KEGG   ORTHOLOGY: K05405
Entry
K05405                      KO                                     
Symbol
IL6
Name
interleukin 6
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01523  Antifolate resistance
map04060  Cytokine-cytokine receptor interaction
map04061  Viral protein interaction with cytokine and cytokine receptor
map04066  HIF-1 signaling pathway
map04068  FoxO signaling pathway
map04151  PI3K-Akt signaling pathway
map04218  Cellular senescence
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04625  C-type lectin receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04640  Hematopoietic cell lineage
map04657  IL-17 signaling pathway
map04659  Th17 cell differentiation
map04668  TNF signaling pathway
map04672  Intestinal immune network for IgA production
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04933  AGE-RAGE signaling pathway in diabetic complications
map04936  Alcoholic liver disease
map05010  Alzheimer disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05132  Salmonella infection
map05133  Pertussis
map05134  Legionellosis
map05135  Yersinia infection
map05142  Chagas disease
map05143  African trypanosomiasis
map05144  Malaria
map05146  Amoebiasis
map05152  Tuberculosis
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05321  Inflammatory bowel disease
map05323  Rheumatoid arthritis
map05332  Graft-versus-host disease
map05410  Hypertrophic cardiomyopathy
map05417  Lipid and atherosclerosis
Disease
H00084  Graft-versus-host disease
H00630  Rheumatoid arthritis
H01479  Castleman disease
H01672  Juvenile idiopathic arthritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05405  IL6; interleukin 6
   04668 TNF signaling pathway
    K05405  IL6; interleukin 6
   04066 HIF-1 signaling pathway
    K05405  IL6; interleukin 6
   04068 FoxO signaling pathway
    K05405  IL6; interleukin 6
   04151 PI3K-Akt signaling pathway
    K05405  IL6; interleukin 6
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05405  IL6; interleukin 6
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05405  IL6; interleukin 6
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K05405  IL6; interleukin 6
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05405  IL6; interleukin 6
   04620 Toll-like receptor signaling pathway
    K05405  IL6; interleukin 6
   04621 NOD-like receptor signaling pathway
    K05405  IL6; interleukin 6
   04623 Cytosolic DNA-sensing pathway
    K05405  IL6; interleukin 6
   04625 C-type lectin receptor signaling pathway
    K05405  IL6; interleukin 6
   04659 Th17 cell differentiation
    K05405  IL6; interleukin 6
   04657 IL-17 signaling pathway
    K05405  IL6; interleukin 6
   04672 Intestinal immune network for IgA production
    K05405  IL6; interleukin 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05405  IL6; interleukin 6
   05202 Transcriptional misregulation in cancer
    K05405  IL6; interleukin 6
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05405  IL6; interleukin 6
   05161 Hepatitis B
    K05405  IL6; interleukin 6
   05171 Coronavirus disease - COVID-19
    K05405  IL6; interleukin 6
   05164 Influenza A
    K05405  IL6; interleukin 6
   05162 Measles
    K05405  IL6; interleukin 6
   05168 Herpes simplex virus 1 infection
    K05405  IL6; interleukin 6
   05163 Human cytomegalovirus infection
    K05405  IL6; interleukin 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05405  IL6; interleukin 6
   05169 Epstein-Barr virus infection
