KEGG   ORTHOLOGY: K10807Help
Entry
K10807                      KO                                     

Name
RRM1
Definition
ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
Pathway
ko00230  Purine metabolism
ko00240  Pyrimidine metabolism
ko00480  Glutathione metabolism
ko00983  Drug metabolism - other enzymes
ko01100  Metabolic pathways
Module
M00053  Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K10807  RRM1; ribonucleoside-diphosphate reductase subunit M1
   00240 Pyrimidine metabolism
    K10807  RRM1; ribonucleoside-diphosphate reductase subunit M1
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K10807  RRM1; ribonucleoside-diphosphate reductase subunit M1
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    K10807  RRM1; ribonucleoside-diphosphate reductase subunit M1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K10807  RRM1; ribonucleoside-diphosphate reductase subunit M1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.1  ribonucleoside-diphosphate reductase
     K10807  RRM1; ribonucleoside-diphosphate reductase subunit M1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Other factors with a suspected DNA repair function
   Modulation of nucleotide pools
    K10807  RRM1; ribonucleoside-diphosphate reductase subunit M1
BRITE hierarchy
Other DBs
RN: R02017 R02019 R02024 R08363 R08364 R11893
GO: 0004748
Genes
HSA: 6240(RRM1)
PTR: 450974(RRM1)
PPS: 100991648(RRM1)
GGO: 101129602(RRM1)
PON: 100172956(RRM1)
NLE: 100599741(RRM1)
MCC: 717990(RRM1)
MCF: 102131278(RRM1)
CSAB: 103247970(RRM1)
RRO: 104665174(RRM1)
RBB: 108543724(RRM1)
CJC: 100385488(RRM1)
SBQ: 101047207(RRM1)
MMU: 20133(Rrm1)
MCAL: 110297993(Rrm1)
MPAH: 110332415(Rrm1)
RNO: 685579(Rrm1)
MUN: 110541570(Rrm1)
CGE: 100761591(Rrm1)
NGI: 103750826(Rrm1)
HGL: 101708047(Rrm1)
CCAN: 109681933(Rrm1) 109681934
OCU: 100345823(RRM1)
TUP: 102488019(RRM1)
CFA: 476823(RRM1)
VVP: 112928709(RRM1)
AML: 100472317
UMR: 103678102(RRM1)
UAH: 113269248(RRM1)
ORO: 101383805(RRM1)
FCA: 101097343(RRM1)
PTG: 102953329(RRM1)
PPAD: 109267118(RRM1)
AJU: 106966008(RRM1)
BTA: 505537(RRM1)
BOM: 102272609(RRM1)
BIU: 109569745(RRM1)
BBUB: 102401333(RRM1)
CHX: 102189416(RRM1)
OAS: 101116171(RRM1)
SSC: 102166900(RRM1)
CFR: 102514637(RRM1)
CDK: 105096519(RRM1)
BACU: 103014342(RRM1)
LVE: 103086289(RRM1)
OOR: 101285550(RRM1)
DLE: 111170548(RRM1)
ECB: 100053126(RRM1)
EPZ: 103558527(RRM1)
EAI: 106831641(RRM1)
MYB: 102262075(RRM1)
MYD: 102756677(RRM1)
MNA: 107544172(RRM1)
HAI: 109372434(RRM1)
DRO: 112316008(RRM1)
