Entry |
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Name |
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Definition |
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Pathway |
ko01110 | Biosynthesis of secondary metabolites |
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Module |
M00101 | Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol |
M00102 | Ergocalciferol biosynthesis, squalene 2,3-epoxide => ergosterol/ergocalciferol |
M00917 | Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09103 Lipid metabolism
00100 Steroid biosynthesis
K05917 CYP51; sterol 14alpha-demethylase
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450
K05917 CYP51; sterol 14alpha-demethylase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.154 sterol 14alpha-demethylase
K05917 CYP51; sterol 14alpha-demethylase
1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.15.36 sterol 14alpha-demethylase (ferredoxin)
K05917 CYP51; sterol 14alpha-demethylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
CYP51 family
K05917 CYP51; sterol 14alpha-demethylase
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Stromstedt M, Rozman D, Waterman MR |
Title |
The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols. |
Journal |
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Sequence |
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Reference |
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Authors |
Aoyama Y, Yoshida Y |
Title |
Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol. |
Journal |
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Reference |
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Authors |
Kushiro M, Nakano T, Sato K, Yamagishi K, Asami T, Nakano A, Takatsuto S, Fujioka S, Ebizuka Y, Yoshida S |
Title |
Obtusifoliol 14alpha-demethylase (CYP51) antisense Arabidopsis shows slow growth and long life. |
Journal |
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Reference |
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Authors |
Bak S, Kahn RA, Olsen CE, Halkier BA |
Title |
Cloning and expression in Escherichia coli of the obtusifoliol 14 alpha-demethylase of Sorghum bicolor (L.) Moench, a cytochrome P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals. |
Journal |
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Sequence |
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Reference |
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Authors |
Jackson CJ, Lamb DC, Marczylo TH, Warrilow AG, Manning NJ, Lowe DJ, Kelly DE, Kelly SL |
Title |
A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily. |
Journal |
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Sequence |
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LinkDB |
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