KEGG ORTHOLOGY: K06503

ORTHOLOGY: K06503

Entry

K06503                      KO

Symbol

TFRC, CD71

Name

transferrin receptor

Pathway

map03273

Virion - Lassa virus and SFTS virus

map04066

HIF-1 signaling pathway

map04144

Endocytosis

map04145

Phagosome

map04216

Ferroptosis

map04350

TGF-beta signaling pathway

map04640

Hematopoietic cell lineage

Disease

H02526

Disorders of adaptive immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03273 Virion - Lassa virus and SFTS virus
    K06503  TFRC, CD71; transferrin receptor
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K06503  TFRC, CD71; transferrin receptor
   04066 HIF-1 signaling pathway
    K06503  TFRC, CD71; transferrin receptor
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K06503  TFRC, CD71; transferrin receptor
   04145 Phagosome
    K06503  TFRC, CD71; transferrin receptor
  09143 Cell growth and death
   04216 Ferroptosis
    K06503  TFRC, CD71; transferrin receptor
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06503  TFRC, CD71; transferrin receptor
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K06503  TFRC, CD71; transferrin receptor
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06503  TFRC, CD71; transferrin receptor
   04090 CD molecules
    K06503  TFRC, CD71; transferrin receptor
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M28: aminopeptidase Y family
   K06503  TFRC, CD71; transferrin receptor
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06503  TFRC, CD71; transferrin receptor
  Exosomal proteins of colorectal cancer cells
   K06503  TFRC, CD71; transferrin receptor
CD molecules [BR:ko04090]
Proteins
  K06503  CD71, TFRC; transferrin receptor (p90, CD71)

Other DBs

GO:

0004998

TC:	9.B.229.1.1

Genes

HSA:	7037(TFRC)

PTR:	460956(TFRC)

PPS:	100986593(TFRC)

GGO:	101150922(TFRC)

PON:	100171944(TFRC)

PPYG:

129032725(TFRC)

NLE:	100605411 101178200(TFRC) 115833935 115833954

SSYN:

129467855(TFRC)

MCC:	711568(TFRC)

MCF:	102136007(TFRC)

MTHB:

126947954

MNI:	105470763(TFRC)

CSAB:

103242011(TFRC)

CATY:

105575113(TFRC)

PANU:

100999281(TFRC)

TGE:	112617270(TFRC)

MLEU:

105538770(TFRC)

RRO:	104676388(TFRC)

RBB:	108523393(TFRC)

TFN:	117084470(TFRC)

PTEH:

111544348(TFRC)

CANG:

105525564(TFRC)

CJC:	100407510(TFRC)

SBQ:	101030435(TFRC)

CIMI:

108312843(TFRC)

ANAN:

105722533(TFRC)

CSYR:

103266607(TFRC)

MMUR:

105879830(TFRC)

LCAT:

123630443(TFRC)

PCOQ:

105807808(TFRC)

OGA:	100965409(TFRC)

MMU:	22042(Tfrc)

MCAL:

110311683(Tfrc)

MPAH:

110329678(Tfrc)

RNO:	64678(Tfrc)

MCOC:

116085827(Tfrc)

ANU:	117717751(Tfrc)

ASYL:

127666339(Tfrc)

MUN:	110547651(Tfrc)

CGE:	100689395(Tfrc)

MAUA:

101833501(Tfrc)

PROB:

127227077(Tfrc)

PLEU:

114685390(Tfrc)

MORG:

121461766(Tfrc)

MFOT:

126512208

AAMP:

119824741(Tfrc)

NGI:	103738518(Tfrc)

HGL:	100913079(Tfrc)

CPOC:

100715633(Tfrc)

CCAN:

109694497(Tfrc)

DORD:

105987976(Tfrc)

DSP:	122096941(Tfrc)

PLOP:

125351806(Tfrc)

NCAR:

124992828

MMMA:

107143201(Tfrc)

ITI:	101970131(Tfrc)

OCU:

100342561

OPI:	101519979(TFRC)

TUP:	102480756(TFRC)

GVR:	103603665(TFRC)

CFA:	403703(TFRC)

CLUD:

112641541(TFRC)

VVP:	112913526(TFRC)

VLG:	121495844(TFRC)

NPO:	129503856(TFRC)

