KEGG   ORTHOLOGY: K08737
Entry
K08737                      KO                                     

Name
MSH6
Definition
DNA mismatch repair protein MSH6
Pathway
ko01524  Platinum drug resistance
ko03430  Mismatch repair
ko05200  Pathways in cancer
ko05210  Colorectal cancer
Disease
H00020  Colorectal cancer
H00876  Mismatch repair deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    K08737  MSH6; DNA mismatch repair protein MSH6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08737  MSH6; DNA mismatch repair protein MSH6
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08737  MSH6; DNA mismatch repair protein MSH6
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08737  MSH6; DNA mismatch repair protein MSH6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K08737  MSH6; DNA mismatch repair protein MSH6
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     K08737  MSH6; DNA mismatch repair protein MSH6
Genes
HSA: 2956(MSH6)
PTR: 459218(MSH6)
PPS: 100986695(MSH6)
GGO: 101148740(MSH6)
PON: 100458732(MSH6)
NLE: 100593553(MSH6)
MCC: 715701(MSH6)
MCF: 102143419(MSH6)
CSAB: 103220318(MSH6)
RRO: 104663162(MSH6)
RBB: 108527513(MSH6)
CJC: 100386465(MSH6)
SBQ: 101039649(MSH6)
MMU: 17688(Msh6)
MCAL: 110284330(Msh6)
MPAH: 110335576(Msh6)
RNO: 100360342(Msh6)
MUN: 110561037(Msh6)
CGE: 100771087(Msh6)
NGI: 103725738(Msh6)
HGL: 101708261(Msh6)
CCAN: 109691597(Msh6)
OCU: 100351645(MSH6)
TUP: 102476727(MSH6)
CFA: 474585(MSH6)
VVP: 112915230(MSH6)
AML: 100471984(MSH6)
UMR: 103671242(MSH6)
UAH: 113245929(MSH6)
ORO: 101368929(MSH6)
ELK: 111148106
FCA: 101082303(MSH6)
PTG: 102953993(MSH6)
PPAD: 109247090(MSH6)
AJU: 106977218(MSH6)
BTA: 540526(MSH6)
BOM: 102269162(MSH6)
BIU: 109566061(MSH6)
BBUB: 102409894(MSH6)
CHX: 102173474(MSH6)
OAS: 101107426(MSH6)
SSC: 100624450(MSH6)
CFR: 102513599(MSH6)
CDK: 105092358(MSH6)
BACU: 102999040(MSH6)
LVE: 103089181(MSH6)
OOR: 101271574(MSH6)
DLE: 111174785(MSH6)
PCAD: 102994456(MSH6)
ECB: 100068065(MSH6)
EPZ: 103558461(MSH6)
EAI: 106825979(MSH6)
MYB: 102245110(MSH6)
MYD: 102755448(MSH6)
MNA: 107544300(MSH6)
HAI: 109389905(MSH6)
DRO: 112297935(MSH6)
PALE: 102892999(MSH6)
RAY: 107509550(MSH6)
MJV: 108394002(MSH6)
LAV: 100677382(MSH6)
TMU: 101345932
MDO: 100033356(MSH6)
SHR: 100919645(MSH6)
PCW: 110218568(MSH6)
OAA: 103168521(MSH6)
GGA: 421291(MSH6)
MGP: 100541959(MSH6)
CJO: 107310861(MSH6)
NMEL: 110396244(MSH6)
APLA: 101799348(MSH6)
ACYG: 106043138(MSH6)
TGU: 100227810(MSH6)
LSR: 110475791(MSH6)
SCAN: 103819208(MSH6)
GFR: 102033560(MSH6)
FAB: 101815194(MSH6)
PHI: 102104034(MSH6)
PMAJ: 107201864(MSH6)
