KEGG   ORTHOLOGY: K08735
Entry
K08735                      KO                                     

Name
MSH2
Definition
DNA mismatch repair protein MSH2
Pathway
ko01524  Platinum drug resistance
ko03430  Mismatch repair
ko05200  Pathways in cancer
ko05210  Colorectal cancer
Disease
H00020  Colorectal cancer
H00027  Ovarian cancer
H00876  Mismatch repair deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    K08735  MSH2; DNA mismatch repair protein MSH2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08735  MSH2; DNA mismatch repair protein MSH2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08735  MSH2; DNA mismatch repair protein MSH2
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08735  MSH2; DNA mismatch repair protein MSH2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K08735  MSH2; DNA mismatch repair protein MSH2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     K08735  MSH2; DNA mismatch repair protein MSH2
Genes
HSA: 4436(MSH2)
PTR: 107973458(MSH2)
PPS: 100984592(MSH2)
GGO: 101145372(MSH2)
PON: 100431828(MSH2)
NLE: 100580147(MSH2)
MCC: 718017(MSH2)
MCF: 101867487(MSH2)
CSAB: 103220322(MSH2)
RRO: 104663167(MSH2)
RBB: 108512671(MSH2)
CJC: 100394665(MSH2)
SBQ: 101044013(MSH2)
MMU: 17685(Msh2)
MCAL: 110312708(Msh2)
MPAH: 110335350(Msh2)
RNO: 81709(Msh2)
MUN: 110552895(Msh2)
CGE: 100768127(Msh2)
NGI: 103725741(Msh2)
HGL: 101706924(Msh2)
CCAN: 109691600(Msh2)
OCU: 103347805(MSH2)
TUP: 102471638(MSH2)
CFA: 494002(MSH2)
VVP: 112915229(MSH2)
AML: 100471735(MSH2)
UMR: 103671767(MSH2)
UAH: 113245944(MSH2)
ORO: 101367758(MSH2)
ELK: 111148098
FCA: 101082051(MSH2)
PTG: 102954275(MSH2)
PPAD: 109247022(MSH2)
AJU: 106977220(MSH2)
BTA: 533115(MSH2)
BOM: 102268614(MSH2)
BIU: 109566059(MSH2)
BBUB: 102409227(MSH2)
CHX: 102172730(MSH2)
OAS: 101107944(MSH2)
SSC: 100337661(MSH2)
CFR: 102512861(MSH2)
CDK: 105092361(MSH2)
BACU: 102999324(MSH2)
LVE: 103088025(MSH2)
OOR: 101272233(MSH2)
DLE: 111174786(MSH2)
PCAD: 102987486(MSH2)
ECB: 100068146(MSH2)
EPZ: 103558101(MSH2)
EAI: 106826002(MSH2)
MYB: 102244813(MSH2)
MYD: 102756016(MSH2)
MNA: 107544316(MSH2)
HAI: 109389912(MSH2)
DRO: 112297937(MSH2)
PALE: 102893728(MSH2)
RAY: 107509554(MSH2)
MJV: 108391861(MSH2)
LAV: 100653677(MSH2)
TMU: 101346702
MDO: 100033358(MSH2)
SHR: 100928256(MSH2)
PCW: 110218513(MSH2)
OAA: 100083981(MSH2)
GGA: 378799(MSH2)
MGP: 100542264(MSH2)
CJO: 107310883(MSH2)
NMEL: 110396247(MSH2)
APLA: 101802532(MSH2)
ACYG: 106043144(MSH2)
TGU: 100226839(MSH2)
LSR: 110475805(MSH2)
