KEGG ORTHOLOGY: K08873

ORTHOLOGY: K08873

Entry

K08873                      KO

Symbol

SMG1

Name

serine/threonine-protein kinase SMG1 [EC:2.7.11.1]

Pathway

map03015

mRNA surveillance pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    K08873  SMG1; serine/threonine-protein kinase SMG1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08873  SMG1; serine/threonine-protein kinase SMG1
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K08873  SMG1; serine/threonine-protein kinase SMG1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08873  SMG1; serine/threonine-protein kinase SMG1
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  PIKK family [OT]
   K08873  SMG1; serine/threonine-protein kinase SMG1
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA surveillance and transport factors
   Surveillance factors
    Other surveillance factors
     K08873  SMG1; serine/threonine-protein kinase SMG1
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     K08873  SMG1; serine/threonine-protein kinase SMG1

Genes

HSA:	23049(SMG1)

PTR:	453961(SMG1)

PPS:

103783967

GGO:	101139405(SMG1)

PON:	100436087(SMG1)

NLE:	100604660(SMG1)

HMH:	116462290(SMG1)

MCC:	693542(SMG1)

MCF:	102137351(SMG1)

MTHB:

126945048

MNI:	105464273(SMG1)

CSAB:

103228997(SMG1)

CATY:

105586795(SMG1)

PANU:

101005953(SMG1)

TGE:

112613721

MLEU:

105536664(SMG1)

RRO:

104667848

RBB:	108540512(SMG1)

TFN:	117097600(SMG1)

PTEH:

111524551(SMG1)

CANG:

105517687(SMG1)

CJC:	100410734(SMG1)

SBQ:	101044279(SMG1)

CIMI:

108308452

CSYR:

103251523(SMG1)

MMUR:

105855200(SMG1)

LCAT:

123632427

PCOQ:

105812991(SMG1)

OGA:	100957431(SMG1)

MMU:	233789(Smg1)

MCAL:

110298287(Smg1)

MPAH:

110318746(Smg1)

RNO:	691397(Smg1)

MCOC:

116102848(Smg1)

ANU:	117710594(Smg1)

MUN:	110554339(Smg1)

CGE:	100752584(Smg1)

MAUA:

101836373(Smg1)

PROB:

127228235(Smg1)

PLEU:

114692138(Smg1)

MORG:

121457323(Smg1)

MFOT:

126502280

AAMP:

119809021(Smg1)

NGI:	103728934(Smg1)

HGL:	101697910(Smg1)

CPOC:

100733275(Smg1)

CCAN:

109684168(Smg1)

DORD:

105982086(Smg1)

DSP:	122101032(Smg1)

PLOP:

125340750(Smg1)

NCAR:

124969845

MMMA:

107146831(Smg1)

OCU:

100354937

OPI:	101536184(SMG1)

TUP:	102485412(SMG1)

GVR:	103593259(SMG1)

CFA:	479832(SMG1)

CLUD:

112640319(SMG1)

VVP:	112923358(SMG1)

VLG:	121487964(SMG1)

NPO:	129519136(SMG1)

AML:	100477904(SMG1)

UMR:	103668640(SMG1)

UAH:	113270747(SMG1)

UAR:	123778612(SMG1)

ELK:

111156104

LLV:

125091183

MPUF:

101673934(SMG1)

MNP:	132026868(SMG1)

MLK:	131819812(SMG1)

NVS:	122896186(SMG1)

ORO:	101375308(SMG1)

EJU:	114199690(SMG1)

ZCA:	113933464(SMG1)

MLX:	118021872(SMG1)

NSU:	110587857(SMG1)

LWW:	102741909(SMG1)

FCA:	101096436(SMG1)

PYU:	121019458(SMG1)

PCOO:

112853107(SMG1)

PBG:	122471617(SMG1)

PVIV:

125154285(SMG1)

LRUF:

124517919

PTG:	102960833(SMG1)

PPAD:

109278389(SMG1)

PUC:

125927923

AJU:

106970547

HHV:	120247849(SMG1)

BTA:	525143(SMG1)

BOM:	102279798(SMG1)

BIU:	109578264(SMG1)

BBUB:

102411117(SMG1)

BBIS:

104983180(SMG1)

CHX:	102174796(SMG1)

OAS:	101111768(SMG1)

BTAX:

128043902(SMG1) 128071281

ODA:	120875255(SMG1)

CCAD:

122433228(SMG1)

MBEZ:

129545410(SMG1)

SSC:	100625964(SMG1)

CFR:	102521533(SMG1)

CBAI:

