Entry |
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Name |
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Definition |
ribonucleoside-diphosphate reductase subunit M2 [EC: 1.17.4.1]
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Pathway |
ko00983 | Drug metabolism - other enzymes |
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Module |
M00053 | Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP |
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Disease |
H00469 | Mitochondrial DNA depletion syndrome |
H01118 | Progressive external ophthalmoplegia |
H01390 | Mitochondrial neurogastrointestinal encephalomyopathy |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
00240 Pyrimidine metabolism
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
09106 Metabolism of other amino acids
00480 Glutathione metabolism
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
09111 Xenobiotics biodegradation and metabolism
00983 Drug metabolism - other enzymes
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
09140 Cellular Processes
09143 Cell growth and death
04115 p53 signaling pathway
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
Enzymes [BR:ko01000]
1. Oxidoreductases
1.17 Acting on CH or CH2 groups
1.17.4 With a disulfide as acceptor
1.17.4.1 ribonucleoside-diphosphate reductase
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
Other factors with a suspected DNA repair function
Modulation of nucleotide pools
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Qiu W, Zhou B, Darwish D, Shao J, Yen Y |
Title |
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits. |
Journal |
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Sequence |
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Reference |
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Authors |
Guittet O, Hakansson P, Voevodskaya N, Fridd S, Graslund A, Arakawa H, Nakamura Y, Thelander L |
Title |
Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. |
Journal |
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Reference |
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Authors |
Nguyen HH, Ge J, Perlstein DL, Stubbe J |
Title |
Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly. |
Journal |
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LinkDB |
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