KEGG   ORTHOLOGY: K06745Help
Entry
K06745                      KO                                     

Name
PDL1, CD274
Definition
programmed cell death 1 ligand 1
Pathway
ko04514  Cell adhesion molecules (CAMs)
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06745  PDL1, CD274; programmed cell death 1 ligand 1
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06745  PDL1, CD274; programmed cell death 1 ligand 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06745  PDL1, CD274; programmed cell death 1 ligand 1
CD molecules [BR:ko04090]
 Proteins
  K06745  CD274; programmed cell death 1 ligand 1
BRITE hierarchy
Genes
HSA: 29126(CD274)
PTR: 464981(CD274)
PPS: 100984141(CD274)
GGO: 101153873(CD274)
PON: 100443891(CD274)
NLE: 100593818(CD274)
MCC: 716043(CD274)
MCF: 102145573(CD274)
CSAB: 103219482(CD274)
RRO: 104663753(CD274)
RBB: 108533064(CD274)
CJC: 100415050(CD274)
SBQ: 101031473(CD274)
MMU: 60533(Cd274)
MCAL: 110286085(Cd274)
MPAH: 110338267(Cd274)
RNO: 499342(Cd274)
MUN: 110547005(Cd274)
CGE: 100759180(Cd274)
NGI: 103748535(Cd274)
HGL: 101719302(Cd274)
CCAN: 109683630(Cd274)
OCU: 100357106(CD274)
TUP: 102500862(CD274)
CFA: 484186(CD274)
VVP: 112922152(CD274)
AML: 100481858(CD274)
UMR: 103663205(CD274)
UAH: 113270154(CD274)
ORO: 101378489(CD274)
ELK: 111153609
FCA: 100127110(CD274)
PTG: 102949251(CD274)
PPAD: 109275496(CD274)
AJU: 106968142(CD274)
BTA: 533834(CD274)
BOM: 102277853(CD274)
BIU: 109562902(CD274)
BBUB: 102412930(CD274)
CHX: 102179284(CD274)
OAS: 101115003(CD274) 114113076
SSC: 574058(CD274)
CFR: 102522327(CD274)
CDK: 105100414(CD274)
BACU: 103015394(CD274)
LVE: 103069737(CD274)
OOR: 101275869(CD274)
DLE: 111174654(CD274)
PCAD: 102983573(CD274)
ECB: 100051703(CD274)
EPZ: 103554263(CD274)
EAI: 106843625(CD274)
MYB: 102254061(CD274)
MYD: 102769396(CD274)
MNA: 107538149(CD274)
HAI: 109394562(CD274)
DRO: 112302711(CD274)
PALE: 102880872(CD274)
RAY: 107507295(CD274)
MJV: 108395456(CD274)
LAV: 100675646(CD274)
TMU: 101359961
MDO: 100018006(CD274)
SHR: 100920966(CD274)
PCW: 110221607(CD274)
OAA: 100074433
GGA: 427224(CD274)
MGP: 100549187
CJO: 107306120(CD274)
NMEL: 110389954
APLA: 101799097(CD274) 101802919
ACYG: 106046390
TGU: 100218757(CD274)
LSR: 110471225
SCAN: 103823843
GFR: 102040903(CD274)
FAB: 101818942(CD274)
PHI: 102108018(CD274)
PMAJ: 107198310
CCAE: 111940684
CCW: 104685175(CD274)
ETL: 114056122(CD274)
FPG: 101921755(CD274)
FCH: 102053679
CLV: 102094944
EGZ: 104125651(CD274)
NNI: 104021427(CD274)
ACUN: 113490411
PADL: 103924938(CD274)
AAM: 106496776(CD274)
ASN: 102373990
PSS: 102456103(CD274) 102456519
CPIC: 101933339 101953917(CD274)
ACS: 100558594
PBI: 103060954
XLA: 108705366 108714240(cd274.L)
XTR: 101731191
SRX: 107713581
IPU: 108278705
PHYP: 113535800
AMEX: 103046587
EEE: 113573775
TRU: 100462947(b7-h1/dc)
LCO: 104923608
OLA: 101170285
ALIM: 106514544
AOCE: 111573741
HCQ: 109517085
SASA: 100196322(pdl1) 106561458
ELS: 105023549
SFM: 108933891(cd274)
CMK: 103177701(cd274)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Dong H, Zhu G, Tamada K, Chen L
  Title
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.
  Journal
Nat Med 5:1365-9 (1999)
DOI:10.1038/70932
  Sequence
[hsa:29126]
Reference
  Authors
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, Honjo T
  Title
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
  Journal
J Exp Med 192:1027-34 (2000)
DOI:10.1084/jem.192.7.1027
  Sequence
[hsa:29126] [mmu:60533]
Reference
  Authors
Keir ME, Butte MJ, Freeman GJ, Sharpe AH
  Title
PD-1 and its ligands in tolerance and immunity.
  Journal
Annu Rev Immunol 26:677-704 (2008)
DOI:10.1146/annurev.immunol.26.021607.090331
LinkDB All DBs

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