KEGG   ORTHOLOGY: K05425
Entry
K05425                      KO                                     
Symbol
IL12B
Name
interleukin 12B
Pathway
map04060  Cytokine-cytokine receptor interaction
map04620  Toll-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04658  Th1 and Th2 cell differentiation
map04936  Alcoholic liver disease
map04940  Type I diabetes mellitus
map05133  Pertussis
map05134  Legionellosis
map05140  Leishmaniasis
map05142  Chagas disease
map05143  African trypanosomiasis
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05162  Measles
map05164  Influenza A
map05168  Herpes simplex virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05321  Inflammatory bowel disease
map05330  Allograft rejection
map05417  Lipid and atherosclerosis
Disease
H00089  IFN-gamma/IL-12 axis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05425  IL12B; interleukin 12B
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05425  IL12B; interleukin 12B
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04622 RIG-I-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04625 C-type lectin receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04658 Th1 and Th2 cell differentiation
    K05425  IL12B; interleukin 12B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05425  IL12B; interleukin 12B
   05205 Proteoglycans in cancer
    K05425  IL12B; interleukin 12B
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K05425  IL12B; interleukin 12B
   05164 Influenza A
    K05425  IL12B; interleukin 12B
   05162 Measles
    K05425  IL12B; interleukin 12B
   05168 Herpes simplex virus 1 infection
    K05425  IL12B; interleukin 12B
  09171 Infectious disease: bacterial
   05133 Pertussis
    K05425  IL12B; interleukin 12B
   05134 Legionellosis
    K05425  IL12B; interleukin 12B
   05152 Tuberculosis
    K05425  IL12B; interleukin 12B
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05425  IL12B; interleukin 12B
   05145 Toxoplasmosis
    K05425  IL12B; interleukin 12B
   05140 Leishmaniasis
    K05425  IL12B; interleukin 12B
   05142 Chagas disease
    K05425  IL12B; interleukin 12B
   05143 African trypanosomiasis
    K05425  IL12B; interleukin 12B
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05425  IL12B; interleukin 12B
   05330 Allograft rejection
    K05425  IL12B; interleukin 12B
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05425  IL12B; interleukin 12B
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K05425  IL12B; interleukin 12B
   04936 Alcoholic liver disease
    K05425  IL12B; interleukin 12B
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05425  IL12B; interleukin 12B
   00536 Glycosaminoglycan binding proteins
    K05425  IL12B; interleukin 12B
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interleukins
   K05425  IL12B; interleukin 12B
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Cytokines
   K05425  IL12B; interleukin 12B
Other DBs
GO: 0005143
Genes
HSA: 3593(IL12B)
PTR: 471723(IL12B)
