KEGG   ORTHOLOGY: K06643
Entry
K06643                      KO                                     

Name
MDM2
Definition
E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
Pathway
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04625  C-type lectin receptor signaling pathway
ko04919  Thyroid hormone signaling pathway
ko05131  Shigellosis
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
Disease
H00025  Penile cancer
H00028  Choriocarcinoma
H00036  Osteosarcoma
H00037  Rhabdomyosarcoma
H00042  Glioma
H01513  Retinoblastoma
H01667  Medulloblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04151 PI3K-Akt signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09143 Cell growth and death
   04110 Cell cycle
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04115 p53 signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04218 Cellular senescence
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05202 Transcriptional misregulation in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05206 MicroRNAs in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05205 Proteoglycans in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05203 Viral carcinogenesis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09162 Cancer: specific types
   05214 Glioma
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05220 Chronic myeloid leukemia
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05218 Melanoma
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05219 Bladder cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05215 Prostate cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05169 Epstein-Barr virus infection
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05165 Human papillomavirus infection
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   01522 Endocrine resistance
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04121 Ubiquitin system
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   MDM2/MDM4 proteins
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Other DBs
GO: 0017163
Genes
HSA: 4193(MDM2)
PTR: 742141(MDM2)
PPS: 100968756(MDM2)
GGO: 101129964(MDM2)
PON: 100171532(MDM2)
NLE: 100601465(MDM2)
MCC: 718284(MDM2)
MCF: 102136323(MDM2)
CSAB: 103238687(MDM2)
RRO: 104658667(MDM2)
RBB: 108532254(MDM2) 108535938
CJC: 100415620(MDM2)
SBQ: 101036938(MDM2)
MMU: 17246(Mdm2)
MCAL: 110303712(Mdm2)
MPAH: 110326473(Mdm2)
RNO: 314856(Mdm2)
MUN: 110562241(Mdm2)
CGE: 100770120(Mdm2)
NGI: 103745079(Mdm2)
HGL: 101724821(Mdm2)
CCAN: 109693333(Mdm2)
OCU: 100340389(MDM2)
TUP: 102473924(MDM2)
CFA: 403693(MDM2)
VVP: 112922285(MDM2)
AML: 100479481(MDM2)
UMR: 103656869(MDM2)
UAH: 113256295(MDM2)
ORO: 101385402(MDM2)
ELK: 111142120
FCA: 493939(MDM2)
PTG: 102965880(MDM2)
PPAD: 109270482(MDM2)
AJU: 106966348(MDM2)
BTA: 540378(MDM2)
BOM: 102287490(MDM2)
BIU: 109558399(MDM2)
BBUB: 102401535(MDM2)
CHX: 102173163(MDM2)
OAS: 101103187 101104979(MDM2)
SSC: 100125959(MDM2)
CFR: 102522420(MDM2)
CDK: 105101086(MDM2)
BACU: 103017808(MDM2)
LVE: 103081431(MDM2)
OOR: 101286234(MDM2)
DLE: 111173763(MDM2)
PCAD: 102980125(MDM2)
ECB: 100052084(MDM2)
EPZ: 103558340(MDM2)
EAI: 106843578(MDM2)
