KEGG ORTHOLOGY: K05091

ORTHOLOGY: K05091

Entry

K05091                      KO

Symbol

KIT, SCFR, CD117

Name

proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04072

Phospholipase D signaling pathway

map04151

PI3K-Akt signaling pathway

map04640

Hematopoietic cell lineage

map04916

Melanogenesis

map05200

Pathways in cancer

map05221

Acute myeloid leukemia

map05224

Breast cancer

map05230

Central carbon metabolism in cancer

Disease

H00003

Acute myeloid leukemia

H00023

Testicular cancer

H00031

Breast cancer

H00170

Piebaldism

H01511

Mast-cell leukemia

H01591

Gastrotintestinal stromal tumor

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04014 Ras signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04015 Rap1 signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04072 Phospholipase D signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   04151 PI3K-Akt signaling pathway
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  09152 Endocrine system
   04916 Melanogenesis
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05230 Central carbon metabolism in cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
   05224 Breast cancer
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit
CD molecules [BR:ko04090]
Proteins
  K05091  CD117, KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Genes

HSA:

3815(KIT)

PTR:	461316(KIT)

PPS:	100985935(KIT)

GGO:	101126389(KIT)

PON:	100437110(KIT)

PPYG:

129035431(KIT)

NLE:	100603893(KIT)

HMH:	116467540(KIT)

SSYN:

129491016(KIT)

MCC:	696759(KIT)

MCF:	102137242(KIT)

MTHB:

126954735

MNI:	105463525(KIT)

CSAB:

103235672(KIT)

CATY:

105591986(KIT)

PANU:

101021734(KIT)

TGE:	112624589(KIT)

MLEU:

105548468(KIT)

RRO:	104658855(KIT)

RBB:	108533749(KIT)

TFN:	117085603(KIT)

PTEH:

111520450(KIT)

CANG:

105525907(KIT)

CJC:	100411615(KIT)

SBQ:	101037282(KIT)

CIMI:

108312361(KIT)

ANAN:

105709295(KIT)

CSYR:

103249195(KIT)

MMUR:

105867869(KIT)

LCAT:

123624843(KIT)

PCOQ:

105807681(KIT)

OGA:	100961872(KIT)

MMU:	16590(Kit)

MCAL:

110294693(Kit)

MPAH:

110330230(Kit)

RNO:	64030(Kit)

MCOC:

116071281(Kit)

ANU:	117700528 117713018(Kit)

ASYL:

127696112(Kit)

MUN:	110565064(Kit)

CGE:	100751027(Kit)

MAUA:

101833265 101844689(Kit)

PROB:

127232399(Kit)

PLEU:

114683608(Kit)

MORG:

121460800(Kit)

MFOT:

126506503

AAMP:

119799770(Kit)

NGI:	103734391(Kit)

HGL:	101726400(Kit)

CPOC:

100726397(Kit)

CCAN:

109698965(Kit)

DORD:

105980320(Kit)

DSP:	122106872(Kit)

PLOP:

125364419(Kit)

NCAR:

124994841

MMMA:

107139239(Kit)

ITI:	101957209(Kit)

OCU:	100327263(KIT)

OPI:	101536689(KIT)

TUP:	102489301(KIT)

GVR:	103595701(KIT)

CFA:	403811(KIT)

CLUD:

112652143(KIT)

VVP:	112912596 112933391(KIT)

VLG:	121473772(KIT)

NPO:	129505409 129517366 129520654(KIT)

AML:	100465243(KIT)

UMR:	103672804(KIT)

UAH:	113262502(KIT)

UAR:	123803989(KIT)

ELK:

111148912

LLV:

125093731

MPUF:

101685038(KIT)

MNP:	132006358(KIT)

MLK:	131824017(KIT)

NVS:	122890087(KIT)

ORO:	101372059(KIT)

EJU:	114206819(KIT)

ZCA:	113924318(KIT)

MLX:	118010521(KIT)

NSU:	110590818(KIT)

LWW:	102726034(KIT)

FCA:	493766(KIT)

PYU:	121035532(KIT)

PCOO:

112858022(KIT)

PBG:	122478870(KIT)

PVIV:

125164043(KIT)

LRUF:

124520981

PTG:	102960767(KIT)

PPAD:

109278960(KIT)

PUC:

125922732

AJU:

106983989

HHV:	120222581(KIT)

BTA:	280832(KIT)

BOM:	102272986(KIT)

BIU:	109560477(KIT)

BBUB:

102410945(KIT)

BBIS:

105002847(KIT)

CHX:	100861386(KIT)

OAS:	780504(KIT)

BTAX:

128049641(KIT)

CSUM:

138082389(KIT)