PPS: 100989950(IL12B)
GGO: 101141274(IL12B)
PON: 100435254(IL12B)
NLE: 100579267 115837257
HMH: 116471783(IL12B)
MCC: 694747(IL12B)
MCF: 102124858(IL12B)
MTHB: 126957215
MNI: 105482347(IL12B)
CSAB: 103244892(IL12B)
CATY: 105581574(IL12B)
PANU: 100126717(IL12B)
TGE: 112626411(IL12B)
MLEU: 105529523(IL12B)
RRO: 104669104(IL12B)
RBB: 108537933(IL12B)
TFN: 117065537(IL12B)
PTEH: 111547191(IL12B)
CANG: 105515783(IL12B)
CJC: 100395403(IL12B)
SBQ: 101049311(IL12B)
CIMI: 108285116(IL12B)
CSYR: 103265030(IL12B)
MMUR: 105871571(IL12B)
LCAT: 123638007(IL12B)
PCOQ: 105810764(IL12B)
OGA: 100962204(IL12B)
MMU: 16160(Il12b)
MCAL: 110304465(Il12b)
MPAH: 110332403(Il12b)
RNO: 64546(Il12b)
MCOC: 116077653(Il12b)
ANU: 117711474(Il12b)
MUN: 110548438(Il12b)
CGE: 100764758(Il12b)
MAUA: 101843678(Il12b)
PROB: 127219792(Il12b)
PLEU: 114689882(Il12b)
MORG: 121464009(Il12b)
MFOT: 126499523
AAMP: 119811033(Il12b)
NGI: 103724546(Il12b)
HGL: 101701309(Il12b)
CPOC: 100135554(Il12b)
CCAN: 109677112(Il12b)
DORD: 106001299(Il12b)
DSP: 122125036(Il12b)
PLOP: 125342078(Il12b)
NCAR: 124987404
MMMA: 107148164(Il12b)
OCU: 100354852
OPI: 101520638 101523854(IL12B)
TUP: 102499876(IL12B)
GVR: 103607235(IL12B)
CFA: 403976(IL12B)
CLUD: 112651834(IL12B)
VVP: 112928651(IL12B)
VLG: 121486324(IL12B)
NPO: 129509743(IL12B)
AML: 100477772(IL12B)
UMR: 103664531(IL12B)
UAH: 113263879(IL12B)
UAR: 123788629(IL12B)
ELK: 111141150
LLV: 125101014
MPUF: 101676232(IL12B)
MNP: 132027813(IL12B)
MLK: 131831849(IL12B)
NVS: 122901988(IL12B)
ORO: 101372789(IL12B)
EJU: 114211944(IL12B)
ZCA: 113929340(IL12B)
MLX: 118016150(IL12B)
NSU: 110587628(IL12B)
LWW: 102740807(IL12B)
FCA: 768273(IL12B)
PYU: 121010131(IL12B)
PCOO: 112861083(IL12B)
PBG: 122493041(IL12B)
PVIV: 125148412(IL12B)
LRUF: 124520689
PTG: 102959546(IL12B)
PPAD: 109257574(IL12B)
PUC: 125934482
AJU: 106967679
HHV: 120240593(IL12B)
BTA: 281857(IL12B)
BOM: 102283689(IL12B)
BIU: 109561305(IL12B)
BBUB: 102409559(IL12B)
BBIS: 104999734(IL12B)
CHX: 100860845(IL12B)
OAS: 443472(IL12B)
BTAX: 128051514(IL12B)
ODA: 120863361(IL12B)
CCAD: 122439617(IL12B)
MBEZ: 129558692(IL12B)
SSC: 397076(IL12B)
CFR: 102515488(IL12B)
CBAI: 105065241(IL12B)
CDK: 105099900(IL12B)
VPC: 102543998(IL12B)
BACU: 103007028(IL12B)
BMUS: 118893547(IL12B)
LVE: 103083704(IL12B)
OOR: 101272835(IL12B)
DLE: 111170635(IL12B)
PCAD: 102980587(IL12B)
PSIU: 116751765(IL12B)
NASI: 112415192(IL12B)
ECB: 100034222(IL12B)
EPZ: 103547779(IL12B)
EAI: 106832166(IL12B)
MYB: 102253394(IL12B)
MYD: 102756968(IL12B)
MMYO: 118659025(IL12B)
MLF: 102435627(IL12B)
PKL: 118710699(IL12B)
EFUS: 103291598(IL12B)
MNA: 107537877(IL12B)
DRO: 112319648(IL12B)
SHON: 118984138(IL12B)
AJM: 119054378(IL12B)
PDIC: 114510060(IL12B)
PHAS: 123811597(IL12B)
MMF: 118615760(IL12B)
PPAM: 129066360(IL12B)
HAI: 109388897(IL12B)
RFQ: 117016848(IL12B)
PALE: 102884214(IL12B)
PGIG: 120614142(IL12B)
PVP: 105289903(IL12B)
RAY: 107521891(IL12B)
MJV: 108409190(IL12B)
TOD: 119235953(IL12B)
SARA: 101542768(IL12B)
SETR: 126011600(IL12B)
