KEGG   ORTHOLOGY: K08367
Entry
K08367                      KO                                     
Symbol
RUNX1, AML1
Name
runt-related transcription factor 1
Pathway
map04530  Tight junction
map04659  Th17 cell differentiation
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
Disease
H00001  B-cell acute lymphoblastic leukemia
H00003  Acute myeloid leukemia
H00004  Chronic myeloid leukemia
H00978  Thrombocytopenia (THC)
H01481  Myelodysplastic syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02412  Atypical chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05202 Transcriptional misregulation in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05220 Chronic myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08367  RUNX1, AML1; runt-related transcription factor 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   Runt
    K08367  RUNX1, AML1; runt-related transcription factor 1
Genes
HSA: 861(RUNX1)
PTR: 101058316(RUNX1)
PPS: 100985479(RUNX1)
GGO: 101124359(RUNX1)
PON: 100449725(RUNX1)
NLE: 100594110(RUNX1)
MCC: 696749(RUNX1)
MCF: 102145008(RUNX1)
CSAB: 103218488(RUNX1)
CATY: 105575404(RUNX1)
PANU: 101020650(RUNX1)
TGE: 112620453(RUNX1)
RRO: 104658772(RUNX1)
RBB: 108536870(RUNX1)
TFN: 117095741(RUNX1)
PTEH: 111525572(RUNX1)
CJC: 100385071(RUNX1)
SBQ: 101047789(RUNX1)
CSYR: 103276661(RUNX1)
MMUR: 105881312(RUNX1)
LCAT: 123630713(RUNX1)
OGA: 100940749(RUNX1)
MMU: 12394(Runx1)
MCAL: 110311558(Runx1)
MPAH: 110329713(Runx1)
RNO: 50662(Runx1)
MCOC: 116086157(Runx1)
MUN: 110542151(Runx1)
CGE: 100758283(Runx1)
MAUA: 101825482(Runx1)
PLEU: 114698416(Runx1)
MORG: 121461825(Runx1)
AAMP: 119824910(Runx1)
NGI: 103736431(Runx1)
HGL: 101705852(Runx1)
CPOC: 100724149(Runx1)
CCAN: 109700411(Runx1)
DORD: 105994104(Runx1)
DSP: 122114233(Runx1)
NCAR: 124992488
OCU: 100358993(RUNX1)
OPI: 101527002(RUNX1)
TUP: 102496134(RUNX1)
CFA: 487746(RUNX1)
VVP: 112910264(RUNX1)
VLG: 121479549(RUNX1)
AML: 100484679(RUNX1)
UMR: 103673224(RUNX1)
UAH: 113262125(RUNX1)
UAR: 123784224(RUNX1)
ELK: 111155817
LLV: 125094779
MPUF: 101682300(RUNX1)
ORO: 101367976(RUNX1)
EJU: 114218980(RUNX1)
ZCA: 113916631(RUNX1)
MLX: 118018850(RUNX1)
FCA: 101084898(RUNX1)
PYU: 121036458(RUNX1)
PBG: 122491197(RUNX1)
PPAD: 109249750(RUNX1)
AJU: 106966472(RUNX1)
HHV: 120229403(RUNX1)
BTA: 529631(RUNX1)
BOM: 102282115(RUNX1)
BIU: 109561422(RUNX1)
BBUB: 102392702(RUNX1)
CHX: 102178020(RUNX1)
OAS: 101108280(RUNX1)
ODA: 120880896(RUNX1)
CCAD: 122445458(RUNX1)
SSC: 100512633(RUNX1)
CFR: 102521748(RUNX1)
CBAI: 105070210(RUNX1)
CDK: 105089882(RUNX1)
