KEGG   ORTHOLOGY: K06538Help
Entry
K06538                      KO                                     

Name
CTLA4, CD152
Definition
cytotoxic T-lymphocyte-associated protein 4
Pathway
ko04514  Cell adhesion molecules (CAMs)
ko04660  T cell receptor signaling pathway
ko05320  Autoimmune thyroid disease
ko05323  Rheumatoid arthritis
Disease
H00081  Hashimoto thyroiditis
H00082  Graves disease
H00083  Allograft rejection
H00108  Autoimmune lymphoproliferative syndromes
H00408  Type 1 diabetes mellitus
H01812  Rasmussen encephalitis
H02123  Celiac disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06538  CTLA4, CD152; cytotoxic T-lymphocyte-associated protein 4
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K06538  CTLA4, CD152; cytotoxic T-lymphocyte-associated protein 4
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K06538  CTLA4, CD152; cytotoxic T-lymphocyte-associated protein 4
   05320 Autoimmune thyroid disease
    K06538  CTLA4, CD152; cytotoxic T-lymphocyte-associated protein 4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06538  CTLA4, CD152; cytotoxic T-lymphocyte-associated protein 4
CD molecules [BR:ko04090]
 Proteins
  K06538  CD152, CTLA4; cytotoxic T-lymphocyte-associated protein 4
BRITE hierarchy
Genes
HSA: 1493(CTLA4)
PTR: 470619(CTLA4)
PPS: 100993018(CTLA4)
GGO: 101129009(CTLA4)
PON: 100449582(CTLA4)
NLE: 100606823(CTLA4)
MCC: 705673(CTLA4)
MCF: 102115124(CTLA4)
CSAB: 103217690(CTLA4)
RRO: 104653594(CTLA4)
RBB: 108537198(CTLA4)
CJC: 100409501(CTLA4)
SBQ: 101042563(CTLA4)
MMU: 12477(Ctla4)
MCAL: 110302725(Ctla4)
MPAH: 110322369(Ctla4)
RNO: 63835(Ctla4)
MUN: 110554772(Ctla4)
CGE: 100765782(Ctla4)
NGI: 103744425(Ctla4)
HGL: 101722788(Ctla4)
CCAN: 109674452(Ctla4)
OCU: 100009412(CTLA4)
TUP: 102483518(CTLA4)
CFA: 403696(CTLA4)
VVP: 112922826(CTLA4)
AML: 100477398(CTLA4)
UMR: 103659775(CTLA4)
UAH: 113250557(CTLA4)
ORO: 101373461(CTLA4)
FCA: 493743(CTLA4)
PTG: 102953912(CTLA4)
AJU: 106976710(CTLA4)
BTA: 281732(CTLA4)
BOM: 102281370(CTLA4)
BIU: 109569818(CTLA4)
BBUB: 102401069(CTLA4)
PHD: 102337914(CTLA4)
CHX: 102179425(CTLA4)
OAS: 443040(CTLA4)
SSC: 397286(CTLA4)
CFR: 102507416(CTLA4)
CDK: 105098983(CTLA4)
BACU: 103017694(CTLA4)
LVE: 103071742(CTLA4)
OOR: 101273418(CTLA4)
DLE: 111171755(CTLA4)
ECB: 100067931(CTLA4)
EPZ: 103557388(CTLA4)
EAI: 106828143(CTLA4)
MYB: 102255002(CTLA4)
MYD: 102773895(CTLA4)
MNA: 107524834(CTLA4)
HAI: 109393953(CTLA4)
RSS: 109445011(CTLA4)
DRO: 112307993(CTLA4)
PALE: 102884443(CTLA4)
LAV: 100655136(CTLA4)
TMU: 101351858
MDO: 100017900(CTLA4)
SHR: 100920550(CTLA4)
PCW: 110198519(CTLA4)
OAA: 100084430(CTLA4)
GGA: 424106(CTLA4)
MGP: 100542850(CTLA4)
CJO: 107316579(CTLA4)
APLA: 101803226(CTLA4)
ACYG: 106030067(CTLA4)
TGU: 100222727(CTLA4)
LSR: 110471096(CTLA4)
SCAN: 103814480(CTLA4)
GFR: 102040356(CTLA4)
FAB: 101807027(CTLA4)
PHI: 102114410(CTLA4)
PMAJ: 107207625(CTLA4)
CCAE: 111932436(CTLA4)
CCW: 104693811(CTLA4)
ETL: 114055757(CTLA4)
FPG: 101924168(CTLA4)
FCH: 102051847(CTLA4)
CLV: 102087637(CTLA4)
NNI: 104010218(CTLA4)
ACUN: 113482546(CTLA4)
AAM: 106492391(CTLA4)
ASN: 102368842(CTLA4)
AMJ: 102563598(CTLA4)
PSS: 102445404 102460241(CTLA4)
CMY: 102947343(CTLA4)
CPIC: 101935125(CTLA4)
ACS: 103282850(ctla4)
PVT: 110072414(CTLA4)
PBI: 103059705(CTLA4)
PMUR: 107289736(CTLA4)
GJA: 107113240
XLA: 108702022(ctla4.L) 108702287(ctla4.S)
XTR: 100493714(ctla4)
DRE: 100004384(si:ch211-67e16.2) 101886406(cd28)
IPU: 108266157
PHYP: 113526233
AMEX: 103044351
EEE: 113578545
MZE: 101470592
OLA: 101173752
XMA: 102220089
XCO: 114148445
PRET: 103482213
KMR: 108238804
LCF: 108872841
SDU: 111218736
MALB: 109972695
PKI: 111840821
LCM: 102356756(CTLA4)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1713603
  Authors
Harper K, Balzano C, Rouvier E, Mattei MG, Luciani MF, Golstein P
  Title
CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
  Journal
J Immunol 147:1037-44 (1991)
  Sequence
[hsa:1493]
Reference
PMID:1714933
  Authors
Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA
  Title
CTLA-4 is a second receptor for the B cell activation antigen B7.
  Journal
J Exp Med 174:561-9 (1991)
DOI:10.1084/jem.174.3.561
Reference
  Authors
Chen L.
  Title
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
  Journal
Nat Rev Immunol 4:336-47 (2004)
DOI:10.1038/nri1349
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