SCAN: 103819297(MSH2)
GFR: 102033642(MSH2)
FAB: 101818579(MSH2)
PHI: 102104578(MSH2)
PMAJ: 107202300(MSH2)
CCAE: 111926310(MSH2)
CCW: 104685720(MSH2)
ETL: 114060415(MSH2)
FPG: 101910374(MSH2)
FCH: 102053065(MSH2)
CLV: 102091445(MSH2)
EGZ: 104134601(MSH2)
NNI: 104018118(MSH2)
ACUN: 113478407(MSH2)
PADL: 103925036(MSH2)
AAM: 106490370(MSH2)
ASN: 102372507(MSH2)
AMJ: 102562032(MSH2)
PSS: 102457455(MSH2)
CMY: 102929651(MSH2)
CPIC: 101937123(MSH2)
ACS: 100562005(msh2)
PVT: 110079560(MSH2)
PBI: 103057506(MSH2)
PMUR: 107284056(MSH2)
TSR: 106554294(MSH2)
PMUA: 114594844(MSH2)
GJA: 107124258(MSH2)
XLA: 595045(msh2.L)
XTR: 100380043(msh2)
NPR: 108804519(MSH2)
DRE: 406845(msh2)
SRX: 107728724 107749362
SANH: 107673650 107698830
SGH: 107550043 107582784
CCAR: 109099945 109099948
IPU: 108274345(msh2)
PHYP: 113527804(msh2)
AMEX: 103047089(msh2)
EEE: 113572822(msh2)
TRU: 101075196(msh2)
TNG: GSTEN00005534G001
LCO: 104923481(msh2)
NCC: 104951045(msh2)
MZE: 101484075(msh2)
ONL: 100697326(msh2)
OLA: 101167993(msh2)
XMA: 102234491(msh2) 106700380
XCO: 114152173(msh2)
PRET: 103481547(msh2)
CVG: 107085521(msh2)
NFU: 107387525(msh2)
KMR: 108248490(msh2)
ALIM: 106516619(msh2)
AOCE: 111577896(msh2)
CSEM: 103381539(msh2)
POV: 109646954
LCF: 108882675(msh2)
SDU: 111219993(msh2)
SLAL: 111655249(msh2)
HCQ: 109530180(msh2)
BPEC: 110174586(msh2)
MALB: 109962934(msh2)
SASA: 106589405(msh2)
OTW: 112224292(msh2)
SALP: 111967793(msh2)
ELS: 105006146(msh2)
SFM: 108931448(msh2)
PKI: 111848461(msh2)
LCM: 102346975 102360187
CMK: 103180793(msh2)
RTP: 109932239(msh2)
BFO: 118422865
CIN: 100183267
SPU: 589363
APLC: 110984624
SKO: 100370530(MSH2)
DME: Dmel_CG4215(spel1)
DER: 6540643
DSE: 6611269
DSI: Dsimw501_GD23963(Dsim_GD23963)
DYA: Dyak_GE19033
DAN: 6497702
DSR: 110185631
DPO: Dpse_GA18039
DPE: 6598122
DMN: 108161674
DWI: 6643724
DGR: Dgri_GH11346 Dgri_GH11754
DMO: Dmoj_GI12901
DAZ: 108611243
DNV: 108649356
DHE: 111600377
DVI: 6634164
MDE: 101891948
LCQ: 111677682
AGA: AgaP_AGAP010282
AAG: 5565480
AALB: 109414444 109622542 115266333
CQU: CpipJ_CPIJ017719
AME: 725348
BIM: 100745953
BTER: 100644548
CCAL: 108630326
OBB: 114873609
SOC: 105202417
MPHA: 105837293
AEC: 105151743
ACEP: 105618910
PBAR: 105424600
VEM: 105558517
HST: 105191066
DQU: 106751800
CFO: 105249227
LHU: 105673743
PGC: 109856928
OBO: 105281999
PCF: 106791815
NVI: 100118035(Msh2)
CSOL: 105359470
MDL: 103575164
TCA: 655722
DPA: 109532708
ATD: 109608594
NVL: 108564757
BMOR: 101743378
BMAN: 114245626
DPL: KGM_203760B