ODA:	120862129(KIT)

CCAD:

122428200(KIT)

MREE:

136152904(KIT)

MBEZ:

129561998(KIT)

SSC:	396810(KIT)

CFR:	102521127(KIT)

CBAI:

105077673(KIT)

CDK:	105091541(KIT)

VPC:	102528563(KIT)

BACU:

102999027(KIT)

BMUS:

118895794(KIT)

LVE:	103070834(KIT)

OOR:	101269214(KIT)

DLE:	111169672(KIT)

PCAD:

102985479(KIT)

PSIU:

116754507(KIT)

NASI:

112400776(KIT)

ECB:	100009704(KIT)

EPZ:	103554972(KIT)

EAI:	106839052(KIT)

MYB:	102263655(KIT)

MYD:	102761085(KIT)

MMYO:

118668862(KIT)

MLF:	102442787(KIT)

MDT:	132219013(KIT)

PKL:	118706624(KIT)

EFUS:

103284972(KIT)

MNA:	107532733(KIT)

DRO:	112316812(KIT)

SHON:

118978582(KIT)

AJM:	119054285(KIT)

PDIC:

114491666(KIT)

PHAS:

123815790(KIT)

MMF:	118615155(KIT)

PPAM:

129077640(KIT)

HAI:	109381816(KIT)

RFQ:	117022389(KIT)

PALE:

102895969(KIT)

PGIG:

120588075(KIT)

PVP:	105293773(KIT)

RAY:	107499790(KIT)

MJV:	108391899(KIT)

TOD:	119261155(KIT)

SARA:

101547411(KIT)

SFUM:

130020631(KIT)

SETR:

126032299(KIT)

LAV:	100655943(KIT)

TMU:

101357486

ETF:	101663524(KIT)

DNM:	101427287(KIT)

MDO:	100017501(KIT)

GAS:	123252398(KIT)

SHR:	100929346(KIT)

AFZ:

127539887

PCW:	110200157(KIT)

TVP:	118854059(KIT)

PBRV:

138175016(KIT)

OAA:	100075317(KIT)

GGA:	378783(KIT)

PCOC:

116225917(KIT)

MGP:	100542786(KIT)

CJO:	107313766(KIT)

TPAI:

128080543(KIT)

LMUT:

125692361(KIT)

NMEL:

110398600(KIT)

APLA:

101796083(KIT)

ACYG:

106030824(KIT)

CATA:

118252124(KIT)

AFUL:

116488883(KIT)

TGU:	100221238(KIT)

LSR:	110470402(KIT)

SCAN:

103826188(KIT)

PMOA:

120497505(KIT)

OTC:	121335186(KIT)

PRUF:

121348846(KIT)

GFR:	102042215(KIT)

FAB:	101812754(KIT)

OMA:	130252532(KIT)

PHI:	102103717(KIT)

PMAJ:

107203543(KIT)

CCAE:

111928444(KIT)

CCW:	104690629(KIT)

CBRC:

103622552(KIT)

ACOE:

138109070(KIT)

ETL:	114058322(KIT)

ZAB:	102075290(KIT)

ZLE:	135446531(KIT)

ACHL:

103802033(KIT)

SVG:	106851452(KIT)

MMEA:

130573948(KIT)

HRT:	120752713(KIT)

SATI:

136360060(KIT)

FPG:	101920758(KIT)

FCH:	102058936(KIT)

CCRI:

104163298(KIT)

NNT:	104406866(KIT)

SHAB:

115610740(KIT)

ACUN:

113479223(KIT)

TALA:

104357918(KIT)

ACHC:

115345123(KIT)

HALD:

104322468(KIT)

HLE:	104836172(KIT)

AGEN:

126051783

HHAR:

128138704(KIT)

GCL:

127016029

CSTI:

104549367(KIT)

LDI:	104351254(KIT)

MNB:	103768083(KIT)

DPUB:

104299165(KIT)

PPUS:

135178370(KIT)

AVIT:

104276022(KIT)

BRHI:

104498390

EGZ:	104129461(KIT)

NNI:	104020818(KIT)

PCAO:

104047773(KIT)

PADL:

103926350(KIT)

AFOR:

103897441(KIT)

FGA:	104070340(KIT)

GSTE:

104251374(KIT)

CLV:	102095499(KIT)

MUI:	104544230(KIT)

PGUU:

104458667(KIT)

PLET:

104617186(KIT)

EHS:	104503388(KIT)

CMAC:

104480516(KIT)

CUCA:

104067161(KIT)

TEO:	104383202(KIT)

OHA:	104334921(KIT)

CPEA:

104393068(KIT)

CVF:	104286437(KIT)

RTD:	128909965(KIT)

AAM:	106490087(KIT)

