KEGG   ORTHOLOGY: K05425Help
Entry
K05425                      KO                                     

Name
IL12B
Definition
interleukin 12B
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04620  Toll-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04940  Type I diabetes mellitus
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05143  African trypanosomiasis
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05162  Measles
ko05164  Influenza A
ko05168  Herpes simplex virus 1 infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05321  Inflammatory bowel disease (IBD)
ko05330  Allograft rejection
Disease
H00089  IFN-gamma/IL-12 axis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K05425  IL12B; interleukin 12B
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05425  IL12B; interleukin 12B
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04622 RIG-I-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04625 C-type lectin receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04658 Th1 and Th2 cell differentiation
    K05425  IL12B; interleukin 12B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05425  IL12B; interleukin 12B
   05205 Proteoglycans in cancer
    K05425  IL12B; interleukin 12B
  09163 Immune disease
   05321 Inflammatory bowel disease (IBD)
    K05425  IL12B; interleukin 12B
   05330 Allograft rejection
    K05425  IL12B; interleukin 12B
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K05425  IL12B; interleukin 12B
  09171 Infectious disease: bacterial
   05133 Pertussis
    K05425  IL12B; interleukin 12B
   05134 Legionellosis
    K05425  IL12B; interleukin 12B
   05152 Tuberculosis
    K05425  IL12B; interleukin 12B
  09172 Infectious disease: viral
   05162 Measles
    K05425  IL12B; interleukin 12B
   05164 Influenza A
    K05425  IL12B; interleukin 12B
   05168 Herpes simplex virus 1 infection
    K05425  IL12B; interleukin 12B
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05425  IL12B; interleukin 12B
   05145 Toxoplasmosis
    K05425  IL12B; interleukin 12B
   05140 Leishmaniasis
    K05425  IL12B; interleukin 12B
   05142 Chagas disease (American trypanosomiasis)
    K05425  IL12B; interleukin 12B
   05143 African trypanosomiasis
    K05425  IL12B; interleukin 12B
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05425  IL12B; interleukin 12B
   00536 Glycosaminoglycan binding proteins
    K05425  IL12B; interleukin 12B
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K05425  IL12B; interleukin 12B
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Haparin
  Cytokines
   K05425  IL12B; interleukin 12B
BRITE hierarchy
Other DBs
GO: 0005143
Genes
HSA: 3593(IL12B)
PTR: 471723(IL12B)
PPS: 100989950(IL12B)
GGO: 101141274(IL12B)
PON: 100435254(IL12B)
NLE: 100579267
MCC: 694747(IL12B)
MCF: 102124858(IL12B)
CSAB: 103244892(IL12B)
RRO: 104669104(IL12B)
RBB: 108537933(IL12B)
CJC: 100395403(IL12B)
SBQ: 101049311(IL12B)
MMU: 16160(Il12b)
MCAL: 110304465(Il12b)
MPAH: 110332403(Il12b)
RNO: 64546(Il12b)
MUN: 110548438(Il12b)
CGE: 100764758(Il12b)
NGI: 103724546(Il12b)
HGL: 101701309(Il12b)
CCAN: 109677112(Il12b)
OCU: 100354852(IL12B)
TUP: 102499876(IL12B)
CFA: 403976(IL12B)
VVP: 112928651(IL12B)
AML: 100477772(IL12B)
UMR: 103664531(IL12B)
UAH: 113263879(IL12B)
ORO: 101372789(IL12B)
FCA: 768273(IL12B)
PTG: 102959546(IL12B)
PPAD: 109257574(IL12B)
AJU: 106967679(IL12B)
BTA: 281857(IL12B)
BOM: 102283689(IL12B)
BIU: 109561305(IL12B)
BBUB: 102409559(IL12B)
CHX: 100860845(IL12B)
OAS: 443472(IL12B)
SSC: 397076(IL12B)
CFR: 102515488(IL12B)
CDK: 105099900(IL12B)
BACU: 103007028(IL12B)
LVE: 103083704(IL12B)
OOR: 101272835(IL12B)
DLE: 111170635(IL12B)
PCAD: 102980587(IL12B)
ECB: 100034222(IL12B)
EPZ: 103547779(IL12B)
EAI: 106832166(IL12B)
MYB: 102253394(IL12B)
MYD: 102756968(IL12B)
MNA: 107537877(IL12B)
HAI: 109388897(IL12B)
DRO: 112319648(IL12B)
PALE: 102884214(IL12B)
RAY: 107521891(IL12B)
MJV: 108409190(IL12B)
LAV: 100657211(IL12B)
TMU: 101344352
MDO: 100030276(IL12B)
SHR: 100932486(IL12B)
PCW: 110212378(IL12B)
OAA: 100074930(IL12B)
GGA: 404671(IL12B)
MGP: 100303696(IL12B)
CJO: 107306820 107320334(IL12B)
NMEL: 110390927 110405552(IL12B)
APLA: 101800211(IL12B)
ACYG: 106034345(IL12B) 106043190
TGU: 100217488(IL12B)
LSR: 110479711
SCAN: 103817383(IL12B)
GFR: 102044384(IL12B)
FAB: 101814108(IL12B)
PHI: 102100519 102100856(IL12B)
PMAJ: 107210594(IL12B)
CCAE: 111935760(IL12B)
CCW: 104689490(IL12B)
ETL: 114067346(IL12B) 114068872
FPG: 101920686(IL12B)
FCH: 102046968(IL12B) 114014855
CLV: 102097579(IL12B)
EGZ: 104133653(IL12B)
NNI: 104019032(IL12B)
ACUN: 113485246(IL12B)
PADL: 103912251(IL12B)
AAM: 106493613(IL12B)
ASN: 102379831(IL12B)
AMJ: 102568125(IL12B) 106737635
PSS: 102449025(IL12B)
CMY: 102939116(IL12B)
CPIC: 101948692(IL12B)
ACS: 103277860(il12b)
PVT: 110072310(IL12B)
PMUR: 107292495
TSR: 106538833(IL12B)
PMUA: 114592861
XLA: 108712268
DRE: 445373(il12ba)
IPU: 108264170 108278485(il12b)
TRU: 101066952 101077588 445913(IL-12_p40)
HCQ: 109524222(il12b) 109527235
LCM: 102348110(IL12B)
CMK: 103177387(il12b) 103188109
RTP: 109917876(il12b)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1674604
  Authors
Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComas W, Motyka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC, et al.
  Title
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.
  Journal
Proc Natl Acad Sci U S A 88:4143-7 (1991)
DOI:10.1073/pnas.88.10.4143
  Sequence
[hsa:3593]
Reference
  Authors
Klinke DJ 2nd
  Title
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.
  Journal
Mol Cancer 9:242 (2010)
DOI:10.1186/1476-4598-9-242
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