CCAE: 111926311(MSH6)
CCW: 104685591(MSH6)
ETL: 114060404(MSH6)
FPG: 101921710(MSH6)
FCH: 102051882(MSH6)
CLV: 102090300(MSH6)
EGZ: 104134625(MSH6)
NNI: 104018105(MSH6)
ACUN: 113478822(MSH6)
PADL: 103924992(MSH6)
AAM: 106490408(MSH6)
ASN: 102388051(MSH6)
AMJ: 102573895(MSH6)
PSS: 102456308(MSH6)
CMY: 102943356(MSH6)
CPIC: 101951836(MSH6)
ACS: 100562407(msh6)
PVT: 110079554(MSH6)
PBI: 103056083(MSH6)
PMUR: 107290122(MSH6)
TSR: 106541523(MSH6)
PMUA: 114594849(MSH6)
GJA: 107124261(MSH6)
XLA: 734294(msh6.L)
XTR: 100145639(msh6)
NPR: 108787598(MSH6)
DRE: 260437(msh6)
SRX: 107725009
SANH: 107679164(msh6)
SGH: 107588437
CCAR: 109102662 109102665
IPU: 108263456(msh6)
PHYP: 113542145(msh6)
AMEX: 103027666(msh6)
EEE: 113588072(msh6)
TRU: 101079280(msh6)
TNG: GSTEN00030759G001
LCO: 104918635(msh6)
NCC: 104951340(msh6)
MZE: 101470032(msh6)
ONL: 100710916(msh6)
OLA: 101160935(msh6)
XMA: 102229772(msh6)
XCO: 114137762(msh6)
PRET: 103477050(msh6)
CVG: 107089290(msh6)
NFU: 107375752(msh6)
KMR: 108234081(msh6)
ALIM: 106532862(msh6)
AOCE: 111567184(msh6)
CSEM: 103387561(msh6)
POV: 109632657(msh6)
LCF: 108894383(msh6)
SDU: 111220543(msh6)
SLAL: 111659027(msh6)
HCQ: 109516232(msh6)
BPEC: 110157016(msh6)
MALB: 109961974(msh6)
SASA: 106589736(msh6)
OTW: 112224594(msh6)
SALP: 111968060(msh6)
ELS: 105028409(msh6)
SFM: 108918060(msh6)
PKI: 111848812(msh6)
LCM: 102366015(MSH6)
CMK: 103180839(msh6)
RTP: 109919222
BFO: 118404634
CIN: 100185806
SPU: 593059
APLC: 110987988
SKO: 102805174
DME: Dmel_CG7003(Msh6)
DER: 6544520
DSE: 6605754
DSI: Dsimw501_GD12570(Dsim_GD12570)
DYA: Dyak_GE19856
DAN: 6493604
DSR: 110176127
DPO: Dpse_GA20021
DPE: 6596937
DMN: 108151407
DWI: 6645793
DGR: Dgri_GH17031
DMO: Dmoj_GI12236
DAZ: 108613429
DNV: 108651428
DHE: 111595124
DVI: 6623428
MDE: 101889577
LCQ: 111685162
AGA: AgaP_AGAP003190
AAG: 5575374
AALB: 109414186
CQU: CpipJ_CPIJ013201
AME: 408815
BIM: 100745752
BTER: 100647842
CCAL: 108625901
OBB: 114872506
SOC: 105205867
MPHA: 105831306
AEC: 105147089
ACEP: 105623738
PBAR: 105431572
VEM: 105565711
HST: 105183383
DQU: 106742167
CFO: 105255559
LHU: 105677715
PGC: 109859322
OBO: 105281412
PCF: 106789002
NVI: 100115613
CSOL: 105362758
MDL: 103578990 106693106 106693943 106693947 106693948
TCA: 660174
DPA: 109543134
ATD: 109596295
NVL: 108567736
BMOR: 101744671
BMAN: 114249524
DPL: KGM_208174B
PMAC: 106709764
PRAP: 110993015
HAW: 110379891
TNL: 113499169
PXY: 105383955 105383986
API: 100166946
DNX: 107173209
AGS: 114122759
RMD: 113560561 113561145
BTAB: 109039982
CLEC: 106668181
PHU: Phum_PHUM253520
ZNE: 110831875
FCD: 110851254
DPX: DAPPUDRAFT_303932
