cacna1s)
TRU: 101064508 101065120
TNG: GSTEN00015785G001 GSTEN00028107G001
LCO: 104932670(cacna1s)
NCC: 104956859(cacna1s)
MZE: 101479917(cacna1s)
ONL: 100704349(cacna1s)
OLA: 101160313 101170269
XMA: 102237099(cacna1s)
XCO: 114148648(cacna1s)
PRET: 103467335(cacna1s)
CVG: 107086768(cacna1s)
NFU: 107390862(cacna1s)
KMR: 108244587
ALIM: 106525038(cacna1s)
AOCE: 111564440(cacna1s) 111586752
CSEM: 103385091 103386795
POV: 109630550(cacna1s)
LCF: 108876486 108877469
SDU: 111219219 111221701
SLAL: 111668619 111668912
HCQ: 109521358 109531393
BPEC: 110164965(cacna1s)
MALB: 109968827(cacna1s)
SASA: 106565294 106567031 106583479
OTW: 112255319
SALP: 111962608 111970366 111976724
ELS: 105013561 105016828
SFM: 108931184 108933625(cacna1s)
PKI: 111834368 111858929
LCM: 102356715(CACNA1S)
CMK: 103190861
RTP: 109922317
CRG: 105331673
PTM: GSPATT00027650001 GSPATT00029652001
 » show all
Reference
  Authors
Pirone A, Schredelseker J, Tuluc P, Gravino E, Fortunato G, Flucher BE, Carsana A, Salvatore F, Grabner M
  Title
Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavalpha1S-subunit.
  Journal
Am J Physiol Cell Physiol 299:C1345-54 (2010)
DOI:10.1152/ajpcell.00008.2010
  Sequence
[hsa:779]
Reference
PMID:8004673
  Authors
Ptacek LJ, Tawil R, Griggs RC, Engel AG, Layzer RB, Kwiecinski H, McManis PG, Santiago L, Moore M, Fouad G, et al.
  Title
Dihydropyridine receptor mutations cause hypokalemic periodic paralysis.
  Journal
Cell 77:863-8 (1994)
DOI:10.1016/0092-8674(94)90135-X
  Sequence
[hsa:779]
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