KEGG   ORTHOLOGY: K05410
Entry
K05410                      KO                                     
Symbol
TBK1
Name
TANK-binding kinase 1 [EC:2.7.11.10]
Pathway
map04014  Ras signaling pathway
map04137  Mitophagy - animal
map04140  Autophagy - animal
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04657  IL-17 signaling pathway
map04936  Alcoholic liver disease
map05014  Amyotrophic lateral sclerosis
map05022  Pathways of neurodegeneration - multiple diseases
map05131  Shigellosis
map05135  Yersinia infection
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05417  Lipid and atherosclerosis
Disease
H02342  Frontotemporal dementia and amyotrophic lateral sclerosis
H02536  Infection-induced acute encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05410  TBK1; TANK-binding kinase 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K05410  TBK1; TANK-binding kinase 1
   04137 Mitophagy - animal
    K05410  TBK1; TANK-binding kinase 1
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05410  TBK1; TANK-binding kinase 1
   04621 NOD-like receptor signaling pathway
    K05410  TBK1; TANK-binding kinase 1
   04622 RIG-I-like receptor signaling pathway
    K05410  TBK1; TANK-binding kinase 1
   04623 Cytosolic DNA-sensing pathway
    K05410  TBK1; TANK-binding kinase 1
   04657 IL-17 signaling pathway
    K05410  TBK1; TANK-binding kinase 1
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05410  TBK1; TANK-binding kinase 1
   05161 Hepatitis B
    K05410  TBK1; TANK-binding kinase 1
   05160 Hepatitis C
    K05410  TBK1; TANK-binding kinase 1
   05171 Coronavirus disease - COVID-19
    K05410  TBK1; TANK-binding kinase 1
   05164 Influenza A
    K05410  TBK1; TANK-binding kinase 1
   05162 Measles
    K05410  TBK1; TANK-binding kinase 1
   05168 Herpes simplex virus 1 infection
    K05410  TBK1; TANK-binding kinase 1
   05163 Human cytomegalovirus infection
    K05410  TBK1; TANK-binding kinase 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05410  TBK1; TANK-binding kinase 1
   05169 Epstein-Barr virus infection
    K05410  TBK1; TANK-binding kinase 1
   05165 Human papillomavirus infection
    K05410  TBK1; TANK-binding kinase 1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05410  TBK1; TANK-binding kinase 1
   05135 Yersinia infection
    K05410  TBK1; TANK-binding kinase 1
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K05410  TBK1; TANK-binding kinase 1
   05022 Pathways of neurodegeneration - multiple diseases
    K05410  TBK1; TANK-binding kinase 1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05410  TBK1; TANK-binding kinase 1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05410  TBK1; TANK-binding kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05410  TBK1; TANK-binding kinase 1
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05410  TBK1; TANK-binding kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K05410  TBK1; TANK-binding kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K05410  TBK1; TANK-binding kinase 1
