KEGG ORTHOLOGY: K05717

ORTHOLOGY: K05717

Entry

K05717                      KO

Symbol

FN1

Name

fibronectin 1

Pathway

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map04512

ECM-receptor interaction

map04810

Regulation of actin cytoskeleton

map04820

Cytoskeleton in muscle cells

map04933

AGE-RAGE signaling pathway in diabetic complications

map05100

Bacterial invasion of epithelial cells

map05135

Yersinia infection

map05146

Amoebiasis

map05165

Human papillomavirus infection

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05222

Small cell lung cancer

Disease

H01260

Glomerulopathy with fibronectin deposits

H02185

Spondylometaphyseal dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K05717  FN1; fibronectin 1
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K05717  FN1; fibronectin 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05717  FN1; fibronectin 1
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K05717  FN1; fibronectin 1
   04810 Regulation of actin cytoskeleton
    K05717  FN1; fibronectin 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05717  FN1; fibronectin 1
   05205 Proteoglycans in cancer
    K05717  FN1; fibronectin 1
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K05717  FN1; fibronectin 1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K05717  FN1; fibronectin 1
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05717  FN1; fibronectin 1
   05100 Bacterial invasion of epithelial cells
    K05717  FN1; fibronectin 1
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05717  FN1; fibronectin 1
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05717  FN1; fibronectin 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05717  FN1; fibronectin 1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05717  FN1; fibronectin 1
   00536 Glycosaminoglycan binding proteins
    K05717  FN1; fibronectin 1
   04990 Domain-containing proteins not elsewhere classified
    K05717  FN1; fibronectin 1
Membrane trafficking [BR:ko04131]
Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    K05717  FN1; fibronectin 1
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of bladder cancer cells
   K05717  FN1; fibronectin 1
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Extracellular matrix molecules
   K05717  FN1; fibronectin 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
Fibronectin (FN) domain-containing proteins
  Fibronectin type I domain-containing proteins
   K05717  FN1; fibronectin 1

Genes

HSA:

2335(FN1)

PTR:	459926(FN1)

PPS:	100992555(FN1)

GGO:	101138168(FN1)

PON:	100449704(FN1)

NLE:	100601303(FN1)

HMH:	116810333(FN1)

MCC:	613269(FN1)

MCF:	102119232(FN1)

MTHB:

126932417

MNI:	105481166(FN1)

CSAB:

103217800(FN1)

CATY:

105580156(FN1)

PANU:

101004025(FN1)

TGE:	112636080(FN1)

MLEU:

105528087(FN1)

RRO:	104669238(FN1)

RBB:	108543178(FN1)

TFN:	117094564(FN1)

PTEH:

111548154(FN1)

CANG:

105504788(FN1)

CJC:	100405983(FN1)

SBQ:	101045340(FN1)

CIMI:

108308919(FN1)

CSYR:

103256200(FN1)

MMUR:

105882608(FN1)

LCAT:

123644039(FN1)

PCOQ:

105816133(FN1)

OGA:	100948167(FN1)

MMU:	14268(Fn1)

MCAL:

110283623(Fn1)

MPAH:

110321151(Fn1)

RNO:	25661(Fn1)

MCOC:

116088545(Fn1)

ANU:	117705295(Fn1)

MUN:	110557288(Fn1)

CGE:	100751189(Fn1)

MAUA:

101826613(Fn1)

PROB:

127226413(Fn1)

PLEU:

114693605(Fn1)

MORG:

121433346(Fn1)

MFOT:

126508782

AAMP:

119820335(Fn1)

NGI:	103727691(Fn1)

HGL:	101718570(Fn1)

CPOC:

100732865(Fn1)

CCAN:

109697804(Fn1)

DORD:

105986628(Fn1)

DSP:	122107516(Fn1)

PLOP:

125350332(Fn1)

NCAR:

124978977

MMMA:

107138669(Fn1)

OCU:	100328589(FN1)

OPI:	101524206(FN1)

TUP:	102490245(FN1)

GVR:	103595436(FN1)

CFA:	403845(FN1)

CLUD:

112656719(FN1)

VVP:	112922455(FN1)

VLG:	121480523(FN1)

NPO:	129522717(FN1)

AML:	100464134(FN1)

UMR:	103662788(FN1)

UAH:	113250491(FN1)

UAR:	123798278(FN1)