PVM: 113803547
TUT: 107364943
DPTE: 113790436
CSCU: 111620331
PTEP: 107448365
CEL: CELE_Y47G6A.11(msh-6)
CBR: CBG14959(Cbr-msh-6)
BMY: Bm1_41770
LOA: LOAG_03556
NAI: NECAME_00196
TSP: Tsp_09358
HRO: HELRODRAFT_187909
LGI: LOTGIDRAFT_143393
PCAN: 112561418
CRG: 105344641
MYI: 110458103
OBI: 106880162
LAK: 106155648
SMM: Smp_042670.1
SHX: MS3_02714
OVI: T265_11255
EGL: EGR_01292
NVE: 5518402
EPA: 110241459
ADF: 107336223 107358065
AMIL: 114963837
PDAM: 113669812
SPIS: 111338428
DGT: 114528604
HMG: 100209507
TAD: TRIADDRAFT_33687
AQU: 100631829
ATH: AT3G24495(MSH7) AT4G02070(MSH6)
ALY: 9308928 9319590
CRB: 17883252 17893384
CSAT: 104707895 104713659 104737578 104746990 104767837 104789526
EUS: EUTSA_v10002887mg EUTSA_v10028364mg
BRP: 103831716 103858779
BNA: 106384159 106391373 106426511 106432426 106438660
BOE: 106327563 106335760
RSZ: 108805924 108847258
THJ: 104804581 104825941
CPAP: 110815038 110818630
CIT: 102617856 102627728
CIC: CICLE_v10007291mg CICLE_v10018525mg
TCC: 18588626 18613685
GRA: 105773605 105794794
GHI: 107901218 107909991 107954361 107962662
GAB: 108458278 108486285
DZI: 111299090 111305013
EGR: 104426818 104438299
GMX: 100776965 100811104 100818859
GSJ: 114366961 114400173 114418574
PVU: PHAVU_001G212500g PHAVU_004G162000g
VRA: 106757872 106758070
VAR: 108329230 108343740
VUN: 114181126 114191536
CCAJ: 109813467 109814728
MTR: MTR_6g086270 MTR_7g109470
CAM: 101498481 101513237
LJA: Lj1g3v0246860.1(Lj1g3v0246860.1) Lj2g3v0777050.1(Lj2g3v0777050.1)
ADU: 107490253 107492388
AIP: 107646082
LANG: 109330037 109343003 109345877
FVE: 101302167 101307930
RCN: 112176461 112190849
PPER: 18767598 18770083
PMUM: 103334050 103340953
PAVI: 110744549 110749301
MDM: 103408170 103424956
PXB: 103938841 103943839 103967167
ZJU: 107426147 107431838
CSV: 101210755 101219303
CMO: 103492760 103497727
MCHA: 111018509 111024229
CMAX: 111493803 111497744
CMOS: 111450579 111461234
CPEP: 111779129 111806177
RCU: 8267354 8284823
JCU: 105637696 105642614
HBR: 110653631 110654086
MESC: 110611202 110613150
POP: 112326168 112327899 18100405 7469064 7495220
PEU: 105116602 105137312
JRE: 108992655 109009934
QSU: 111991391 112006841 112030170
VVI: 100255608 100260983(MSH7)
SLY: 100462656 112941390
SPEN: 107008263 107025913
SOT: 102602160 102603118
CANN: 107877977
NTA: 107805046 107810164 107823139 107825338
NSY: 104238915 104248427
NTO: 104093899 104119443
NAU: 109220078 109228919
INI: 109182884 109186417
SIND: 105162107 105163053
OEU: 111399384 111405737
HAN: 110877154 110909917
LSV: 111882195 111883911
CCAV: 112501052 112505827
DCR: 108211379 108223219