LAV: 100657211(IL12B)
TMU: 101344352
ETF: 101650484(IL12B)
DNM: 101432053(IL12B)
MDO: 100030276(IL12B)
GAS: 123235575(IL12B)
SHR: 100932486(IL12B)
AFZ: 127546715
PCW: 110212378(IL12B)
OAA: 100074930(IL12B)
GGA: 404671(IL12B)
PCOC: 116225955 116231896(IL12B)
MGP: 100303696(IL12B)
CJO: 107306820 107320334(IL12B)
TPAI: 128081483(IL12B)
LMUT: 125700445(IL12B)
NMEL: 110390927 110405552(IL12B)
APLA: 101800211(IL12B)
ACYG: 106034345(IL12B) 106043190
CATA: 118256742(IL12B)
AFUL: 116494936(IL12B)
TGU: 100217488(IL12B) 115494797
LSR: 110468736 110479711(IL12B)
SCAN: 103817383(IL12B) 103823110
PMOA: 120498678(IL12B) 120509207
OTC: 121332435(IL12B)
PRUF: 121365592(IL12B)
GFR: 102044384(IL12B)
FAB: 101814108(IL12B)
OMA: 130258777(IL12B)
PHI: 102100519 102100856(IL12B)
PMAJ: 107202840 107210594(IL12B)
CCAE: 111935760(IL12B)
CCW: 104689490(IL12B) 104690841
CBRC: 103611483(IL12B)
ETL: 114067346(IL12B) 114068872
ZAB: 102064202(IL12B)
ACHL: 103806855(IL12B)
SVG: 106860454(IL12B)
MMEA: 130583417(IL12B)
HRT: 120759324(IL12B)
FPG: 101920686(IL12B)
FCH: 102046968(IL12B) 114014855
CLV: 102097579(IL12B)
EGZ: 104133653(IL12B)
NNI: 104019032(IL12B)
PCRI: 104024355(IL12B)
PLET: 104619834(IL12B)
EHS: 104509798(IL12B)
PCAO: 104053283(IL12B)
ACUN: 113485246(IL12B)
TALA: 104362597(IL12B)
PADL: 103912251(IL12B)
AFOR: 103904300(IL12B)
ACHC: 115334335(IL12B)
HALD: 104316525(IL12B)
HLE: 104839011(IL12B)
AGEN: 126050806
GCL: 127022112
CCRI: 104162398(IL12B)
CSTI: 104550175(IL12B)
CMAC: 104482775(IL12B)
MUI: 104542091(IL12B)
BREG: 104641614(IL12B)
FGA: 104069678(IL12B)
GSTE: 104260245(IL12B)
LDI: 104340042(IL12B)
MNB: 103769572(IL12B)
OHA: 104330549(IL12B)
NNT: 104407355(IL12B)
SHAB: 115615709(IL12B)
DPUB: 104304030(IL12B)
PGUU: 104465780(IL12B)
ACAR: 104518036(IL12B)
CPEA: 104392549(IL12B)
AVIT: 104269152(IL12B)
CVF: 104283845(IL12B)
RTD: 128916376(IL12B)
CUCA: 104062908(IL12B)
TEO: 104382108(IL12B)
BRHI: 104501251(IL12B)
AAM: 106493613(IL12B)
AROW: 112978176(IL12B)
NPD: 112954426(IL12B)
TGT: 104578175(IL12B)
DNE: 112994363(IL12B)
SCAM: 104151047(IL12B)
ASN: 102379831(IL12B)
AMJ: 102568125(IL12B) 106737635
CPOO: 109310277(IL12B)
GGN: 109290116(IL12B)
PSS: 102449025(IL12B)
CMY: 102939116(IL12B)
CCAY: 125641222(IL12B)
DCC: 119860616(IL12B)
CPIC: 101948692(IL12B)
TST: 117881164(IL12B)
CABI: 116833140(IL12B)
MRV: 120370753(IL12B)
ACS: 103277860(il12b) 103282245
ASAO: 132765564(IL12B)
PVT: 110072310(IL12B)
SUND: 121920389
PBI: 112540630 112542313
PMUR: 107292495
CTIG: 120311467
TSR: 106538833(IL12B)
PGUT: 117657780
APRI: 131191152
PTEX: 113433541 113447163
NSS: 113423754
PMUA: 114592861
PRAF: 128409598
ZVI: 118076513(IL12B)
HCG: 128344008(IL12B)
STOW: 125430087(IL12B)
EMC: 129327588(IL12B)
XLA: 108712268(il12b.S)
XTR: 100493914 116409688(il12b)
NPR: 108803420
RTEM: 120930493(IL12B)
BBUF: 121007691(IL12B)
BGAR: 122926526(IL12B)
MUO: 115476413(IL12B)
GSH: 117351829(IL12B)
DRE: 445373(il12ba)
SRX: 107723799 107740171
SANH: 107664334 107664336 107669056
SGH: 107554450 107602578
CCAR: 109069813