PALE: 102879969(RRM1)
RAY: 107517357(RRM1)
MJV: 108388557(RRM1)
LAV: 100677500(RRM1)
TMU: 101347185
MDO: 100013713(RRM1)
SHR: 100913408(RRM1)
PCW: 110195189(RRM1)
OAA: 100073391(RRM1)
GGA: 419081(RRM1)
MGP: 100545411(RRM1)
CJO: 107308587(RRM1)
NMEL: 110392111(RRM1)
APLA: 101796445(RRM1)
ACYG: 106048561(RRM1)
TGU: 100218893(RRM1)
LSR: 110474947(RRM1)
SCAN: 103823822(RRM1)
GFR: 102044314(RRM1)
FAB: 101812731(RRM1)
PHI: 102102024(RRM1)
PMAJ: 107207454(RRM1)
CCAE: 111943781(RRM1) 111946182
CCW: 104698094(RRM1) 104698099
ETL: 114070910(RRM1) 114073146
FPG: 101915772(RRM1)
FCH: 102046747(RRM1)
CLV: 102092480(RRM1)
EGZ: 104122179(RRM1)
NNI: 104014845(RRM1)
ACUN: 113476025(RRM1)
PADL: 103925511(RRM1)
AAM: 106489774(RRM1)
ASN: 102385541(RRM1)
AMJ: 102570766(RRM1)
PSS: 102462750(RRM1)
CMY: 102936455(RRM1)
CPIC: 101944456(RRM1)
ACS: 100562780(rrm1)
PVT: 110078155(RRM1)
PBI: 103055237(RRM1)
PMUR: 107298422(RRM1)
TSR: 106556770(RRM1)
PMUA: 114595152(RRM1)
XLA: 108710085 399431(rrm1.L)
XTR: 100145720(rrm1)
NPR: 108803090(RRM1)
DRE: 30740(rrm1)
IPU: 108279224(rrm1)
PHYP: 113541760(rrm1)
AMEX: 103038586(rrm1)
EEE: 113573958(rrm1)
PRET: 103474651(rrm1) 103475859
MALB: 109974364(rrm1)
SASA: 100195484(rir1) 106567863
ELS: 105023907(rrm1)
SFM: 108921253(rrm1)
PKI: 111852165(rrm1)
LCM: 102359247(RRM1)
CMK: 103191328(rrm1)
RTP: 109936713(rrm1)
CIN: 100183856
SPU: 581431
APLC: 110976922
DME: Dmel_CG5371(RnrL)
DER: 6541743
DSI: Dsimw501_GD22272(Dsim_GD22272)
DSR: 110183356
DPE: 6588723
DMN: 108163451
DWI: 6652768
DAZ: 108609704
DNV: 108649554
DHE: 111597781
MDE: 101890541
LCQ: 111680954
AAG: 110680439
AME: 725673
BIM: 100747811
BTER: 100648861
CCAL: 108622027
CSOL: 105360570
DPA: 109535521
BMOR: 101741714
PMAC: 106714132
PRAP: 110998446
HAW: 110371668
TNL: 113497121
PXY: 105393854
BTAB: 109036078
CLEC: 106672623
ZNE: 110841396
FCD: 110851853
PVM: 113824641
TUT: 107363626
CEL: CELE_T23G5.1(rnr-1)
CBR: CBG10154(Cbr-rnr-1)
BMY: Bm1_17945
PCAN: 112560420
CRG: 105348744
MYI: 110452449
OBI: 106875815
SHX: MS3_11185
EGL: EGR_01293
EPA: 110232445
ADF: 107346621
AMIL: 114955645
PDAM: 113682522
DGT: 114527415
HMG: 100202999(rrm1)
AQU: 100638722
ATH: AT2G21790(RNR1)
CPAP: 110812918
TCC: 18611720
DZI: 111292457
EGR: 104415850
LJA: Lj1g3v1222710.1(Lj1g3v1222710.1) Lj4g3v2775590.1(Lj4g3v2775590.1)
ADU: 107480342
AIP: 107630954
FVE: 101311513
PXB: 103961828
ZJU: 107408486
CSV: 101210105
CMO: 103485237
RCU: 8283227
MESC: 110628467
VVI: 100261117
SIND: 105171121
CCAV: 112515319
BVG: 104895476
CQI: 110682052
OSA: 4340258
