KEGG ORTHOLOGY: K07889

ORTHOLOGY: K07889

Entry

K07889                      KO

Symbol

RAB5C

Name

Ras-related protein Rab-5C

Pathway

map04014

Ras signaling pathway

map04137

Mitophagy - animal

map04144

Endocytosis

map04145

Phagosome

map04148

Efferocytosis

map04962

Vasopressin-regulated water reabsorption

map05132

Salmonella infection

map05146

Amoebiasis

map05152

Tuberculosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07889  RAB5C; Ras-related protein Rab-5C
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K07889  RAB5C; Ras-related protein Rab-5C
   04145 Phagosome
    K07889  RAB5C; Ras-related protein Rab-5C
   04137 Mitophagy - animal
    K07889  RAB5C; Ras-related protein Rab-5C
   04148 Efferocytosis
    K07889  RAB5C; Ras-related protein Rab-5C
09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K07889  RAB5C; Ras-related protein Rab-5C
09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K07889  RAB5C; Ras-related protein Rab-5C
   05152 Tuberculosis
    K07889  RAB5C; Ras-related protein Rab-5C
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K07889  RAB5C; Ras-related protein Rab-5C
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07889  RAB5C; Ras-related protein Rab-5C
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K07889  RAB5C; Ras-related protein Rab-5C
   04031 GTP-binding proteins
    K07889  RAB5C; Ras-related protein Rab-5C
Membrane trafficking [BR:ko04131]
Endocytosis
  Rab GTPases and associated proteins
   Rab GTPases
    K07889  RAB5C; Ras-related protein Rab-5C
Endosome - Lysosome transport
  Rab GTPases and associated proteins
   Rab GTPases
    K07889  RAB5C; Ras-related protein Rab-5C
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K07889  RAB5C; Ras-related protein Rab-5C
  Exosomal proteins of other body fluids (saliva and urine)
   K07889  RAB5C; Ras-related protein Rab-5C
  Exosomal proteins of colorectal cancer cells
   K07889  RAB5C; Ras-related protein Rab-5C
  Exosomal proteins of bladder cancer cells
   K07889  RAB5C; Ras-related protein Rab-5C
GTP-binding proteins [BR:ko04031]
Small (monomeric) G-proteins
  Rab Family
   Rab5/17/22/31 [OT]
    K07889  RAB5C; Ras-related protein Rab-5C

Genes

HSA:	5878(RAB5C)

PTR:	454678(RAB5C)

PPS:	100985866(RAB5C)

GGO:	101126272(RAB5C)

PON:	100174605(RAB5C)

PPYG:

129017266(RAB5C)

NLE:	115830348(RAB5C)

HMH:	116474856(RAB5C)

SSYN:

129469983(RAB5C)

MCC:	709308(RAB5C)

MCF:	102116190(RAB5C)

MTHB:

126938528

MNI:	105472127(RAB5C)

CSAB:

103243420(RAB5C)

CATY:

105579663(RAB5C)

PANU:

103878847(RAB5C)

TGE:	112610415(RAB5C)

MLEU:

105552963(RAB5C)

RRO:	104680360(RAB5C)

RBB:	108518346(RAB5C)

TFN:	117066969(RAB5C)

PTEH:

111537377(RAB5C)

CANG:

105503017(RAB5C)

CJC:	100410452(RAB5C)

SBQ:	101045231(RAB5C)

CIMI:

108289830(RAB5C)

ANAN:

105711350(RAB5C)

CSYR:

103276762(RAB5C)

MMUR:

105859435(RAB5C)

LCAT:

123620954(RAB5C)

PCOQ:

105820246(RAB5C)

OGA:	100961515(RAB5C)

MMU:	19345(Rab5c)

MCAL:

110305560(Rab5c)

MPAH:

110331416(Rab5c)

RNO:	287709(Rab5c)

MCOC:

116078733(Rab5c) 116102056

ANU:	117711342(Rab5c)

ASYL:

127694216(Rab5c)

MUN:	110550900(Rab5c)

CGE:	100754413(Rab5c)

MAUA:

101833039(Rab5c)

PROB:

127216257(Rab5c)

PLEU:

114682792(Rab5c)

MORG:

121442499(Rab5c)

MFOT:

126494831 126510313

AAMP:

119812846(Rab5c)

NGI:	103735889(Rab5c)

HGL:	101696324(Rab5c)

CPOC:

100716247(Rab5c)

CCAN:

109695774(Rab5c)

DORD:

106003222(Rab5c)

DSP:	122100607 122103267(Rab5c)

PLOP:

125365387(Rab5c)

NCAR:

124959718 124979683

MMMA:

107150576(Rab5c)

ITI:	101965324(Rab5c)

OCU:

100348021

OPI:	101527032(RAB5C)

TUP:	102491203(RAB5C)

GVR:	103595346(RAB5C)

CFA:	403941(RAB5C)

CLUD:

112655680(RAB5C)

VVP:	112910783(RAB5C)

VLG:	121473647(RAB5C)

NPO:	129517291(RAB5C)

AML:	100469007(RAB5C)

UMR:	103672568(RAB5C)

UAH:	113265429(RAB5C)

UAR:	123781866(RAB5C)

ELK:

111151692

LLV:

125087087

MPUF:

101694461(RAB5C)

MNP:	132003597(RAB5C)

MLK:	131816225(RAB5C)

NVS:	122906201(RAB5C)

ORO:	101371029(RAB5C)

EJU:	114201386(RAB5C)

ZCA:	113908252(RAB5C)

MLX:	118024904(RAB5C)

NSU:	110573231(RAB5C)

FCA:	101094966(RAB5C)

PYU:	121045014(RAB5C)

PCOO:

112854063(RAB5C)

PBG:	122485595(RAB5C)

PVIV:

125158557(RAB5C)

LRUF:

124522107

LGF:	123603723(RAB5C)

AJU:

106972606

PTG:	102956967(RAB5C)

PPAD:

109258524(RAB5C)

PUC:

125926561

PLEZ:

122205930(RAB5C)

HHV:	120248450(RAB5C)

BTA:	613749(RAB5C)

BOM:	102284247(RAB5C)

BIU:	109574120(RAB5C)

BBUB:

102389317(RAB5C)

BBIS:

104990444(RAB5C)

CHX:	102185034(RAB5C)

OAS:	101122039(RAB5C)

BTAX:

128064681(RAB5C)

CSUM:

138083017(RAB5C)

ODA:	120867130(RAB5C)

CCAD:

122441670(RAB5C)

MREE:

136149586(RAB5C)

OVR:	110133805(RAB5C)

MBEZ:

129544418(RAB5C)

SSC:	100523862(RAB5C)

CFR:	102510298(RAB5C)

CBAI:

105080121(RAB5C)

CDK:	105090453(RAB5C)

VPC:	102543269(RAB5C)

BACU:

102999714 103013898

BMUS:

118886997(RAB5C)

LVE:	103080992(RAB5C)

OOR:	101279258(RAB5C)

LALB:

132511184(RAB5C)

DLE:	111166267(RAB5C)

PCAD:

102984866(RAB5C)

PSIU:

116744981(RAB5C)

NASI:

112398251(RAB5C)

ECB:	100053004(RAB5C)

EPZ:	103550370(RAB5C)

EAI:	106826414(RAB5C)

MYB:	102242981(RAB5C)

MYD:	102758064(RAB5C)

MMYO:

118671515(RAB5C)

MLF:	102427535(RAB5C)

MDT:	132218645(RAB5C)

MYUM:

138995081(RAB5C)

PKL:	118726615(RAB5C)

EFUS:

103293097(RAB5C)

MNA:	107544208(RAB5C)

DRO:	112298559(RAB5C)

SHON:

118977983(RAB5C)

AJM:	119037516(RAB5C)

PDIC:

114503432(RAB5C)

PHAS:

123816777(RAB5C)

MMF:	118634576(RAB5C)

PPAM:

129086904(RAB5C)

HAI:	109395780(RAB5C)

RFQ:	117013111(RAB5C)

PALE:

102885637(RAB5C)

PGIG:

120611108(RAB5C)

PVP:	105306300(RAB5C)

RAY:	107513817(RAB5C)

MJV:	108388342 118972640

TOD:	119231048(RAB5C)

SARA:

101551386(RAB5C)

SFUM:

130035410(RAB5C)

SETR:

126019115(RAB5C)

