KEGG   ORTHOLOGY: K06451Help
Entry
K06451                      KO                                     

Name
CD3E
Definition
T-cell surface glycoprotein CD3 epsilon chain
Pathway
ko04640  Hematopoietic cell lineage
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko05142  Chagas disease (American trypanosomiasis)
ko05162  Measles
ko05166  Human T-cell leukemia virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05340  Primary immunodeficiency
Disease
H00091  T-B+Severe combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04660 T cell receptor signaling pathway
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04658 Th1 and Th2 cell differentiation
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04659 Th17 cell differentiation
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09163 Immune disease
   05340 Primary immunodeficiency
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05170 Human immunodeficiency virus 1 infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05162 Measles
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05169 Epstein-Barr virus infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09174 Infectious disease: parasitic
   05142 Chagas disease (American trypanosomiasis)
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
CD molecules [BR:ko04090]
 Proteins
  K06451  CD3e; CD3E antigen, epsilon polypeptide (TiT3 complex)
BRITE hierarchy
Genes
HSA: 916(CD3E)
PTR: 742330(CD3E)
PPS: 100978919(CD3E)
GGO: 101149676(CD3E)
PON: 100440004(CD3E)
NLE: 100582516(CD3E)
MCC: 699467(CD3E)
MCF: 102133065(CD3E)
CSAB: 103248584(CD3E)
RRO: 104665572(CD3E)
RBB: 108536387(CD3E)
CJC: 100403944(CD3E)
SBQ: 101030803(CD3E)
MMU: 12501(Cd3e)
MCAL: 110302127(Cd3e)
MPAH: 110328560(Cd3e)
RNO: 315609(Cd3e)
MUN: 110549111(Cd3e)
CGE: 100757488(Cd3e)
NGI: 103728619(Cd3e)
HGL: 101711464(Cd3e)
CCAN: 109684407(Cd3e)
OCU: 100008616(CD3E) 100339529
TUP: 102499022(CD3E)
CFA: 442981(CD3E)
VVP: 112920227(CD3E)
AML: 100482462(CD3E)
UMR: 103662338(CD3E)
UAH: 113260003(CD3E)
ORO: 101385667(CD3E)
FCA: 493936(CD3E)
PTG: 102969557(CD3E)
AJU: 106966166(CD3E)
BTA: 281054(CD3E)
BOM: 102272861(CD3E)
BIU: 109569940(CD3E)
BBUB: 102390460(CD3E)
PHD: 102324466(CD3E)
CHX: 102190711(CD3E)
OAS: 443437(CD3E)
SSC: 397455(CD3E)
CFR: 102518964(CD3E)
CDK: 105090174(CD3E)
BACU: 103003476(CD3E)
LVE: 103070290(CD3E)
OOR: 101279986(CD3E)
DLE: 111166898(CD3E)
ECB: 100629532(CD3E)
EPZ: 103546676(CD3E)
EAI: 106840276(CD3E)
MYB: 102240865(CD3E)
MYD: 102753033(CD3E)
MNA: 107530780(CD3E)
HAI: 109385284(CD3E)
RSS: 109437209(CD3E)
DRO: 112314382(CD3E)
PALE: 102894744(CD3E)
LAV: 100654724(CD3E)
TMU: 101359660
MDO: 100031478(CD3E)
SHR: 100919058(CD3E)
PCW: 110207187(CD3E)
OAA: 103164647(CD3E)
GGA: 396062(CD3E)
MGP: 100542967(CD3E)
CJO: 107324151(CD3E)
APLA: 101792798(CD3E)
ACYG: 106039831(CD3E)
LSR: 110470447(CD3E)
SCAN: 103822978(CD3E)
GFR: 102033069(CD3E)
FAB: 101805814(CD3E)
PHI: 102100748(CD3E)
PMAJ: 107214303(CD3E)
CCAE: 111939275(CD3E)
CCW: 104692070(CD3E)
ETL: 114056274(CD3E)
FPG: 101916374(CD3E)
FCH: 102052256(CD3E)
CLV: 102092091(CD3E)
EGZ: 104124563(CD3E)
NNI: 104019038(CD3E)
ACUN: 113488553(CD3E)
AAM: 106491550(CD3E)
ASN: 102385481(CD3E)
AMJ: 102572715(CD3E)
PSS: 102444605(CD3E)
CMY: 102940609(CD3E)
CPIC: 101932898(CD3E)
ACS: 103281392(cd3e)
PVT: 110079214(CD3E)
PBI: 103063950(CD3E)
PMUR: 107284819(CD3E)
XLA: 108696460(cd3e.L) 108697598(cd3e.S)
XTR: 100101735(cd3e)
NPR: 108792155(CD3E)
SRX: 107710512(cd3e) 107757322
SGH: 107557646(cd3e) 107575792
CCAR: 109113691(cd3e)
IPU: 108278371(cd3e)
PHYP: 113544469(cd3e)
EEE: 113581196(cd3e)
TRU: 654301(cd3e)
LCO: 104930465(cd3e)
NCC: 104958452(cd3e)
MZE: 101473479(cd3e)
XMA: 111612026(cd3e)
PRET: 108166815(cd3e)
NFU: 107372865(cd3e)
CSEM: 103377690
LCF: 108890654(cd3e)
SDU: 111232876(cd3e)
HCQ: 109529377(cd3e)
MALB: 109951826(cd3e)
SASA: 100136516(cd3e)
OTW: 112265197(cd3e)
SFM: 108932125(cd3e) 108932308
LCM: 102349686(CD3E)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3012357
  Authors
Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C
  Title
Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex.
  Journal
Nature 321:431-4 (1986)
DOI:10.1038/321431a0
  Sequence
[hsa:916]
Reference
  Authors
de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F
  Title
Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.
  Journal
J Clin Invest 114:1512-7 (2004)
DOI:10.1172/JCI22588
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