KEGG   ORTHOLOGY: K08735
Entry
K08735                      KO                                     
Symbol
MSH2
Name
DNA mismatch repair protein MSH2
Pathway
map01524  Platinum drug resistance
map03430  Mismatch repair
map05200  Pathways in cancer
map05210  Colorectal cancer
Disease
H00020  Colorectal cancer
H00027  Ovarian cancer
H00876  Mismatch repair deficiency
H02565  Hereditary nonpolyposis colorectal cancer
H02566  Muir-Torre syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    K08735  MSH2; DNA mismatch repair protein MSH2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08735  MSH2; DNA mismatch repair protein MSH2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08735  MSH2; DNA mismatch repair protein MSH2
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08735  MSH2; DNA mismatch repair protein MSH2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K08735  MSH2; DNA mismatch repair protein MSH2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     K08735  MSH2; DNA mismatch repair protein MSH2
Genes
HSA: 4436(MSH2)
PTR: 107973458(MSH2)
PPS: 100984592(MSH2)
GGO: 101145372(MSH2)
PON: 100431828(MSH2)
NLE: 100580147(MSH2)
MCC: 718017(MSH2)
MCF: 101867487(MSH2)
CSAB: 103220322(MSH2)
CATY: 105590609(MSH2)
PANU: 101005434(MSH2)
TGE: 112636958(MSH2)
RRO: 104663167(MSH2)
RBB: 108512671(MSH2)
TFN: 117062345(MSH2)
PTEH: 111550430(MSH2)
CJC: 100394665(MSH2)
SBQ: 101044013(MSH2)
CSYR: 103274425(MSH2)
MMUR: 105866365(MSH2)
LCAT: 123636896(MSH2)
OGA: 100957320(MSH2)
MMU: 17685(Msh2)
MCAL: 110312708(Msh2)
MPAH: 110335350(Msh2)
RNO: 81709(Msh2)
MCOC: 116079775(Msh2)
MUN: 110552895(Msh2)
CGE: 100768127(Msh2)
MAUA: 101841101(Msh2)
PLEU: 114695418 114709214(Msh2)
MORG: 121432904(Msh2)
AAMP: 119806951(Msh2)
NGI: 103725741(Msh2)
HGL: 101706924(Msh2)
CPOC: 100724489(Msh2)
CCAN: 109691600(Msh2)
DORD: 105986810(Msh2)
DSP: 122104558(Msh2)
NCAR: 124963728
OCU: 103347805(MSH2)
OPI: 101516282(MSH2)
TUP: 102471638(MSH2)
CFA: 494002(MSH2)
CLUD: 112671834(MSH2)
VVP: 112915229(MSH2)
VLG: 121492051(MSH2)
AML: 100471735(MSH2)
UMR: 103671767(MSH2)
UAH: 113245944(MSH2)
UAR: 123785910(MSH2)
ELK: 111148098
LLV: 125109049
MPUF: 101671728(MSH2)
ORO: 101367758(MSH2)
EJU: 114209827(MSH2)
ZCA: 113938212(MSH2)
MLX: 118008158(MSH2)
FCA: 101082051(MSH2)
PYU: 121016315(MSH2)
PBG: 122496821(MSH2)
PTG: 102954275(MSH2)
PPAD: 109247022(MSH2)
AJU: 106977220(MSH2)
HHV: 120241029(MSH2)
BTA: 533115(MSH2)
BOM: 102268614(MSH2)
BIU: 109566059(MSH2)
BBUB: 102409227(MSH2)
CHX: 102172730(MSH2)
OAS: 101107944(MSH2)
ODA: 120851730(MSH2)
CCAD: 122441650(MSH2)