VPC: 102539586(RUNX1)
BACU: 103006498(RUNX1)
LVE: 103074813(RUNX1)
OOR: 101288785(RUNX1)
DLE: 111163859(RUNX1)
PCAD: 102984857(RUNX1)
PSIU: 116752916(RUNX1)
ECB: 100051950(RUNX1)
EPZ: 103549174(RUNX1)
EAI: 106832821(RUNX1)
MYB: 102247211(RUNX1)
MYD: 102768477(RUNX1)
MMYO: 118675205(RUNX1)
MLF: 102436751(RUNX1)
MNA: 107533502(RUNX1)
PKL: 118714829(RUNX1)
HAI: 109391240(RUNX1)
DRO: 112305670(RUNX1)
SHON: 118983269(RUNX1)
AJM: 119035732(RUNX1)
PDIC: 114490064(RUNX1)
PHAS: 123827989(RUNX1)
MMF: 118616857(RUNX1)
RFQ: 117034711(RUNX1)
PALE: 102879444(RUNX1)
PGIG: 120598670(RUNX1)
PVP: 105295829(RUNX1)
RAY: 107520364(RUNX1)
MJV: 108384793(RUNX1)
TOD: 119257211(RUNX1)
SARA: 101541108(RUNX1)
LAV: 100665882(RUNX1)
TMU: 101357079
DNM: 101443635(RUNX1)
MDO: 100025525(RUNX1)
GAS: 123242465(RUNX1)
SHR: 100921236(RUNX1)
PCW: 110214791(RUNX1)
OAA: 100082553(RUNX1)
GGA: 396152(RUNX1)
PCOC: 116241954(RUNX1)
MGP: 100540674(RUNX1)
CJO: 107323234(RUNX1)
NMEL: 110402700(RUNX1)
APLA: 101799657(RUNX1)
ACYG: 106043406(RUNX1)
AFUL: 116495487(RUNX1)
TGU: 100222588(RUNX1)
LSR: 110475368(RUNX1)
SCAN: 103815716 108961955
PMOA: 120502541(RUNX1)
OTC: 121334718(RUNX1)
PRUF: 121357999
GFR: 102042762
FAB: 101820379(RUNX1)
PHI: 102099092(RUNX1)
PMAJ: 107207834 107209383(RUNX1)
CCAE: 111929229(RUNX1)
CCW: 104696772(RUNX1)
ETL: 114071857 114072382
FPG: 101916329(RUNX1) 106112951
FCH: 102053520(RUNX1)
CLV: 102087117(RUNX1)
EGZ: 104128174(RUNX1)
NNI: 104020181(RUNX1)
PLET: 104616076
ACUN: 113478993(RUNX1)
TALA: 104361251(RUNX1)
PADL: 103920324(RUNX1)
ACHC: 115343870(RUNX1)
AAM: 106494897(RUNX1)
AROW: 112971833(RUNX1)
NPD: 112948161(RUNX1)
DNE: 112996178(RUNX1)
ASN: 102385681(RUNX1)
AMJ: 102572910(RUNX1)
CPOO: 109305802(RUNX1)
GGN: 109302327(RUNX1)
PSS: 102455885(RUNX1)
CMY: 102944269(RUNX1)
CPIC: 101938129(RUNX1)
TST: 117867441(RUNX1)
CABI: 116823670(RUNX1)
MRV: 120369420(RUNX1)
ACS: 100564051(runx1)
PVT: 110076828(RUNX1)
SUND: 121927358(RUNX1)
PBI: 103055722(RUNX1)
PMUR: 107291521
TSR: 106549617(RUNX1)
PGUT: 117678673(RUNX1)
VKO: 123029379(RUNX1)
PMUA: 114596073(RUNX1)
ZVI: 118084720(RUNX1)
GJA: 107117549
STOW: 125431869(RUNX1)
XLA: 108709238 379657(runx1.L)
XTR: 100485449(runx1)
NPR: 108791098(RUNX1)
RTEM: 120927927(RUNX1)
BBUF: 120994505(RUNX1)
BGAR: 122930826(RUNX1)
DRE: 58126(runx1)
SRX: 107709287(runx1) 107751097
SANH: 107653683 107698911
SGH: 107555250 107571884
CCAR: 109071062
CAUA: 113044609 113097601
PPRM: 120460533(runx1)
MAMB: 125272953(runx1)
IPU: 108259037(runx1)
PHYP: 113537666(runx1)
SMEO: 124378141(runx1)