ELK:

111143733

LLV:

125095065

MPUF:

101692402(FN1)

MNP:	132013520(FN1)

MLK:	131827486(FN1)

NVS:	122902278(FN1)

ORO:	101365197(FN1)

EJU:	114215923(FN1)

ZCA:	113919318(FN1)

MLX:	118012071(FN1)

NSU:	110592312(FN1)

LWW:	102730856(FN1)

FCA:	101081746(FN1)

PYU:	121031029(FN1)

PCOO:

112866897(FN1)

PBG:	122481737(FN1)

PVIV:

125172662(FN1)

LRUF:

124515423

PTG:	102970250(FN1)

PPAD:

109265107(FN1)

PUC:

125911221

AJU:

106970125

HHV:	120232421(FN1)

BTA:	280794(FN1)

BOM:	102280180(FN1)

BBUB:

102410593(FN1)

BBIS:

105003740(FN1)

CHX:	102182645(FN1)

OAS:	100216462(FN1)

BTAX:

128068063(FN1) 128071425

ODA:	120854519(FN1)

CCAD:

122426410(FN1)

MBEZ:

129537610(FN1)

SSC:	397620(FN1)

CFR:	102518759(FN1)

CBAI:

105072931(FN1)

CDK:	105086605(FN1)

VPC:	102530383(FN1)

BACU:

103018975(FN1)

BMUS:

118897777(FN1)

LVE:	103084224(FN1)

OOR:	101275475(FN1)

DLE:	111171803(FN1)

PCAD:

102978142(FN1)

PSIU:

116756945(FN1)

NASI:

112411833(FN1)

ECB:	100034189(FN1)

EPZ:	103563053(FN1)

EAI:	106832715(FN1)

MYB:	102244892(FN1)

MYD:	102753951(FN1)

MMYO:

118661269(FN1)

MLF:	102440437(FN1)

PKL:

118709040

EFUS:

103289335(FN1)

MNA:	107524737(FN1)

DRO:	112307828(FN1)

AJM:	119062561(FN1)

PDIC:

114495587(FN1)

PHAS:

123829917(FN1)

MMF:	118625141(FN1)

PPAM:

129080366(FN1)

HAI:	109380590(FN1)

RFQ:	117026176(FN1)

PALE:

102891509(FN1)

PGIG:

120587617(FN1)

PVP:	105291123(FN1)

RAY:	107513401(FN1)

MJV:	108407058(FN1)

TOD:	119256180(FN1)

SARA:

101549777(FN1)

SETR:

126023916(FN1)

LAV:	100667853(FN1)

TMU:

101361092

ETF:	101653760(FN1)

DNM:	101432628(FN1)

MDO:	100014118(FN1)

GAS:	123242727(FN1)

SHR:	100927509(FN1)

AFZ:

127553139

PCW:	110219415(FN1)

OAA:	100078116(FN1)

GGA:	396133(FN1)

PCOC:

116236056(FN1)

MGP:	100551213(FN1)

CJO:	107316471(FN1)

TPAI:

128076844(FN1)

LMUT:

125696592(FN1)

NMEL:

110399842(FN1)

APLA:

101800175(FN1)

ACYG:

106034457(FN1)

CATA:

118243103(FN1)

AFUL:

116490459(FN1)

TGU:	100231676(FN1)

LSR:	110474100(FN1)

SCAN:

103814579(FN1)

PMOA:

120511486(FN1)

OTC:	121339679(FN1)

PRUF:

121349601(FN1)

GFR:	102039500(FN1)

FAB:	101807963(FN1)

OMA:	130255380(FN1)

PHI:	102104961(FN1)

PMAJ:

107207628(FN1)

CCAE:

111931693(FN1)

CCW:	104694587(FN1)

CBRC:

103624340(FN1)

ETL:	114060672(FN1)

ZAB:	102064120(FN1)

ACHL:

103810608(FN1)

SVG:	106856555(FN1)

MMEA:

130588885(FN1)

HRT:	120755371(FN1)

FPG:	101911302(FN1)

FCH:	102054264(FN1)

CLV:	102090641(FN1)

EGZ:	104124152(FN1)

NNI:	104010144(FN1)

PCRI:

104024487(FN1)

PLET:

104626353(FN1)

EHS:	104515341(FN1)

PCAO:

104042264(FN1)