SSC: 100337661(MSH2)
CFR: 102512861(MSH2)
CBAI: 105079035(MSH2)
CDK: 105092361(MSH2)
VPC: 102530680(MSH2)
BACU: 102999324(MSH2)
LVE: 103088025(MSH2)
OOR: 101272233(MSH2)
DLE: 111174786(MSH2)
PCAD: 102987486(MSH2)
PSIU: 116764668(MSH2)
ECB: 100068146(MSH2)
EPZ: 103558101(MSH2)
EAI: 106826002(MSH2)
MYB: 102244813(MSH2)
MYD: 102756016(MSH2)
MMYO: 118669023(MSH2)
MLF: 102430470(MSH2)
MNA: 107544316(MSH2)
PKL: 118717337(MSH2)
HAI: 109389912(MSH2)
DRO: 112297937(MSH2)
SHON: 119001326(MSH2)
AJM: 119060910(MSH2)
PDIC: 114499358(MSH2)
PHAS: 123811513(MSH2)
MMF: 118630892(MSH2)
RFQ: 117033262(MSH2)
PALE: 102893728(MSH2)
PGIG: 120621666(MSH2)
PVP: 105292910(MSH2)
RAY: 107509554(MSH2)
MJV: 108391861(MSH2)
TOD: 119259324(MSH2)
SARA: 101541291(MSH2)
LAV: 100653677(MSH2)
TMU: 101346702
DNM: 101422880(MSH2)
MDO: 100033358(MSH2)
GAS: 123234704(MSH2)
SHR: 100928256(MSH2)
PCW: 110218513(MSH2)
OAA: 100083981(MSH2)
GGA: 378799(MSH2)
PCOC: 116232457(MSH2)
MGP: 100542264(MSH2)
CJO: 107310883(MSH2)
NMEL: 110396247(MSH2)
APLA: 101802532(MSH2)
ACYG: 106043144(MSH2)
AFUL: 116487116(MSH2)
TGU: 100226839(MSH2)
LSR: 110475805(MSH2)
SCAN: 103819297(MSH2)
PMOA: 120501438(MSH2)
OTC: 121346398(MSH2)
PRUF: 121365326(MSH2)
GFR: 102033642(MSH2)
FAB: 101818579(MSH2)
PHI: 102104578(MSH2)
PMAJ: 107202300(MSH2)
CCAE: 111926310(MSH2)
CCW: 104685720(MSH2)
CBRC: 103612842(MSH2)
ETL: 114060415(MSH2)
ZAB: 102060819(MSH2)
FPG: 101910374(MSH2)
FCH: 102053065(MSH2)
CLV: 102091445(MSH2)
EGZ: 104134601(MSH2)
NNI: 104018118(MSH2)
PLET: 104614135(MSH2)
ACUN: 113478407(MSH2)
TALA: 104358576(MSH2)
PADL: 103925036(MSH2)
ACHC: 115350171(MSH2)
HALD: 104320350(MSH2)
CCRI: 104166874(MSH2)
CSTI: 104550128(MSH2)
EHS: 104503248(MSH2)
FGA: 104084127(MSH2)
GSTE: 104261078(MSH2)
LDI: 104353377(MSH2)
MNB: 103768592(MSH2)
AAM: 106490370(MSH2)
AROW: 112974937(MSH2)
NPD: 112954822(MSH2)
DNE: 112980032(MSH2)
ASN: 102372507(MSH2)
AMJ: 102562032(MSH2)
CPOO: 109319629(MSH2)
GGN: 109296757(MSH2)
PSS: 102457455(MSH2)
CMY: 102929651(MSH2)
CPIC: 101937123(MSH2)
TST: 117874356(MSH2)
CABI: 116819753(MSH2)
MRV: 120401727(MSH2)
ACS: 100562005(msh2)
PVT: 110079560(MSH2)
SUND: 121915282(MSH2)
PBI: 103057506(MSH2)
PMUR: 107284056(MSH2)
TSR: 106554294(MSH2)
PGUT: 117671535(MSH2)
VKO: 123022880(MSH2)
PMUA: 114594844(MSH2)
ZVI: 118083046(MSH2)
GJA: 107124258(MSH2)
STOW: 125437283(MSH2)
XLA: 595045(msh2.L)
XTR: 100380043(msh2)
NPR: 108804519(MSH2)
RTEM: 120937986(MSH2)
BBUF: 120999424(MSH2)
BGAR: 122934298(MSH2)
DRE: 406845(msh2)
PPRM: 120471567(msh2)
MAMB: 125255644(msh2)
IPU: 108274345(msh2)
PHYP: 113527804(msh2)