MYB: 102256024(MDM2)
MYD: 102771162(MDM2)
MNA: 107526860(MDM2)
HAI: 109381699(MDM2)
DRO: 112319061(MDM2)
PALE: 102884281(MDM2)
RAY: 107512674(MDM2)
MJV: 108394490(MDM2)
LAV: 100669448(MDM2)
TMU: 101349408
MDO: 100021398(MDM2) 103092862
SHR: 100919874(MDM2) 100920321
PCW: 110211045(MDM2)
OAA: 100080712(MDM2)
GGA: 395609(MDM2)
MGP: 100546889(MDM2)
CJO: 107310502(MDM2)
NMEL: 110392787(MDM2)
APLA: 101805150(MDM2)
ACYG: 106046963(MDM2)
TGU: 100228592(MDM2)
LSR: 110477995(MDM2)
SCAN: 103813452(MDM2)
GFR: 102041787(MDM2)
FAB: 101813089(MDM2)
PHI: 102099986(MDM2)
PMAJ: 107204718(MDM2)
CCAE: 111932718(MDM2)
CCW: 104698375(MDM2)
ETL: 114062165(MDM2)
FPG: 101924125(MDM2)
FCH: 102048171(MDM2)
CLV: 102085264(MDM2)
EGZ: 104132910(MDM2)
NNI: 104011004(MDM2)
ACUN: 113490049(MDM2)
PADL: 103919957(MDM2)
AAM: 106488755(MDM2)
ASN: 102385768(MDM2)
AMJ: 102561091(MDM2)
PSS: 102447336(MDM2)
CMY: 102948375(MDM2)
CPIC: 101936483(MDM2)
ACS: 100556723(mdm2)
PVT: 110075109(MDM2)
PBI: 103063483(MDM2)
PMUR: 107284408(MDM2)
TSR: 106538064(MDM2)
PMUA: 114605045(MDM2)
GJA: 107105724(MDM2)
XLA: 108711092(mdm2.L) 108713153
XTR: 394853(mdm2)
NPR: 108804551(MDM2)
DRE: 30637(mdm2)
IPU: 108279728(mdm2)
PHYP: 113523888(mdm2) 113525266
AMEX: 103039064(mdm2)
EEE: 113569662(mdm2)
TRU: 101068181(mdm2)
LCO: 104927096
NCC: 104955413
MZE: 101466094(mdm2)
ONL: 100697160(mdm2)
OLA: 101174634(mdm2)
XMA: 102234130(mdm2)
XCO: 114160947(mdm2)
PRET: 103459095(mdm2)
CVG: 107090500(mdm2)
NFU: 107387038(mdm2)
KMR: 108249644(mdm2)
ALIM: 106535795(mdm2)
AOCE: 111586407
CSEM: 103382446(mdm2)
POV: 109643735(mdm2)
LCF: 108880253 108895890(mdm2)
SDU: 111224985(mdm2)
SLAL: 111657669(mdm2)
HCQ: 109532684(mdm2)
BPEC: 110161709(mdm2)
MALB: 109967598(mdm2)
OTW: 112262208(mdm2)
SALP: 112078930(mdm2)
ELS: 105017801(mdm2)
SFM: 108936337(mdm2)
PKI: 111851197(mdm2)
LCM: 102353921(MDM2)
CMK: 103185308(mdm2)
RTP: 109934681
CIN: 100181157
SPU: 100893740
AAG: 110680648
AALB: 109405526
CSOL: 105361370
MDL: 103575237
TCA: 664204
NVL: 108569162
BMOR: 101745393
BMAN: 114251521
PMAC: 106714638
HAW: 110372415
PXY: 105381544
API: 100163302
DNX: 107161622
AGS: 114132537
RMD: 113549656
BTAB: 109030066
ZNE: 110841453
PVM: 113813833
CSCU: 111637161
PTEP: 107444458
PCAN: 112565919
CRG: 105324709
OBI: 106871879
EPA: 110244124
ADF: 107350549
AMIL: 114950841
DGT: 114522379
HMG: 100205294
 » show all
Reference
  Authors
Tamborini E, Della Torre G, Lavarino C, Azzarelli A, Carpinelli P, Pierotti MA, Pilotti S
  Title
Analysis of the molecular species generated by MDM2 gene amplification in liposarcomas.
  Journal
Int J Cancer 92:790-6 (2001)
DOI:10.1002/ijc.1271
  Sequence
[hsa:4193]
Reference
  Authors
Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K
  Title
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
  Journal
J Biol Chem 285:4909-19 (2010)
DOI:10.1074/jbc.M109.042341
Reference
PMID:1614537
  Authors
Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B
  Title
Amplification of a gene encoding a p53-associated protein in human sarcomas.
  Journal
Nature 358:80-3 (1992)
DOI:10.1038/358080a0
  Sequence
[hsa:4193]
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