CAUA: 113057745 113057981 113114494(il12b)
CGIB: 127971788 128027181
PTET: 122357160(il12ba)
LROH: 127176354(il12ba)
OMC: 131552864(il12ba)
PPRM: 120474357(il12ba)
RKG: 130095193(il12ba)
MAMB: 125258949(il12ba)
CIDE: 127494824
MASI: 127413191 127417814
TROS: 130564021(il12ba)
TDW: 130437751(il12ba)
MANU: 129422536(il12ba)
IPU: 108264170(si:dkey-88e18.2) 108278485(il12bb)
PHYP: 113526905 113529121 113541713
SMEO: 124386286(il12ba)
TFD: 113636009(il12ba)
TVC: 132856116(il12ba)
AMEX: 103028022 103036896 103041682
CMAO: 118806450(il12ba)
EEE: 113571296 113580518 113581527
TRU: 101066952 101077588 445913(IL-12_p40)
TFS: 130525906(il12b2) 130531080(il12ba) 130537568(il12bb)
TNG: GSTEN00031652G001
LCO: 104922998 104924236(il12b) 104938187
NCC: 104944410 104956797 104958169
TBEN: 117472651(si:dkey-88e18.2) 117475162(il12ba) 117490406(il12bb)
CGOB: 115012977 115014708 115019119
PGEO: 117452273(si:dkey-88e18.2) 117454236(il12ba) 117458894(il12bb)
GACU: 117540244(il12bb) 117545217(il12ba) 117560348(si:dkey-88e18.2)
EMAC: 134859849(il12ba) 134871663(il12bb) 134874216(il12b2)
ELY: 117253185(si:dkey-88e18.2) 117260978(il12ba) 117272368(il12bb)
EFO: 125890339(si:dkey-88e18.2) 125894593(il12ba) 125898296
PLEP: 121944600(si:dkey-88e18.2) 121947757(il12ba) 121953039(il12bb)
SLUC: 116036907(il12bb) 116052081(il12ba) 116054264(si:dkey-88e18.2)
ECRA: 117945492(si:dkey-88e18.2) 117951870(il12ba) 117956129(il12bb)
ESP: 116686750 116689639 116697243 116701090
PFLV: 114556107 114563165 114566315
GAT: 120816901(il12ba) 120821794(il12bb) 120830416(si:dkey-88e18.2)
PPUG: 119210060(il12ba) 119215092(il12bb) 119225100(si:dkey-88e18.2)
AFB: 129090530(il12ba) 129100825(si:dkey-88e18.2) 129113850(il12bb)
CLUM: 117735756(si:dkey-88e18.2) 117737664(il12ba) 117742683(il12bb)
PSWI: 130191715(il12bb) 130196829(il12b2)
MSAM: 119882122 119888093 119888129(il12ba) 119892504 119895157(il12bb)
SCHU: 122875711(si:dkey-88e18.2) 122880857(il12ba) 122888396(il12bb)
CUD: 121509815(si:dkey-88e18.2) 121516183(il12ba) 121519111(il12bb)
ALAT: 119007358(il12ba) 119020042(si:dkey-88e18.2) 119031730(il12bb)
MZE: 101481035 101487119 101487544
ONL: 100690857 100695399 100706746
OAU: 116310975(si:dkey-88e18.2) 116319695(il12bb) 116324586(il12ba)
OLA: 101170029(il12b) 101175425 101175485
OML: 112142961(il12bb) 112148544(si:dkey-88e18.2) 112153451(il12ba)
CSAI: 133447505(il12ba) 133451121(il12b2) 133460219(il12bb)
XMA: 102220212 102220488 102226505
XCO: 114139172 114153313 114154064
XHE: 116714324 116728504 116729424
PRET: 103470011 103470881(il12b) 103475671
PFOR: 103138978 103145876 103154071
PLAI: 106955427(il12b) 106955695 106958053
PMEI: 106906948 106917165 106926612
GAF: 122828041(si:dkey-88e18.2) 122837553(il12ba) 122844571(il12bb)
PPRL: 129362619(il12ba) 129366135(si:dkey-88e18.2) 129373487(il12bb)
CVG: 107084201 107086324 107089666
CTUL: 119778201(si:dkey-88e18.2) 119780972(il12ba) 119792692(il12bb)
GMU: 124860173(il12ba) 124876947(il12bb) 124877456(si:dkey-88e18.2)
NFU: 107374587 107386759 107394352
