KEGG   ORTHOLOGY: K05718
Entry
K05718                      KO                                     

Name
ITGAL, CD11a
Definition
integrin alpha L
Pathway
ko04015  Rap1 signaling pathway
ko04514  Cell adhesion molecules
ko04650  Natural killer cell mediated cytotoxicity
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05144  Malaria
ko05150  Staphylococcus aureus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05169  Epstein-Barr virus infection
ko05323  Rheumatoid arthritis
ko05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K05718  ITGAL, CD11a; integrin alpha L
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K05718  ITGAL, CD11a; integrin alpha L
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05718  ITGAL, CD11a; integrin alpha L
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05718  ITGAL, CD11a; integrin alpha L
   04670 Leukocyte transendothelial migration
    K05718  ITGAL, CD11a; integrin alpha L
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05718  ITGAL, CD11a; integrin alpha L
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K05718  ITGAL, CD11a; integrin alpha L
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K05718  ITGAL, CD11a; integrin alpha L
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05718  ITGAL, CD11a; integrin alpha L
   05169 Epstein-Barr virus infection
    K05718  ITGAL, CD11a; integrin alpha L
  09174 Infectious disease: parasitic
   05144 Malaria
    K05718  ITGAL, CD11a; integrin alpha L
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05718  ITGAL, CD11a; integrin alpha L
   04515 Cell adhesion molecules
    K05718  ITGAL, CD11a; integrin alpha L
   04090 CD molecules
    K05718  ITGAL, CD11a; integrin alpha L
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K05718  ITGAL, CD11a; integrin alpha L
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K05718  ITGAL, CD11a; integrin alpha L
CD molecules [BR:ko04090]
 Proteins
  K05718  CD11a, ITGAL; integrin, alpha L
Genes
HSA: 3683(ITGAL)
PTR: 454045(ITGAL)
PPS: 100968171(ITGAL)
GGO: 101139540(ITGAL)
PON: 100451665(ITGAL)
NLE: 100600240(ITGAL)
MCC: 711945(ITGAL)
MCF: 102117706(ITGAL)
CSAB: 103231906(ITGAL)
RRO: 104681602(ITGAL)
RBB: 108535405(ITGAL)
CJC: 100390790(ITGAL)
SBQ: 101049788(ITGAL)
MMU: 16408(Itgal)
MCAL: 110299482(Itgal)
MPAH: 110338926(Itgal)
RNO: 308995(Itgal)
MUN: 110548001(Itgal)
CGE: 100770691(Itgal)
NGI: 103726419(Itgal)
HGL: 101723643(Itgal)
CCAN: 109683028(Itgal)
OCU: 100356927(ITGAL)
TUP: 102469543(ITGAL)
CFA: 489905(ITGAL)
VVP: 112929237(ITGAL)
AML: 100464009(ITGAL)
UMR: 103657863(ITGAL)
UAH: 113267681(ITGAL)
ORO: 101370679(ITGAL)
ELK: 111162178
FCA: 101085940(ITGAL)
PTG: 102951540(ITGAL)
PPAD: 109259024(ITGAL)
AJU: 106979092(ITGAL)
BTA: 281874(ITGAL)
BOM: 102281951(ITGAL)
BIU: 109578145(ITGAL)
BBUB: 102412430(ITGAL)
CHX: 102172115(ITGAL)
OAS: 641296(ITGAL)
SSC: 733681(ITGAL)
CFR: 102519794(ITGAL)
CDK: 105102736(ITGAL)
BACU: 103015686(ITGAL)
LVE: 103086254(ITGAL)
OOR: 101278885(ITGAL)
DLE: 111182142(ITGAL)
PCAD: 102973622
ECB: 100065508(ITGAL)
EPZ: 103547219(ITGAL)
EAI: 106831918(ITGAL)
MYB: 102245292(ITGAL)
MYD: 102754113(ITGAL)
MNA: 107541988(ITGAL)
HAI: 109374220(ITGAL)
DRO: 112304654(ITGAL)
PALE: 102879417(ITGAL)
RAY: 107515868(ITGAL)
MJV: 108399261(ITGAL)
LAV: 100658239(ITGAL)
TMU: 101355641
MDO: 100017790(ITGAL)
SHR: 100932849(ITGAL)
PCW: 110223126(ITGAL)
OAA: 100090742(ITGAL)
ASN: 102379989
AMJ: 102574904(ITGAL)
PSS: 102448841(ITGAL)
CMY: 102935120(ITGAL)
CPIC: 101951426
ACS: 103280821(itgal)
PVT: 110090083(ITGAL)
PBI: 103063786
TSR: 106549614(ITGAL)
PMUA: 114581671(ITGAL)
GJA: 107111209(ITGAL)
XLA: 108701717
XTR: 100495488(itgal)
DRE: 557935(zmp:0000001082)
SRX: 107755319
SANH: 107690075
SGH: 107572597
CCAR: 109082665
IPU: 108258823
PHYP: 113524847
EEE: 113568533
NCC: 104956319
XMA: 102232813
XCO: 114143997
PRET: 103463430
CVG: 107085482
NFU: 107397049
KMR: 108251354
ALIM: 106526910
AOCE: 111575069
CSEM: 103384365
POV: 109627556
SLAL: 111660400
HCQ: 109521850(itgal)
MALB: 109956782
ELS: 105021449
SFM: 108933547
PKI: 111850807
 » show all
Reference
PMID:2537322
  Authors
Larson RS, Corbi AL, Berman L, Springer T
  Title
Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.
  Journal
J Cell Biol 108:703-12 (1989)
DOI:10.1083/jcb.108.2.703
  Sequence
[hsa:3683]
Reference
  Authors
Knight JM, Lee SH, Roberts L, Smith CW, Weiss ST, Kheradmand F, Corry DB
  Title
CD11a polymorphisms regulate TH2 cell homing and TH2-related disease.
  Journal
J Allergy Clin Immunol 133:189-97.e1-8 (2014)
DOI:10.1016/j.jaci.2013.03.049
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