KEGG ORTHOLOGY: K08550

ORTHOLOGY: K08550

Entry

K08550                      KO

Symbol

ESR1, NR3A1

Name

estrogen receptor alpha

Pathway

map01522

Endocrine resistance

map04915

Estrogen signaling pathway

map04917

Prolactin signaling pathway

map04919

Thyroid hormone signaling pathway

map04961

Endocrine and other factor-regulated calcium reabsorption

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05207

Chemical carcinogenesis - receptor activation

map05224

Breast cancer

Disease

H00031

Breast cancer

H01730

Myocardial infarction

H02061

Estrogen resistance syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K08550  ESR1, NR3A1; estrogen receptor alpha
   04917 Prolactin signaling pathway
    K08550  ESR1, NR3A1; estrogen receptor alpha
   04919 Thyroid hormone signaling pathway
    K08550  ESR1, NR3A1; estrogen receptor alpha
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K08550  ESR1, NR3A1; estrogen receptor alpha
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08550  ESR1, NR3A1; estrogen receptor alpha
   05205 Proteoglycans in cancer
    K08550  ESR1, NR3A1; estrogen receptor alpha
   05207 Chemical carcinogenesis - receptor activation
    K08550  ESR1, NR3A1; estrogen receptor alpha
  09162 Cancer: specific types
   05224 Breast cancer
    K08550  ESR1, NR3A1; estrogen receptor alpha
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08550  ESR1, NR3A1; estrogen receptor alpha
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08550  ESR1, NR3A1; estrogen receptor alpha
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08550  ESR1, NR3A1; estrogen receptor alpha
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys4 estrogen receptor-like
    K08550  ESR1, NR3A1; estrogen receptor alpha
Nuclear receptors [BR:ko03310]
3. Estrogen like
  3A. Estrogen receptor
   K08550  ESR1, NR3A1; estrogen receptor alpha

Other DBs

GO:

0030284

Genes

HSA:	2099(ESR1)

PTR:	463079(ESR1)

PPS:	100980011(ESR1)

GGO:	101138953(ESR1)

PON:	100441912(ESR1)

PPYG:

129038137(ESR1)

NLE:	100580202(ESR1)

HMH:	116463161 116463211

SSYN:

129475457(ESR1)

MCC:	613025(ESR1)

MCF:	102115223(ESR1)

MTHB:

126952370

MNI:	105489041(ESR1)

CSAB:

103240732(ESR1)

CATY:

105588850(ESR1)

PANU:

100303417(ESR1)

TGE:	112623840(ESR1)

MLEU:

105551527(ESR1)

RRO:	104657857(ESR1)

RBB:	108539131(ESR1)

TFN:	117097264(ESR1)

PTEH:

111538618(ESR1)

CANG:

105513022(ESR1)

CJC:	100385918(ESR1)

SBQ:

101034130

CIMI:

108310528(ESR1)

ANAN:

105717168(ESR1)

CSYR:

103267361(ESR1)

MMUR:

105858071(ESR1)

LCAT:

123633382(ESR1)

PCOQ:

105812377(ESR1)

OGA:	100954847(ESR1)

MMU:	13982(Esr1)

MCAL:

110303039(Esr1)

MPAH:

110337903(Esr1)

RNO:	24890(Esr1)

MCOC:

116078810(Esr1)

ANU:	117700168(Esr1)

MUN:	110566125(Esr1)

CGE:	100768474(Esr1)

MAUA:

101825539(Esr1)

PROB:

127237696(Esr1)

PLEU:

114707480(Esr1)

MORG:

121466556(Esr1)

MFOT:

126497559

AAMP:

119820547(Esr1)

NGI:	103745757(Esr1)

HGL:	101715977(Esr1)

CPOC:

100713276(Esr1)

DORD:

105993676(Esr1)

DSP:	122100252(Esr1)

PLOP:

125357415(Esr1)

NCAR:

124988588

MMMA:

107156275(Esr1)

OCU:

100351261

OPI:	101521523(ESR1)

TUP:	102497715(ESR1)

CFA:	403640(ESR1)

CLUD:

112644313(ESR1)

VVP:	112919529(ESR1)

VLG:	121484134(ESR1)

NPO:	129500554(ESR1)