LAV:	100669020(RAB5C)

ETF:	101655554(RAB5C)

DNM:	101440834(RAB5C)

MDO:	100011633(RAB5C)

GAS:	123247994(RAB5C)

SHR:	100922389(RAB5C)

AFZ:

127560131

PCW:	110198476(RAB5C)

TVP:	118848959(RAB5C)

PBRV:

138145971(RAB5C)

OAA:	100085869(RAB5C)

TACU:

119934962(RAB5C)

GGA:	395197(RAB5C)

PCOC:

116233614(RAB5C)

MGP:	100545454(RAB5C)

CJO:	107325126(RAB5C)

TPAI:

128089071(RAB5C)

LMUT:

125684583(RAB5C)

NMEL:

110388541(RAB5C)

APLA:

119714085(RAB5C)

ACYG:

106048024(RAB5C)

CATA:

118259151(RAB5C)

AFUL:

116498559(RAB5C)

TGU:	100190713(RAB5C)

LSR:	110471846(RAB5C)

SCAN:

103821593(RAB5C)

PMOA:

120496557(RAB5C)

OTC:	121347587(RAB5C)

PRUF:

121351110(RAB5C)

ATRC:

139601463(RAB5C)

GFR:	102036958(RAB5C)

FAB:	101808051(RAB5C)

OMA:	130264002(RAB5C)

PHI:	102100820(RAB5C)

PMAJ:

107215163(RAB5C)

CCAE:

111939965(RAB5C)

CCW:	104697759(RAB5C)

CBRC:

103620218(RAB5C)

ACOE:

138099201(RAB5C)

ETL:	114063663(RAB5C)

ZAB:	102066559(RAB5C)

ZLE:	135458401(RAB5C)

SVG:	106858645(RAB5C)

MMEA:

130581432(RAB5C)

HRT:	120763672(RAB5C)

SATI:

136372079(RAB5C)

CCIC:

134053206(RAB5C)

FPG:	101918606(RAB5C)

FCH:	102053873(RAB5C)

CCRI:

104156512(RAB5B)

NNT:	104410000(RAB5C)

SHAB:

115617600(RAB5C)

ACUN:

113489175(RAB5C)

TALA:

104369118(RAB5C)

ACHC:

115344277(RAB5C)

HALD:

104317167(RAB5C)

HLE:	104842940(RAB5C)

AGEN:

126038680

HHAR:

128141016(RAB5C)

GCL:

127026553

CSTI:

104551415

LDI:	104347472(RAB5C)

MNB:	103771545(RAB5C)

PPUS:

135191791(RAB5C)

AVIT:

104274821

BRHI:

104491890(RAB5C)

EGZ:	104124452(RAB5C)

NNI:	104009874(RAB5C)

PCRI:

104026117(RAB5C)

PCAO:

104049679

PADL:

103919498(RAB5C)

AFOR:

103901801(RAB5C)

FGA:	104071624(RAB5C)

GSTE:

104254277(RAB5C)

CBOY:

140662552(RAB5C)

CLV:	102090435(RAB5C)

MUI:	104539875(RAB5C)

PGUU:

104466778(RAB5C)

PLET:

104618628(RAB5C)

EHS:	104508586(RAB5C)

CMAC:

104485796(RAB5C)

CUCA:

104054406(RAB5C)

TEO:	104371114(RAB5C)

BREG:

104641627(RAB5C)

OHA:	104333123(RAB5C)

CPEA:

104385659(RAB5C)

CVF:	104294771(RAB5C)

RTD:	128919115(RAB5C)

CRID:

134524361(RAB5C)

AAM:	106487626(RAB5C)

AROW:

112968726(RAB5C)

NPD:	112951795(RAB5C)

TGT:	104581035(RAB5C)

DNE:	112992608(RAB5C)

SCAM:

104152412(RAB5C)

ASN:	102377004(RAB5C)

AMJ:	102574972(RAB5C)

CPOO:

109320361(RAB5C)

GGN:	109289836(RAB5C)

PSS:	102459749(RAB5C)

CMY:	102932413(RAB5C)

CCAY:

125626720(RAB5C)

DCC:	119849065(RAB5C)

CPIC:

101938017(RAB5C)

CABI:

116829922(RAB5C)