PMAC: 106713550
PRAP: 110993151
HAW: 110380087
TNL: 113498334
PXY: 105385526 105390604
API: 100160952
DNX: 107161324
AGS: 114128384
RMD: 113553385
BTAB: 109039150
CLEC: 106665222
PHU: Phum_PHUM253730
ZNE: 110838930
FCD: 110845892
DPX: DAPPUDRAFT_325677
PVM: 113820839
TUT: 107369494
DPTE: 113791662
CSCU: 111632815
PTEP: 107442808
CEL: CELE_H26D21.2(msh-2)
CBR: CBG12022(Cbr-msh-2)
BMY: Bm1_40840
LOA: LOAG_03335
NAI: NECAME_06630
TSP: Tsp_09659
HRO: HELRODRAFT_190918
LGI: LOTGIDRAFT_195636
PCAN: 112566662
CRG: 105335553
MYI: 110460651
OBI: 106868054
LAK: 106156484
SMM: Smp_199070
SHX: MS3_10731
OVI: T265_03039
EGL: EGR_08102
NVE: 5509902
EPA: 110249970
ADF: 107351410
AMIL: 114961970
PDAM: 113668608
SPIS: 111341692
DGT: 114537619
HMG: 100200908
TAD: TRIADDRAFT_56718
AQU: 100641505
ATH: AT3G18524(MSH2)
ALY: 9319206
CRB: 17891110
CSAT: 104746225 104783514
EUS: EUTSA_v10020006mg
BRP: 103859754
BNA: 106360022 106439551 106442281
BOE: 106335377
RSZ: 108862549
THJ: 104820406
CPAP: 110825125
CIT: 102614656
CIC: CICLE_v10018746mg
TCC: 18604054
GRA: 105798704
GHI: 107888755 107897679
GAB: 108457313
DZI: 111291050
EGR: 104421462
GMX: 100792272
GSJ: 114393536
PVU: PHAVU_003G177100g
VRA: 106769444
VAR: 108323623
VUN: 114177191
CCAJ: 109809762
MTR: MTR_4g111945
CAM: 101505823
LJA: Lj4g3v1787050.1(Lj4g3v1787050.1)
ADU: 107469314
AIP: 107630408
LANG: 109345095 109354109
FVE: 101293489
RCN: 112180984
PPER: 18777066
PMUM: 103342205
PAVI: 110754162
MDM: 103415348 103437966
PXB: 103938503
ZJU: 107418858
CSV: 101215589
CMO: 103494106
MCHA: 111007070
CMAX: 111484889
CMOS: 111430121
CPEP: 111780449
RCU: 8286743
JCU: 105650645
HBR: 110651472
MESC: 110624712
POP: 7484706
PEU: 105114805
JRE: 109012023
QSU: 112015745 112024698 112037582
VVI: 100268052(MSH2)
SLY: 100462655(MSH2)
SPEN: 107021249
SOT: 102598532
CANN: 107855430
NTA: 107825761
NSY: 104244948
NTO: 104117972
NAU: 109227481
INI: 109184200
SIND: 105158113 105180373
OEU: 111406449
HAN: 110941615
LSV: 111915654
CCAV: 112513365
DCR: 108192774
BVG: 104908225
SOE: 110789489
CQI: 110698411 110726111
NNU: 104603050
PSOM: 113298056 113303031
OSA: 4338271
DOSA: Os05t0274200-01(Os05g0274200)
OBR: 102704890
BDI: 100842311
ATS: 109751240(LOC109751240)
SBI: 8060623
ZMA: 100279876(mus1)
SITA: 101753902
PDA: 103704345
EGU: 105041044
MUS: 103987730
DCT: 110093633
PEQ: 110023469
AOF: 109822519
ATR: 18433612
SMO: SELMODRAFT_268576 SELMODRAFT_407609 SELMODRAFT_85179
PPP: 112275272
VCN: VOLCADRAFT_96164
MNG: MNEG_16523 MNEG_9220
