KEGG   ORTHOLOGY: K04859
Entry
K04859                      KO                                     

Name
CACNA2D2
Definition
voltage-dependent calcium channel alpha-2/delta-2
Pathway
ko04010  MAPK signaling pathway
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04921  Oxytocin signaling pathway
ko05410  Hypertrophic cardiomyopathy
ko05412  Arrhythmogenic right ventricular cardiomyopathy
ko05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
   04261 Adrenergic signaling in cardiomyocytes
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
   05414 Dilated cardiomyopathy
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
Other DBs
GO: 0005245
TC: 8.A.18.2
Genes
HSA: 9254(CACNA2D2)
PTR: 460396(CACNA2D2)
PPS: 100995074(CACNA2D2)
PON: 100451685(CACNA2D2)
NLE: 100594884(CACNA2D2)
MCC: 702429(CACNA2D2)
MCF: 102115452(CACNA2D2)
CSAB: 103227681(CACNA2D2)
RRO: 104667936(CACNA2D2)
RBB: 108526929(CACNA2D2)
CJC: 100408470(CACNA2D2)
SBQ: 101041145(CACNA2D2)
MMU: 56808(Cacna2d2)
MCAL: 110301155(Cacna2d2)
MPAH: 110327210(Cacna2d2)
RNO: 300992(Cacna2d2)
MUN: 110564620(Cacna2d2)
CGE: 100769472(Cacna2d2)
NGI: 103750148(Cacna2d2)
HGL: 101710707(Cacna2d2)
CCAN: 109693218(Cacna2d2)
OCU: 100340494(CACNA2D2)
TUP: 102494398(CACNA2D2)
CFA: 100688870(CACNA2D2)
VVP: 112910957(CACNA2D2)
AML: 100480599(CACNA2D2)
UMR: 103675085(CACNA2D2)
UAH: 113256916(CACNA2D2)
ORO: 101372567(CACNA2D2)
ELK: 111144160
FCA: 101095887(CACNA2D2)
PTG: 102967999(CACNA2D2)
PPAD: 109247849(CACNA2D2)
AJU: 106979199(CACNA2D2)
BTA: 785909(CACNA2D2)
BOM: 102284671(CACNA2D2)
BIU: 109575879(CACNA2D2)
BBUB: 102393363(CACNA2D2)
CHX: 102175908(CACNA2D2)
OAS: 101115165(CACNA2D2)
SSC: 100517557(CACNA2D2)
CFR: 102517655(CACNA2D2)
CDK: 105087368(CACNA2D2)
BACU: 103003434(CACNA2D2)
LVE: 103076085(CACNA2D2)
OOR: 101280475(CACNA2D2)
DLE: 111174353(CACNA2D2)
PCAD: 102993151
ECB: 100061645(CACNA2D2)
EPZ: 103559270(CACNA2D2)
EAI: 106830655(CACNA2D2)
MYB: 102239809(CACNA2D2)
MNA: 107540175(CACNA2D2)
HAI: 109377855(CACNA2D2)
DRO: 112309612(CACNA2D2)
PALE: 102891516(CACNA2D2)
RAY: 107513293(CACNA2D2)
MJV: 108402854
LAV: 100667110(CACNA2D2)
TMU: 101344991
MDO: 100028700(CACNA2D2)
SHR: 100918097(CACNA2D2)
PCW: 110217120(CACNA2D2)
OAA: 100088778(CACNA2D2)
GGA: 430150(CACNA2D2)
MGP: 100543169(CACNA2D2)
CJO: 107319584(CACNA2D2)
NMEL: 110404640(CACNA2D2)
ACYG: 106042802
TGU: 100232652(CACNA2D2)
LSR: 110469921(CACNA2D2)
SCAN: 103817134(CACNA2D2)
GFR: 102043893(CACNA2D2)
FAB: 101819244(CACNA2D2)
PHI: 102113307(CACNA2D2)
PMAJ: 107210462(CACNA2D2)
CCAE: 111935189(CACNA2D2)
CCW: 104683432(CACNA2D2)
ETL: 114058765(CACNA2D2)
FPG: 101920293(CACNA2D2)
FCH: 102049917(CACNA2D2)
CLV: 102096453(CACNA2D2)
EGZ: 104126694(CACNA2D2)
NNI: 104008753(CACNA2D2)
ACUN: 113484677(CACNA2D2)
PADL: 103915105(CACNA2D2)
AAM: 106485955(CACNA2D2)
ASN: 102380559(CACNA2D2)
AMJ: 102558555(CACNA2D2)
PSS: 102448752(CACNA2D2)
CMY: 102944836(CACNA2D2)
CPIC: 101944341(CACNA2D2)
ACS: 100564773(cacna2d2)
PVT: 110076599(CACNA2D2)
PBI: 103063628(CACNA2D2)
PMUR: 107288727(CACNA2D2)
TSR: 106542392(CACNA2D2)
PMUA: 114590871(CACNA2D2)
GJA: 107116010(CACNA2D2)
XTR: 100038148(cacna2d2)
NPR: 108801947(CACNA2D2)
DRE: 541376(cacna2d2a) 568759(cacna2d2b)
IPU: 108254802(cacna2d2) 108271986
PHYP: 113537403(cacna2d2) 113539524
AMEX: 103024805 103030690(cacna2d2)
TRU: 101072949 101074206(cacna2d2)
LCO: 104919490(cacna2d2) 104931346
MZE: 101472221 101483348(cacna2d2)
ONL: 100701765 102079371(cacna2d2)
OLA: 101155679(cacna2d2) 101156079
PRET: 103464512(cacna2d2) 103464608
CVG: 107089332(cacna2d2) 107102913
NFU: 107385140 107385904(cacna2d2)
KMR: 108231343(cacna2d2) 108247395
ALIM: 106516038 106516127(cacna2d2) 106534307
CSEM: 103385691(cacna2d2) 103385816
POV: 109638508 109638546(cacna2d2)
LCF: 108889381 108899190(cacna2d2)
SDU: 111222853(cacna2d2) 111222860
SLAL: 111653834(cacna2d2) 111660766
BPEC: 110168563(cacna2d2) 110168769
SALP: 111970080(cacna2d2) 111970558 112070377
ELS: 105025419(cacna2d2) 105028112
SFM: 108925615(cacna2d2) 108933831
PKI: 111848782(cacna2d2) 111860018
LCM: 102364100(CACNA2D2)
CMK: 103176814(cacna2d2)
RTP: 109919291
APLC: 110989216
PCAN: 112571742
CRG: 105342560
MYI: 110446696
OBI: 106868291
LAK: 106161874
NVE: 5519294
AMIL: 114963907
DGT: 114524128
 » show all
Reference
  Authors
Carboni GL, Gao B, Nishizaki M, Xu K, Minna JD, Roth JA, Ji L
  Title
CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity.
  Journal
Oncogene 22:615-26 (2003)
DOI:10.1038/sj.onc.1206134
  Sequence
[hsa:9254]
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