105073727(SMG1)

CDK:	105091147(SMG1)

VPC:	102531963(SMG1)

BACU:

103007210(SMG1)

BMUS:

118881049(SMG1)

LVE:	103068946(SMG1)

OOR:	101270604(SMG1)

DLE:	111163541(SMG1)

PCAD:

102993856(SMG1)

PSIU:

116739624(SMG1)

NASI:

112399178(SMG1)

ECB:	100050143(SMG1)

EPZ:	103554522(SMG1)

EAI:	106833216(SMG1)

MYB:	102249244(SMG1)

MYD:	102756348(SMG1)

MMYO:

118656386(SMG1)

MLF:	102431928(SMG1)

PKL:	118703809(SMG1)

EFUS:

103286080(SMG1)

MNA:	107524363(SMG1)

DRO:	112314992(SMG1)

SHON:

119002034(SMG1)

AJM:	119055053(SMG1)

PDIC:

114510793(SMG1)

PHAS:

123806355(SMG1)

MMF:	118641422(SMG1)

PPAM:

129083719(SMG1)

HAI:	109395676(SMG1)

RFQ:	117019726(SMG1)

PALE:

102885992(SMG1)

PGIG:

120620441(SMG1)

PVP:

105303741

RAY:	107516811(SMG1)

MJV:	108398932(SMG1)

TOD:	119241887(SMG1)

SARA:

101549879(SMG1)

SETR:

126030984(SMG1)

LAV:	100665068(SMG1)

TMU:

101344613

ETF:	101641623(SMG1)

DNM:	101416653(SMG1)

MDO:	100018609(SMG1)

GAS:	123234520(SMG1)

SHR:	100929642(SMG1)

AFZ:

127537783

PCW:	110193478(SMG1)

OAA:	100078545(SMG1)

GGA:	416605(SMG1)

PCOC:

116237577(SMG1)

MGP:	100544926(SMG1)

CJO:	107320645(SMG1)

TPAI:

128078923(SMG1)

LMUT:

125700574(SMG1)

NMEL:

110405715(SMG1)

APLA:

101804814(SMG1)

ACYG:

106033465(SMG1)

CATA:

118249117(SMG1)

AFUL:

116495078(SMG1)

TGU:	100224160(SMG1)

LSR:	110475555(SMG1)

SCAN:

103817897(SMG1)

PMOA:

120512989(SMG1)

OTC:	121334377(SMG1)

PRUF:

121350669(SMG1)

GFR:	102038662(SMG1)

FAB:	101808169(SMG1)

OMA:	130259141(SMG1)

PHI:	102104941(SMG1)

PMAJ:

107210974(SMG1)

CCAE:

111936263(SMG1)

CCW:	104685068(SMG1)

CBRC:

103615635(SMG1)

ETL:	114058242(SMG1)

ZAB:	102074414(SMG1)

ACHL:

103808191(SMG1)

SVG:	106848730(SMG1)

MMEA:

130584278(SMG1)

HRT:	120759904(SMG1)

FPG:	101922854(SMG1)

FCH:	102060149(SMG1)

CLV:	102085693(SMG1)

EGZ:	104135846(SMG1)

NNI:	104015169(SMG1)

PCRI:

104024375(SMG1)

PLET:

104626130

EHS:	104506906(SMG1)

PCAO:

104053303

ACUN:

113485542(SMG1)

TALA:

104355682(SMG1)

PADL:

103917636(SMG1)

AFOR:

103900906(SMG1)

ACHC:

115335626(SMG1)

HALD:

104310510(SMG1)

HLE:	104833684(SMG1)

AGEN:

126034238

GCL:

127022647

CCRI:

104154893(SMG1)

CSTI:

104563400(SMG1)

CMAC:

104478979(SMG1)

BREG:

104641075(SMG1)

FGA:	104069446(SMG1)

GSTE:

104257237(SMG1)

LDI:	104348335(SMG1)

MNB:	103773070(SMG1)

OHA:	104333691(SMG1)

NNT:	104407176(SMG1)

SHAB:

115606112(SMG1)

DPUB:

104299446(SMG1)

PGUU:

104457832(SMG1)

ACAR:

104517821(SMG1)

CPEA:

104393776(SMG1)

AVIT:

104276297(SMG1)

CVF:	104287874(SMG1)

RTD:	128914318(SMG1)

CUCA:

104063818(SMG1)

TEO:	104382577(SMG1)

BRHI:

104494545(SMG1)

AAM:	106486636(SMG1)

AROW:

112974216(SMG1)