CSL: COCSUDRAFT_37328
CVR: CHLNCDRAFT_36258
APRO: F751_2623
OLU: OSTLU_28688
OTA: OT_ostta10g02100
BPG: Bathy01g00720
MIS: MICPUN_55256
MPP: MICPUCDRAFT_31481
CME: CYME_CMP114C
GSL: Gasu_29550
CCP: CHC_T00003068001
SCE: YOL090W(MSH2)
AGO: AGOS_AFR603C
ERC: Ecym_2796
KLA: KLLA0_F02706g
KMX: KLMA_30578(MSH2)
LTH: KLTH0C09988g
VPO: Kpol_1053p38
ZRO: ZYRO0B06160g
CGR: CAGL0I07733g
NCS: NCAS_0A08670(NCAS0A08670)
NDI: NDAI_0G05110(NDAI0G05110)
TPF: TPHA_0A00740(TPHA0A00740)
TBL: TBLA_0B02380(TBLA0B02380)
TDL: TDEL_0D05170(TDEL0D05170)
KAF: KAFR_0C01330(KAFR0C01330)
ZMK: HG535_0H03200
PPA: PAS_chr1-4_0634
DHA: DEHA2B15818g
PIC: PICST_68406
PGU: PGUG_02306
SPAA: SPAPADRAFT_48774
LEL: LELG_05698
CAL: CAALFM_C407120CA(MSH2)
CTP: CTRG_03762
COT: CORT_0B00260
CDU: CD36_46590
CTEN: CANTEDRAFT_123827
YLI: YALI0F00154g
CLU: CLUG_02700
CLUS: A9F13_07g01485
CAUR: CJI97_005394
SLB: AWJ20_1043(MSH2)
PKZ: C5L36_0B05590
BNN: FOA43_000776
NCR: NCU02230(msh2)
NTE: NEUTE1DRAFT124099(NEUTE1DRAFT_124099)
SMP: SMAC_03669(putative msh2)
PAN: PODANSg1782
TTT: THITE_2117183
MTM: MYCTH_2308779
CTHR: CTHT_0016610
MGR: MGG_00879
TMN: UCRPA7_2497
SSCK: SPSK_00411
FGR: FGSG_06330
FPU: FPSE_01162
FVR: FVEG_05004
FOX: FOXG_08082
NHE: NECHADRAFT_38537
TRE: TRIREDRAFT_61042
TRR: M419DRAFT_8232
MAW: MAC_04666
MAJ: MAA_04555
CMT: CCM_01340
PLJ: VFPFJ_02207
VAL: VDBG_03348
VDA: VDAG_02253
CFJ: CFIO01_05825
ELA: UCREL1_10471
PFY: PFICI_12231
SSL: SS1G_11798
BFU: BCIN_02g08740(Bcmsh2)
MBE: MBM_06832
PSCO: LY89DRAFT_787089
GLZ: GLAREA_01955
ANI: AN5006.2
AFM: AFUA_3G09850
ACT: ACLA_037660
NFI: NFIA_067450
AOR: AO090005001261
ANG: ANI_1_490144(An16g03520)
AFV: AFLA_084930
PCS: Pc12g15640
PDP: PDIP_76360
TMF: PMAA_025750
TRG: TRUGW13939_03274
CIM: CIMG_01937
CPW: CPC735_045850
PBL: PAAG_07894
PBN: PADG_08183
URE: UREG_06875
ABE: ARB_01205
TVE: TRV_05311
AJE: HCAG_05457
BGH: BDBG_02477
PNO: SNOG_09508(SNOG_09507)
PTE: PTT_15308
BZE: COCCADRAFT_83306
BSC: COCSADRAFT_118766
BOR: COCMIDRAFT_8663
AALT: CC77DRAFT_959178
ZTR: MYCGRDRAFT_72798
PFJ: MYCFIDRAFT_49240
BCOM: BAUCODRAFT_501656
NPA: UCRNP2_9924
TML: GSTUM_00006266001
SPO: SPBC19G7.01c(msh2)
CNE: CNA07480
CNB: CNBA7300
CGI: CGB_A8580C
TMS: TREMEDRAFT_30126
TASA: A1Q1_03197
PPL: POSPLDRAFT_103942 POSPLDRAFT_90815
TVS: TRAVEDRAFT_171157
DSQ: DICSQDRAFT_101887
PCO: PHACADRAFT_207767
SHS: STEHIDRAFT_65505
HIR: HETIRDRAFT_152464
PSQ: PUNSTDRAFT_143768
ADL: AURDEDRAFT_167424
FME: FOMMEDRAFT_131906
GTR: GLOTRDRAFT_116966
LBC: LACBIDRAFT_252536
