KEGG ORTHOLOGY: K07412

ORTHOLOGY: K07412

Entry

K07412                      KO

Symbol

CYP2B

Name

cytochrome P450 family 2 subfamily B [EC:1.14.14.1]

Pathway

map00140

Steroid hormone biosynthesis

map00590

Arachidonic acid metabolism

map00830

Retinol metabolism

map01100

Metabolic pathways

map05207

Chemical carcinogenesis - receptor activation

Reaction

R03408

R07001

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07048

R07050

R07051

R07052

R08390

R08391

R08392

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
   00590 Arachidonic acid metabolism
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07412  CYP2B; cytochrome P450 family 2 subfamily B
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K07412  CYP2B; cytochrome P450 family 2 subfamily B

Genes

PCOQ:

105820475 105820477 105820598

OGA:

105888244

MMU:	13088(Cyp2b10) 13089(Cyp2b13) 13090(Cyp2b19) 13094(Cyp2b9) 243881(Cyp2b23)

MCAL:

110288440 110288965 110297861 110298448 110298729 110298847

MPAH:

110336742

RNO:	103691072(Cyp2b14) 103691092 24300(Cyp2b1) 286953(Cyp2b3) 292728(Cyp2b21) 29295(Cyp2b12) 361523(Cyp2b2) 685222(Cyp2b15)

MCOC:

116100420 116101862 116101866

ANU:	117710642 117710646 117714125

MUN:	110541208 110541305 110561195 110566202

CGE:	100759787 100760248 100762876 100763166 100763652 100765152 100765441 113837198 113838302

MAUA:

101833813 101844221 101844487 101844759 110339371 110339777 121135526 121135543

PROB:

127238392 127238393 127238561 127238677

PLEU:

114681539 114681540 114685303 114685307 114685311 114709908

MORG:

121449160 121449161 121449216 121449230 121449273 121449308 121449313

MFOT:

126491014 126491015 126491016 126491474 126492551 126492557 126492560 126494574 126494580

AAMP:

119820529 119820530 119820531 119820542 119820560 119820577 119820578 119821048 119821050

NGI:	103734444 103734445

HGL:	101700457 101713256

CPOC:

100719649 100720199 100728848

CCAN:

109680163 109703253

DORD:

106000902 106002870

DSP:	122097399 122097400

PLOP:

125338988 125338999

NCAR:

124966667 124966693 124966955

MMMA:

107151434 107151634

OCU:	100327257(CYP2B4) 100328947(CYP2B5) 100328948 100353574 127486083

OPI:

101530662

TUP:	102479421 102494535

GVR:

103600497

CFA:	474177(CYP2B6)

CLUD:

VVP:

VLG:

NPO:

AML:	100464347 100471209

UMR:	103677389 103677390

UAH:	113243545 113243547

UAR:	123782650 123782733

ELK:	111161484 111161535

LLV:	125089181 125089182

MPUF:

101673760 101674033

MNP:	132005762 132005763

MLK:	131817740 131817741

NVS:	122912057 122912058

ORO:	101366852 101385757

EJU:

114202558

ZCA:	113936245 113936360

MLX:

118022638

NSU:

110590260

FCA:	105259649(CYP2B6) 105260134

PYU:	121026667 121026668

PCOO:

112851322

PBG:	122494012 122494013

PVIV:

125152576 125153441 125153673

LRUF:

124511102 124511733

PPAD:

109261476

PUC:

125915742

AJU:	128313207 128313238

HHV:

120243430

BTA:	504769(CYP2B6) 530571(CYP2B39)

BOM:	102282243 102287777

BIU:	109572039 109573028

BBUB:

102389842 102403709

BBIS:

104995375 104995377

CHX:	102169213 102177329 108633257 108634920

OAS:	105614373 114117814 114117992

BTAX:

128063721 128063735 128063836 128063962

ODA:	120872403 120872470 120873272 120873273 120873274

CCAD:

122420841 122420842 122421523 122421559

MBEZ:

129546790

SSC:	102165015 403104(CYP2B22)

CFR:	102506939 102510644

CBAI:

105062874 105062875

CDK:	105093362 105093363

VPC:	102540531 102541423

ECB:	100068569 100068603

EPZ:	103562352 103562353 103567950

EAI:	106843260 106843311 106843807 123281262

MYB:

102245131

MYD:

102751643

MMYO:

118674745

MLF:	102434131 102434449

MDT:

