KEGG ORTHOLOGY: K10174

ORTHOLOGY: K10174

Entry

K10174                      KO

Symbol

TBR1

Name

T-box brain protein 1

Disease

H02371

Intellectual developmental disorder with autism and speech delay

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K10174  TBR1; T-box brain protein 1
Transcription factors [BR:ko03000]
Eukaryotic type
  Other transcription factors
   T-box
    K10174  TBR1; T-box brain protein 1

Genes

HSA:	10716(TBR1)

PTR:	739449(TBR1)

PPS:	100995193(TBR1)

GGO:	101138413(TBR1)

PON:	100436343(TBR1)

PPYG:

129032005(TBR1)

NLE:	100596646(TBR1)

HMH:	116810747(TBR1)

SSYN:

129489428(TBR1)

MCC:	701176(TBR1)

MCF:	102129716(TBR1)

MTHB:

126932943

MNI:	105483352(TBR1)

CSAB:

103217174(TBR1)

CATY:

105576042(TBR1)

PANU:

101021420(TBR1)

TGE:	112636046(TBR1)

MLEU:

105548125(TBR1)

RRO:	104666028(TBR1)

RBB:	108517713(TBR1)

TFN:	117094950(TBR1)

PTEH:

111546074(TBR1)

CANG:

105515317(TBR1)

CJC:	100394386(TBR1)

SBQ:	101043489(TBR1)

CIMI:

108317432(TBR1)

ANAN:

105708868(TBR1)

CSYR:

103251334(TBR1)

MMUR:

105855039(TBR1)

LCAT:

123643961(TBR1)

PCOQ:

105819567(TBR1)

OGA:	100956831(TBR1)

MMU:	21375(Tbr1)

MCAL:

110289611(Tbr1)

MPAH:

110318518(Tbr1)

RNO:	680427(Tbr1)

MCOC:

116090222(Tbr1)

ANU:	117703786(Tbr1)

ASYL:

127684178(Tbr1)

MUN:	110539382(Tbr1)

CGE:	100764093(Tbr1)

MAUA:

101832878(Tbr1)

PROB:

127222482(Tbr1)

PLEU:

114691521(Tbr1)

MORG:

121433303(Tbr1)

MFOT:

126489542

AAMP:

119819658(Tbr1)

NGI:	103744088(Tbr1)

HGL:	101696910(Tbr1)

CPOC:

100717884(Tbr1)

CCAN:

109692592(Tbr1)

DORD:

105994913(Tbr1)

DSP:	122110796(Tbr1)

DMER:

138826803(Tbr1)

PLOP:

125350002(Tbr1)

NCAR:

124981230

MMMA:

107136636(Tbr1)

ITI:	101957756(Tbr1)

OCU:

100340143

OPI:	101524284(TBR1)

TUP:	102490118(TBR1)

GVR:	103590838(TBR1)

CFA:	488370(TBR1)

CLUD:

112674683(TBR1)

VVP:	112916467(TBR1)

VLG:	121471894(TBR1)

NPO:	129498720(TBR1)

AML:	100484289(TBR1)

UMR:	103659866(TBR1)

UAH:	113249138(TBR1)

UAR:	123782963(TBR1)

ELK:

111145325

LLV:

125096455

MPUF:

101670867(TBR1)

MNP:	132012973(TBR1)

MLK:	131827171(TBR1)

NVS:	122901821(TBR1)

ORO:	101379452(TBR1)

EJU:	114216539(TBR1)

ZCA:	113919988(TBR1)

MLX:	118011817(TBR1)

NSU:	110592246(TBR1)

LWW:	102742496(TBR1)

FCA:	101096826(TBR1)

PYU:	121030610(TBR1)

PCOO:

112866061(TBR1)

PBG:	122481380(TBR1)

PVIV:

125173602(TBR1)

LRUF:

124514118

LGF:	123598982(TBR1)

AJU:

106984847

PTG:	102950443(TBR1)

PPAD:

109271917(TBR1)

PUC:

125911591

PLEZ:

122227825(TBR1)

HHV:	120246117(TBR1)

BTA:	505142(TBR1)

BOM:	102288194(TBR1)

BIU:	109576487(TBR1)

BBUB:

102396246(TBR1)

BBIS:

105002425(TBR1)

CHX:	102191744(TBR1)

OAS:	101110826(TBR1)

BTAX:

128043575(TBR1)

CSUM:

138076888(TBR1)

ODA:	120854849(TBR1)

CCAD:

122453774(TBR1)

MREE:

136163449(TBR1)

OVR:	110132839(TBR1)

MBEZ:

129538223(TBR1)

SSC:	100154282(TBR1)

CFR:	102520647(TBR1)

CBAI:

105081947(TBR1)

CDK:	105093691(TBR1)

VPC:	102535439(TBR1)

BACU:

103005933(TBR1)

BMUS:

118898440(TBR1)

LVE:	103069377(TBR1)

OOR:	101274810(TBR1)

LALB:

132521811(TBR1)

GMF:	115848959(TBR1)

DDP:	132428155(TBR1)

DLE:	111172794(TBR1)

PCAD:

102976975(TBR1)

PSIU:

116756876(TBR1)

PPHC:

136125774(TBR1)

NASI:

112393624(TBR1)

ECB:	100061032(TBR1)

EPZ:	103558683(TBR1)

EAI:	106843155(TBR1)

MYB:	102240582(TBR1)

MYD:	102759205(TBR1)

MMYO:

118662234(TBR1)

MLF:	102423030(TBR1)

MDT:	132238596(TBR1)

MYUM:

139015669(TBR1)

PKL:	118709077(TBR1)

EFUS:

103283374(TBR1)

MNA:	107545761(TBR1)

DRO:	112322219(TBR1)

SHON:

118985957(TBR1)

AJM:	119045638(TBR1)

PDIC:

114495615(TBR1)

PHAS:

123812173(TBR1)

MMF:	118625604(TBR1)

PPAM:

129061653(TBR1)

HAI:	109379837(TBR1)

RFQ:	117025525(TBR1)

PALE:

102888280(TBR1)

PGIG:

120596969(TBR1)

PVP:	105291047(TBR1)

RAY:	107508547(TBR1)

MJV:	108399179(TBR1)

TOD:	119254766(TBR1)

SARA:

101557154(TBR1)

SFUM:

130019649(TBR1)

SETR:

126009025(TBR1)

LAV:	100676479(TBR1)

TMU:

101361428

ETF:	101650651(TBR1)

DNM:	101428766(TBR1)

MDO:	100015711(TBR1)

GAS:	123239287(TBR1)

SHR:	100934167(TBR1)

AFZ:

127554617

PCW:	110220714(TBR1)

TVP:	118835369(TBR1)

PBRV:

138154973(TBR1)

MLAO:

141523466(TBR1)

OAA:	100082087(TBR1)

TACU:

119932601(TBR1)

GGA:	429029(TBR1)

PCOC:

116232921(TBR1)

MGP:

104911767

CJO:	107317038(TBR1)

TPAI:

128076940(TBR1)

LMUT:

125697073(TBR1)

NMEL:

110400044(TBR1)

APLA:

101802264(TBR1)

ACYG:

106029822(TBR1)

CATA:

118243052(TBR1)

AFUL:

116490942(TBR1)

TGU:	100217910(TBR1)

LSR:	110468372(TBR1)

SCAN:

103814386(TBR1)

PMOA:

120498978(TBR1)

OTC:	121335430(TBR1)

PRUF:

121356608(TBR1)

ATRC:

139593740(TBR1)

GFR:	102040018(TBR1)

FAB:	101812710(TBR1)

OMA:	130255803(TBR1)

PHI:	102106919(TBR1)

PMAJ:

107207441(TBR1)

CCAE:

111945207(TBR1)

CCW:	104694180(TBR1)

CBRC:

103625589(TBR1)

ACOE:

138113375(TBR1)

ETL:	114065790(TBR1)

ZAB:	102064573(TBR1)

ZLE:	135450422(TBR1)

SVG:	106855898(TBR1)

MMEA:

130574359(TBR1)

HRT:	120755112(TBR1)

SATI:

136363556(TBR1)

CCIC:

134047316(TBR1)

FPG:	101915673(TBR1)

FCH:	102050758(TBR1)

SHAB:

115609115(TBR1)

TALA:

116959040(TBR1)

ACHC:

115342836(TBR1)

HLE:	104831824(TBR1)

AGEN:

126040472

HHAR:

128144568(TBR1)

GCL:

127018181

DPUB:

104309781(TBR1)

PPUS:

135186493(TBR1)

EGZ:	104127991(TBR1)