AML:	100484518(ESR1)

UMR:	103666963(ESR1)

UAH:	113259567(ESR1)

UAR:	123797461(ESR1)

ELK:

111158708

LLV:

125102786

MPUF:

101690352(ESR1)

MNP:	132018399(ESR1)

MLK:	131833450(ESR1)

NVS:	122903255(ESR1)

ORO:	101376152(ESR1)

EJU:	114209347(ESR1)

ZCA:	113927528(ESR1)

MLX:	118001078(ESR1)

NSU:	110583291(ESR1) 110583746

LWW:	102743496(ESR1)

FCA:	552888(ESR1)

PYU:	121013301(ESR1)

PCOO:

112862113(ESR1)

PBG:	122490107(ESR1)

PVIV:

125166385(ESR1)

LRUF:

124529259

PTG:	102969728(ESR1)

PPAD:

109256413(ESR1)

AJU:

106976266

HHV:	120222308 120237592

BTA:	407238(ESR1)

BOM:	102266924(ESR1)

BBUB:

102408657(ESR1)

BBIS:

104989272(ESR1)

CHX:	102189484(ESR1)

OAS:	443228(ESR1)

BTAX:

128053203(ESR1)

ODA:	120862622(ESR1)

CCAD:

122434032(ESR1)

MBEZ:

129561076(ESR1)

SSC:	397435(ESR1)

CFR:	102519728(ESR1)

CBAI:

105077329(ESR1)

CDK:	105100955(ESR1)

VPC:	102529341(ESR1)

BACU:

103009601(ESR1)

BMUS:

118905365(ESR1)

LVE:	103069191(ESR1)

OOR:	101279259(ESR1)

DLE:	111167007(ESR1)

PCAD:

102978428(ESR1)

PSIU:

116763684(ESR1)

NASI:

112401557(ESR1)

ECB:	791249(ESR1)

EPZ:	103547564(ESR1)

EAI:	106822682(ESR1)

MYB:	102261068(ESR1)

MYD:	102765890(ESR1)

MMYO:

118660409(ESR1)

MLF:	102440234(ESR1)

MDT:	132236787(ESR1)

PKL:	118705569(ESR1)

EFUS:

103301582(ESR1)

MNA:	107535956(ESR1)

DRO:	112297404(ESR1)

SHON:

118990270(ESR1)

AJM:

119057914

PDIC:

114494656(ESR1)

PHAS:

123821760(ESR1)

MMF:	118621009(ESR1)

PPAM:

129067858(ESR1)

HAI:	109380859(ESR1)

RFQ:	117020528(ESR1)

PALE:

102877910(ESR1)

PGIG:

120593483(ESR1)

PVP:	105293851(ESR1)

RAY:	107513028(ESR1)

MJV:	108405771(ESR1)

TOD:	119253014(ESR1)

SARA:

101543178(ESR1)

SETR:

125996530(ESR1)

LAV:	100677316(ESR1)

TMU:

101351018

ETF:	101650948(ESR1)

DNM:	101413338(ESR1)

MDO:	100027187(ESR1)

GAS:	123243675(ESR1)

SHR:	100935401(ESR1)

AFZ:

127562338

PCW:	110208556(ESR1)

TVP:	118856706(ESR1)

OAA:	120637981(ESR1)

GGA:	396099(ESR1)

PCOC:

116241292(ESR1)

MGP:	100542782(ESR1)

CJO:	107311566(ESR1)

TPAI:

128075153(ESR1)

LMUT:

125689226(ESR1)

NMEL:

110390765(ESR1)

APLA:

101802318(ESR1)

ACYG:

106034288(ESR1)

CATA:

118244165(ESR1)

AFUL:

116487797(ESR1)

TGU:	751998(ESR1)

LSR:	110476028(ESR1)

SCAN:

103820578(ESR1)

PMOA:

120501293(ESR1)

OTC:	121346178(ESR1)

PRUF:

121354855(ESR1)

GFR:	102032661(ESR1)

FAB:	101819288(ESR1)

OMA:	130251719(ESR1)

PHI:	102108976(ESR1)

PMAJ:

107201411(ESR1)

CCAE:

111926710(ESR1)

CCW:	104690175(ESR1)

CBRC:

103619348(ESR1)

ETL:	114069851(ESR1)

ZAB:	102065835(ESR1)

ZLE:	135445559(ESR1)

ACHL:

103811272(ESR1)

SVG:	106860492(ESR1)

MMEA:

130579266(ESR1)

HRT:	120750476(ESR1)

SATI:

136359137(ESR1)

FPG:	101918191(ESR1)

FCH:	102046059(ESR1)

SHAB:

115613474(ESR1)

ACUN:

113478628(ESR1)

TALA:

104368363(ESR1)

ACHC:

115344770(ESR1)

HALD:

104316588(ESR1)

HLE:	104840723(ESR1)

AGEN:

126038882

GCL:

127014221

CSTI:

104563767(ESR1)

MNB:	103779180(ESR1)

DPUB:

104297154(ESR1)

EGZ:	104131114(ESR1)

NNI:	104013764(ESR1)

PCRI:

104035821(ESR1)

PCAO:

104048092

PADL:

103917043(ESR1)

AFOR:

103900691(ESR1)

CLV:	102095459(ESR1)

PGUU:

104464207(ESR1)

PLET:

104617773(ESR1)

CMAC:

104480208(ESR1)

CUCA:

104062275(ESR1)

TEO:	104375571(ESR1)

BREG:

104636486(ESR1)

OHA:	104328686(ESR1)

ACAR:

104532872

CPEA:

104390765(ESR1)

CVF:	104285583(ESR1)

RTD:	128906837(ESR1)

AAM:	106496902(ESR1)

AROW:

112974652(ESR1)

NPD:	112951660(ESR1)

TGT:	104568813(ESR1)

DNE:	112996625(ESR1)

SCAM:

104140142(ESR1)

ASN:	102376369(ESR1)

AMJ:	102564196(ESR1)

CPOO:

109320108(ESR1)

GGN:	109304642(ESR1)

PSS:	102456765(ESR1)

CMY:	102934699(ESR1)

CCAY:

125634048(ESR1)

DCC:	119853213(ESR1)

CPIC:

101933533(ESR1)

TST:	117874831(ESR1)

CABI:

116820545(ESR1)

MRV:	120400946(ESR1)

ACS:	100337547(esr1)

ASAO:

132761064(ESR1)

PVT:	110085184(ESR1)

SUND:

121921063(ESR1)

PBI:	103062891 103066127

PMUR:

107292771(ESR1)

CTIG:

120313893(ESR1)

TSR:	106549259 106552445(ESR1)

PGUT:

117666420(ESR1)

APRI:

131191336(ESR1)

PTEX:

113439222

NSS:	113420408(ESR1)

VKO:	123019633(ESR1)

PMUA:

114594259(ESR1)

PRAF:

128410661(ESR1)

ZVI:	118082004(ESR1)

HCG:	128343509(ESR1)

GJA:	107123010(ESR1)

STOW:

125428488(ESR1)

EMC:	129345794(ESR1)

XLA:	398733(esr1.S) 398734(esr1.L)

XTR:	394461(esr1)

NPR:	108790124(ESR1)

RTEM:

120937561(ESR1)

BBUF:

120998710(ESR1)

BGAR:

122935734(ESR1)

MUO:	115466899(ESR1)

GSH:	117358135(ESR1)

DRE:	259252(esr1)

SRX:

107737325

SANH:

107659219

SGH:	107555768 107556167

CCAR:

109100963 109113729

CAUA:

113063161 113120951

CGIB:

127938711 127984291

PTET:

122324587 122325032(esr1)

LROH:

127183331(esr1)

OMC:	131526940(esr1)

PPRM:

120494111(esr1)

RKG:	130091821(esr1)

MAMB:

125277891(esr1)

CIDE:

127501900

CERY:

137018962(esr1)

MASI:

127410337 127415909

TROS:

130565856(esr1)

TDW:	130434062(esr1)

MANU:

129428944(esr1)

IPU:	100304474(esr1)

IFU:	128601024(esr1)

PHYP:

113532161(esr1)

SMEO:

124377035(esr1)

TFD:	113653769(esr1)

TVC:	132843059(esr1)

TRN:	134320778(esr1)

AMEX:

103043741(esr1)

CMAO:

118815704(esr1)