MRV:	120392201(RAB5C)

ACS:	100566945(rab5c)

ASAO:

132778216(RAB5C)

PVT:	110074881(RAB5C)

SUND:

121934553(RAB5C)

PBI:	103067681(RAB5C)

VKO:	123030672(RAB5C)

PMUA:

114582609(RAB5C)

PRAF:

128399307(RAB5C)

ZVI:	118095181(RAB5C)

HCG:	128329998(RAB5C)

GJA:	107111472(RAB5C)

STOW:

125445077(RAB5C)

EMC:	129340294(RAB5C)

XLA:	380406(rab5c.L)

XTR:	594914(rab5c)

NPR:	108788937(RAB5C)

RTEM:

120918456(RAB5C)

BBUF:

121003426(RAB5C)

BGAR:

122940669(RAB5C)

PWL:	138299439(RAB5C)

MUO:	115481635(RAB5C)

GSH:	117347263(RAB5C)

DRE:	386807(rab5c)

SRX:	107729178 107755567

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122341534(rab5c)

LROH:

127155639(rab5c)

OMC:	131537535(rab5c)

PPRM:

120489695(rab5c)

RKG:	130071207(rab5c)

MAMB:

125279566(rab5c)

CIDE:

127509102

CERY:

137017488(rab5c)

MASI:

127450506 127451136

TROS:

130561680(rab5c)

TDW:	130425818(rab5c)

MANU:

129436244(rab5c)

PDAB:

135758952 135770120

IPU:	108274320 108278386(rab5c)

IFU:	128601990(rab5c) 128616945

PHYP:

113528140(rab5c) 113535328

SMEO:

124389403 124396751(rab5c)

TFD:	113652213(rab5c) 113662145

TVC:	132840932 132860804(rab5c)

CGAR:

128541202 128544439(rab5c)

NGRA:

132868795(rab5c) 132897989

TRN:	134321516 134335911(rab5c)

AMEX:

103035226 103045387(rab5c)

CMAO:

118809135 118820917(rab5c)

EEE:	113581775 113591521

CHAR:

105890789(rab5c) 105891187

SPIL:

134070170 134077411(rab5c)

TRU:	101069188 101071574(rab5c)

TFS:	130514629(rab5c) 130539963

TNG:	GSTEN00005991G001 GSTEN00022051G001

LCO:	104924139 104926007(rab5c)

NCC:	104958098 104967606

TBEN:

117469347 117473863 117492593(rab5c)

CGOB:

115011997(rab5c) 115024996

PGEO:

117451151(rab5c) 117464962

GACU:

117545136 117548825(rab5c)

EMAC:

134870689 134877680(rab5c)

ELY:	117260217 117268908(rab5c)

EFO:	125880172(rab5c) 125880788

PLEP:

121956656(rab5c) 121958625

SLUC:

116059728(rab5c) 116061315

ECRA:

117936701 117958453(rab5c)

ESP:	116671114 116703299(rab5c)

PFLV:

114547890 114569879(rab5c)

GAT:	120819402 120827609(rab5c)

PPUG:

119212889 119220770(rab5c)

AFB:	129091180 129098424(rab5c)

CLUM:

117734820(rab5c) 117748854

PSWI:

130188178(rab5c) 130203892

CANA:

137786562(rab5c) 137789921

CVE:	137878252(rab5c) 137886710

MSAM:

119892408(rab5c) 119915848

SCHU:

122867179 122868951(rab5c)

CUD:	121528891 121529635(rab5c)

SPUL:

138593196 138604046(rab5c)

LMIX:

132954497(rab5c) 132955244

ALAT:

119010193 119013397(rab5c)

ASTR:

137588132 137609139(rab5c)

MZE:	101465912 101481749(rab5c)

ONL:	100691790(rab5c) 100706267

OAU:	116312470(rab5c) 116329813

OLA:	101162840(rab5c)

OML:	112146764(rab5c)

CSAI:

133418799 133421642(rab5c)

XMA:	102225780(rab5c) 102231109

XCO:	114152177 114159736(rab5c)

XHE:	116726739 116735234(rab5c)

PRET:

103469407(rab5c) 103481258

PFOR:

103142193(rab5c) 103142197 103155714

PLAI:

106939465 106949789

PMEI:

106921571(rab5c) 106926197

GAF:	122822047(rab5c) 122822824

PPRL:

129368301 129373875(rab5c)

CVG:	107099621(rab5c) 107099752

CTUL:

119778882(rab5c) 119792209

GMU:	124863445 124863662 124875730

NFU:	107381932 107387854(rab5c)

KMR:	108243817(rab5c) 108245972

ALIM:

106516981 106528044(rab5c)

NWH:	119421383(rab5c) 119423665

AOCE:

111566728 111584799(rab5c)

EJA:	138197766(rab5c) 138201919

BFRE:

138617074 138627002(rab5c)

MCEP:

124997719(rab5c) 125022721

CSEM:

103381469 103393176

POV:	109627133 109634069(rab5c)

SSEN:

122759630 122785136(rab5c)

SSOE:

131448810 131475007(rab5c)

HHIP:

117753448 117765902(rab5c)

HSP:	118100966 118124099(rab5c)

PPLT:

128427011 128458453(rab5c)

SMAU:

118287121 118289512(rab5c)

LCF:	108887069 108901243 108901708

SDU:	111217644(rab5c) 111220140

SLAL:

111652822(rab5c) 111665760

XGL:	120785250(rab5c) 120794782

HCQ:

109532252

SSCV:

125983329(rab5c)

SBIA:

133514091(rab5c)

PEE:	133414671(rab5c)

PTAO:

133465545(rab5c)

BPEC:

110154185 110161503(rab5c)

ENY:	140358118(rab5c) 140368973

MALB:

109963089 109964250(rab5c)

BSPL:

114845616 114860715(rab5c)

SJO:	128378565(rab5c) 128381364

SSCO:

133999285(rab5c) 134003448

GMH:	115531050 115532521(rab5c)

SASA:

106579142(rab5c) 106607292

STRU:

115161258(rab5c) 115197954 115200986

OTW:	112223781 112225986 112258656

OMY:	110486260 110491689 110538189(rab5c)

OGO:	123998556 124016348 124048430

ONE:	115104124 115106648 115110279

OKI:	109865531(rab5c) 109893319 109898420

OKE:	118364587 118365265 118372173

OMM:	135504826 135554037 135555724

OCLA:

139364713 139368224 139421169

SALP:

111977866(rab5c) 111981322 111981331

SNH:	120034134 120035891 120046303

CCLU:

121547179 121550536 121559236

ELS:	105013346(rab5c) 105027630

OEP:	134007325(rab5c) 134031240

SFM:	108919841 108941832

PKI:	111842550 111856002

AANG:

118217043 118221183(rab5c)

AROT:

135247880(rab5c)

CCOG:

133122482(rab5c)

LOC:	102695880(rab5c)

PSPA:

121301896 121324073

ARUT:

117433222 117435086

PSEX:

120518161(rab5c)

LCM:	102367408(RAB5C)

CMK:

103189179

CPLA:

122539848(rab5c)

HOC:

132830807

LERI:

129710204(rab5c)

PMRN:

116948277

LRJ:

133345184

LOA:	LOAG_01129

XEN:

124453295

RES:

135681337

DDI:	DDB_G0271984(rab5A)

DPP:	DICPUDRAFT_93331

DFA:	DFA_04685(rab5A)

PTI:	PHATRDRAFT_51511(Rab5a)

FCY:	FRACYDRAFT_212147

TPS:	THAPSDRAFT_261381

AAF:	AURANDRAFT_55091

PIF:	PITG_20193

PSOJ:

PHYSODRAFT_346157

SPAR:

SPRG_07066

NGR:	NAEGRDRAFT_55970

EHX:	EMIHUDRAFT_437972(Rab5b-1)

GTT:	GUITHDRAFT_159784

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Reference

PMID:8646882

Authors

Han HJ, Sudo K, Inazawa J, Nakamura Y

Title

Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene.

Journal

Cytogenet Cell Genet 73:137-9 (1996)
DOI:10.1159/000134325

Sequence

[hsa:5878]

Reference

PMID:29437530

Authors

Miller CM, Wan WB, Seth PP, Harris EN

Title

Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation.

Journal

Nucleic Acid Ther 28:86-96 (2018)
DOI:10.1089/nat.2017.0694

LinkDB

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