SMEO: 124389389(msh2)
TFD: 113662683(msh2)
AMEX: 103047089(msh2)
EEE: 113572822(msh2)
TRU: 101075196(msh2)
LCO: 104923481(msh2)
NCC: 104951045(msh2)
CGOB: 115024267(msh2)
ELY: 117246632(msh2)
EFO: 125881076(msh2)
PLEP: 121958614(msh2)
SLUC: 116061193(msh2)
ECRA: 117936971(msh2)
PFLV: 114547687(msh2)
GAT: 120819393(msh2)
PPUG: 119212741(msh2)
MSAM: 119887533 119915639(msh2)
CUD: 121528796(msh2)
ALAT: 119009610(msh2)
MZE: 101484075(msh2)
ONL: 100697326(msh2)
OAU: 116328817(msh2)
OLA: 101167993(msh2)
OML: 112154462(msh2)
XMA: 102234491(msh2) 106700380
XCO: 114152173(msh2)
XHE: 116727350(msh2)
PRET: 103481547(msh2)
PFOR: 103145126(msh2)
PLAI: 106948652(msh2)
PMEI: 106904243(msh2)
GAF: 122823810(msh2)
CVG: 107085521(msh2)
CTUL: 119781922(msh2)
GMU: 124874594(msh2)
NFU: 107387525(msh2)
KMR: 108248490(msh2)
ALIM: 106516619(msh2)
NWH: 119423730(msh2)
AOCE: 111577896(msh2)
MCEP: 125022085(msh2)
CSEM: 103381539(msh2)
POV: 109646954
SSEN: 122759633(msh2)
HHIP: 117753037(msh2)
HSP: 118100354(msh2)
LCF: 108882675(msh2)
SDU: 111219993(msh2)
SLAL: 111655249(msh2)
XGL: 120794634(msh2)
HCQ: 109530180(msh2)
BPEC: 110174586(msh2)
MALB: 109962934(msh2)
BSPL: 114845765(msh2)
SASA: 106589405(msh2)
OTW: 112224292(msh2)
OMY: 110498971(msh2)
OGO: 124040051(msh2)
ONE: 115144068(msh2)
SALP: 111967793(msh2)
SNH: 120029538(msh2)
CCLU: 121547358(msh2)
ELS: 105006146(msh2)
SFM: 108931448(msh2)
PKI: 111848461(msh2)
AANG: 118221143(msh2) 118221159
LOC: 102688193(msh2)
PSPA: 121316326(msh2)
ARUT: 117402246(msh2)
CMK: 103180793(msh2)
RTP: 109932239(msh2)
BFO: 118422865
BBEL: 109464620
CIN: 100183267
SCLV: 120326151
SPU: 589363
APLC: 110984624
SKO: 100370530(MSH2)
DME: Dmel_CG4215(spel1)
DER: 6540643
DSE: 6611269
DSI: Dsimw501_GD23963(Dsim_GD23963)
DAN: 6497702
DSR: 110185631
DPO: 4816708
DPE: 6598122
DMN: 108161674
DWI: 6643724
DGR: 6562506
DAZ: 108611243
DNV: 108649356
DHE: 111600377
DVI: 6634164
CCAT: 101458715
BOD: 106616250
MDE: 101891948
LCQ: 111677682
LSQ: 119613478
HIS: 119650191
ACOZ: 120958458
AARA: 120903201
ASTE: 118510965
AAG: 5565480
CPII: 120431328
CNS: 116343551
BCOO: 119070823
AME: 725348
ACER: 107994303
ALAB: 122721108
BIM: 100745953
BBIF: 117204257
BVK: 117239864
BVAN: 117158238
BTER: 100644548
BPYO: 122571185
CCAL: 108630326
OBB: 114873609
MGEN: 117219850
NMEA: 116426923
CGIG: 122397572
SOC: 105202417
MPHA: 105837293
AEC: 105151743
ACEP: 105618910
PBAR: 105424600
VEM: 105558517
HST: 105191066
DQU: 106751800
CFO: 105249227
FEX: 115241144
LHU: 105673743
PGC: 109856928
OBO: 105281999
PCF: 106791815
PFUC: 122524617
VPS: 122628225
NVI: 100118035(Msh2)
