KEGG   ORTHOLOGY: K07201
Entry
K07201                      KO                                     

Name
FOXO1
Definition
forkhead box protein O1
Pathway
ko04068  FoxO signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04910  Insulin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04922  Glucagon signaling pathway
ko04931  Insulin resistance
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05131  Shigellosis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05215  Prostate cancer
Disease
H00037  Rhabdomyosarcoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K07201  FOXO1; forkhead box protein O1
   04152 AMPK signaling pathway
    K07201  FOXO1; forkhead box protein O1
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K07201  FOXO1; forkhead box protein O1
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07201  FOXO1; forkhead box protein O1
   04922 Glucagon signaling pathway
    K07201  FOXO1; forkhead box protein O1
   04919 Thyroid hormone signaling pathway
    K07201  FOXO1; forkhead box protein O1
  09149 Aging
   04211 Longevity regulating pathway
    K07201  FOXO1; forkhead box protein O1
   04213 Longevity regulating pathway - multiple species
    K07201  FOXO1; forkhead box protein O1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07201  FOXO1; forkhead box protein O1
   05202 Transcriptional misregulation in cancer
    K07201  FOXO1; forkhead box protein O1
  09162 Cancer: specific types
   05215 Prostate cancer
    K07201  FOXO1; forkhead box protein O1
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K07201  FOXO1; forkhead box protein O1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K07201  FOXO1; forkhead box protein O1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K07201  FOXO1; forkhead box protein O1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K07201  FOXO1; forkhead box protein O1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K07201  FOXO1; forkhead box protein O1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix other regulators
    K07201  FOXO1; forkhead box protein O1
Genes
HSA: 2308(FOXO1)
PTR: 467352(FOXO1)
PPS: 100996020(FOXO1)
GGO: 101151399(FOXO1)
PON: 100460676(FOXO1)
NLE: 100594615(FOXO1)
MCC: 700030(FOXO1)
MCF: 102116712(FOXO1)
CSAB: 103214322(FOXO1)
RRO: 104671116(FOXO1)
RBB: 108514115(FOXO1)
CJC: 100397393(FOXO1)
SBQ: 101053657(FOXO1)
MMU: 56458(Foxo1)
MCAL: 110291168(Foxo1)
MPAH: 110319907(Foxo1)
RNO: 84482(Foxo1)
MUN: 110549421(Foxo1)
CGE: 100768647(Foxo1)
NGI: 103747066(Foxo1)
HGL: 101707441(Foxo1)
CCAN: 109688921(Foxo1)
OCU: 100358471(FOXO1)
TUP: 102489658(FOXO1)
CFA: 477295(FOXO1)
VVP: 112918703(FOXO1)
AML: 100471182(FOXO1)
UMR: 103677704(FOXO1)
UAH: 113251282(FOXO1)
ORO: 101373912(FOXO1)
ELK: 111158571
FCA: 101096628(FOXO1)
PTG: 102969147(FOXO1)
PPAD: 109266009(FOXO1)
AJU: 106972644(FOXO1)
BTA: 506618(FOXO1)
BOM: 102284612(FOXO1)
BIU: 109566997(FOXO1)
BBUB: 102396402(FOXO1)
CHX: 102184915(FOXO1)
OAS: 101107877(FOXO1)
SSC: 397077(FOXO1)
CFR: 102511562(FOXO1)
CDK: 105091004(FOXO1)
BACU: 103020667(FOXO1)
LVE: 103086905(FOXO1)
OOR: 101285637(FOXO1)
DLE: 111175267(FOXO1)
PCAD: 102980680(FOXO1)
ECB: 100050481(FOXO1)
EPZ: 103552024(FOXO1)
EAI: 106848479(FOXO1)
MYB: 102253962(FOXO1)
MYD: 102766094(FOXO1)
