Entry
Symbol
RRM2
Name
ribonucleoside-diphosphate reductase subunit M2 [EC:
1.17.4.1 ]
Pathway
map00983 Drug metabolism - other enzymes
Module
M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP
M00938 Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Reaction
R02017 2'-deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
R02018 2'-deoxyuridine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
R02019 2'-deoxyguanosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
R02024 2'-deoxycytidine diphosphate:oxidized-thioredoxin 2'-oxidoreductase
R08363 2'-deoxyribonucleoside-diphosphate:tryparedoxin-disulfide 2'-oxidoreductase
R08364 2'-deoxyribonucleoside-diphosphate:trypanothione-disulfide 2'-oxidoreductase
R11893 5-fluorodeoxyuridine-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
Disease
H00469 Mitochondrial DNA depletion syndrome
H01118 Progressive external ophthalmoplegia
H01390 Mitochondrial neurogastrointestinal encephalomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
00240 Pyrimidine metabolism
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
09106 Metabolism of other amino acids
00480 Glutathione metabolism
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
09111 Xenobiotics biodegradation and metabolism
00983 Drug metabolism - other enzymes
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
09140 Cellular Processes
09143 Cell growth and death
04115 p53 signaling pathway
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.17 Acting on CH or CH2 groups
1.17.4 With a disulfide as acceptor
1.17.4.1 ribonucleoside-diphosphate reductase
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
DNA repair and recombination proteins [BR:ko03400 ]
Eukaryotic type
Other factors with a suspected DNA repair function
Modulation of nucleotide pools
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
BRITE hierarchy
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Genes
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Taxonomy Virus taxonomy UniProt
Reference
Authors
Qiu W, Zhou B, Darwish D, Shao J, Yen Y
Title
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits.
Journal
Sequence
Reference
Authors
Guittet O, Hakansson P, Voevodskaya N, Fridd S, Graslund A, Arakawa H, Nakamura Y, Thelander L
Title
Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.
Journal
Reference
Authors
Elledge SJ, Davis RW
Title
Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability.
Journal
Sequence
Reference
Authors
Nguyen HH, Ge J, Perlstein DL, Stubbe J
Title
Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly.
Journal
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