KEGG ORTHOLOGY: K06618

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06618  RB1; retinoblastoma-associated protein
   04218 Cellular senescence
    K06618  RB1; retinoblastoma-associated protein
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06618  RB1; retinoblastoma-associated protein
   05203 Viral carcinogenesis
    K06618  RB1; retinoblastoma-associated protein
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K06618  RB1; retinoblastoma-associated protein
   05225 Hepatocellular carcinoma
    K06618  RB1; retinoblastoma-associated protein
   05226 Gastric cancer
    K06618  RB1; retinoblastoma-associated protein
   05214 Glioma
    K06618  RB1; retinoblastoma-associated protein
   05220 Chronic myeloid leukemia
    K06618  RB1; retinoblastoma-associated protein
   05218 Melanoma
    K06618  RB1; retinoblastoma-associated protein
   05219 Bladder cancer
    K06618  RB1; retinoblastoma-associated protein
   05215 Prostate cancer
    K06618  RB1; retinoblastoma-associated protein
   05224 Breast cancer
    K06618  RB1; retinoblastoma-associated protein
   05222 Small cell lung cancer
    K06618  RB1; retinoblastoma-associated protein
   05223 Non-small cell lung cancer
    K06618  RB1; retinoblastoma-associated protein
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K06618  RB1; retinoblastoma-associated protein
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06618  RB1; retinoblastoma-associated protein
   05161 Hepatitis B
    K06618  RB1; retinoblastoma-associated protein
   05160 Hepatitis C
    K06618  RB1; retinoblastoma-associated protein
   05163 Human cytomegalovirus infection
    K06618  RB1; retinoblastoma-associated protein
   05167 Kaposi sarcoma-associated herpesvirus infection
    K06618  RB1; retinoblastoma-associated protein
   05169 Epstein-Barr virus infection
    K06618  RB1; retinoblastoma-associated protein
   05165 Human papillomavirus infection
    K06618  RB1; retinoblastoma-associated protein
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K06618  RB1; retinoblastoma-associated protein
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06618  RB1; retinoblastoma-associated protein
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K06618  RB1; retinoblastoma-associated protein
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06618  RB1; retinoblastoma-associated protein
Transcription factors [BR:ko03000]
Eukaryotic type
  Other transcription factors
   Pocket domain Rb
    K06618  RB1; retinoblastoma-associated protein

Genes

HSA:

5925(RB1)

PTR:	452715(RB1)

PPS:	100973837(RB1)

GGO:	101133237(RB1)

PON:	100462155(RB1)

NLE:	100588629(RB1)

MCC:	704871(RB1)

MCF:	102145859(RB1)

CSAB:

103214406(RB1)

RRO:	104662760(RB1)

RBB:	108530701(RB1)

CJC:	100397928(RB1)

SBQ:	101038309(RB1)

MMU:	19645(Rb1)

MCAL:

110309179(Rb1)

MPAH:

110325233(Rb1)

RNO:	24708(Rb1)

MUN:	110553592(Rb1)

CGE:	100752928(Rb1)

NGI:	103726779(Rb1)

HGL:	101703701(Rb1)

CCAN:

109691094(Rb1)

OCU:	100357431(RB1)

TUP:	102499507(RB1)

CFA:	476915(RB1)

VVP:	112933932(RB1)

AML:	100477714(RB1)

UMR:	103677688(RB1)

UAH:	113251325(RB1)

ORO:	101386367(RB1)

ELK:

111146911

FCA:	101101356(RB1)

PTG:	102952365(RB1)

PPAD:

109265951(RB1)

AJU:	106971960(RB1)

BTA:	534712(RB1)

BOM:	102267169(RB1)

BIU:	109566987(RB1)

BBUB:

102400134(RB1)

CHX:	102183886(RB1)

OAS:	100144755(RB1)

SSC:	100151828(RB1)

CFR:	102516870(RB1)

CDK:	105101803(RB1)

BACU:

103013752(RB1)

LVE:	103072166(RB1)

OOR:	101272870(RB1)

DLE:	111175081(RB1)

PCAD:

102995201(RB1)

ECB:	100057080(RB1)

EPZ:	103549440(RB1)

EAI:	106829635(RB1)

MYB:	102251785(RB1)

MYD:	102766251(RB1)

MNA:	107531399(RB1)

HAI:	109387138(RB1)

DRO:	112313044(RB1)

PALE:

102893019(RB1)

RAY:	107520925(RB1)