CSOL: 105359470
TPRE: 106650580
MDL: 103575164
CGLO: 123273705
FAS: 105267753
DAM: 107048354
AGIF: 122858067
CCIN: 107275204
TCA: 655722
DPA: 109532708
SOY: 115886714
ATD: 109608594
CSET: 123316071
AGB: 108914081
LDC: 111506456
NVL: 108564757
APLN: 108741664
PPYR: 116164748
OTU: 111421767
BMOR: 101743378
BMAN: 114245626
MSEX: 115444017
BANY: 112045785
PMAC: 106713550
PPOT: 106102987
PRAP: 110993151
ZCE: 119833824
HAW: 110380087
HZE: 124633708
TNL: 113498334
SLIU: 111357676
OFU: 114350243
API: 100160952
DNX: 107161324
AGS: 114128384
RMD: 113553385
BTAB: 109039150
DCI: 103513577
CLEC: 106665222
HHAL: 106682669
FOC: 113213993
TPAL: 117652691
ZNE: 110838930
CSEC: 111866053
FCD: 110845892
DMK: 116921064
PVM: 113820839
PCHN: 125025948
HAME: 121861200
PCLA: 123762046
PTRU: 123512099
HAZT: 108669509
EAF: 111695587
LSM: 121123639
PPOI: 119100826
DSV: 119461563
RSAN: 119395934
RMP: 119185177
VDE: 111246541
VJA: 111265491
TUT: 107369494
DPTE: 113791662
DFR: 124499013
CSCU: 111632815
PTEP: 107442808
SDM: 118184361
CEL: CELE_H26D21.2(msh-2)
CBR: CBG_12022(Cbr-msh-2)
BMY: BM_BM4680(Bma-msh-2)
TSP: Tsp_09659
PCAN: 112566662
BGT: 106078541
GAE: 121371045
HRF: 124145198
HRJ: 124255738
CRG: 105335553
MYI: 110460651
PMAX: 117327597
MMER: 123551025
OBI: 106868054
OSN: 115209288
LAK: 106156484
EGL: EGR_08102
NVE: 5509902
EPA: 110249970
ATEN: 116286300
ADF: 107351410
AMIL: 114961970
PDAM: 113668608
SPIS: 111341692
DGT: 114537619
HMG: 100200908
AQU: 100641505
ATH: AT3G18524(MSH2)
ALY: 9319206
CRB: 17891110
BRP: 103859754
BOE: 106335377
RSZ: 108862549
THJ: 104820406
CPAP: 110825125
CIT: 102614656
PVY: 116146891
MINC: 123196715
TCC: 18604054
GRA: 105798704
GAB: 108457313
DZI: 111291050
EGR: 104421462
GMX: 100792272
GSJ: 114393536
VRA: 106769444
VAR: 108323623
VUN: 114177191
CCAJ: 109809762
APRC: 113845926
CAM: 101505823
LJA: Lj4g3v1787050.1(Lj4g3v1787050.1)
ADU: 107469314
AIP: 107630408
FVE: 101293489
RCN: 112180984
PPER: 18777066
PMUM: 103342205
PAVI: 110754162
PDUL: 117628589
PXB: 103938503
ZJU: 107418858
MNT: 21405122
CSV: 101215589
CMO: 103494106
BHJ: 120079711
MCHA: 111007070
CMAX: 111484889
CMOS: 111430121
CPEP: 111780449
RCU: 8286743
JCU: 105650645
HBR: 110651472
MESC: 110624712
POP: 7484706
PEU: 105114805
PALZ: 118030219
JRE: 109012023
QLO: 115963458
TWL: 119980271
VVI: 100268052(MSH2)
VRI: 117904825
SLY: 100462655(MSH2)
SPEN: 107021249
SOT: 102598532
SSTN: 125874351
CANN: 107855430
NTA: 107825761
NSY: 104244948
NTO: 104117972
NAU: 109227481
INI: 109184200
ITR: 116010608
OEU: 111406449
EGT: 105948973
SSPL: 121746533
HAN: 110941615
ECAD: 122579291