BVG: 104894756 104902177
SOE: 110777148 110777243
CQI: 110691046 110707809 110733055 110734307
NNU: 104595228 104598798
PSOM: 113299799 113303707 113333262 113346891
OSA: 4325353 4347016
DOSA: Os01t0180600-01(Os01g0180600) Os09t0407600-01(Os09g0407600)
OBR: 102713228 102722145
BDI: 100821236 100837570
ATS: 109772035(LOC109772035) 109786772(LOC109786772)
SBI: 8055803 8056514
ZMA: 542006 542626
SITA: 101762866 101764941
PDA: 103709742 103715035
EGU: 105040286 105053216
MUS: 103985334 103991568
DCT: 110107080 110108313
PEQ: 110023120 110026063
AOF: 109827295 109845173 109851315
ATR: 18431226 18432071
SMO: SELMODRAFT_114224 SELMODRAFT_125776 SELMODRAFT_129323 SELMODRAFT_410679
PPP: 112273630 112286571
VCN: VOLCADRAFT_105835
MNG: MNEG_2780
CSL: COCSUDRAFT_18682 COCSUDRAFT_40713
CVR: CHLNCDRAFT_139631
APRO: F751_5249
OLU: OSTLU_31967 OSTLU_40782
OTA: OT_ostta06g02640
BPG: Bathy05g00030 Bathy05g02800
MIS: MICPUN_62040
MPP: MICPUCDRAFT_40215 MICPUCDRAFT_69392
CME: CYME_CMI229C
GSL: Gasu_26500
CCP: CHC_T00006922001
SCE: YDR097C(MSH6)
AGO: AGOS_AGR116W
ERC: Ecym_3519
KLA: KLLA0_C17732g
KMX: KLMA_30293(MSH6)
LTH: KLTH0G14476g
VPO: Kpol_1075p4
ZRO: ZYRO0B11792g
CGR: CAGL0G08129g
NCS: NCAS_0B03980(NCAS0B03980)
NDI: NDAI_0J01520(NDAI0J01520)
TPF: TPHA_0B03370(TPHA0B03370)
TBL: TBLA_0F03840(TBLA0F03840)
TDL: TDEL_0A01290(TDEL0A01290)
KAF: KAFR_0A02370(KAFR0A02370)
PPA: PAS_chr2-1_0094
PIC: PICST_81012(MSH6)
PGU: PGUG_03193
SPAA: SPAPADRAFT_51026
LEL: LELG_00304
CAL: CAALFM_C113170CA(MSH6)
CTP: CTRG_03593
COT: CORT_0A01850
CDU: CD36_12230
CTEN: CANTEDRAFT_94346
YLI: YALI0F26499g
CLU: CLUG_04826
CLUS: A9F13_27g00506
CAUR: CJI97_002221
SLB: AWJ20_1503(MSH6)
PKZ: C5L36_0B10540
NCR: NCU08135(msh6)
NTE: NEUTE1DRAFT124150(NEUTE1DRAFT_124150)
SMP: SMAC_03612(putative msh56)
PAN: PODANSg1954
TTT: THITE_2117497
MTM: MYCTH_2308482
CTHR: CTHT_0017720
MGR: MGG_00704
TMN: UCRPA7_7416
SSCK: SPSK_02949
FGR: FGSG_07549
FPU: FPSE_10585
FVR: FVEG_12745
FOX: FOXG_15416
NHE: NECHADRAFT_48223
TRE: TRIREDRAFT_62301
TRR: M419DRAFT_67842
MAW: MAC_02355
MAJ: MAA_06876
CMT: CCM_06095
PLJ: VFPFJ_07634
VAL: VDBG_03965
VDA: VDAG_01192
CFJ: CFIO01_09424
SAPO: SAPIO_CDS7645
ELA: UCREL1_7088
PFY: PFICI_15128
SSL: SS1G_04335
BFU: BCIN_01g04490(Bcmsh6)
MBE: MBM_04714
PSCO: LY89DRAFT_643546
GLZ: GLAREA_04205
ANI: AN1708.2
AFM: AFUA_4G08300
ACT: ACLA_047670
NFI: NFIA_107860
AOR: AO090023000729
ANG: ANI_1_590184(An04g03050)
AFV: AFLA_111360
PCS: Pc13g07990
PDP: PDIP_88090
TMF: PMAA_046840
TRG: TRUGW13939_10071
CIM: CIMG_08825
CPW: CPC735_063470
PBL: PAAG_03178 PAAG_08713
PBN: PADG_03063