ACUN:

113482082(FN1)

TALA:

104365509(FN1)

PADL:

103921663(FN1)

AFOR:

103903850(FN1)

ACHC:

115342628(FN1)

HALD:

104323572(FN1)

HLE:	104841534(FN1)

AGEN:

126039181

GCL:

127018551

CCRI:

104163583(FN1)

CSTI:

104563507(FN1)

CMAC:

104476302(FN1)

MUI:	104548967(FN1)

BREG:

104633398(FN1)

FGA:	104082668(FN1)

GSTE:

104260347(FN1)

LDI:	104355075(FN1)

MNB:

103768526

OHA:	104327807(FN1)

NNT:	104408766(FN1)

SHAB:

115608501(FN1)

DPUB:

104300539(FN1)

PGUU:

104466274(FN1)

ACAR:

104531794(FN1)

CPEA:

104388156(FN1)

AVIT:

104276952(FN1)

CVF:	104288739(FN1)

RTD:	128912526(FN1)

CUCA:

104067399(FN1)

TEO:	104378114(FN1)

BRHI:

104490692(FN1)

AROW:

112976562(FN1)

NPD:	112954779(FN1)

TGT:

104572308

DNE:	112979374(FN1)

SCAM:

104151158(FN1)

ASN:	102381879(FN1)

AMJ:	102569824(FN1)

CPOO:

109322680(FN1)

GGN:	109301970(FN1)

PSS:	102450093(FN1)

CMY:	102932170(FN1)

CCAY:

125644851(FN1)

DCC:	119863178(FN1)

CPIC:

101948945

TST:	117884854(FN1)

CABI:

116839406(FN1)

MRV:	120374345(FN1)

ACS:	100563512(fn1)

ASAO:

132778446(FN1)

PVT:	110081893(FN1)

SUND:

121917568(FN1)

PBI:	103048603(FN1)

PMUR:

107292554(FN1)

CTIG:

120307303(FN1)

TSR:	106544514(FN1)

APRI:

131199787(FN1)

PTEX:

113440972(FN1)

NSS:	113415656(FN1)

VKO:	123024256(FN1)

PMUA:

114583263(FN1)

PRAF:

128401392(FN1)

ZVI:	118096795(FN1)

HCG:	128339417(FN1)

GJA:	107121182(FN1)

STOW:

125425836(FN1)

EMC:	129324014(FN1)

XLA:	121393057 397744(fn1.S)

XTR:	595087(fn1)

NPR:	108789839(FN1)

RTEM:

120943877(FN1)

BBUF:

121007631(FN1)

BGAR:

122944776(FN1)

MUO:	115474973(FN1)

GSH:	117361085(FN1)

DRE:	100005469(fn1a)

SRX:	107716781 107721590

SANH:

107668382 107688749

SGH:	107551060 107602895

CCAR:

109070067

CAUA:

113053560

CGIB:

127965162 128019622

PTET:

122351690(fn1a)

LROH:

127170881(fn1a)

OMC:	131546899(fn1a)

PPRM:

120487008(fn1a)

RKG:	130078234(fn1a)

MAMB:

125270110(fn1a)

CIDE:

127518558

MASI:

127447244 127448301

TROS:

130555747(fn1a)

TDW:	130427308(fn1a)

MANU:

129451535(fn1a)

IPU:	108266812(fn1a)

IFU:	128608981(fn1a)

PHYP:

113524456

SMEO:

124382844(fn1a)

TFD:	113654352(fn1a)

TVC:	132850304(fn1a)

AMEX:

103029343

CMAO:

118806930(fn1a)

EEE:

113584274

CHAR:

105899465

TRU:	101061998 101071818

TFS:	130516662(fn1b) 130528320(fn1a)

TNG:	GSTEN00031621G001

LCO:	104918250 104919608

NCC:	104967072(fn1)

TBEN:

117471879(fn1b) 117485577

CGOB:

115006385 115026080

PGEO:

117466813

GACU:

117553351(fn1a)

EMAC:

134867286(fn1a)

ELY:	117251302(fn1a) 117268049(fn1b)

EFO:	125882513(fn1b) 125899445(fn1a)

PLEP:

121947868(fn1b) 121949574(fn1a)

SLUC:

116037776(fn1a) 116054713(fn1b)

ECRA:

117949833(fn1b) 117952774

ESP:	116698421 116706203(fn1)