DOSA: Os02t0804900-01(Os02g0804900) Os06t0168600-01(Os06g0168600)
ATS: 109742339(LOC109742339) 109759604(LOC109759604)
PDA: 103723590
MUS: 103971825
DCT: 110107491
PEQ: 110027962
ATR: 18436844
CRE: CHLREDRAFT_185583(RIR1)
SCE: YER070W(RNR1) YIL066C(RNR3)
KMX: KLMA_50048(RNR1) KLMA_70170(RNR1)
NCS: NCAS_0A13590(NCAS0A13590) NCAS_0E03350(NCAS0E03350)
NDI: NDAI_0A02440(NDAI0A02440) NDAI_0E04890(NDAI0E04890)
TPF: TPHA_0J00970(TPHA0J00970) TPHA_0K00840(TPHA0K00840)
TBL: TBLA_0C04740(TBLA0C04740) TBLA_0J01350(TBLA0J01350)
TDL: TDEL_0A05600(TDEL0A05600) TDEL_0H01880(TDEL0H01880)
KAF: KAFR_0B01350(KAFR0B01350) KAFR_0B01360(KAFR0B01360) KAFR_0L01000(KAFR0L01000)
PIC: PICST_29856(RNR1.1) PICST_75662(RNR1.2)
SLB: AWJ20_1616(RNR1) AWJ20_3212(RNR1)
NCR: NCU03539(un-24)
NTE: NEUTE1DRAFT123455(NEUTE1DRAFT_123455)
SMP: SMAC_07771(putative un24)
MGR: MGG_07000
SSCK: SPSK_03956
MAW: MAC_05602
MAJ: MAA_08816
CMT: CCM_01863
MBE: MBM_05003
ANI: AN4380.2
ANG: ANI_1_252184(An04g01080)
ABE: ARB_02698
TVE: TRV_05425
PTE: PTT_14367
SPO: SPAC1F7.05(cdc22)
CNE: CNE03330
CNB: CNBE3330
LBC: LACBIDRAFT_176996(LbRNRalpha1) LACBIDRAFT_318621(LbRNRalpha2)
ABP: AGABI1DRAFT58613(AGABI1DRAFT_58613)
ABV: AGABI2DRAFT223838(AGABI2DRAFT_223838)
MGL: MGL_1749
MRT: MRET_4377
DDI: DDB_G0284071(rnrA)
DFA: DFA_05803(rnrA)
PYO: PY17X_0614100(PY03473)
PCB: PCHAS_061330(PC301951.00.0)
TAN: TA05060
TPV: TP03_0528
BBO: BBOV_I004870(19.m02176)
CPV: cgd6_1950
SMIN: v1.2.000159.t1(symbB.v1.2.000159.t1) v1.2.013017.t1(symbB.v1.2.013017.t1) v1.2.013018.t1(symbB.v1.2.013018.t1) v1.2.017980.t1(symbB.v1.2.017980.t1) v1.2.037033.t1(symbB.v1.2.037033.t1)
TPS: THAPSDRAFT_268807(RIR1_2) THAPSDRAFT_370(RIR1_1)
SPAR: SPRG_04116
VG: 1485960(CPXV083_CDS) 922130(SlnVgp023) 932637(CamMLVgp071)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
  Authors
Qiu W, Zhou B, Darwish D, Shao J, Yen Y
  Title
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits.
  Journal
Biochem Biophys Res Commun 340:428-34 (2006)
DOI:10.1016/j.bbrc.2005.12.019
  Sequence
[hsa:6240]
Reference
  Authors
Domkin V, Thelander L, Chabes A
  Title
Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex.
  Journal
J Biol Chem 277:18574-8 (2002)
DOI:10.1074/jbc.M201553200
Reference
  Authors
Valsecchi ME, Holdbrook T, Leiby BE, Pequignot E, Littman SJ, Yeo CJ, Brody JR, Witkiewicz AK
  Title
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?
  Journal
BMC Cancer 12:104 (2012)
DOI:10.1186/1471-2407-12-104
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