NPD:	112960045(SMG1)

TGT:	104576924(SMG1)

DNE:	112981012(SMG1)

SCAM:

104149759(SMG1)

ASN:	102382911(SMG1)

AMJ:	102561568(SMG1)

CPOO:

109314567(SMG1)

GGN:	109294456(SMG1)

PSS:	102452685(SMG1)

CMY:	102940096(SMG1)

CCAY:

125643379(SMG1)

DCC:	119862267(SMG1)

CPIC:

101943977(SMG1)

TST:	117884542(SMG1)

CABI:

116836519

MRV:	120373022(SMG1)

ACS:	100563306(smg1)

ASAO:

132781829(SMG1)

PVT:	110083991(SMG1)

SUND:

121937510(SMG1)

PBI:	103052061(SMG1)

PMUR:

107297060(SMG1)

CTIG:

120315864(SMG1)

TSR:	106540041(SMG1) 106540042

PGUT:

117670798(SMG1)

APRI:

131185014(SMG1)

PTEX:

113438734(SMG1)

NSS:	113421861(SMG1)

VKO:	123025268(SMG1)

PMUA:

114584767(SMG1)

PRAF:

128402153(SMG1)

ZVI:	118092507(SMG1)

HCG:	128336481(SMG1)

GJA:	107118525(SMG1)

STOW:

125431419(SMG1)

EMC:	129340621(SMG1)

XLA:	108703118(smg1.S) 779188(smg1.L)

XTR:	100145499(smg1)

NPR:	108800538(SMG1)

RTEM:

120943539(SMG1)

BBUF:

121008890(SMG1)

BGAR:

122945179(SMG1)

MUO:	115476449(SMG1)

GSH:	117369027(SMG1)

DRE:	569810(smg1)

SRX:	107729485 107732845

SANH:

107658410 107674133

SGH:	107564004 107583093

CCAR:

109048735 109050269

CAUA:

113046182 113047057

CGIB:

127949367 127952476

PTET:

122332758(smg1)

LROH:

127159243(smg1)

OMC:	131536439(smg1)

PPRM:

120490285(smg1)

RKG:	130097233(smg1)

MAMB:

125276695(smg1)

CIDE:

127508404

MASI:

127450736 127451342

TROS:

130561043(smg1)

TDW:	130426866(smg1)

MANU:

129436104(smg1)

IPU:

108280619

IFU:	128603866(smg1)

PHYP:

113528613(smg1)

SMEO:

124396848(smg1)

TFD:	113663163(smg1)

TVC:	132861131(smg1)

AMEX:

103039818(smg1)

CMAO:

118821831(smg1)

EEE:	113580894(smg1)

CHAR:

105899954(smg1)

TRU:	101066341(smg1)

TFS:	130522448(smg1)

TNG:	GSTEN00026506G001

LCO:	104938332(smg1)

TBEN:

117469356(smg1)

CGOB:

115011915(smg1)

PGEO:

117451313(smg1)

GACU:

117560062(smg1)

EMAC:

134878178(smg1)

ELY:	117269039(smg1)

EFO:	125878797(smg1)

PLEP:

121957055(smg1)

SLUC:

116045023(smg1)

ECRA:

117957623(smg1)

ESP:	116702574(smg1)

PFLV:

114570341(smg1)

GAT:	120827379(smg1)

PPUG:

119219868(smg1)

AFB:	129097863(smg1)

CLUM:

117735644(smg1)

PSWI:

130189074(smg1)

MSAM:

119918350(smg1)

SCHU:

122869297(smg1)

CUD:	121503483(smg1)

ALAT:

119015568(smg1)

MZE:	101471377(smg1)

ONL:	100701416(smg1)

OAU:	116315889(smg1)

OLA:	101156392(smg1)

OML:	112144569(smg1)

CSAI:

133422498(smg1)

XMA:	102231795(smg1)

XCO:	114148599(smg1)

XHE:	116735924(smg1)

PRET:

103468267(smg1)

PFOR:

103149252(smg1)

PLAI:

106952127(smg1)

PMEI:

106917912(smg1)

GAF:	122821325(smg1)

PPRL:

129363317(smg1)

CVG:	107100319(smg1)

CTUL:

119793632(smg1)

GMU:	124862620 124864453

NFU:	107391573(smg1)

KMR:	108249832(smg1)

ALIM:

106529448(smg1)

AOCE:

111578285(smg1)

MCEP:

124997790(smg1)

CSEM:

103393521(smg1)

POV:	109639465(smg1)

SSEN:

122785676(smg1)

HHIP:

117767001(smg1)

HSP:	118123442(smg1)

SMAU:

118288465(smg1)

LCF:

108898468

SDU:	111227933(smg1)

SLAL:

111647790(smg1)

XGL:	120783427(smg1)

HCQ:	109524771(smg1)

SSCV:

125983024

SBIA:

133514230(smg1)

PEE:	133414551(smg1)

PTAO:

133465640(smg1)

BPEC:

110167831(smg1)

MALB:

109964693(smg1)

BSPL:

114861159(smg1)

SJO:	128378438(smg1)

SASA:

106601970(smg1)

STRU:

115181491 115208725

OMY:	110487146 110519445

OKI:	109883746 109883951

SNH:	120040304 120042479

CCLU:

121551686 121570162

ELS:	105030485(smg1)

SFM:	108937355(smg1)

PKI:	111849179(smg1)

AANG:

118220944(smg1)

LOC:	102682392(smg1)

PSPA:

121300491 121330619(smg1)

ARUT:

117418214 117431505

PSEX:

120542707(smg1)

LCM:	102361116(SMG1)

CMK:	103178861(smg1)

RTP:	109916520(smg1)

CPLA:

122560908(smg1)

HOC:	132825311(smg1)

LERI:

129707095(smg1)

PMRN:

116946174(SMG1)

LRJ:	133353603(SMG1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG32743(nonC)

DER:

6551643

DSE:

6612198

DSI:	Dsimw501_GD16819(Dsim_GD16819)

DYA:	Dyak_GE16777

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21612

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ003187 CpipJ_CPIJ003189

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210337 KGM_210338

BANY:

MJU:

NIQ:

VCD:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

CCRC:

AAGE:

HAW:	110375567(nonC)

HZE:

TNL:

SLIU:

OFU:

PXY:	105385860 105385861

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM042140 Phum_PHUM042160

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_228726

DMK:

116925869

DPZ:

124330097

PVM:

113822425

PJA:	122246929 122250177

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

EAF:	111704601 111704604

LSM:

TCF:

DSV:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_C48B6.6(smg-1)

CBR:	CBG_12735(Cbr-smg-1)

CRQ:	GCK72_001850

LOA:	LOAG_16705

HRO:	HELRODRAFT_194220

LGI:	LOTGIDRAFT_229624

PVUL:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111118848 111118849

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_142710

SHX:	MS3_00004091(SMG1_1)

OVI:	T265_06209

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_60833

AQU:

100641883

ALY:

9322057

EUS:	EUTSA_v10022517mg

BRP:

103844331

BNA:	106408590 106445619

BOE:

RSZ:

THJ:

CIT:

CIC:	CICLE_v10027657mg

PVY:

MINC:

TCC:

GRA:

GHI:	107921970 107925423

GAB:

108489099

HSYR:

120134258 120145464 120199927

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_011G050300g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj3g3v3337380.1(Lj3g3v3337380.1) Lj3g3v3337380.2(Lj3g3v3337380.2) Lj3g3v3337380.3(Lj3g3v3337380.3) Lj3g3v3337380.4(Lj3g3v3337380.4)

ADU:

107476732

AIP:

107628950

AHF:	112736823 112788911

LANG:

PCIN:

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:	117911104 117911223

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107800078 107823315

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110698537 110705010

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119283648 119295015

TAES:

123086925 123091050 123096059

TUA:

LPER:

LRD:

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	121999634 122006393

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_114908 SELMODRAFT_88215

PPP:

112287799

MIS:	MICPUN_59761

MBR:	MONBRDRAFT_33611

SRE:	PTSG_06227

DDI:	DDB_G0275845(smg1)

DPP:	DICPUDRAFT_157099

DFA:	DFA_01049(smg1)

NGD:	NGA_2076120

PIF:	PITG_13150

PSOJ:

PHYSODRAFT_516964

SPAR:

SPRG_22295

» show all

Reference

PMID:21911475

Authors

Brown JA, Roberts TL, Richards R, Woods R, Birrell G, Lim YC, Ohno S, Yamashita A, Abraham RT, Gueven N, Lavin MF

Title

A novel role for hSMG-1 in stress granule formation.

Journal

Mol Cell Biol 31:4417-29 (2011)
DOI:10.1128/MCB.05987-11

Sequence

[hsa:23049]

Reference

PMID:11331269

Authors

Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP

Title

Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein.

Journal

J Biol Chem 276:22709-14 (2001)
DOI:10.1074/jbc.C100144200

Sequence

[hsa:23049]

LinkDB

DBGET integrated database retrieval system