Membrane trafficking [BR:ko04131]
 Autophagy
  Xenophagy
   Other xenophagy associated proteins
    K05410  TBK1; TANK-binding kinase 1
Genes
HSA: 29110(TBK1)
PTR: 452047(TBK1)
PPS: 100990211(TBK1)
GGO: 101138038(TBK1)
PON: 100433568(TBK1)
NLE: 100582856(TBK1)
MCC: 717427(TBK1)
MCF: 102144774(TBK1)
MTHB: 126930857
CSAB: 103238638(TBK1)
CATY: 105600541(TBK1)
PANU: 100999858(TBK1)
TGE: 112635245(TBK1)
RRO: 104680828(TBK1)
RBB: 108529966(TBK1)
TFN: 117089816(TBK1)
PTEH: 111539247 111551230(TBK1)
CANG: 105502730(TBK1)
CJC: 100399701(TBK1)
SBQ: 101053608(TBK1)
CSYR: 103271912(TBK1)
MMUR: 105880966(TBK1)
LCAT: 123639558(TBK1)
PCOQ: 105824183(TBK1)
OGA: 100940759(TBK1)
MMU: 56480(Tbk1)
MCAL: 110303265(Tbk1)
MPAH: 110326206(Tbk1)
RNO: 299827(Tbk1)
MCOC: 116076589(Tbk1)
MUN: 110549049(Tbk1)
CGE: 100770091
MAUA: 101842633(Tbk1)
PLEU: 114693293(Tbk1)
MORG: 121461912(Tbk1)
MFOT: 126515694
AAMP: 119803361(Tbk1)
NGI: 103730726(Tbk1)
HGL: 101713766(Tbk1)
CPOC: 100731956(Tbk1)
CCAN: 109698137(Tbk1)
DORD: 105989073(Tbk1)
DSP: 122124190(Tbk1)
NCAR: 124983333
OCU: 100358771
OPI: 101524697(TBK1)
TUP: 102484078(TBK1)
GVR: 103590122(TBK1)
CFA: 481145(TBK1)
CLUD: 112677914(TBK1)
VVP: 112922304(TBK1)
VLG: 121491543(TBK1)
AML: 100484104(TBK1)
UMR: 103656833(TBK1)
UAH: 113256330(TBK1)
UAR: 123787173(TBK1)
ELK: 111142106
LLV: 125106807
MPUF: 101676992(TBK1)
ORO: 101362394(TBK1)
EJU: 114214962(TBK1)
ZCA: 113921986(TBK1)
MLX: 118008624(TBK1)
NSU: 110570585(TBK1)
LWW: 102749350(TBK1)
FCA: 101091955(TBK1)
PYU: 121040822(TBK1)
PBG: 122473944(TBK1)
LRUF: 124501448
PTG: 102960158(TBK1)
PPAD: 109270431(TBK1)
AJU: 106981360(TBK1)
HHV: 120233179(TBK1)
BTA: 533141(TBK1)
BOM: 102279479(TBK1)
BIU: 109559273(TBK1)
BBUB: 102403644(TBK1)
BBIS: 104989798(TBK1)
CHX: 102181474(TBK1)
OAS: 101110830(TBK1)
ODA: 120857688(TBK1)
CCAD: 122427358(TBK1)
SSC: 100125828(TBK1)
CFR: 102514948(TBK1)
CBAI: 105081359(TBK1)
CDK: 105089261(TBK1)
VPC: 102530199(TBK1)
BACU: 103013353(TBK1)
LVE: 103081814(TBK1)
OOR: 101290315(TBK1)
DLE: 111173795(TBK1)
PCAD: 102994775(TBK1)
PSIU: 116760755(TBK1)
ECB: 100051650(TBK1)
EPZ: 103557811(TBK1)
EAI: 106824389(TBK1)
MYB: 102241250(TBK1)
MYD: 102769631(TBK1)
MMYO: 118651925(TBK1)
MLF: 102424113(TBK1)
MNA: 107527094(TBK1)
PKL: 118730716(TBK1)
HAI: 109381695(TBK1)
DRO: 112319039(TBK1)
SHON: 118998723(TBK1)
AJM: 119045546(TBK1)
PDIC: 114513223(TBK1)
PHAS: 123812878(TBK1)
MMF: 118624185(TBK1)
RFQ: 117028150(TBK1)
PALE: 102878859(TBK1)
PGIG: 120605013(TBK1)
PVP: 105301118(TBK1)
RAY: 107508222(TBK1)
MJV: 108399262(TBK1)
TOD: 119248120(TBK1)
SARA: 101542553(TBK1)
LAV: 100661026(TBK1)
TMU: 101345902
ETF: 101649686(TBK1)
DNM: 101429820(TBK1)
GAS: 123250320(TBK1)
SHR: 100915362(TBK1)
PCW: 110211020(TBK1)
OAA: 100076520(TBK1)
GGA: 417825(TBK1)
PCOC: 116226617(TBK1)
MGP: 100542773(TBK1)
CJO: 107310131(TBK1)
NMEL: 110392745(TBK1)
APLA: 101800085(TBK1)
ACYG: 106047239(TBK1)
AFUL: 116501853(TBK1)
TGU: 100225715(TBK1)
LSR: 110479843(TBK1)
SCAN: 103820400(TBK1)
PMOA: 120499842(TBK1)
OTC: 121339472(TBK1)
PRUF: 121352548(TBK1)