EEE:

113570417

CHAR:

122132687

TRU:	101077800(esr1)

TFS:	130516147(esr1)

TNG:	GSTEN00023070G001

LCO:	104931018(esr1)

NCC:	104965323(esr1)

TBEN:

117486831 117492515(esr1)

CGOB:

115028847(esr1)

PGEO:

117440199(esr1)

GACU:

117537525(esr1)

EMAC:

134876612(esr1)

ELY:	117271155(esr1)

EFO:	125897205(esr1)

PLEP:

121955673(esr1)

SLUC:

116066218(esr1)

ECRA:

117961534(esr1)

ESP:	116705833(esr1)

PFLV:

114572734

GAT:	100190863(esr1)

PPUG:

119194583(esr1)

AFB:	129106909(esr1)

CLUM:

117727053(esr1)

PSWI:

130202895(esr1)

MSAM:

119908548(esr1)

SCHU:

122862776(esr1)

CUD:	121521948(esr1)

ALAT:

119012309(armt1)

MZE:

101479381

ONL:	100534514(esr1)

OAU:	116310753(esr1)

OLA:	101162413(esr1)

OML:	112157948(esr1)

CSAI:

133418564(esr1)

XMA:	102235986(esr1)

XCO:	114158784(esr1)

XHE:	116734455(esr1)

PRET:

103457510(esr1)

PFOR:

103134767(esr1)

PLAI:

106946715(esr1)

PMEI:

106920052(esr1)

GAF:	122825500(esr1)

PPRL:

129352446(esr1)

CVG:	107081657 107101861(esr1)

CTUL:

119781241(esr1)

GMU:	124881941(esr1)

NFU:

107377558

KMR:	108240123(esr1)

ALIM:

106519793(esr1)

NWH:	119418558(esr1)

AOCE:

111571044

MCEP:

124998943(esr1)

CSEM:

103380669

POV:	109636049(esr1)

SSEN:

122784445(esr1)

HHIP:

117758481(esr1)

HSP:	118099080(esr1)

PPLT:

128460352(esr1)

SMAU:

118290272(esr1)

LCF:	108880883(esr1)

SDU:	111236823(esr1)

SLAL:

111655594(esr1)

XGL:	120789303(esr1)

HCQ:	109531021(esr1)

SSCV:

125990206

SBIA:

133496967(esr1)

PEE:	133416966(esr1)

PTAO:

133468323(esr1)

BPEC:

110175149(esr1)

MALB:

109952736

BSPL:

114849650(esr1)

SJO:	128377630(esr1)

SASA:

100136461(esr1) 100846971

STRU:

115182237(esr1)

OTW:	112217720(esr1)

OMY:	100136026(esr1) 100136309

OGO:	123991021 123995230(esr1)

ONE:	115139262(esr1)

OKI:	109866292 109900320

OKE:	118373789(esr1)

SALP:

111954041 111972669(esr1)

SNH:	120019067(esr1)

CCLU:

121548785(esr1)

ELS:	105017493(esr1)

SFM:	108921694(esr1)

PKI:

111858013

AANG:

118229331(esr1)

LOC:	102698804(esr1)

PSPA:

121315846 121316966(esr1)

ARUT:

117402328 117410343(esr1)

PSEX:

120525470(esr1)

CMK:	103179230(esr1)

RTP:	109913159(esr1)

CPLA:

122553043(esr1)

HOC:	132819585(esr1)

LERI:

129699335(esr1)

PMRN:

103091711

LRJ:

133342284

BFO:	118426196 118427878

BBEL:

109469175 109481556

SKO:

102800833

PTRU:

123501477

LGI:	LOTGIDRAFT_132166

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MMER:

RPHI:

MAEA:

OBI:

OSN:

LJP:

LAK:

Reference

PMID:21124311

Authors

Nilsson S, Gustafsson JA

Title

Estrogen receptors: therapies targeted to receptor subtypes.

Journal

Clin Pharmacol Ther 89:44-55 (2011)
DOI:10.1038/clpt.2010.226

Reference

PMID:3754034

Authors

Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P

Title

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.

Journal

Nature 320:134-9 (1986)
DOI:10.1038/320134a0

Sequence

[hsa:2099]

LinkDB

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