URE: UREG_02739
ABE: ARB_00228
TVE: TRV_05220
AJE: HCAG_06242
BGH: BDBG_02426
PNO: SNOG_00833
PTE: PTT_11611
BZE: COCCADRAFT_94113
BSC: COCSADRAFT_198733
BOR: COCMIDRAFT_3903
AALT: CC77DRAFT_1037140
ZTR: MYCGRDRAFT_98500
PFJ: MYCFIDRAFT_25225
BCOM: BAUCODRAFT_111690
NPA: UCRNP2_6249
TML: GSTUM_00001828001
SPO: SPCC285.16c(msh6)
CNE: CNK02590
CNB: CNBK0960
CGI: CGB_K1250C
TMS: TREMEDRAFT_40008
TASA: A1Q1_04720
PPL: POSPLDRAFT_105751
TVS: TRAVEDRAFT_172942
DSQ: DICSQDRAFT_183231
PCO: PHACADRAFT_116507
SHS: STEHIDRAFT_93831
HIR: HETIRDRAFT_157347
PSQ: PUNSTDRAFT_87965
ADL: AURDEDRAFT_99449
FME: FOMMEDRAFT_162551
GTR: GLOTRDRAFT_80226
LBC: LACBIDRAFT_297730
MRR: Moror_15708
CCI: CC1G_07657
SCM: SCHCODRAFT_258263
ABP: AGABI1DRAFT78171(AGABI1DRAFT_78171)
ABV: AGABI2DRAFT207943(AGABI2DRAFT_207943)
CPUT: CONPUDRAFT_156614
SLA: SERLADRAFT_365596
WSE: WALSEDRAFT_21205
WIC: J056_003601
UMA: UMAG_11009
PFP: PFL1_06902
MGL: MGL_2919
MRT: MRET_3520
PGR: PGTG_17874
MLR: MELLADRAFT_46541
ECU: ECU10_0710
EIN: Eint_100660
EHE: EHEL_100710
ERO: EROM_100580
NCE: NCER_101770
MBR: MONBRDRAFT_29248
SRE: PTSG_04067
DDI: DDB_G0268614(msh6)
DPP: DICPUDRAFT_55353
DFA: DFA_09956(msh6)
EHI: EHI_193340(139.t00016)
EDI: EDI_272020
EIV: EIN_016630
ACAN: ACA1_089000 ACA1_340910
PFA: PF3D7_0505500
PFD: PFDG_00730
PFH: PFHG_00892
PYO: PY17X_1106200
PCB: PCHAS_110480(PC000601.02.0)
PBE: PBANKA_1105100
PKN: PKH_102750
PVX: PVX_097835
PCY: PCYB_103610
TAN: TA19305
TPV: TP01_0185
TOT: TOT_010001218
BEQ: BEWA_032500
BBO: BBOV_I004430(19.m02191)
BMIC: BMR1_02g00420
CPV: cgd8_370
CHO: Chro.80049
TGO: TGME49_290640
TET: TTHERM_00142230 TTHERM_00150000 TTHERM_00194810 TTHERM_00426230
PTM: GSPATT00003111001 GSPATT00004789001 GSPATT00018574001 GSPATT00024779001 GSPATT00029349001
SMIN: v1.2.026874.t1(symbB.v1.2.026874.t1)
PTI: PHATRDRAFT_53969
FCY: FRACYDRAFT_212924(MSH6)
TPS: THAPSDRAFT_261781(MutS)
AAF: AURANDRAFT_71064
PIF: PITG_03351
PSOJ: PHYSODRAFT_353490
SPAR: SPRG_05442
EHX: EMIHUDRAFT_462330
GTT: GUITHDRAFT_99074 GUITHDRAFT_99983(Msh6)
NGR: NAEGRDRAFT_78068
TVA: TVAG_484110
GLA: GL50803_0034058
 » show all
Reference
  Authors
Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC
  Title
The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
  Journal
Oncogene 23:3749-56 (2004)
DOI:10.1038/sj.onc.1207462
  Sequence
[hsa:2956]
Reference
  Authors
Lee SD, Surtees JA, Alani E
  Title
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  Journal
J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099
  Sequence
[sce:YDR097C]
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