PADL:

103918182(TBR1)

CBOY:

140657576(TBR1)

CLV:	102088853(TBR1)

CNIC:

135990449(TBR1)

CUCA:

104054521(TBR1)

CPEA:

104387353(TBR1)

RTD:	128912895(TBR1)

CRID:

134518880(TBR1)

AAM:	106499098(TBR1)

AROW:

112972037(TBR1)

NPD:	112944873(TBR1)

TGT:	104572106(TBR1)

DNE:	112997483(TBR1)

ASN:	102380625(TBR1)

AMJ:	102573679(TBR1)

CPOO:

109323244(TBR1)

GGN:	109301505(TBR1)

PSS:	102462568(TBR1)

CMY:	102944502(TBR1)

CCAY:

125626883(TBX21) 125644771(TBR1)

DCC:	119849050(TBX21) 119863849(TBR1)

CPIC:

101953379(TBR1)

TST:	117884904(TBR1)

CABI:

116831419(TBX21) 116838411(TBR1)

MRV:	120374512(TBR1) 120392008(TBX21)

ACS:	100554704(tbr1)

ASAO:

132776316(TBR1) 132778196(TBX21)

PVT:	110081578(TBR1)

SUND:

121919217 121925903 121933527(TBX21)

PBI:	103052411(TBR1)

PMUR:

107290151(TBR1)

CTIG:

120303079(TBR1) 120303559(TBX21)

TSR:

106540672

PGUT:

117664576(TBX21) 117670779(TBR1)

PCAE:

139327218(TBR1)

APRI:

131189146(TBR1) 131198778(TBX21)

PTEX:

113433913(TBR1) 113442951(TBX21)

NSS:	113413497(TBX21) 113416475(TBR1) 113416530

VKO:	123017163(TBR1) 123030667(TBX21)

PMUA:

114605583(TBR1)

PRAF:

128400053(TBX21) 128423215(TBR1)

ZVI:	118092528(TBR1)

HCG:	128329702(TBR1) 128330209(TBX21)

GJA:	107126125(TBR1)

STOW:

125427399(TBR1) 125444902(TBX21)

EMC:	129324860(TBR1) 129340336(TBX21)

XLA:	108701844(tbr1.L) 108702968(tbr1.S)

XTR:	780042(tbr1)

NPR:	108787202(TBR1)

RTEM:

120944073(TBR1)

ACAT:

141147051(TBR1)

BBUF:

121008109(TBR1)

BGAR:

122945681(TBR1)

DTC:	141049355(TBR1)

PWL:	138284923(TBR1) 138299324(TBX21)

MUO:	115474623(TBR1) 115481922(TBX21)

GSH:	117347081(TBX21) 117361133(TBR1)

DRE:	564699(tbr1a) 58042(tbr1b) 797797(tbx21)

SRX:	107722921 107730596 107743770 107753796

SANH:

107655964 107674767 107675014(tbx21) 107676286 107677868

SGH:	107561569 107563776 107563833 107565723 107593157

CCAR:

109053479 109057831 109073819(tbx21) 109095803(tbr1b) 109096475 109099253

CAUA:

113052926 113055024 113074333 113108243 113110958 113111488(tbx21)

CGIB:

127965283 127968537 127969015 128020276 128025339

PTET:

122351841(tbr1b) 122353995(tbr1a) 122355628(tbx21)

LROH:

127171216(tbr1b) 127172911(tbr1a) 127174114(tbx21)

GRF:	141340794(tbr1b)

OMC:	131546756(tbr1b) 131549019(tbr1a) 131551034(tbx21)

PPRM:

120468915(tbr1a) 120474556(tbx21) 120487037(tbr1b)

RKG:	130077462(tbr1b) 130086674(tbr1a) 130088767(tbx21)

MAMB:

125255143(tbx21) 125256429(tbr1a) 125270768(tbr1b)

CIDE:

127518870 127522301 127524064

CERY:

137007655(tbx21) 137021261(tbr1a) 137036474(tbr1b)

MASI:

127422934 127425832 127427246 127448246

TROS:

130555335(tbr1b) 130569252(tbx21) 130570886(tbr1a)

TDW:	130409952(tbr1a) 130427161(tbr1b) 130438651(tbx21)

MANU:

129421298(tbx21) 129427425(tbr1a) 129452430(tbr1b)

PDAB:

135719054(tbr1a) 135733596(tbr1b) 135744413(tbx21)

IPU:	108266223(tbr1b) 108270775(tbr1a) 108273685

IFU:	128608939(tbr1b) 128613829(tbr1a) 128616774(tbx21)

PHYP:

113523930(tbr1) 113527067 113527758(tbx21)

SMEO:

124380369(tbr1b) 124388906(tbx21) 124390772(tbr1a)

TFD:	113638983(tbx21) 113654212(tbr1b) 113658957

TVC:	132838381(tbx21) 132850001 132850268(tbr1b)

CGAR:

128523838(tbr1b) 128541512(tbx21) 128543103(tbr1a)

NGRA:

132891947(tbr1b) 132898357(tbx21) 132899041(tbr1a)

TRN:	134321914(tbx21) 134324516(tbr1b) 134331895(tbr1a)

AMEX:

103026223(tbr1b) 103045195(tbx21)

CMAO:

118809446(tbx21) 118810245(tbr1b)

EEE:	113577534(tbr1) 113582534 113583980(tbx21)

CHAR:

105888902(tbx21) 105907946(tbr1b) 105911662(tbr1a)

SPIL:

134070728(tbx21) 134071037(tbr1a) 134078232(tbr1b)

TRU:	101061765(tbx21) 101071189(tbr1)

TFS:	130536302(tbx21)

TNG:	GSTEN00030575G001

LCO:	104920063(tbr1) 104925153(tbx21)

NCC:	104945478(tbx21) 104955247(tbr1)

TBEN:

117473671(tbx21) 117485770(tbr1b)

CGOB:

115024545(tbx21) 115026311(tbr1)

PGEO:

117464502(tbx21) 117466851(tbr1b)

GACU:

117547078(tbx21) 117556793(tbr1b)

EMAC:

134867339(tbr1b) 134870382(tbx21)

ELY:	117247729(tbx21) 117250995(tbr1b)

EFO:	125880759(tbx21) 125899585(tbr1b)

PLEP:

121958707(tbx21)

SLUC:

116049134(tbr1b) 116061287(tbx21)

ECRA:

117936518(tbx21) 117953469(tbr1b)

ESP:	116671637(tbx21) 116698337(tbr1)

PFLV:

114548010(tbx21) 114564512(tbr1)

GAT:	120819518(tbx21)

PPUG:

119228612(tbr1b)

AFB:	129091546(tbx21)

CLUM:

117748734(tbx21) 117750458(tbr1b)

PSWI:

130203706(tbx21) 130205765(tbr1b)

CANA:

137782672(tbr1b) 137790016(tbx21)

CVE:	137867398(tbr1b) 137891961(tbx21)

MSAM:

119915394(tbx21)

SCHU:

122867701(tbx21) 122885867(tbr1b)

CUD:	121522522(tbr1b) 121528450(tbx21)

SPUL:

138592171(tbr1b) 138593889(tbx21)

LMIX:

132955540(tbx21) 132987352(tbr1b)

ALAT:

119009579(tbx21) 119025265(tbr1b)

ASTR:

137588679(tbx21) 137604776(tbr1b)

MZE:	101473077(tbx21) 101484261(tbr1)

ONL:	100705768(tbx21) 100706824(tbr1)

OAU:	116335656(tbx21)

OLA:	101154909(tbr1) 101175440(tbx21)

OML:	112153905(tbx21) 112155611(tbr1b)

CSAI:

133419688(tbx21) 133445974(tbr1b)

XMA:	102226020(tbx21) 102232625(tbr1)

XCO:	114147500(tbr1) 114152381(tbx21)

XHE:	116722513(tbr1) 116727736(tbx21)

PRET:

103461695(tbr1) 103481714(tbx21)

PFOR:

103134372(tbr1) 103152023(tbx21)

PLAI:

106945416(tbx21) 106958459(tbr1)

PMEI:

106909747(tbr1) 106915954(tbx21)

GAF:	122823253(tbx21)

PPRL:

129368257(tbx21)

CVG:	107082031(tbr1) 107093795(tbx21)

CTUL:

119782454(tbx21)

GMU:	124875770(tbx21)

NFU:	107387442(tbx21) 107390073(tbr1)

KMR:	108240727(tbr1b) 108248041(tbx21)

ALIM:

106511624 106521956(tbx21) 106523297(tbr1)