GFR: 102044344(TBK1)
FAB: 101809300(TBK1)
PHI: 102112102(TBK1)
PMAJ: 107204371(TBK1)
CCAE: 111932465(TBK1)
CCW: 104698356(TBK1)
CBRC: 103614801(TBK1)
ETL: 114059395(TBK1)
ZAB: 102060602(TBK1)
ACHL: 103807489(TBK1)
FPG: 101911068(TBK1)
FCH: 102051211(TBK1)
CLV: 102085310(TBK1)
EGZ: 104122201(TBK1)
NNI: 104011019(TBK1)
PLET: 104616382(TBK1)
PCAO: 104047645(TBK1)
ACUN: 113491384(TBK1)
TALA: 104362697(TBK1)
PADL: 103919972(TBK1)
AFOR: 103900421(TBK1)
ACHC: 115336293(TBK1)
HALD: 104317701(TBK1)
HLE: 104828206(TBK1)
AGEN: 126034369
GCL: 127025833
CCRI: 104155212(TBK1)
CSTI: 104550346(TBK1)
EHS: 104503497(TBK1)
CMAC: 104482554(TBK1)
MUI: 104534147(TBK1)
FGA: 104069515(TBK1)
GSTE: 104254181(TBK1)
LDI: 104340499(TBK1)
MNB: 103779532(TBK1)
OHA: 104326820(TBK1)
NNT: 104399433(TBK1)
DPUB: 104305210(TBK1)
PGUU: 104459027(TBK1)
ACAR: 104518023(TBK1)
CPEA: 104388826(TBK1)
AVIT: 104276769(TBK1)
CVF: 104288935(TBK1)
CUCA: 104055187(TBK1)
TEO: 104381288(TBK1)
BRHI: 104489937(TBK1)
AAM: 106488940(TBK1)
AROW: 112968150(TBK1)
NPD: 112958829(TBK1)
TGT: 104574964(TBK1)
DNE: 112978730(TBK1)
SCAM: 104142062(TBK1)
ASN: 102383892(TBK1)
AMJ: 106737001(TBK1)
CPOO: 109315543(TBK1)
GGN: 109295691(TBK1)
PSS: 102457979(TBK1)
CMY: 102938424(TBK1)
CPIC: 101947523(TBK1)
TST: 117877447(TBK1)
CABI: 116821811(TBK1)
MRV: 120383914(TBK1)
ACS: 100553575(tbk1)
PVT: 110075119(TBK1)
SUND: 121931127(TBK1)
PBI: 103049737(TBK1)
PMUR: 107291767(TBK1)
CTIG: 120307413(TBK1)
TSR: 106548060(TBK1)
PGUT: 117655703(TBK1)
VKO: 123019877(TBK1)
PMUA: 114605270(TBK1)
ZVI: 118091139(TBK1)
GJA: 107110994(TBK1)
STOW: 125434685(TBK1)
XLA: 108712371(tbk1.S) 446351(tbk1.L)
XTR: 100216212(tbk1)
NPR: 108804572(TBK1)
RTEM: 120932004(TBK1)
BBUF: 120980341(TBK1)
BGAR: 122928028(TBK1)
DRE: 692289(tbk1)
SANH: 107658761(tbk1) 107662237
CCAR: 109074335(tbk1)
MAMB: 125245043(tbk1)
IPU: 108279669(tbk1)
PHYP: 113532072(tbk1)
SMEO: 124401336(tbk1)
TFD: 113647260(tbk1)
AMEX: 103023014(tbk1)
EEE: 113586262(tbk1)
TRU: 101071013(tbk1)
LCO: 104933406(tbk1)
ELY: 117249427(tbk1)
EFO: 125882857(tbk1)
PLEP: 121961280(tbk1)
SLUC: 116034681(tbk1)
PFLV: 114550466(tbk1)
GAT: 120817720(tbk1)
PPUG: 119210711(tbk1)
MSAM: 119895285(tbk1)
CUD: 121505465(tbk1)
ALAT: 119032484(tbk1)
MZE: 101474803(tbk1)
ONL: 100711888(tbk1)
OAU: 116321846(tbk1)
OLA: 101168192(tbk1)
OML: 112157575(tbk1)
XMA: 102227107(tbk1)
XCO: 114160765(tbk1)
XHE: 116737134(tbk1)
PRET: 103459804(tbk1)
PFOR: 103129555(tbk1)
PLAI: 106939540
PMEI: 106917087(tbk1)
GAF: 122826758(tbk1)
CVG: 107092989(tbk1)
CTUL: 119790587(tbk1)
GMU: 124883140(tbk1)
NFU: 107387745(tbk1)
KMR: 108229325(tbk1)
ALIM: 106529896
NWH: 119427971(tbk1)
AOCE: 111576738(tbk1)
MCEP: 125000296(tbk1)
CSEM: 103382474(tbk1)
POV: 109645317(tbk1)
SSEN: 122766945(tbk1)
HSP: 118101335(tbk1)
LCF: 108882406
SDU: 111229518(tbk1)
SLAL: 111671054(tbk1)
XGL: 120800421(tbk1)
HCQ: 109532591(tbk1)
BPEC: 110161450(tbk1)
MALB: 109967667(tbk1)
BSPL: 114861284(tbk1)
SASA: 100861582(tbk1)
OGO: 124026129(tbk1)
CCLU: 121563465(tbk1)
ELS: 105026533(tbk1)