AML:	100478898(TFRC)

UMR:	103678941(TFRC)

UAH:	113252881(TFRC)

UAR:	123802115(TFRC)

ELK:

111154946

LLV:

125102774

MPUF:

101684580(TFRC)

MNP:	132011890(TFRC)

MLK:	131824666(TFRC)

NVS:	122908843(TFRC)

ORO:	101370739(TFRC)

EJU:	114206968(TFRC)

ZCA:	113916269(TFRC)

MLX:	118006987(TFRC)

NSU:	110582700(TFRC)

LWW:	102745899(TFRC)

FCA:	493880(TFRC)

PYU:	121036378(TFRC)

PCOO:

112849595(TFRC)

PBG:	122491555(TFRC)

PVIV:

125174624(TFRC)

LRUF:

124526088

LGF:	123611015(TFRC)

AJU:

106987467

PTG:	102963407(TFRC)

PPAD:

109266237(TFRC)

PUC:

125921579

PLEZ:

122198662(TFRC)

HHV:	120244375(TFRC)

BTA:	504698(TFRC)

BOM:	102278238(TFRC)

BIU:	109556162(TFRC)

BBUB:

102407099(TFRC)

BBIS:

104984539(TFRC)

CHX:	102172197(TFRC)

OAS:	100885768(TFRC)

BTAX:

128045410(TFRC)

CSUM:

138086546(TFRC)

ODA:	120870094(TFRC)

CCAD:

122444668(TFRC)

MREE:

136173085(TFRC)

OVR:	110134922(TFRC)

MBEZ:

129540337(TFRC)

SSC:	397062(TFRC)

CFR:	102506651(TFRC)

CBAI:

105072396(TFRC)

CDK:	105101295(TFRC)

VPC:	102533975(TFRC)

BACU:

103011795(TFRC)

BMUS:

118894408(TFRC)

LVE:	103086023(TFRC)

OOR:	101275788(TFRC)

LALB:

132521124(TFRC)

DLE:	111172045(TFRC)

PCAD:

102985437(TFRC)

PSIU:

116752947(TFRC)

NASI:

112406077(TFRC)

ECB:	100034089(TFRC)

EPZ:	103542392(TFRC)

EAI:	106824420(TFRC)

MYB:	102245632(TFRC)

MYD:	102755413(TFRC)

MMYO:

118675500(TFRC)

MLF:	102433587(TFRC)

MDT:	132230292(TFRC)

MYUM:

139003944(TFRC)

PKL:	118722785(TFRC)

EFUS:

103298720(TFRC)

MNA:	107527264(TFRC)

DRO:	112320552(TFRC)

SHON:

118978285(TFRC)

AJM:	119050872(TFRC)

PDIC:

114490442(TFRC)

PHAS:

123826990(TFRC)

MMF:	118616858(TFRC)

PPAM:

129071803(TFRC)

HAI:	109387796(TFRC)

RFQ:	117033503(TFRC)

PALE:

102894294(TFRC)

PGIG:

120593015(TFRC)

PVP:	105309732(TFRC)

RAY:	107505262(TFRC)

MJV:	108383826(TFRC)

TOD:	119257431(TFRC)

SARA:

101537770(TFRC)

SFUM:

130035419(TFRC)

SETR:

126010840(TFRC)

LAV:	100667228(TFRC)

TMU:

101357703

ETF:	101651198(TFRC)

DNM:	101429828(TFRC)

MDO:	100015188(TFRC)

GAS:	123242337(TFRC)

AFZ:

127554186

PCW:	110208163(TFRC)

TVP:	118840407(TFRC)

PBRV:

138143744(TFRC)

OAA:	100086559(TFRC)

TACU:

119927288(TFRC)

GGA:	396191(TFR2)

PCOC:

116235355(TFRC)

MGP:	100550142(TFRC)

CJO:	107318226(TFRC)

TPAI:

128082606(TFRC)

LMUT:

125697415(TFRC)

NMEL:

110397523(TFRC)

APLA:

101803068(TFRC)

ACYG:

106044826(TFRC)

CATA:

118247206(TFRC)

AFUL:

116492373(TFRC)

TGU:	100219280(TFRC)

LSR:	110473894(TFRC)

SCAN:

103815373(TFRC)

PMOA:

120504400(TFRC)