MNA: 107537551(FOXO1)
HAI: 109387667(FOXO1)
DRO: 112312153(FOXO1)
PALE: 102892244(FOXO1)
RAY: 107497776(FOXO1)
MJV: 108409638(FOXO1)
LAV: 100655740(FOXO1)
TMU: 101340503
MDO: 100021587(FOXO1)
SHR: 100928882(FOXO1)
PCW: 110196617(FOXO1)
OAA: 100082288(FOXO1)
GGA: 374231(FOXO1)
MGP: 100540055(FOXO1)
CJO: 107308196(FOXO1)
NMEL: 110388188(FOXO1)
APLA: 101795447(FOXO1)
ACYG: 106035078(FOXO1)
TGU: 100217629(FOXO1)
LSR: 110468577(FOXO1)
SCAN: 103812564(FOXO1)
GFR: 102039410(FOXO1)
FAB: 101809090(FOXO1)
PHI: 102099738(FOXO1)
PMAJ: 107210372(FOXO1)
CCAE: 111944362(FOXO1)
CCW: 104689938(FOXO1)
ETL: 114059362(FOXO1)
FPG: 101915696(FOXO1)
FCH: 102057600(FOXO1)
CLV: 102086772(FOXO1)
EGZ: 104129682(FOXO1)
NNI: 104010936(FOXO1)
ACUN: 113482931(FOXO1)
PADL: 103913472(FOXO1)
AAM: 106489240(FOXO1)
ASN: 102388853(FOXO1)
AMJ: 102576430(FOXO1)
PSS: 102449767(FOXO1)
CMY: 102939461(FOXO1)
CPIC: 101940772(FOXO1)
ACS: 100557662(foxo1)
PVT: 110076126(FOXO1)
PBI: 103062993(FOXO1)
PMUR: 107289857(FOXO1)
TSR: 106545297(FOXO1)
PMUA: 114593612(FOXO1)
GJA: 107110257(FOXO1)
XLA: 108709932(foxo1.S) 444991(foxo1.L)
XTR: 493378(foxo1)
NPR: 108787037(FOXO1)
DRE: 567969(foxo1b) 768121(foxo1a)
SRX: 107726642 107736053 107740375 107746988 107751405
SANH: 107670538 107686122 107691691 107699815
SGH: 107561479 107577289 107588742 107593464
CCAR: 109048466 109074678 109078089 109083902 109103872
IPU: 108277356 108277791(foxo1)
PHYP: 113524179 113539229(foxo1)
AMEX: 103032706(foxo1) 103046520
EEE: 113578626(foxo1) 113590924
TRU: 101072628 101073915
TNG: GSTEN00022123G001 GSTEN00035220G001
LCO: 104925216 104937129
NCC: 104957347(foxo1) 104967635
MZE: 101468133 101469585
ONL: 100699299 100706939
OLA: 100301620(foxo1) 101164740
XMA: 102236896(foxo1) 102237615
XCO: 114153516 114161639(foxo1)
PRET: 103475003 103475797(foxo1)
CVG: 107095350 107099244
NFU: 107380205(foxo1) 107386483
KMR: 108236025(foxo1a) 108245221
ALIM: 106516356 106520575
AOCE: 111563615 111588523
CSEM: 103378152(foxo1) 103395707
POV: 109628830 109630392
LCF: 108876119 108893933
SDU: 111224434 111234491
SLAL: 111654758 111666300
HCQ: 109512429 109530782
BPEC: 110158469 110164373(foxo1)
MALB: 109959485 109968458(foxo1)
SASA: 106560693 106581554 106602890
OTW: 112218371(foxo1) 112228186 112239895
SALP: 111951028(foxo1) 111962019 112071347
ELS: 105007737 105008116(foxo1)
SFM: 108921676 108941767
PKI: 111850649 111851322
LCM: 102347273(FOXO1)
CMK: 103177236(foxo1)
RTP: 109926926(foxo1)
SPU: 585334
DGT: 114535699
 » show all
Reference
  Authors
Bois PR, Izeradjene K, Houghton PJ, Cleveland JL, Houghton JA, Grosveld GC
  Title
FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma.
  Journal
J Cell Biol 170:903-12 (2005)
DOI:10.1083/jcb.200501040
Reference
  Authors
Zhang X, Gan L, Pan H, Guo S, He X, Olson ST, Mesecar A, Adam S, Unterman TG
  Title
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.
  Journal
J Biol Chem 277:45276-84 (2002)
DOI:10.1074/jbc.M208063200
  Sequence
[hsa:2308]
Reference
PMID:9479491
  Authors
Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC
  Title
Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
  Journal
Genomics 47:187-99 (1998)
DOI:10.1006/geno.1997.5122
  Sequence
[hsa:2308]
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