KEGG   ORTHOLOGY: K11217Help
Entry
K11217                      KO                                     

Name
JAK1
Definition
Janus kinase 1 [EC:2.7.10.2]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04151  PI3K-Akt signaling pathway
ko04217  Necroptosis
ko04380  Osteoclast differentiation
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04621  NOD-like receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko05140  Leishmaniasis
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05212  Pancreatic cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K11217  JAK1; Janus kinase 1
   04151 PI3K-Akt signaling pathway
    K11217  JAK1; Janus kinase 1
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11217  JAK1; Janus kinase 1
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11217  JAK1; Janus kinase 1
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K11217  JAK1; Janus kinase 1
   04658 Th1 and Th2 cell differentiation
    K11217  JAK1; Janus kinase 1
   04659 Th17 cell differentiation
    K11217  JAK1; Janus kinase 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K11217  JAK1; Janus kinase 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11217  JAK1; Janus kinase 1
   05203 Viral carcinogenesis
    K11217  JAK1; Janus kinase 1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K11217  JAK1; Janus kinase 1
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K11217  JAK1; Janus kinase 1
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K11217  JAK1; Janus kinase 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K11217  JAK1; Janus kinase 1
   05162 Measles
    K11217  JAK1; Janus kinase 1
   05164 Influenza A
    K11217  JAK1; Janus kinase 1
   05161 Hepatitis B
    K11217  JAK1; Janus kinase 1
   05160 Hepatitis C
    K11217  JAK1; Janus kinase 1
   05168 Herpes simplex virus 1 infection
    K11217  JAK1; Janus kinase 1
   05163 Human cytomegalovirus infection
    K11217  JAK1; Janus kinase 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K11217  JAK1; Janus kinase 1
   05169 Epstein-Barr virus infection
    K11217  JAK1; Janus kinase 1
   05165 Human papillomavirus infection
    K11217  JAK1; Janus kinase 1
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K11217  JAK1; Janus kinase 1
   05140 Leishmaniasis
    K11217  JAK1; Janus kinase 1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K11217  JAK1; Janus kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K11217  JAK1; Janus kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K11217  JAK1; Janus kinase 1
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   K11217  JAK1; Janus kinase 1
BRITE hierarchy
Other DBs
GO: 0004715
Genes
HSA: 3716(JAK1)
PTR: 743373(JAK1)
PPS: 100972202(JAK1)
GGO: 101133331(JAK1)
PON: 100433477(JAK1)
NLE: 100588162(JAK1)
MCC: 677689(JAK1)
MCF: 102123983(JAK1)
CSAB: 103224682(JAK1)
RRO: 104668074(JAK1)
RBB: 108532886(JAK1)
CJC: 100385835(JAK1)
SBQ: 101031615(JAK1)
MMU: 16451(Jak1)
MCAL: 110292243(Jak1)
MPAH: 110322912(Jak1)
RNO: 84598(Jak1)
MUN: 110555551(Jak1)
CGE: 100754824(Jak1)
NGI: 103732475(Jak1)
HGL: 101710283(Jak1)
CCAN: 109699504(Jak1)
OCU: 100352594(JAK1)
TUP: 102471806(JAK1)
CFA: 442952(JAK1)
VVP: 112907887(JAK1)
AML: 100473460(JAK1)
UMR: 103663059(JAK1)
UAH: 113254577(JAK1)
ORO: 101365648(JAK1)
ELK: 111142881
FCA: 101084377(JAK1)
PTG: 102960189(JAK1)
PPAD: 109266731(JAK1)
AJU: 106983739(JAK1)
BTA: 537201(JAK1)
BOM: 102286137(JAK1)
BIU: 109556202(JAK1)
BBUB: 102405285(JAK1)
CHX: 102182846(JAK1)
OAS: 101110716(JAK1)
SSC: 397202(JAK1)
CFR: 102519873(JAK1)
CDK: 105107124(JAK1)
BACU: 103004050(JAK1)
LVE: 103072682(JAK1)
OOR: 101275383(JAK1)
DLE: 111178461(JAK1)
PCAD: 102988182(JAK1)
ECB: 100054008(JAK1)
EPZ: 103560394(JAK1)
EAI: 106838751(JAK1)
MYB: 102260801(JAK1)
MYD: 102756517(JAK1)
MNA: 107533604(JAK1)
HAI: 109384938(JAK1)
DRO: 112309187(JAK1)
PALE: 102880365(JAK1)
RAY: 107517940(JAK1)
MJV: 108405993(JAK1)
LAV: 100655548(JAK1)
TMU: 101346613
MDO: 100031307(JAK1)
SHR: 100916991(JAK1)
PCW: 110212891(JAK1)
OAA: 100082981(JAK1)
GGA: 395681(JAK1)
MGP: 100551269
CJO: 107317736(JAK1)
NMEL: 110402219(JAK1)
APLA: 101794879(JAK1)
ACYG: 106043591(JAK1)
TGU: 100228920
LSR: 110473260(JAK1)
GFR: 102041288(JAK1)
FAB: 101805872(JAK1)
PHI: 102100416(JAK1)
PMAJ: 107208260(JAK1)
CCW: 104695136(JAK1)
ETL: 114061064(JAK1)
FPG: 101921412(JAK1)
FCH: 102048655(JAK1)
CLV: 102098386(JAK1)
EGZ: 104123929(JAK1)
NNI: 104009246(JAK1)
ACUN: 113482681(JAK1)
PADL: 103913972(JAK1)
AAM: 106487285(JAK1)
ASN: 102382170(JAK1)
AMJ: 106736893(JAK1)
PSS: 102454892(JAK1)
CMY: 102944623(JAK1)
CPIC: 101947775(JAK1)
ACS: 100559328(jak1)
PVT: 110085695(JAK1)
PBI: 103059257(JAK1)
PMUR: 107294340(JAK1)
TSR: 106550876(JAK1) 106553050
PMUA: 114598891(JAK1)
GJA: 107124605(JAK1)
XLA: 108714222 446697(jak1.L)
XTR: 100038172(jak1)
NPR: 108792339(JAK1)
DRE: 30280(jak1)
IPU: 108267483 108271771(jak1)
PHYP: 113531996(jak1) 113539949
AMEX: 103033818(jak1) 103044144
TRU: 101072065(jak1)
LCO: 109139938(jak1)
NCC: 104950514(jak1)
MZE: 101464192(jak1)
ONL: 100690671(jak1)
OLA: 101175389(jak1)
XMA: 102225542(jak1)
XCO: 114150872(jak1)
PRET: 103463041(jak1)
CVG: 107087221(jak1)
NFU: 107392913(jak1)
KMR: 108238415(jak1)
ALIM: 106521643(jak1)
AOCE: 111582047(jak1)
CSEM: 103395542(jak1)
POV: 109636630(jak1)
LCF: 108897047(jak1)
SDU: 111220102(jak1)
SLAL: 111645354(jak1)
HCQ: 109518981(jak1)
BPEC: 110167954(jak1)
MALB: 109961706(jak1)
SALP: 111957137 111975385(jak1)
ELS: 105011918(jak1) 105024705
SFM: 108935121 108935468(jak1)
PKI: 111834843(jak1) 111841014
LCM: 102356392 102364080(JAK1)
CMK: 103189591(jak1)
RTP: 109918768(jak1)
OBI: 106876525
MESC: 110614209
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1848670
  Authors
Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zurcher G, Ziemiecki A
  Title
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.
  Journal
Mol Cell Biol 11:2057-65 (1991)
DOI:10.1128/MCB.11.4.2057
  Sequence
[hsa:3716]
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