KEGG   ORTHOLOGY: K05425
Entry
K05425                      KO                                     

Name
IL12B
Definition
interleukin 12B
Pathway
map04060  Cytokine-cytokine receptor interaction
map04620  Toll-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04658  Th1 and Th2 cell differentiation
map04940  Type I diabetes mellitus
map05133  Pertussis
map05134  Legionellosis
map05140  Leishmaniasis
map05142  Chagas disease
map05143  African trypanosomiasis
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05162  Measles
map05164  Influenza A
map05168  Herpes simplex virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05321  Inflammatory bowel disease
map05330  Allograft rejection
map05417  Lipid and atherosclerosis
Disease
H00089  IFN-gamma/IL-12 axis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05425  IL12B; interleukin 12B
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05425  IL12B; interleukin 12B
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04622 RIG-I-like receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04625 C-type lectin receptor signaling pathway
    K05425  IL12B; interleukin 12B
   04658 Th1 and Th2 cell differentiation
    K05425  IL12B; interleukin 12B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05425  IL12B; interleukin 12B
   05205 Proteoglycans in cancer
    K05425  IL12B; interleukin 12B
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K05425  IL12B; interleukin 12B
   05164 Influenza A
    K05425  IL12B; interleukin 12B
   05162 Measles
    K05425  IL12B; interleukin 12B
   05168 Herpes simplex virus 1 infection
    K05425  IL12B; interleukin 12B
  09171 Infectious disease: bacterial
   05133 Pertussis
    K05425  IL12B; interleukin 12B
   05134 Legionellosis
    K05425  IL12B; interleukin 12B
   05152 Tuberculosis
    K05425  IL12B; interleukin 12B
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05425  IL12B; interleukin 12B
   05145 Toxoplasmosis
    K05425  IL12B; interleukin 12B
   05140 Leishmaniasis
    K05425  IL12B; interleukin 12B
   05142 Chagas disease
    K05425  IL12B; interleukin 12B
   05143 African trypanosomiasis
    K05425  IL12B; interleukin 12B
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05425  IL12B; interleukin 12B
   05330 Allograft rejection
    K05425  IL12B; interleukin 12B
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05425  IL12B; interleukin 12B
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K05425  IL12B; interleukin 12B
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05425  IL12B; interleukin 12B
   00536 Glycosaminoglycan binding proteins
    K05425  IL12B; interleukin 12B
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K05425  IL12B; interleukin 12B
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Cytokines
   K05425  IL12B; interleukin 12B
Other DBs
GO: 0005143
Genes
HSA: 3593(IL12B)
PTR: 471723(IL12B)
PPS: 100989950(IL12B)
GGO: 101141274(IL12B)
PON: 100435254(IL12B)
NLE: 100579267 115837257
MCC: 694747(IL12B)
MCF: 102124858(IL12B)
CSAB: 103244892(IL12B)
CATY: 105581574(IL12B)
PANU: 100126717(IL12B)
RRO: 104669104(IL12B)
RBB: 108537933(IL12B)
TFN: 117065537(IL12B)
CJC: 100395403(IL12B)
SBQ: 101049311(IL12B)
MMUR: 105871571(IL12B)
MMU: 16160(Il12b)
MCAL: 110304465(Il12b)
MPAH: 110332403(Il12b)
RNO: 64546(Il12b)
MCOC: 116077653(Il12b)
MUN: 110548438(Il12b)
CGE: 100764758(Il12b)
PLEU: 114689882(Il12b)
NGI: 103724546(Il12b)
HGL: 101701309(Il12b)
CCAN: 109677112(Il12b)
OCU: 100354852(IL12B)
TUP: 102499876(IL12B)
CFA: 403976(IL12B)
VVP: 112928651(IL12B)
VLG: 121486324(IL12B)
AML: 100477772(IL12B)
UMR: 103664531(IL12B)
UAH: 113263879(IL12B)
ORO: 101372789(IL12B)