NWH:	119419588(tbr1b) 119423833(tbx21)

AOCE:

111575752(tbr1b) 111588325(tbx21)

EJA:	138204691(tbx21)

BFRE:

138624396(tbx21)

MCEP:

125018155(tbr1b) 125022631(tbx21)

CSEM:

103381907(tbx21) 103392153(tbr1)

POV:	109631198(tbr1) 109644679

SSEN:

122759044(tbx21) 122759341(tbr1b)

SSOE:

131448742(tbr1b) 131448756(tbx21)

HHIP:

117753280(tbx21) 117755236(tbr1b)

HSP:	118100979(tbx21) 118120145(tbr1b)

PPLT:

128427165(tbx21) 128456329(tbr1b)

SMAU:

118287301(tbx21)

LCF:

108892042

SDU:	111218522(tbr1) 111219787(tbx21)

SLAL:

111654515(tbr1) 111655417(tbx21)

XGL:	120793933(tbx21)

HCQ:	109514786(tbr1)

SSCV:

125991494(tbx21)

SBIA:

133495368(tbx21)

PEE:	133417980(tbx21)

PTAO:

133469237(tbx21)

BPEC:

110154247(tbx21) 110163952(tbr1)

ENY:	140369253 140372529

MALB:

109957070(tbr1) 109962800(tbx21)

BSPL:

114845755(tbx21) 114847759(tbr1b)

SJO:	128368432(tbr1b) 128381435(tbx21)

SSCO:

134003376(tbx21)

GMH:

115531153

SASA:

100526824(tbx21) 106574400 106575293 106581806(tbr1) 106586185 106589292

STRU:

115156067 115158512 115160713 115179626 115196095 115201045

OTW:	112223583 112224152 112225190 112236043 112255409 112266459

OMY:	100500940(tbx21) 110499122 110501502 110520066 110527428

OGO:	124008773 124039877 124042625 124043834 124048261

ONE:	115106469 115115320 115129747 115143683 115145087

OKI:	109865406 109870241 109870681 109890102 109902481

OKE:	118357650 118367044(tbx21) 118367112 118372277 118385998

OMM:	135505027 135519616 135542609 135547181

OCLA:

139368062 139373173 139376411 139380286 139397600 139412995

SALP:

111959361 111967669 111970872 111970876 111974656 111978761

SNH:	120030000 120045462 120057856 120064410

CCLU:

121535957 121536824 121546885 121547957 121552025

ELS:	105007324(tbx21) 105020010 105022444(tbr1)

OEP:	134007725(tbr1a) 134017881(tbr1b) 134031949(tbx21)

SFM:	108918674(tbx21) 108927923(tbr1)

PKI:	111834597(tbr1)

AANG:

118220130(tbx21) 118223600

AROT:

135247659(tbx21) 135250755

CCOG:

133121910(tbx21) 133124599

LOC:	102689215(tbx21) 102696783(tbr1)

PSPA:

121301907 121322268 121323281 121323917

ARUT:

117413035 117426573 117433336 117434601

PSEX:

120517347(tbx21) 120531775

LCM:	102355892(TBR1)

RTP:	109927516(tbx21) 109932611(tbr1b)

CPLA:

122539811(tbx21) 122551631

HOC:	132817079 132830700(tbx21)

LERI:

129698826(tbr1a) 129710170(tbx21)

HAKA:

140728534(tbr1b) 140741324(tbx21)

PMRN:

116940952(TBR1) 116943951 116946159

LRJ:	133344843(TBR1) 133345037 133356834

BFO:

BBEL:

SPU:

AAMU:

AFIL:

PFLL:

CBR:

PVUL:

GAE:

HRF:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

MMER:

RPHI:

MAEA:

LJP:

LAK:	106150390 106161613

LLON:

135503057

» show all

Reference

PMID:7619531

Authors

Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L, Rubenstein JL

Title

T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex.

Journal

Neuron 15:63-78 (1995)
DOI:10.1016/0896-6273(95)90065-9

Sequence

[hsa:10716]

Reference

PMID:30250039

Authors

den Hoed J, Sollis E, Venselaar H, Estruch SB, Deriziotis P, Fisher SE

Title

Functional characterization of TBR1 variants in neurodevelopmental disorder.

Journal

Sci Rep 8:14279 (2018)
DOI:10.1038/s41598-018-32053-6

Sequence

[hsa:10716]

LinkDB

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