AROW:

112974611(KIT)

NPD:	112942654(KIT)

TGT:	104577327(KIT)

DNE:	112979444(KIT)

SCAM:

104139533(KIT)

ASN:	102378355(KIT)

AMJ:	102573437(KIT)

CPOO:

109322321(KIT)

GGN:	109303657(KIT)

PSS:	102451068(KIT)

CMY:	102935862(KIT)

CCAY:

125635913(KIT)

DCC:	119854727(KIT)

CPIC:

101936545(KIT)

TST:	117878405(KIT)

CABI:

116821226(KIT)

MRV:	120407027(KIT)

ACS:	100551543(kit)

ASAO:

132776650(KIT)

PVT:	110078419(KIT)

SUND:

121930281(KIT)

PBI:	103064280(KIT)

PMUR:

107294049(KIT)

CTIG:

120316820(KIT)

TSR:	106550391 106556266

PGUT:

117662143(KIT)

APRI:

131202949(KIT)

PTEX:

113435806(KIT)

NSS:	113422761(KIT)

VKO:	123017038(KIT)

PMUA:

114604149(KIT)

PRAF:

128420652(KIT)

ZVI:	118083927(KIT)

HCG:	128328467(KIT)

GJA:	107106035(KIT)

STOW:

125440237(KIT)

EMC:	129336533(KIT)

XLA:	373579(kit.L) 373727(g67.L) 373772(kit.S)

XTR:	100216090(kit)

NPR:	108803804(KIT)

RTEM:

120922887(KIT)

BBUF:

120990208(KIT)

BGAR:

122941768(KIT)

MUO:	115461529(KIT)

GSH:	117360835(KIT)

DRE:	30256(kita) 497629(kitb)

SRX:	107718397 107746005 107754153 107755246

SANH:

107656054 107665375 107683958 107702363

SGH:	107551583 107591536 107597437 107601906

CCAR:

109058118 109063396 109070909 109113016

CAUA:

113037949 113044205 113063320 113106610 113106976 113120987

CGIB:

127938097 127963116 127983684 127987524

PTET:

122325240(kita) 122341723(kitb)

LROH:

127171630(kitb) 127183278(kita)

OMC:	131527494(kita) 131532462(kitb)

PPRM:

120493524(kitb) 120493839(kita)

RKG:	130089509(kitb) 130097536(kita)

MAMB:

125272588(kitb) 125277997(kita)

CIDE:

127502651 127520728

CERY:

137018883(kita) 137031967(kitb)

MASI:

127410267 127416228 127443355 127444701

TROS:

130553467(kitb) 130566113(kita)

TDW:	130434613(kita) 130440036(kitb)

MANU:

129428965(kita) 129444735(kitb)

IPU:	108258027(kita) 108260969(kitb)

IFU:	128601015(kita) 128604316(kitb)

PHYP:

113544438 113546833(kit)

SMEO:

124377049(kita) 124381679(kitb)

TFD:	113642585(kita) 113660651(kitb)

TVC:	132843455(kita) 132860868(kitb)

TRN:	134320611(kita) 134326340(kitb)

AMEX:

103022298(kita) 103024973(kitb)

CMAO:

118815386(kita) 118816588(kitb)

EEE:	113586384(kit) 113591595

CHAR:

105895097(kita) 105908497(kitb)

TRU:	101073765(kit) 101078652

TFS:	130527083(kitb) 130528845(kita)

TNG:	GSTEN00006766G001 GSTEN00032762G001

LCO:	104919090 104937413

NCC:	104947075(kit) 104968028

TBEN:

117481679(kitb) 117495115(kita)

CGOB:

115006950(kit) 115014745

PGEO:

117444789(kita) 117445777(kitb)

GACU:

117538061(kitb) 117555074(kita)

EMAC:

134864028(kitb) 134869677(kita)

ELY:	117253553(kita) 117254624(kitb)

EFO:	125886243(kitb) 125895405(kita)

PLEP:

121940439(kita) 121941887(kitb)

SLUC:

116040457(kitb) 116058801(kita)

ECRA:

117936515(kitb) 117950146(kita)

ESP:	116695596(kit) 116706861

PFLV:

114561268(kit) 114570046

GAT:	120824108(kita) 120824891(kitb)

PPUG:

119217068(kita) 119218477(kitb)

AFB:	129094388(kita) 129096503(kitb)

CLUM:

117729797(kita) 117732269(kitb)

PSWI:

130190566(kitb) 130193704(kita)

CANA:

137794951(kitb) 137795395(kita)

CVE:	137883753(kita) 137885398(kitb)

MSAM:

119899140(kitb) 119901063(kita)

SCHU:

122873228(kitb) 122877459(kita)