    K05405  IL6; interleukin 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05405  IL6; interleukin 6
   05132 Salmonella infection
    K05405  IL6; interleukin 6
   05135 Yersinia infection
    K05405  IL6; interleukin 6
   05133 Pertussis
    K05405  IL6; interleukin 6
   05134 Legionellosis
    K05405  IL6; interleukin 6
   05152 Tuberculosis
    K05405  IL6; interleukin 6
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05405  IL6; interleukin 6
   05144 Malaria
    K05405  IL6; interleukin 6
   05142 Chagas disease
    K05405  IL6; interleukin 6
   05143 African trypanosomiasis
    K05405  IL6; interleukin 6
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05405  IL6; interleukin 6
   05321 Inflammatory bowel disease
    K05405  IL6; interleukin 6
   05332 Graft-versus-host disease
    K05405  IL6; interleukin 6
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K05405  IL6; interleukin 6
   05020 Prion disease
    K05405  IL6; interleukin 6
   05022 Pathways of neurodegeneration - multiple diseases
    K05405  IL6; interleukin 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05405  IL6; interleukin 6
   05410 Hypertrophic cardiomyopathy
    K05405  IL6; interleukin 6
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05405  IL6; interleukin 6
   04932 Non-alcoholic fatty liver disease
    K05405  IL6; interleukin 6
   04931 Insulin resistance
    K05405  IL6; interleukin 6
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05405  IL6; interleukin 6
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05405  IL6; interleukin 6
   01523 Antifolate resistance
    K05405  IL6; interleukin 6
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05405  IL6; interleukin 6
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K05405  IL6; interleukin 6
Other DBs
GO: 0005138
Genes
HSA: 3569(IL6)
PTR: 463288(IL6)
PPS: 100967827(IL6)
GGO: 101151687(IL6)
PON: 100453941(IL6)
NLE: 100586527(IL6)
MCC: 705819(IL6)
MCF: 102138971(IL6)
CSAB: 103226390(IL6)
CATY: 105595383(IL6)
PANU: 100381195(IL6)
TGE: 112621592(IL6)
RRO: 104675233(IL6)
RBB: 108529326(IL6)
TFN: 117072793(IL6)
PTEH: 111545050(IL6)
CJC: 100393440(IL6)
SBQ: 101034757(IL6)
CSYR: 103268608(IL6)
MMUR: 105875882(IL6)
LCAT: 123646908(IL6)
OGA: 100949231(IL6)
MMU: 16193(Il6)
MCAL: 110295330(Il6)
MPAH: 110317140(Il6)
RNO: 24498(Il6)
MCOC: 116097436(Il6)
MUN: 110539463(Il6)
CGE: 100689186(Il6)
MAUA: 101839443(Il6)
PLEU: 114689756(Il6)
MORG: 121439902(Il6)
AAMP: 119808459(Il6)
NGI: 103740849(Il6)
HGL: 101702602(Il6)
CPOC: 106027696(Il6)
CCAN: 109679557(Il6)
DORD: 105991375(Il6)
NCAR: 124990183
OCU: 100008733(IL6)
OPI: 101531329(IL6)
CFA: 403985(IL6)
CLUD: 112670562(IL6)
VVP: 112915865(IL6)
VLG: 121474963(IL6)
AML: 100477151(IL6) 117803984
UMR: 103658871(IL6)
UAH: 113261280(IL6)
UAR: 123788681(IL6)
ELK: 111147365
LLV: 125081177
MPUF: 101671465(IL6)
ORO: 101377851(IL6)
EJU: 114221211(IL6)
ZCA: 113911910(IL6)
MLX: 118020856(IL6)
FCA: 493687(IL6)
PYU: 121028638(IL6)
PBG: 122487989(IL6)
PTG: 102968780(IL6)
PPAD: 109263814(IL6)
AJU: 106982277(IL6)
HHV: 120236228(IL6)
BTA: 280826(IL6)
BOM: 102287919(IL6)
BIU: 109558077(IL6)
BBUB: 102415101(IL6)
CHX: 100860785(IL6)
OAS: 443406(IL6)
ODA: 120878073(IL6)
CCAD: 122438196(IL6)
SSC: 399500(IL6)
CFR: 102515320(IL6)
CBAI: 105079801(IL6)
CDK: 105095065(IL6)
VPC: 102529729(IL6)
BACU: 103008558(IL6)
LVE: 103081545(IL6)
OOR: 101281783(IL6)
DLE: 111181978(IL6)
PCAD: 102980126(IL6)
PSIU: 116759822(IL6)
ECB: 100034196(IL6)
EPZ: 103561141(IL6)
EAI: 106824372(IL6)
MYB: 102243367(IL6)
MYD: 102760336(IL6)
MMYO: 118666134(IL6)