OTC:	121336524(TFRC)

PRUF:

121353660(TFRC)

ATRC:

139594999(TFRC)

GFR:	102041725(TFRC)

FAB:	101807835(TFRC)

OMA:	130256555(TFRC)

PHI:	102100671(TFRC)

PMAJ:

107208655(TFRC)

CCAE:

111922490(TFRC)

CCW:	104687936(TFRC)

CBRC:

103625152(TFRC)

ACOE:

138114734(TFRC)

ETL:	114057584(TFRC)

ZAB:	102072342(TFRC)

ZLE:	135451505(TFRC)

ACHL:

103808590(TFRC)

SVG:	106850386(TFRC)

MMEA:

130574163(TFRC)

HRT:	120756927(TFRC)

SATI:

136365462(TFRC)

CCIC:

134047581(TFRC)

FPG:	101918864(TFRC)

FCH:	102049025(TFRC)

CCRI:

104168009(TFRC)

NNT:	104399585(TFRC)

SHAB:

115612329(TFRC)

ACUN:

113483383(TFRC)

TALA:

104362102(TFRC)

ACHC:

115347118(TFRC)

HALD:

104314743(TFRC)

HLE:	104835177(TFRC)

AGEN:

126039401

HHAR:

128148967(TFRC)

GCL:

127019886

CSTI:

104550280(TFRC)

LDI:	104340142(TFRC)

MNB:	103780664(TFRC)

DPUB:

104302943(TFRC)

PPUS:

135186794(TFRC)

AVIT:

104267123(TFRC)

BRHI:

104487834(TFRC)

EGZ:	104123369(TFRC)

NNI:	104015660(TFRC)

PCRI:

104036592(TFRC)

PCAO:

104042728(TFRC)

PADL:

103916574(TFRC)

AFOR:

103901468(TFRC)

FGA:	104069490(TFRC)

GSTE:

104250598(TFRC)

CLV:	102083822(TFRC)

MUI:	104548582(TFRC)

PGUU:

104457768(TFRC)

PLET:

104628877(TFRC)

EHS:	104503499(TFRC)

CMAC:

104472938(TFRC)

CUCA:

104063180(TFRC)

TEO:	104369808(TFRC)

BREG:

104628976(TFRC)

OHA:	104326842(TFRC)

ACAR:

104530990(TFRC)

CPEA:

104390617(TFRC)

CVF:	104284963(TFRC)

RTD:	128911000(TFRC)

CRID:

134517086(TFRC)

AAM:	106498260(TFRC)

AROW:

112968501(TFRC)

NPD:	112952421(TFRC)

TGT:	104572441(TFRC)

DNE:	112979367(TFRC)

SCAM:

104148808(TFRC)

ASN:	102379517(TFRC)

AMJ:	102560462(TFRC)

CPOO:

109308290

GGN:	109288089(TFRC)

PSS:	102461118(TFRC)

CMY:	102932579(TFRC)

CCAY:

125642602(TFRC)

DCC:	119861942(TFRC)

CPIC:

101936345(TFRC)

TST:	117882566(TFRC)

CABI:

116823011(TFRC)

MRV:	120371731(TFRC)

ACS:

100567559

ASAO:

132769784(TFRC)

PVT:	110091399(TFRC)

SUND:

121925338(TFRC)

PBI:	103066564(TFRC)

PMUR:

107298125(TFRC)

CTIG:

120317304(TFRC)

PGUT:

117660020(TFRC)

APRI:

131200710(TFRC)

PMUA:

114598184(TFRC)

PRAF:

128413331(TFRC)

ZVI:	118093631(TFRC)

HCG:	128350885(TFRC)

GJA:	107122245(TFRC)

STOW:

125435059(TFRC)

EMC:	129332775(TFRC)

XLA:	108716958(tfrc.L) 108718059(tfrc.S)

XTR:	108644432(tfrc)

NPR:	108791174(TFRC)

RTEM:

120936879(TFRC)

BBUF:

120997999(TFRC)

BGAR:

122933770(TFRC)

PWL:	138265243(TFRC)

MUO:	115478591(TFRC)

GSH:	117366566(TFRC)

DRE:	494477(tfr1a) 494478(tfr1b)

SRX:	107705306 107721915 107725872 107728405

SANH:

107653522 107660323 107663677 107685451

SGH:	107550442 107564243 107586743 107590232

CCAR:

109050630(tfr1b) 109061839 109099116(tfr1a) 109102145

CAUA:

113045743 113066175 113115164

CGIB:

127946164 127950930 128013314 128022479

PTET:

122329880(tfr1b) 122359995(tfr1a)

LROH:

127155643(tfr1b) 127174763(tfr1a)

OMC:	131531211(tfr1a) 131533384(tfr1b)

PPRM:

120479508(tfr1a) 120488440(tfr1b)

RKG:	130083984(tfr1b) 130097979(tfr1a)

MAMB:

125257631(tfr1b) 125271658(tfr1a)

CIDE:

127505846 127506843

CERY:

137003251(tfr1a) 137013784(tfr1b)

MASI:

127431613 127434491 127434492 127441478 127442010

TROS:

130547311(tfr1b) 130554428(tfr1a)

TDW:	130413565(tfr1b) 130417937(tfr1a)

MANU:

129425533(tfr1b) 129442563(tfr1a)

PDAB:

135740221(tfr1b) 135765683(tfr1a)

IPU:	108256648(tfr1b) 108280488 108280489

IFU:	128599803(tfr1b) 128624298(tfr1a) 128624299

PHYP:

113541083 113546400 113546402

SMEO:

124375260(tfr1b) 124402841(tfr1a) 124402842

TFD:	113650136(tfr1a) 113650137 113660336(tfr1b)

TVC:	132839984(tfr1b) 132844560(tfr1a) 132844565

CGAR:

128512835 128512836 128512993 128513957(tfr1b)

NGRA:

132867012(tfr1b) 132871864 132871865(tfr1a)

TRN:	134300817(tfr1b) 134302855 134302888

AMEX:

103028780(tfr1b) 103033646 103035460(tfr1a)

CMAO:

118797436 118797437 118798800(tfr1b)

EEE:	113576148 113590114 113590665(tfrc)

CHAR:

105894720(tfr1b) 105899223(tfr1a)

SPIL:

134066273(tfr1b) 134071644(tfr1a)

TRU:	101065250(tfrc) 101076812

TFS:	130513950(tfr1b) 130538897(tfr1a)

TNG:	GSTEN00015046G001 GSTEN00025484G001

LCO:	104932773 104937014 109137608

NCC:	104945571 104948626(tfrc)

TBEN:

117488822(tfr1a) 117496075(tfr1b)

CGOB:

115022702(tfrc) 115025660

PGEO:

117461886 117465616(tfr1b)

GACU:

117544753(tfr1b) 117545610(tfr1a)

EMAC:

134865784 134884164(tfr1b)

ELY:	117264423(tfr1b) 117271418(tfr1a)

EFO:	125881679(tfr1b) 125901572

PLEP:

121951222 121960488(tfr1b)

SLUC:

116045518(tfr1a) 116048550(tfr1b)

ECRA:

117937566(tfr1b) 117954279(tfr1a)

ESP:	116671948 116699220(tfrc)

PFLV:

114549294 114565829(tfrc)

GAT:	120811530(tfr1b) 120816346(tfr1a)

PPUG:

119198984(tfr1b) 119209384

AFB:	129089051 129110521(tfr1b)

CLUM:

117745991(tfr1a) 117749428(tfr1b)

PSWI:

130197543 130206345(tfr1b)

CANA:

137782038(tfr1a) 137788913(tfr1b)

CVE:	137865921 137872044(tfr1b) 137888209

MSAM:

119887120 119902413(tfr1a) 119912484(tfr1b)

SCHU:

122866882(tfr1b) 122887581(tfr1a)

CUD:	121519681(tfr1a) 121527257(tfr1b) 121527579

SPUL:

138596008(tfr1b) 138611701

LMIX:

132978928 132994081(tfr1b)

ALAT:

119008467(tfr1b) 119011089(tfr1a)

ASTR:

137611872 137614098(tfr1b)

MZE:	101482579 101486604 106674511 106675711

ONL:	100695592 100702695 102081239 109195420

OAU:	116314271 116324427(tfr1b) 120434440 120434441

OLA:	101171362(tfrc) 101172614

OML:	112147141 112151523(tfr1b)

CSAI:

133423121(tfr1b) 133453101

XMA:	102225844 102228337(tfrc)

XCO:	114136987 114147191(tfrc)

XHE:	116711929 116721856(tfrc)

PRET:

103456751 103479192

PFOR:

103140049(tfrc) 103140536

PLAI:

106935766 106958041(tfrc)

PMEI:

106903610 106914950

GAF:	122823947(tfr1b) 122841612(tfr1a)

PPRL:

129362172 129378953(tfr1b)

CVG:	107083638(tfrc) 107094809

CTUL:

119771464 119779296(tfr1a)

GMU:	124858340(tfr1b) 124869863

NFU:	107383062 107384334 107384335

KMR:	108234733(tfr1b) 108238212 108238324

ALIM:

106521311 106533798

NWH:	119414977 119426855(tfr1b)

AOCE:

111570218(tfr1b) 111587282(tfr1a)

EJA:	138204464(tfr1b) 138207392(tfr1a)

BFRE:

138619734(tfr1b) 138632571(tfr1a)

MCEP:

125010806 125024380(tfr1b)

CSEM:

103377341 103396196

POV:	109639640 109641300(tfrc)

SSEN:

122771334(tfr1a) 122780366(tfr1b)

SSOE:

131456940(tfr1b) 131470394(tfr1a)

HHIP:

117754186(tfr1b) 117778092(tfr1a)

HSP:	118098678(tfr1b) 118117619(tfr1a)

PPLT:

128425837(tfr1b) 128454047(tfr1a)

SMAU:

118291050(tfr1b) 118310982(tfr1a)

LCF:	108883853 108883855 108885109(tfr1b)

SDU:	111224349 111229135 111229136

SLAL:

111645761(tfrc) 111666515

XGL:	120789577(tfr1b) 120798582(tfr1a)

HCQ:	109520564 109524701

SSCV:

125984592 125986164(tfr1b)

SBIA:

133492596(tfr1b) 133511368(tfr1a)

PEE:	133396482(tfr1b) 133411978(tfr1a)

PTAO:

133470115(tfr1b) 133489535(tfr1a)

BPEC:

110161276 110173509(tfrc)

BSPL:

114844087 114844089(tfr1a) 114853573(tfr1b)

SJO:	128369338 128382313(tfr1b)

SSCO:

133990327 134002091(tfr1b)

GMH:	115537235 115549275

SASA:

106568779 106579454 106590464 106597167

STRU:

115151496 115170147 115195465

OTW:	112215422(tfr1b) 112227235 112247530

OMY:	100653457 110509090(tfr1a) 110535367(tfr1b)

OGO:	123991295(tfr1b) 124039536 124042145

ONE:	115103362 115104968 115130110

OKI:	109872237 109899240(tfrc) 109909891

OKE:	118371246(tfr1b) 118382477 118394405

OMM:	135517213 135522804(tfr1b) 135558377

OCLA:

139366956 139375827 139420272 139420274

SALP:

111979266 112074240

SNH:	120020718(tfr1a) 120027777(tfr1b) 120050961

CCLU:

121534922 121549819(tfr1b) 121569276 121580603

ELS:	105021980 105024999(tfrc)

SFM:	108927770 108935263(tfrc)

PKI:	111839917 111847402(tfrc)

AANG:

118225464 118230761

AROT:

135253331 135256746(tfr1b)

CCOG:

133126083 133128360

LOC:	102691036(tfrc)

PSPA:

121323039 121326661

ARUT:

117417093(tfr1a) 117423218

PSEX:

120536086

LCM:	102364389(TFRC)

CMK:

RTP:

HOC:

LERI:

VJA:

BGT:

CRG:

CANU:

CVN:

Reference

PMID:6090955

Authors

Schneider C, Owen MJ, Banville D, Williams JG

Title

Primary structure of human transferrin receptor deduced from the mRNA sequence.

Journal

Nature 311:675-8 (1984)
DOI:10.1038/311675b0

Sequence

[hsa:7037]

Reference

PMID:3568132

Authors

Rothenberger S, Iacopetta BJ, Kuhn LC

Title

Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site.

Journal

Cell 49:423-31 (1987)
DOI:10.1016/0092-8674(87)90295-9

Sequence

[hsa:7037]

LinkDB

DBGET integrated database retrieval system