ELK: 111141150
MPUF: 101676232(IL12B)
EJU: 114211944(IL12B)
MLX: 118016150(IL12B)
FCA: 768273(IL12B)
PTG: 102959546(IL12B)
PPAD: 109257574(IL12B)
AJU: 106967679(IL12B)
HHV: 120240593(IL12B)
BTA: 281857(IL12B)
BOM: 102283689(IL12B)
BIU: 109561305(IL12B)
BBUB: 102409559(IL12B)
CHX: 100860845(IL12B)
OAS: 443472(IL12B)
ODA: 120863361(IL12B)
SSC: 397076(IL12B)
CFR: 102515488(IL12B)
CDK: 105099900(IL12B)
BACU: 103007028(IL12B)
LVE: 103083704(IL12B)
OOR: 101272835(IL12B)
DLE: 111170635(IL12B)
PCAD: 102980587(IL12B)
ECB: 100034222(IL12B)
EPZ: 103547779(IL12B)
EAI: 106832166(IL12B)
MYB: 102253394(IL12B)
MYD: 102756968(IL12B)
MMYO: 118659025(IL12B)
MNA: 107537877(IL12B)
HAI: 109388897(IL12B)
DRO: 112319648(IL12B)
SHON: 118984138(IL12B)
AJM: 119054378(IL12B)
MMF: 118615760(IL12B)
PALE: 102884214(IL12B)
RAY: 107521891(IL12B)
MJV: 108409190(IL12B)
LAV: 100657211(IL12B)
TMU: 101344352
MDO: 100030276(IL12B)
SHR: 100932486(IL12B)
PCW: 110212378(IL12B)
OAA: 100074930(IL12B)
GGA: 404671(IL12B)
PCOC: 116225955 116231896(IL12B)
MGP: 100303696(IL12B)
CJO: 107306820 107320334(IL12B)
NMEL: 110390927 110405552(IL12B)
APLA: 101800211(IL12B)
ACYG: 106034345(IL12B) 106043190
TGU: 100217488(IL12B) 115494797
LSR: 110468736 110479711(IL12B)
SCAN: 103817383(IL12B) 103823110
PMOA: 120498678(IL12B) 120509207
GFR: 102044384(IL12B)
FAB: 101814108(IL12B)
PHI: 102100519 102100856(IL12B)
PMAJ: 107202840 107210594(IL12B)
CCAE: 111935760(IL12B)
CCW: 104689490(IL12B) 104690841
ETL: 114067346(IL12B) 114068872
FPG: 101920686(IL12B)
FCH: 102046968(IL12B) 114014855
CLV: 102097579(IL12B)
EGZ: 104133653(IL12B)
NNI: 104019032(IL12B)
ACUN: 113485246(IL12B)
PADL: 103912251(IL12B)
AAM: 106493613(IL12B)
ASN: 102379831(IL12B)
AMJ: 102568125(IL12B) 106737635
CPOO: 109310277(IL12B)
GGN: 109290116(IL12B)
PSS: 102449025(IL12B)
CMY: 102939116(IL12B)
CPIC: 101948692(IL12B)
TST: 117881164(IL12B)
CABI: 116833140(IL12B)
ACS: 103277860(il12b) 103282245
PVT: 110072310(IL12B)
PMUR: 107292495
TSR: 106538833(IL12B)
PGUT: 117657780
PMUA: 114592861
ZVI: 118076513(IL12B)
XLA: 108712268(il12b.S)
XTR: 100493914 116409688(il12b)
NPR: 108803420
DRE: 445373(il12ba)
IPU: 108264170 108278485(il12b)
TRU: 101066952 101077588 445913(IL-12_p40)
ELY: 117253185(si:dkey-88e18.2) 117260978(il12ba) 117272368(il12bb)
PLEP: 121944600(si:dkey-88e18.2) 121947757(il12ba) 121953039(il12bb)
SLUC: 116036907(il12bb) 116052081(il12ba) 116054264(si:dkey-88e18.2)
GAT: 120816901(il12ba) 120821794(il12bb) 120830416(si:dkey-88e18.2)
CUD: 121509815(si:dkey-88e18.2) 121516183(il12ba) 121519111(il12bb)
OAU: 116310975(si:dkey-88e18.2) 116319695(il12bb) 116324586(il12ba)
OML: 112142961(il12bb) 112148544(si:dkey-88e18.2) 112153451(il12ba)
KMR: 108233659(si:dkey-88e18.2) 108238912(il12bb) 108245805(il12ba)
XGL: 120785554(il12ba) 120802827(il12bb) 120805575(si:dkey-88e18.2)
HCQ: 109524222(il12b) 109527235
OMY: 100136086(si:dkey-88e18.2) 110489482 110504616 110533322 110537792(il12bb)
LOC: 102697617(il12b) 102699198
ARUT: 117403858(si:dkey-88e18.2) 117412916 117431159
LCM: 102348110(IL12B)
CMK: 103177387(il12b) 103188109
RTP: 109917876(il12b)
 » show all
Reference
PMID:1674604
  Authors
Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComas W, Motyka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC, et al.
  Title
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.
  Journal
Proc Natl Acad Sci U S A 88:4143-7 (1991)
DOI:10.1073/pnas.88.10.4143
  Sequence
[hsa:3593]
Reference
  Authors
Klinke DJ 2nd
  Title
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12.
  Journal
Mol Cancer 9:242 (2010)
DOI:10.1186/1476-4598-9-242
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