MLF: 102431882(IL6)
MNA: 107540295(IL6)
PKL: 118714203(IL6)
HAI: 109387871(IL6)
DRO: 112306851(IL6)
AJM: 119042560(IL6)
PDIC: 114508090(IL6)
PHAS: 123811876(IL6)
MMF: 118620458(IL6)
RFQ: 117012414(IL6)
PALE: 102895746(IL6)
PGIG: 120602335(IL6)
PVP: 105293152(IL6)
RAY: 107518120(IL6)
MJV: 108398622(IL6)
TOD: 119243289(IL6)
SARA: 101540363(IL6)
LAV: 100660846(IL6)
TMU: 101351590
DNM: 101429481 101443963(IL6)
MDO: 103104339(IL6)
GAS: 123255152(IL6)
SHR: 105750762(IL6)
PCW: 110213115(IL6)
OAA: 100083298(IL6)
GGA: 395337(IL6)
PCOC: 116227028(IL6)
MGP: 100548599(IL6)
CJO: 107309150(IL6)
NMEL: 110394224(IL6)
APLA: 101798321(IL6)
ACYG: 106030150(IL6)
AFUL: 116486491(IL6)
TGU: 100220682(IL6)
LSR: 110474585(IL6)
SCAN: 103813132(IL6)
PMOA: 120501209(IL6)
OTC: 121339595(IL6)
PRUF: 121353190(IL6)
GFR: 102040265(IL6)
FAB: 101806545(IL6)
PHI: 102109522(IL6)
PMAJ: 107215587(IL6)
CCAE: 111924309(IL6)
CCW: 104689316(IL6)
CBRC: 103613552(IL6)
ETL: 114063967(IL6)
ZAB: 102065743(IL6)
FPG: 101911163(IL6)
FCH: 102047657(IL6)
CLV: 102097240(IL6)
EGZ: 104126108(IL6)
NNI: 104013985(IL6)
PLET: 104615743(IL6)
ACUN: 113476314(IL6)
TALA: 104367691(IL6)
PADL: 103918452(IL6)
ACHC: 115339802(IL6)
HALD: 104319966(IL6)
CCRI: 104156476(IL6)
CSTI: 104552073(IL6)
EHS: 104517166(IL6)
FGA: 104076983(IL6)
LDI: 104345065(IL6)
MNB: 103776824(IL6)
AAM: 106483538(IL6)
AROW: 112974163(IL6)
NPD: 112942428(IL6)
DNE: 112986051(IL6)
ASN: 102377828(IL6)
AMJ: 102567649(IL6)
CPOO: 109307916(IL6)
GGN: 109291522(IL6)
PSS: 102450313(IL6)
CMY: 102935916(IL6)
CPIC: 101951588(IL6)
TST: 117871704(IL6)
CABI: 116831337(IL6)
MRV: 120398388(IL6)
ACS: 103279135(il6)
PVT: 110073207(IL6)
SUND: 121935009(IL6)
PBI: 103067562(IL6)
PMUR: 107282781(IL6)
PGUT: 117655168(IL6)
VKO: 123033826(IL6)
ZVI: 118092352(IL6)
GJA: 107116125(IL6)
STOW: 125440811(IL6)
XLA: 108718487(il6.L)
XTR: 100493927(il6)
NPR: 108797293
RTEM: 120940157(IL6)
BBUF: 121002283(IL6)
BGAR: 122939048(IL6)
DRE: 100885851(il6)
SRX: 107755962
CCAR: 109055884
MAMB: 125276183(il6)
IPU: 108257494(il6)
SMEO: 124376403(il6)
TFD: 113661640(il6)
AMEX: 111191914
TRU: 503562(il-6)
NCC: 104965305
CGOB: 115015308
ELY: 117264168
PLEP: 121958089
SLUC: 116066855(il6)
ECRA: 117956362(il6)
PFLV: 114568648
GAT: 120826656
PPUG: 119219687
MSAM: 119903250
CUD: 121524196
ALAT: 119017429
MZE: 101476515
ONL: 102077017
OAU: 116311957
OML: 112137441
CVG: 107085859
CTUL: 119785896
GMU: 124879677
NFU: 107383629
NWH: 119426113
AOCE: 111573783
CSEM: 103394639
POV: 109631714
SSEN: 122785986
HHIP: 117770770
HSP: 118124722
LCF: 108897837
SDU: 111223243
SLAL: 111659317
XGL: 120786412
HCQ: 109513551
BPEC: 110167338
MALB: 109963919
SASA: 106570581(IL6) 106588787
OTW: 112235861(il6) 112264462
OMY: 100136689(il6) 110496949
OGO: 124013382 124042693(il6)
SNH: 120022750 120041044(il6)
ELS: 105012469
SFM: 108933304(il6)
PKI: 111846921(il6)
AANG: 118234251
LOC: 107078662(il6)
PSPA: 121315084(il6)
ARUT: 117394993(il6)
LCM: 102347088(IL6)
CMK: 103185303(il6)
RTP: 109925317(il6) 109925335
 » show all
Reference
  Authors
Fonseca JE, Santos MJ, Canhao H, Choy E
  Title
Interleukin-6 as a key player in systemic inflammation and joint destruction.
  Journal
Autoimmun Rev 8:538-42 (2009)
DOI:10.1016/j.autrev.2009.01.012
Reference
PMID:3500852
  Authors
Yasukawa K, Hirano T, Watanabe Y, Muratani K, Matsuda T, Nakai S, Kishimoto T
  Title
Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.
  Journal
EMBO J 6:2939-45 (1987)
DOI:10.1002/j.1460-2075.1987.tb02598.x
  Sequence
[hsa:3569]
LinkDB

DBGET integrated database retrieval system