MJV:

108384777

LAV:	100673196(RB1)

TMU:

101355952

MDO:	100022630(RB1)

SHR:	100914196(RB1)

PCW:	110213446(RB1)

OAA:	100083537(RB1)

GGA:	386582(RB1)

MGP:	100549197 104917517

CJO:	107308151(RB1)

NMEL:

110387715(RB1)

APLA:

101793414(RB1)

ACYG:

106035039(RB1)

TGU:	100217687(RB1)

LSR:	110469557(RB1)

SCAN:

103812574(RB1)

GFR:	102036868(RB1)

FAB:	101806985(RB1)

PHI:	102105165(RB1)

PMAJ:

107203084(RB1)

CCAE:

111938847(RB1)

CCW:	104690005(RB1)

ETL:	114060928(RB1)

FPG:	101918471(RB1)

FCH:	102054877(RB1)

CLV:	102084576(RB1)

EGZ:	104131621(RB1)

NNI:	104010954(RB1)

ACUN:

113489292(RB1)

PADL:

103913489(RB1)

AAM:	106489167(RB1)

ASN:	102379703(RB1)

AMJ:	102564411(RB1)

PSS:	102445665(RB1)

CMY:	102937814(RB1)

CPIC:

101930889(RB1)

ACS:	100567638(rb1)

PVT:	110091007(RB1)

PBI:	103062466(RB1)

PMUR:

107284299(RB1)

TSR:	106543703(RB1)

PMUA:

114582635(RB1)

GJA:	107112871(RB1)

XLA:	108709804(rb1.S)

XTR:	100493114(rb1)

NPR:	108792451(RB1)

DRE:	777733(rb1)

SRX:	107718950 107731452

SANH:

107681157 107703523

SGH:	107548180 107551603

CCAR:

109079645 109082733(rb1)

IPU:	108279123(rb1)

PHYP:

113541559(rb1)

AMEX:

103040648(rb1)

EEE:	113574008(rb1)

TRU:	101069848 115246431

TNG:	GSTEN00022163G001

LCO:	104919743(rb1)

NCC:	104954675(rb1)

MZE:	101480728(rb1)

ONL:	100708745(rb1)

OLA:	100049519(rb1)

XMA:	102230233(rb1)

XCO:	114153224(rb1)

PRET:

103475763 103475858

CVG:	107098241(rb1)

NFU:	107386518(rb1)

KMR:	108248278(rb1)

ALIM:

106516385(rb1)

AOCE:

111577644(rb1)

CSEM:

103395441(rb1)

POV:	109628702(rb1)

LCF:	108893878(rb1)

SDU:	111234349(rb1)

SLAL:

111653978(rb1)

HCQ:	109512505(rb1)

BPEC:

110168135(rb1)

MALB:

109959496(rb1)

SASA:

100380330(rb1)

OTW:	112228649(rb1)

SALP:

111950388(rb1)

ELS:	105023905(rb1)

SFM:	108934475(rb1)

PKI:	111838068(rb1)

LCM:	102347219 102366565(RB1)

CMK:	103177409(rb1)

RTP:	109937908(rb1)

BFO:

SPU:

APLC:

SKO:

PTEP:

PCAN:

CRG:

MYI:

OBI:

LAK:	106159872 106169307

ADF:

AMIL:

PDAM:

SPIS:

TAD:	TRIADDRAFT_60210

CME:	CYME_CMT038C

DFA:	DFA_11907(rblA)

PTM:	GSPATT00020039001 GSPATT00022277001

PIF:	PITG_16462

PSOJ:

PHYSODRAFT_354183

SPAR:

SPRG_08426

NGR:	NAEGRDRAFT_80903

» show all

Reference

PMID:1756735

Authors

Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E

Title

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

Journal

EMBO J 10:4279-90 (1991)
DOI:10.1002/j.1460-2075.1991.tb05006.x

Sequence

[hsa:5925]

Reference

PMID:15084261

Authors

Ren S, Rollins BJ

Title

Cyclin C/cdk3 promotes Rb-dependent G0 exit.

Journal

Cell 117:239-51 (2004)
DOI:10.1016/S0092-8674(04)00300-9

Sequence

[hsa:5925]

Reference

PMID:3823889

Authors

Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY

Title

Human retinoblastoma susceptibility gene: cloning, identification, and sequence.

Journal

Science 235:1394-9 (1987)
DOI:10.1126/science.3823889

Sequence

[hsa:5925]

LinkDB

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