CUD:	121508502(kitb) 121511801(kita)

SPUL:

138594275(kitb) 138607105(kita)

ALAT:

119028307(kita) 119029433(kitb)

ASTR:

137599178(kita) 137599996(kitb)

MZE:	101472356(kit) 101477603

ONL:	100692323(kit) 100706409

OAU:	116326005(kitb) 116331301(kita)

OLA:	101161964(kit) 101164953

OML:	112137013(kita) 112156999(kitb)

CSAI:

133457133(kitb) 133458270(kita)

XMA:	102225575(kit) 102237809

XCO:	114144177 114151106(kit)

XHE:	116719795 116726148(kit)

PRET:

103463839(kit) 103468941

PFOR:

103137116(kit) 103137773

PLAI:

106954373 106963478(kit)

PMEI:

106918698 106924200(kit)

GAF:	122829997(kitb) 122838006(kita)

PPRL:

129369995(kita)

CVG:	107091570(kit) 107093495

CTUL:

119780619(kita) 119788451(kitb)

GMU:	124868634(kitb) 124874526(kita)

NFU:	107382191 107393389(kit)

KMR:	108241514(kitb) 108243393(kita)

ALIM:

106515208 106524095(kit)

NWH:	119407522(kitb) 119408215(kita)

AOCE:

111569601(kit) 111569809

EJA:	138198923(kita) 138209326(kitb)

BFRE:

138620296(kitb) 138621301(kita)

MCEP:

125003666(kitB) 125009650(kitA)

CSEM:

103376706(kit) 103383759

POV:	109625665(kit) 109637735

SSEN:

122760340(kitb) 122780312(kita)

HHIP:

117760289(kitb) 117760333(kita)

HSP:	118101384(kitb) 118121339(kita)

PPLT:

128434002(kitb) 128448387(kita)

SMAU:

118312626(kitb) 118317853(kita)

LCF:	108879101(kita) 108896458

SDU:	111226336(kit) 111231521

SLAL:

111644342(kit) 111664577

XGL:	120790846(kita) 120800656(kitb)

HCQ:	109511237 109532261(kit)

SSCV:

125968580(kitb) 125970928(kita)

SBIA:

133503120(kita) 133505791(kitb)

PEE:	133404064(kitb) 133405986(kita)

PTAO:

133477078(kitb) 133480406(kita)

BPEC:

110154760(kit) 110172572

MALB:

109958402 109962036

BSPL:

114852997(kitb) 114854103(kita)

SJO:	128361358(kita) 128368926(kitb)

SSCO:

133984479(kita) 133991205(kitb)

SASA:

106560270 106584118(kit) 106591942

STRU:

115158530 115190784 115190837 115192385(kit)

OTW:	112217226 112249117 112251136

OMY:	110513598 110516210 110521672 110524560

OGO:	123997190 124018481 124037858

ONE:	115108535 115145128(kit)

OKI:	109886525 109898026(kit) 109902719 116360108

OKE:	118358651(kita) 118392541 127923922

SALP:

111972317(kit) 111976175

SNH:	120036035(kitb) 120052583(kita) 120054924

CCLU:

121533962 121540154 121551907 121564566(kitb)

ELS:	105011837(kit) 105020866

SFM:	108922805(kit)

PKI:	111850065(kit)

AANG:

118225724(kita) 118226705(kitb)

CCOG:

133120480(kita) 133130824

LOC:	102682431(kit)

PSPA:

121298152 121320044(kita)

ARUT:

117409565 117420778

PSEX:

120527609(kita)

LCM:	102363945(KIT)

CMK:	103178222(kita)

RTP:	109928941(kita)

CPLA:

122550150(kita) 122556473

HOC:

132815303

LERI:

129697451(kita)

PMRN:

116943494 116943571 116955069 116955687 116955693

LRJ:	133347777 133350045(FLT3) 133350110 133350133 133357667 133357749

DSM:

IEL:

DMK:

Reference

PMID:2448137

Authors

Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A

Title

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

Journal

EMBO J 6:3341-51 (1987)
DOI:10.1002/j.1460-2075.1987.tb02655.x

Sequence

[hsa:3815]

Reference

PMID:16226710

Authors

Roskoski R Jr

Title

Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor.

Journal

Biochem Biophys Res Commun 338:1307-15 (2005)
DOI:10.1016/j.bbrc.2005.09.150

Reference

PMID:1698611

Authors

Nocka K, Buck J, Levi E, Besmer P

Title

Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.

Journal

EMBO J 9:3287-94 (1990)
DOI:10.1002/j.1460-2075.1990.tb07528.x

Sequence

[mmu:16590]

LinkDB

DBGET integrated database retrieval system