KMR: 108233659(si:dkey-88e18.2) 108238912(il12bb) 108245805(il12ba)
ALIM: 106519869 106521898(il12b) 106524033
NWH: 119409099(il12ba) 119413863(si:dkey-88e18.2) 119420855
AOCE: 111566717 111567434 111588038(il12b)
MCEP: 125007734(il12ba) 125012641(si:dkey-88e18.2) 125021783(il12bb)
CSEM: 103391417(il12b) 103395539 103397823
POV: 109624692(il12b) 109635772 109636980
SSEN: 122769935(si:dkey-88e18.2) 122778289(il12ba) 122779594
HHIP: 117767964(si:dkey-88e18.2) 117769247(il12ba) 117774863(il12bb)
HSP: 118112354(il12ba) 118115660(si:dkey-88e18.2) 118122246
SMAU: 118301647(il12bb) 118314177(si:dkey-88e18.2) 118319527(il12ba)
LCF: 108881460(si:dkey-88e18.2) 108882723(il12ba) 108893814(il12bb)
SDU: 111217197 111226679 111236515
SLAL: 111654923 111664628 111672061
XGL: 120785554(il12ba) 120802827(il12bb) 120805575(si:dkey-88e18.2)
HCQ: 109524222(il12b) 109527235
SSCV: 125988535 125994686(si:dkey-88e18.2)
SBIA: 133499642(il12b2) 133508724(il12ba)
PEE: 133400601(il12b2) 133407780(il12ba)
PTAO: 133475123(il12b2) 133485149(il12ba)
BPEC: 110155929 110157238 110162255
MALB: 109956595 109957002(il12b) 109960025
BSPL: 114862735(il12b2) 114865013(il12ba) 114869364(il12bb)
SJO: 128363354(il12ba) 128364895(si:dkey-88e18.2) 128370876(il12bb)
SASA: 106567437 106603888(IL12B) 106604286 106607975(IL12B) 106612126
STRU: 115148491 115153954 115163975 115167701 115205629
OTW: 112228305 112235243 112235249 112235857(si:dkey-88e18.2) 112258298(il12bb)
OMY: 100136086(si:dkey-88e18.2) 110489482 110504616 110533322 110537792(il12bb)
OGO: 123992386 123995050 124000567 124011619 124033204(si:dkey-88e18.2)
ONE: 115105225 115111959 115119504 115128126 115129126
OKI: 109876323 109879844 109880015 109892998 109904970
OKE: 118376493(si:dkey-88e18.2) 118376823 118380892 118389797 118390834
SALP: 111965541 111967079 111981620 112073152
SNH: 120039058 120042910 120044412 120055440(si:dkey-88e18.2) 120056435
CCLU: 121538036 121574057 121580153 121584077(si:dkey-88e18.2) 121586084
ELS: 105006256 105009140 105011273(il12b)
SFM: 108934271 108936842 108938524
PKI: 111839189 111850579 111860726(il12b)
AANG: 118222641(il12ba) 118236355 118237126(si:dkey-88e18.2)
LOC: 102697617(il12b) 102699198
PSPA: 121297552 121307915 121327412
ARUT: 117403858(si:dkey-88e18.2) 117412916 117431159
LCM: 102348110(IL12B)
RTP: 109917876(il12ba) 125484189
CPLA: 122556860(il12ba) 122560228
HOC: 132823534(il12ba)
LERI: 129694839 129701885
 » show all
Reference
PMID:1674604
  Authors
Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComas W, Motyka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC, et al.
  Title
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.
  Journal
Proc Natl Acad Sci U S A 88:4143-7 (1991)
DOI:10.1073/pnas.88.10.4143
  Sequence
[hsa:3593]
Reference
PMID:20843320
  Authors
Klinke DJ 2nd
  Title
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.
  Journal
Mol Cancer 9:242 (2010)
DOI:10.1186/1476-4598-9-242
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