TFD: 113648874(runx1)
AMEX: 103025657
EEE: 113582633
TRU: 100049631(runx1)
TNG: GSTEN00034595G001
LCO: 104936698
NCC: 104961881
CGOB: 115018094
ELY: 117249915(runx1)
PLEP: 121964414
SLUC: 116036434(runx1)
ECRA: 117939492(runx1)
PFLV: 114551073
GAT: 120821894(runx1)
PPUG: 119221892(runx1)
MSAM: 119900649(runx1)
CUD: 121506178(runx1)
ALAT: 119015595(runx1)
MZE: 101482179
ONL: 100691239
OAU: 116326998(runx1)
OLA: 101173202
OML: 112141993(runx1)
XMA: 102230567
XCO: 114140828
XHE: 116715855
PRET: 103477443
PFOR: 103130586
PLAI: 106962496
PMEI: 106908239
GAF: 122826911(runx1)
CVG: 107098178
CTUL: 119779581(runx1)
GMU: 124861290(runx1)
NFU: 107384523
KMR: 108249382(runx1)
ALIM: 106534917
NWH: 119428785(runx1)
AOCE: 111562778
CSEM: 103389730
POV: 109640042(runx1)
SSEN: 122765146(runx1)
HHIP: 117777362(runx1)
HSP: 118103459(runx1)
LCF: 108902563
SDU: 111232758
SLAL: 111670267
XGL: 120798265(runx1)
HCQ: 109528744
BPEC: 110156597
MALB: 109952206 109961125
BSPL: 114848842(runx1)
SASA: 106574394 106575592 106595378
OTW: 112267670(runx1) 121846747
OMY: 110495653 110527326
OGO: 124008497 124011043
ONE: 115129817
SNH: 120042747 120051428(runx1)
ELS: 105019777(runx1)
SFM: 108931706 108938311(runx1)
PKI: 111856070(runx1)
AANG: 118214293(runx1) 118223562
LOC: 102682529(runx1)
PSPA: 121320993 121327982
ARUT: 117407217
LCM: 102360635(RUNX1)
CMK: 103186755(runx1)
RTP: 109914103(runx1)
BFO: 118423548
BBEL: 109469252
CIN: 100178299
SCLV: 120337759
SPU: 373468(SpRunt-1) 576197
APLC: 110978851
SKO: 100302713(runt)
LSQ: 119612135
SOY: 115887579 115887589
CSET: 123317073 123317220 123317565
AGB: 108903535 108903536 108907089 111691513
LDC: 111512323
APLN: 108738268 108738269 108741870
PPYR: 116178939 116179797
OTU: 111416297 111419177
MSEX: 115440233
BANY: 112045253
PXU: 106126612
PRAP: 110998564
SLIU: 111354210
AGS: 114126750
DCI: 103516019
NLU: 120356734
DMK: 116918153 116921892
HAZT: 108676912
DFR: 124492668 124498985
SDM: 118187943
BGT: 106059914
GAE: 121370556 121391817
HRF: 124111835
HRJ: 124255217
CRG: 105336942
MMER: 123551407
NVE: 5504767
EPA: 110249929
ATEN: 116304530
ADF: 107351415
AMIL: 114961964
PDAM: 113676023
SPIS: 111342489
DGT: 114535050
XEN: 124441926
TAD: TRIADDRAFT_25179
AQU: 100638951
MPHI: EG856_01160
 » show all
Reference
PMID:1720541
  Authors
Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M
  Title
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
  Journal
Proc Natl Acad Sci U S A 88:10431-4 (1991)
DOI:10.1073/pnas.88.23.10431
  Sequence
[hsa:861]
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