LSV: 111915654
CCAV: 112513365
DCR: 108192774
CSIN: 114263749
BVG: 104908225
SOE: 110789489
NNU: 104603050
MING: 122079289
TSS: 122664174
NCOL: 116246737
OSA: 4338271
DOSA: Os05t0274200-01(Os05g0274200)
OBR: 102704890
BDI: 100842311
ATS: 109751240
TUA: 125552003
SBI: 8060623
ZMA: 100279876
SITA: 101753902
SVS: 117849597
PHAI: 112884001
PDA: 103704345
EGU: 105041044
MUS: 103987730
DCT: 110093633
PEQ: 110023469
AOF: 109822519
ATR: 18433612
PPP: 112275272
APRO: F751_2623
SCE: YOL090W(MSH2)
SEUB: DI49_2315
ERC: Ecym_2796
KMX: KLMA_30578(MSH2)
NCS: NCAS_0A08670(NCAS0A08670)
NDI: NDAI_0G05110(NDAI0G05110)
TPF: TPHA_0A00740(TPHA0A00740)
TBL: TBLA_0B02380(TBLA0B02380)
TDL: TDEL_0D05170(TDEL0D05170)
KAF: KAFR_0C01330(KAFR0C01330)
KNG: KNAG_0K00810(KNAG0K00810)
CAL: CAALFM_C407120CA(MSH2)
SLB: AWJ20_1043(MSH2)
NCR: NCU02230(msh2)
NTE: NEUTE1DRAFT124099(NEUTE1DRAFT_124099)
SMP: SMAC_03669(putative msh2)
MGR: MGG_00879
SSCK: SPSK_00411
MAW: MAC_04666
MAJ: MAA_04555
CMT: CCM_01340
BFU: BCIN_02g08740(Bcmsh2)
MBE: MBM_06832
ANI: AN5006.2
ANG: ANI_1_490144(An16g03520)
ALUC: AKAW2_70299S(MSH2)
ACHE: ACHE_20937A(MSH2)
APUU: APUU_30820S(MSH2)
ABE: ARB_01205
TVE: TRV_05311
PNO: SNOG_09508(SNOG_09507)
PTE: PTT_15308
SPO: SPBC19G7.01c(msh2)
CNE: CNA07480
CNB: CNBA7300
TASA: A1Q1_03197
SCM: SCHCO_02601119(SCHCODRAFT_02601119)
ABP: AGABI1DRAFT131867(AGABI1DRAFT_131867)
ABV: AGABI2DRAFT187339(AGABI2DRAFT_187339)
MGL: MGL_3578
MRT: MRET_4268
DDI: DDB_G0275809(msh2)
DFA: DFA_02479(msh2)
EHI: EHI_123830 EHI_172750(113.t00021)
PCB: PCHAS_080460(PC000592.00.0) PCHAS_101790(PC301346.00.0)
TAN: TA20735
TPV: TP01_0456
BBO: BBOV_I003810(19.m02277)
CPV: cgd8_3950
SMIN: v1.2.002929.t1(symbB.v1.2.002929.t1)
FCY: FRACYDRAFT_157228(MSH2_a)
SPAR: SPRG_01049
GTT: GUITHDRAFT_116240(Msh2)
 » show all
Reference
PMID:8252616
  Authors
Fishel R, Lescoe MK, Rao MR, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R
  Title
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
  Journal
Cell 75:1027-38 (1993)
DOI:10.1016/0092-8674(93)90546-3
  Sequence
[hsa:4436]
Reference
  Authors
Seifert M, Scherer SJ, Edelmann W, Bohm M, Meineke V, Lobrich M, Tilgen W, Reichrath J
  Title
The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.
  Journal
J Invest Dermatol 128:203-13 (2008)
DOI:10.1038/sj.jid.5700941
  Sequence
[hsa:4436]
Reference
  Authors
Lee SD, Surtees JA, Alani E
  Title
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  Journal
J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099
  Sequence
[sce:YOL090W]
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