PKL:

EFUS:

DRO:

AJM:	119042877 119064581

PDIC:

PHAS:

MMF:

PPAM:

HAI:	109376598 109376600

RFQ:

117035075

PGIG:

120595325

PVP:	105311372 105311521

RAY:

107521826

MJV:

108405662

TOD:	119248644 119249343 119249344

SARA:

101545542 101545812 101546075 101546339 101546853 101547109 101552590

SETR:

126027511 126028124 126028126 126028128 126028134 126028139 126028181 126028182 126028540 126028542

LAV:	100667350 100677786

TMU:

101341442

ETF:	101648079 101648692

DNM:	101434321 101439883

MDO:

100018927

GAS:	123242991 123242992

SHR:	100931571 105749943

AFZ:

127556219

PCW:	110198215 110198316 110203819 110204171

TVP:	118837371 118837372 118837766 118837784

OAA:

CABI:

ASAO:

PCHN:

HAME:

PCLA:

HAZT:

108665744 108667155 108682011

PPOI:

119094960

ABRU:

129968506

UDV:	129220285 129233366

SDM:	118179726 118184819

CANU:

OED:

PMAX:

RPHI:

OSN:	115217139 115217246 115217542 115231109 115231157

» show all

Reference

PMID:6306654 (CYP2B2)

Authors

Mizukami Y, Sogawa K, Suwa Y, Muramatsu M, Fujii-Kuriyama Y

Title

Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.

Journal

Proc Natl Acad Sci U S A 80:3958-62 (1983)
DOI:10.1073/pnas.80.13.3958

Sequence

[rno:361523]

Reference

PMID:3396451 (CYP2B3)

Authors

Labbe D, Jean A, Anderson A

Title

A constitutive member of the rat cytochrome P450IIB subfamily: full-length coding sequence of the P450IIB3 cDNA.

Journal

DNA 7:253-60 (1988)
DOI:10.1089/dna.1988.7.253

Sequence

[rno:286953]

Reference

PMID:3219345 (CYP2B9 CYP2B10)

Authors

Noshiro M, Lakso M, Kawajiri K, Negishi M

Title

Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.

Journal

Biochemistry 27:6434-43 (1988)
DOI:10.1021/bi00417a035

Sequence

[mmu:13094 13088]

Reference

PMID:2116765 (CYP2B11)

Authors

Graves PE, Elhag GA, Ciaccio PJ, Bourque DP, Halpert JR

Title

cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

Journal

Arch Biochem Biophys 281:106-15 (1990)
DOI:10.1016/0003-9861(90)90419-y

Sequence

[cfa:474177]

Reference

PMID:1445240 (CYP2B12)

Authors

Friedberg T, Grassow MA, Bartlomowicz-Oesch B, Siegert P, Arand M, Adesnik M, Oesch F

Title

Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver.

Journal

Biochem J 287 ( Pt 3):775-83 (1992)
DOI:10.1042/bj2870775

Sequence

[rno:29295]

Reference

PMID:8294026 (CYP2B15)

Authors

Nakayama K, Suwa Y, Mizukami Y, Sogawa K, Fujii-Kuriyama Y

Title

Cloning and sequencing of a novel rat cytochrome P450 2B-encoding gene.

Journal

Gene 136:333-6 (1993)
DOI:10.1016/0378-1119(93)90490-t

Sequence

[rno:685222]

Reference

PMID:9799616 (CYP2B19)

Authors

Keeney DS

Title

The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes.

Journal

Genomics 53:417-9 (1998)
DOI:10.1006/geno.1998.5533

Sequence

[mmu:13090]

Reference

PMID:11159754 (CYP2B21)

Authors

Brookman-Amissah N, Mackay AG, Swann PF

Title

Isolation and sequencing of the cDNA of a novel cytochrome P450 from rat oesophagus.

Journal

Carcinogenesis 22:155-60 (2001)
DOI:10.1093/carcin/22.1.155

Sequence

[rno:292728]

Reference

PMID:16315095 (CYP2B22)

Authors

Kawahigashi H, Hirose S, Ozawa K, Ido Y, Kojima M, Ohkawa H, Ohkawa Y

Title

Analysis of substrate specificity of pig CYP2B22 and CYP2C49 towards herbicides by transgenic rice plants.

Journal

Transgenic Res 14:907-17 (2005)
DOI:10.1007/s11248-005-0199-x

Sequence

[ssc:403104]

LinkDB

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