KEGG   ORTHOLOGY: K05405Help
Entry
K05405                      KO                                     

Name
IL6
Definition
interleukin 6
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01523  Antifolate resistance
ko04060  Cytokine-cytokine receptor interaction
ko04061  Viral protein interaction with cytokine and cytokine receptor
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04640  Hematopoietic cell lineage
ko04657  IL-17 signaling pathway
ko04659  Th17 cell differentiation
ko04668  TNF signaling pathway
ko04672  Intestinal immune network for IgA production
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05020  Prion diseases
ko05132  Salmonella infection
ko05133  Pertussis
ko05134  Legionellosis
ko05135  Yersinia infection
ko05142  Chagas disease (American trypanosomiasis)
ko05143  African trypanosomiasis
ko05144  Malaria
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05321  Inflammatory bowel disease (IBD)
ko05323  Rheumatoid arthritis
ko05332  Graft-versus-host disease
ko05410  Hypertrophic cardiomyopathy (HCM)
Disease
H00084  Graft-versus-host disease
H01479  Castleman disease
H01672  Juvenile idiopathic arthritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K05405  IL6; interleukin 6
   04668 TNF signaling pathway
    K05405  IL6; interleukin 6
   04066 HIF-1 signaling pathway
    K05405  IL6; interleukin 6
   04068 FoxO signaling pathway
    K05405  IL6; interleukin 6
   04151 PI3K-Akt signaling pathway
    K05405  IL6; interleukin 6
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05405  IL6; interleukin 6
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05405  IL6; interleukin 6
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K05405  IL6; interleukin 6
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05405  IL6; interleukin 6
   04620 Toll-like receptor signaling pathway
    K05405  IL6; interleukin 6
   04621 NOD-like receptor signaling pathway
    K05405  IL6; interleukin 6
   04623 Cytosolic DNA-sensing pathway
    K05405  IL6; interleukin 6
   04625 C-type lectin receptor signaling pathway
    K05405  IL6; interleukin 6
   04659 Th17 cell differentiation
    K05405  IL6; interleukin 6
   04657 IL-17 signaling pathway
    K05405  IL6; interleukin 6
   04672 Intestinal immune network for IgA production
    K05405  IL6; interleukin 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05405  IL6; interleukin 6
   05202 Transcriptional misregulation in cancer
    K05405  IL6; interleukin 6
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05405  IL6; interleukin 6
   05321 Inflammatory bowel disease (IBD)
    K05405  IL6; interleukin 6
   05332 Graft-versus-host disease
    K05405  IL6; interleukin 6
  09164 Neurodegenerative disease
   05020 Prion diseases
    K05405  IL6; interleukin 6
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy (HCM)
    K05405  IL6; interleukin 6
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K05405  IL6; interleukin 6
   04931 Insulin resistance
    K05405  IL6; interleukin 6
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05405  IL6; interleukin 6
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K05405  IL6; interleukin 6
   05135 Yersinia infection
    K05405  IL6; interleukin 6
   05133 Pertussis
    K05405  IL6; interleukin 6
   05134 Legionellosis
    K05405  IL6; interleukin 6
   05152 Tuberculosis
    K05405  IL6; interleukin 6
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05405  IL6; interleukin 6
   05162 Measles
    K05405  IL6; interleukin 6
   05164 Influenza A
    K05405  IL6; interleukin 6
   05161 Hepatitis B
    K05405  IL6; interleukin 6
   05168 Herpes simplex virus 1 infection
    K05405  IL6; interleukin 6