SFM: 108931981(tbk1)
PKI: 111847018(tbk1)
AANG: 118232151(tbk1)
LOC: 102687024(tbk1)
PSPA: 121318530(tbk1)
ARUT: 117419798(tbk1)
PSEX: 120539645(tbk1)
LCM: 102356087(TBK1)
CMK: 103179820(tbk1)
RTP: 109935579
CIN: 778650(ikk-epsilon)
SCLV: 120338723
SKO: 100372702
DME: Dmel_CG2615(IKKepsilon)
DER: 6548886
DSE: 6618180
DSI: Dsimw501_GD24274(Dsim_GD24274)
DAN: 6498161
DSR: 110184957
DPO: 4816995
DPE: 6589367
DMN: 108163389
DWI: 6642105
DGR: 6562287
DAZ: 108611159
DNV: 108649817
DHE: 111594743
DVI: 6627493
CCAT: 101448706
BOD: 106622227
RZE: 108358749
MDE: 101896529
SCAC: 106083076
LCQ: 111681682
LSQ: 119604733
HIS: 119650979
ACOZ: 120957464
AARA: 120900916
ASTE: 118510642
AAG: 5566387
AALB: 109420658
CPII: 120416603
CNS: 116341159
BCOO: 119078662
AME: 413493
ACER: 107999416
ALAB: 122716694
BIM: 100748635
BBIF: 117209723
BVK: 117235088
BVAN: 117158702
BTER: 100644806
BPYO: 122569381
CCAL: 108629605
OBB: 114871063
MGEN: 117221678
NMEA: 116433124
CGIG: 122396699
SOC: 105203581
MPHA: 105828924
AEC: 105151453
ACEP: 105620284
PBAR: 105426672
VEM: 105561849
HST: 105187659
DQU: 106749034
CFO: 105250722
FEX: 115240033
LHU: 105677180
PGC: 109853369
OBO: 105288233
PCF: 106789451
PFUC: 122522607
VPS: 122637965
NVI: 100122336
CSOL: 105359204
TPRE: 106659803
MDL: 103579561
CGLO: 123266235
FAS: 105272072
DAM: 107048976
AGIF: 122850683
CINS: 118066724
LHT: 122505361
CCIN: 107267072
TCA: 100141977 658218(ik2)
SOY: 115887944
ATD: 109595698
CSET: 123308519
LDC: 111504248
NVL: 108561216
OTU: 111424559
BMOR: 101737865
BMAN: 114243763
MSEX: 115452801
BANY: 112046106
NIQ: 126774776
PMAC: 106715712
PPOT: 106102154
PXU: 106114462
PRAP: 110994808
PBX: 123715977
PNAP: 125049888
ZCE: 119831974
CCRC: 123699261
HAW: 110376308
HZE: 124637926
TNL: 113505335
SLIU: 111363019
OFU: 114361757
PXY: 105395113
CFEL: 113365737
API: 100168269
DNX: 107165510
AGS: 114121351
RMD: 113555489
DCI: 103512606
CLEC: 106666211
HHAL: 106688729
NLU: 111048243
FOC: 113205975
TPAL: 117643106
ZNE: 110836419
CSEC: 111863609
SGRE: 126272613
FCD: 110842355
DMK: 116919393
DPZ: 124342336
PVM: 113828454
PCHN: 125047696
HAME: 121874198
PCLA: 123773107
PTRU: 123511842
HAZT: 108677742
EAF: 111704300
LSM: 121114505
RSAN: 119372539
RMP: 119163178
TUT: 107368313
DPTE: 113796829
DFR: 124490353
CSCU: 111620135
PTEP: 107450450
SDM: 118183469
BMY: BM_BM9065(Bm9065)
OSN: 115210407
NVE: 5516342
ATEN: 116301657
ADF: 107358025
AMIL: 114966040
PDAM: 113678513
SPIS: 111325021
DGT: 114533538
HMG: 100201666
AQU: 100636688
 » show all
Reference
  Authors
Pomerantz JL, Baltimore D
  Title
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
  Journal
EMBO J 18:6694-704 (1999)
DOI:10.1093/emboj/18.23.6694
  Sequence
[hsa:29110]
Reference
  Authors
Kishore N, Huynh QK, Mathialagan S, Hall T, Rouw S, Creely D, Lange G, Caroll J, Reitz B, Donnelly A, Boddupalli H, Combs RG, Kretzmer K, Tripp CS
  Title
IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.
  Journal
J Biol Chem 277:13840-7 (2002)
DOI:10.1074/jbc.M110474200
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