PFLV:

114560228

GAT:	120832631(fn1b) 120834004(fn1a)

PPUG:

119197765(fn1b) 119228822(fn1a)

AFB:	129104149(fn1a) 129107726(fn1b)

CLUM:

117750175 117750662(fn1b)

PSWI:

130192235(fn1b) 130202043

MSAM:

119890165(fn1b) 119903882(fn1a)

SCHU:

122874655(fn1b) 122885588(fn1a)

CUD:	121509690(fn1b) 121522365(fn1a)

ALAT:

119017996(fn1b) 119025589(fn1a)

MZE:	101472390 101472884

ONL:	100689834 100696180

OAU:	116311691(fn1b) 116312576(fn1a)

OLA:	100529198(fn1)

OML:	112154941(fn1a)

CSAI:

133446146(fn1a) 133460284(fn1b)

XMA:

102230011

XCO:	114142634 114147970

XHE:	116718246 116722921

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122840309(fn1a)

PPRL:

129374395(fn1a)

CVG:

107092660

CTUL:

119782307(fn1b) 119785178(fn1a)

GMU:	124866598(fn1b) 124871206(fn1a)

NFU:

107390187

KMR:	108238549(fn1a)

ALIM:

106523165

NWH:	119419532(fn1a)

AOCE:

111564840 111578352

MCEP:

125005127(fn1b) 125017564(fn1a)

CSEM:

103378692 103392484

POV:	109624813 109631336

SSEN:

122761707(fn1a) 122772612

HHIP:

117754556(fn1b) 117754714

HSP:	118104612(fn1b) 118120537(fn1a)

SMAU:

118301928(fn1b) 118320527(fn1a)

LCF:	108887968(fn1b) 108902821(fn1a)

SDU:	111218037 111238642

SLAL:

111652560 111668768

XGL:	120795024(fn1b) 120801800(fn1a)

HCQ:	109522067 109525855

SSCV:

125966868 125973249

SBIA:

133497742(fn1b) 133511941(fn1a)

PEE:	133399297(fn1b) 133410329(fn1a)

PTAO:

133467879(fn1b) 133486503(fn1a)

BPEC:

110156167 110172841

MALB:

109964120 109968550

BSPL:

114847380(fn1a) 114851923

SJO:	128362194(fn1b) 128367596(fn1a)

SASA:

100380696(finc) 106582526

STRU:

115155431 115179279 115196398

OTW:	112225680(fn1a) 112239140(fn1b)

OMY:	110501963(fn1a) 110527224 110528732

OGO:	124019654 124025561 124032040(fn1a)

ONE:	115121478(fn1)

OKI:	109876465 109881500

OKE:

118379528

SNH:	120033673(fn1b) 120064057(fn1a)

CCLU:

121536060(fn1b) 121536419 121554856(fn1a)

ELS:	105019714(fn1) 105030358

SFM:	108918444 108920636

PKI:	111840678(fn1)

AANG:

118222974

LOC:	102684349(fn1)

PSPA:

121322143 121323388

ARUT:

117409768 117426324

PSEX:

120530689

LCM:	102367537(FN1)

CMK:	103176556(fn1b)

CPLA:

HOC:

LERI:

PMRN:

LRJ:	133345074 133358303

» show all

Reference

PMID:16322219

Authors

Kay RA, Ellis IR, Jones SJ, Perrier S, Florence MM, Schor AM, Schor SL

Title

The expression of migration stimulating factor, a potent oncofetal cytokine, is uniquely controlled by 3'-untranslated region-dependent nuclear sequestration of its precursor messenger RNA.

Journal

Cancer Res 65:10742-9 (2005)
DOI:10.1158/0008-5472.CAN-05-2038

Sequence

[hsa:2335]

Reference

PMID:11209058

Authors

Yi M, Ruoslahti E

Title

A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis.

Journal

Proc Natl Acad Sci U S A 98:620-4 (2001)
DOI:10.1073/pnas.98.2.620

Reference

PMID:3031656

Authors

Dean DC, Bowlus CL, Bourgeois S

Title

Cloning and analysis of the promotor region of the human fibronectin gene.

Journal

Proc Natl Acad Sci U S A 84:1876-80 (1987)
DOI:10.1073/pnas.84.7.1876

Sequence

[hsa:2335]

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