   05163 Human cytomegalovirus infection
    K05405  IL6; interleukin 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05405  IL6; interleukin 6
   05169 Epstein-Barr virus infection
    K05405  IL6; interleukin 6
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05405  IL6; interleukin 6
   05144 Malaria
    K05405  IL6; interleukin 6
   05142 Chagas disease (American trypanosomiasis)
    K05405  IL6; interleukin 6
   05143 African trypanosomiasis
    K05405  IL6; interleukin 6
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05405  IL6; interleukin 6
   01523 Antifolate resistance
    K05405  IL6; interleukin 6
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05405  IL6; interleukin 6
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K05405  IL6; interleukin 6
BRITE hierarchy
Other DBs
GO: 0005138
Genes
HSA: 3569(IL6)
PTR: 463288(IL6)
PPS: 100967827(IL6)
GGO: 101151687(IL6)
PON: 100453941(IL6)
NLE: 100586527(IL6)
MCC: 705819(IL6)
MCF: 102138971(IL6)
CSAB: 103226390(IL6)
RRO: 104675233(IL6)
RBB: 108529326(IL6)
CJC: 100393440(IL6)
SBQ: 101034757(IL6)
MMU: 16193(Il6)
MCAL: 110295330(Il6)
MPAH: 110317140(Il6)
RNO: 24498(Il6)
MUN: 110539463(Il6)
CGE: 100689186(Il6)
NGI: 103740849(Il6)
HGL: 101702602(Il6)
CCAN: 109679557(Il6)
OCU: 100008733(IL6)
CFA: 403985(IL6)
VVP: 112915865(IL6)
AML: 100477151(IL6)
UMR: 103658871(IL6)
UAH: 113261280(IL6)
ORO: 101377851(IL6)
FCA: 493687(IL6)
PTG: 102968780(IL6)
AJU: 106982277(IL6)
BTA: 280826(IL6)
BOM: 102287919(IL6)
BIU: 109558077(IL6)
BBUB: 102415101(IL6)
PHD: 102319665(IL6)
CHX: 100860785(IL6)
OAS: 443406(IL6)
SSC: 399500(IL6)
CFR: 102515320(IL6)
CDK: 105095065(IL6)
BACU: 103008558(IL6)
LVE: 103081545(IL6)
OOR: 101281783(IL6)
DLE: 111181978(IL6)
ECB: 100034196(IL6)
EPZ: 103561141(IL6)
EAI: 106824372(IL6)
MYB: 102243367(IL6)
MYD: 102760336(IL6)
MNA: 107540295(IL6)
HAI: 109387871(IL6)
RSS: 109444944(IL6)
DRO: 112306851(IL6)
PALE: 102895746(IL6)
LAV: 100660846(IL6)
TMU: 101351590
MDO: 103104339(IL6)
SHR: 105750762(IL6)
PCW: 110213115(IL6)
OAA: 100083298(IL6)
GGA: 395337(IL6)
MGP: 100548599(IL6)
CJO: 107309150(IL6)
APLA: 101798321(IL6)
ACYG: 106030150(IL6)
TGU: 100220682(IL6)
LSR: 110474585(IL6)
SCAN: 103813132(IL6)
GFR: 102040265(IL6)
FAB: 101806545(IL6)
PHI: 102109522(IL6)
PMAJ: 107215587(IL6)
CCAE: 111924309(IL6)
CCW: 104689316(IL6)
ETL: 114063967(IL6)
FPG: 101911163(IL6)
FCH: 102047657(IL6)
CLV: 102097240(IL6)
EGZ: 104126108(IL6)
NNI: 104013985(IL6)
ACUN: 113476314(IL6)
AAM: 106483538(IL6)
ASN: 102377828(IL6)
AMJ: 102567649(IL6)
PSS: 102450313(IL6)
CMY: 102935916(IL6)
CPIC: 101951588(IL6)
ACS: 103279135(il6)
PVT: 110073207(IL6)
PBI: 103067562(IL6)
PMUR: 107282781(IL6)
GJA: 107116125(IL6)
XLA: 108718487
XTR: 100493927(il6)
NPR: 108797293
DRE: 100885851(il6)
SRX: 107755962
CCAR: 109055884
IPU: 108257494(il6)
AMEX: 111191914
EEE: 113572039
TRU: 503562(il-6)
LCO: 104922047
NCC: 104965305
MZE: 101476515
XMA: 102227782
NFU: 107383629
KMR: 108238952
CSEM: 103394639
LCF: 108897837
SDU: 111223243
HCQ: 109513551
BPEC: 110167338
SASA: 106570581(IL6) 106588787
OTW: 112235861
ELS: 105012469
SFM: 108933304(il6)
PKI: 111846921(il6)
LCM: 102347088(IL6)
CMK: 103185302 103185303(il6)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Fonseca JE, Santos MJ, Canhao H, Choy E
  Title
Interleukin-6 as a key player in systemic inflammation and joint destruction.
  Journal
Autoimmun Rev 8:538-42 (2009)
DOI:10.1016/j.autrev.2009.01.012
Reference
PMID:3500852
  Authors
Yasukawa K, Hirano T, Watanabe Y, Muratani K, Matsuda T, Nakai S, Kishimoto T
  Title
Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.
  Journal
EMBO J 6:2939-45 (1987)
  Sequence
[hsa:3569]
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