MRR: Moror_4758
CCI: CC1G_05221
SCM: SCHCODRAFT_257642
ABP: AGABI1DRAFT131867(AGABI1DRAFT_131867)
ABV: AGABI2DRAFT187339(AGABI2DRAFT_187339)
CPUT: CONPUDRAFT_168162
SLA: SERLADRAFT_433333 SERLADRAFT_436679
WSE: WALSEDRAFT_35672
WIC: J056_002202
UMA: UMAG_03025
PFP: PFL1_01208
MGL: MGL_3578
MRT: MRET_4268
PGR: PGTG_02693
MLR: MELLADRAFT_118031
ECU: ECU03_0540
EIN: Eint_030450
EHE: EHEL_030450
ERO: EROM_030430
NCE: NCER_100600
MBR: MONBRDRAFT_34327
SRE: PTSG_09461
DDI: DDB_G0275809(msh2)
DPP: DICPUDRAFT_50444
DFA: DFA_02479(msh2)
EHI: EHI_123830 EHI_172750(113.t00021)
EDI: EDI_226120 EDI_294890
EIV: EIN_074260
ACAN: ACA1_031570 ACA1_172850
PFA: PF3D7_0706700 PF3D7_1427500
PFD: PFDG_03571 PFDG_04019
PFH: PFHG_05165 PFHG_05295
PYO: PY17X_0807000 PY17X_1018600
PCB: PCHAS_080460(PC000592.00.0) PCHAS_101790(PC301346.00.0)
PBE: PBANKA_0804300 PBANKA_1017100
PKN: PKH_010510 PKH_132290
PVX: PVX_085160 PVX_087875
PCY: PCYB_011410 PCYB_133110
TAN: TA20735
TPV: TP01_0456
TOT: TOT_010000401
BEQ: BEWA_029560
BBO: BBOV_I003810(19.m02277)
BMIC: BMR1_03g00250
CPV: cgd8_3950
CHO: Chro.80453
TGO: TGME49_261000
TET: TTHERM_00295920
PTM: GSPATT00000151001 PTMB.344c
SMIN: v1.2.002929.t1(symbB.v1.2.002929.t1)
PTI: PHATRDRAFT_19604
FCY: FRACYDRAFT_157228(MSH2_a)
TPS: THAPSDRAFT_32661
AAF: AURANDRAFT_25096 AURANDRAFT_7199
PIF: PITG_02805
PSOJ: PHYSODRAFT_261139
SPAR: SPRG_01049
EHX: EMIHUDRAFT_451702 EMIHUDRAFT_458255(mutS)
GTT: GUITHDRAFT_116240(Msh2)
TBR: Tb10.26.1030
TBG: TbgDal_X13330
TCR: 507711.320 509643.80
LMA: LMJF_33_0410
LIF: LINJ_33_0420
LDO: LDBPK_330420
LMI: LMXM_32_0410
LBZ: LBRM_33_0400
LPAN: LPMP_330420
NGR: NAEGRDRAFT_34984
TVA: TVAG_300740
GLA: GL50803_00113252
 » show all
Reference
PMID:8252616
  Authors
Fishel R, Lescoe MK, Rao MR, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R
  Title
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
  Journal
Cell 75:1027-38 (1993)
DOI:10.1016/0092-8674(93)90546-3
  Sequence
[hsa:4436]
Reference
  Authors
Seifert M, Scherer SJ, Edelmann W, Bohm M, Meineke V, Lobrich M, Tilgen W, Reichrath J
  Title
The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.
  Journal
J Invest Dermatol 128:203-13 (2008)
DOI:10.1038/sj.jid.5700941
  Sequence
[hsa:4436]
Reference
  Authors
Lee SD, Surtees JA, Alani E
  Title
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  Journal
J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099
  Sequence
[sce:YOL090W]
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