KEGG ORTHOLOGY: K08367

ORTHOLOGY: K08367

Entry

K08367 KO

Name

RUNX1, AML1

Definition

runt-related transcription factor 1

Pathway

ko04530

Tight junction

ko04659

Th17 cell differentiation

ko05200

Pathways in cancer

ko05202

Transcriptional misregulation in cancer

ko05220

Chronic myeloid leukemia

ko05221

Acute myeloid leukemia

Disease

H00001

B-cell acute lymphoblastic leukemia

H00003

Acute myeloid leukemia

H00004

Chronic myeloid leukemia

H00978

Thrombocytopenia (THC)

H01481

Myelodysplastic syndrome

H02410

Myelodysplastic/myeloproliferative neoplasms

H02411

Chronic myelomonocytic leukemia

H02412

Atypical chronic myeloid leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08367  RUNX1, AML1; runt-related transcription factor 1
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08367  RUNX1, AML1; runt-related transcription factor 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05202 Transcriptional misregulation in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05220 Chronic myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08367  RUNX1, AML1; runt-related transcription factor 1
Transcription factors [BR:ko03000]
Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   Runt
    K08367  RUNX1, AML1; runt-related transcription factor 1

Genes

HSA:	861(RUNX1)

PTR:	101058316(RUNX1)

PPS:	100985479(RUNX1)

GGO:	101124359(RUNX1)

PON:	100449725(RUNX1)

NLE:	100594110(RUNX1)

MCC:	696749(RUNX1)

MCF:	102145008(RUNX1)

CSAB:

103218488(RUNX1)

RRO:	104658772(RUNX1)

RBB:	108536870(RUNX1)

CJC:	100385071(RUNX1)

SBQ:	101047789(RUNX1)

MMU:	12394(Runx1)

MCAL:

110311558(Runx1)

MPAH:

110329713(Runx1)

RNO:	50662(Runx1)

MUN:	110542151(Runx1)

CGE:	100758283(Runx1)

NGI:	103736431(Runx1)

HGL:	101705852(Runx1)

CCAN:

109700411(Runx1)

OCU:	100358993(RUNX1)

TUP:	102496134(RUNX1)

CFA:	487746(RUNX1)

VVP:	112910264(RUNX1)

AML:	100484679(RUNX1)

UMR:	103673224(RUNX1)

UAH:	113262125(RUNX1)

ORO:	101367976(RUNX1)

ELK:

111155817

FCA:	101084898(RUNX1)

PPAD:

109249750(RUNX1)

AJU:	106966472(RUNX1)

BTA:	529631(RUNX1)

BOM:	102282115(RUNX1)

BIU:	109561422(RUNX1)

BBUB:

102392702(RUNX1)

CHX:	102178020(RUNX1)

OAS:	101108280(RUNX1)

SSC:	100512633(RUNX1)

CFR:	102521748(RUNX1)

CDK:	105089882(RUNX1)

BACU:

103006498(RUNX1)

LVE:	103074813(RUNX1)

OOR:	101288785(RUNX1)

DLE:	111163859(RUNX1)

PCAD:

102984857(RUNX1)

ECB:	100051950(RUNX1)

EPZ:	103549174(RUNX1)

EAI:	106832821(RUNX1)

MYB:	102247211(RUNX1)

MYD:	102768477(RUNX1)

MNA:	107533502(RUNX1)

HAI:	109391240(RUNX1)

DRO:	112305670(RUNX1)

PALE:

102879444(RUNX1)

RAY:	107520364(RUNX1)

MJV:	108384793(RUNX1)

LAV:	100665882(RUNX1)

TMU:

101357079

MDO:	100025525(RUNX1)

SHR:	100921236(RUNX1)

PCW:	110214791(RUNX1)

OAA:	100082553(RUNX1)

GGA:	396152(RUNX1)

MGP:	100540674(RUNX1)

CJO:	107323234(RUNX1)

NMEL:

110402700(RUNX1)

APLA:

101799657(RUNX1)

ACYG:

106043406(RUNX1)

TGU:	100222588(RUNX1)

LSR:	110475368(RUNX1)

SCAN:

103815716 108961955

GFR:

102042762

FAB:	101820379(RUNX1)

PHI:	102099092(RUNX1)

PMAJ:

107207834 107209383(RUNX1)

CCAE:

111929229(RUNX1)

ETL:	114071857 114072382

FPG:	101916329(RUNX1) 106112951

FCH:	102053520(RUNX1)

CLV:	102087117(RUNX1)

EGZ:	104128174(RUNX1)

NNI:	104020181(RUNX1)

ACUN:

113478993(RUNX1)

PADL:

103920324(RUNX1)

AAM:	106494897(RUNX1)

ASN:	102385681(RUNX1)

AMJ:	102572910(RUNX1)

PSS:	102455885(RUNX1)

CMY:	102944269(RUNX1)

CPIC:

101938129(RUNX1)

ACS:	100564051(runx1)

PVT:	110076828(RUNX1)

PBI:	103055722(RUNX1)

PMUR:

107291521

TSR:	106549617(RUNX1)

PMUA:

114596073(RUNX1)

GJA:

107117549

XLA:	108709238 379657(runx1.L)

XTR:	100485449(runx1)

NPR:	108791098(RUNX1)

DRE:	58126(runx1)

SRX:	107709287(runx1) 107751097

SANH:

107653683 107698911

SGH:	107555250 107571884

CCAR:

109071062

IPU:	108259037(runx1)

PHYP:

113537666(runx1)

AMEX:

103025657

EEE:

113582633

TRU:	100049631(runx1)

TNG:	GSTEN00034595G001

LCO:

NCC:

MZE:

ONL:

OLA:

XMA:

XCO:

PRET:

CVG:

NFU:

KMR:	108249382(runx1)

ALIM:

106534917

AOCE:

111562778

CSEM:

103389730

POV:	109640042(runx1)

LCF:

SDU:

SLAL:

HCQ:

BPEC:

MALB:

SASA:

106574394 106575592 106595378

OTW:	112238382(runx1)

ELS:	105019777(runx1)

SFM:	108931706 108938311(runx1)

PKI:	111856070(runx1)

LCM:	102360635(RUNX1)

CMK:	103186755(runx1)

RTP:	109914103(runx1)

BFO:

118423548

CIN:

100178299

SPU:	373468(SpRunt-1) 576197

APLC:

110978851

SKO:	100302713(runt)

AGS:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

TAD:	TRIADDRAFT_25179

AQU:

100638951

MPHI:

EG856_01160

» show all

Reference

PMID:1720541

Authors

Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M

Title

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

Journal

Proc Natl Acad Sci U S A 88:10431-4 (1991)
DOI:10.1073/pnas.88.23.10431

Sequence

[hsa:861]

LinkDB

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