KEGG   ORTHOLOGY: K11424
Entry
K11424                      KO                                     

Name
WHSC1, MMSET, NSD2
Definition
[histone H3]-lysine36 N-dimethyltransferase NSD2 [EC:2.1.1.357]
Pathway
ko00310  Lysine degradation
ko01100  Metabolic pathways
ko05202  Transcriptional misregulation in cancer
Disease
H00010  Multiple myeloma
H01773  4p deletion syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11424  WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K11424  WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11424  WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.357  [histone H3]-lysine36 N-dimethyltransferase
     K11424  WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11424  WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2
Other DBs
RN: R03875 R04866 R04867
GO: 0046975
Genes
HSA: 7468(NSD2)
PTR: 461070(NSD2)
PPS: 100993332(NSD2)
GGO: 101140725(NSD2)
PON: 100433878(NSD2)
NLE: 100586897(NSD2)
MCC: 100429321(NSD2)
MCF: 102132914(NSD2)
CSAB: 103246476(NSD2)
RRO: 104678937(NSD2)
CJC: 100407883(NSD2)
SBQ: 101052056(WHSC1)
MMU: 107823(Nsd2)
MCAL: 110294647(Nsd2)
MPAH: 110330238(Nsd2)
RNO: 680537(Nsd2)
MUN: 110557276(Nsd2)
CGE: 100763780(Nsd2)
HGL: 101709487(Nsd2)
CCAN: 109694996(Nsd2)
OCU: 100347860(NSD2)
TUP: 102501548(NSD2)
CFA: 479077(NSD2)
VVP: 112920183(NSD2)
AML: 100482078(NSD2)
UMR: 103676545(NSD2)
UAH: 113245739(NSD2)
ORO: 101380855(WHSC1)
ELK: 111149264
FCA: 101083169(NSD2)
PPAD: 109269561(NSD2)
AJU: 106978842(NSD2)
BTA: 540769(NSD2)
BOM: 102264389(NSD2)
BIU: 109560728(NSD2)
BBUB: 102389379(NSD2)
CHX: 102186471(NSD2)
OAS: 101103648(NSD2)
SSC: 100515039(NSD2)
CFR: 102513372(NSD2)
CDK: 105100861(NSD2)
LVE: 103085661(NSD2)
OOR: 101272234(WHSC1)
DLE: 111164888(NSD2)
PCAD: 102996664(NSD2)
ECB: 100051090(NSD2)
EPZ: 103540385(NSD2)
EAI: 106823803(NSD2)
HAI: 109390921(NSD2)
MJV: 108383898(WHSC1)
LAV: 100673480(NSD2)
TMU: 101350220
MDO: 100022914(NSD2)
SHR: 100913447(NSD2)
PCW: 110212243(NSD2)
OAA: 100086259(NSD2)
GGA: 422897(WHSC1)
MGP: 100543303
CJO: 107313892(NSD2)
NMEL: 110397470(NSD2)
APLA: 101792888(NSD2)
ACYG: 106034357(WHSC1)
TGU: 100222807(NSD2)
LSR: 110473288(NSD2)
SCAN: 103823716(NSD2)
GFR: 102033219(NSD2)
FAB: 101814945(NSD2)
PMAJ: 107202885(WHSC1)
CCAE: 111928265(NSD2)
CCW: 104690790(NSD2)
ETL: 114070725
FPG: 101916059(NSD2)
FCH: 102059826(NSD2)
CLV: 102095738(NSD2)
EGZ: 104130173(WHSC1)
NNI: 104018071(WHSC1)
ACUN: 113478988(NSD2)
PADL: 103920916(WHSC1)
AAM: 106498711(NSD2)
ASN: 102372149(NSD2)
AMJ: 102573644(NSD2)
PSS: 102464028(NSD2)
CMY: 102940729(NSD2)
CPIC: 101932511(NSD2)
ACS: 100563747(nsd2)
PBI: 103055475(NSD2)
PMUR: 107291440(NSD2)
TSR: 106554241(WHSC1)
PMUA: 114596957(NSD2)
GJA: 107121904(NSD2)
XLA: 108697691(nsd2.L) 431996(nsd2.S)
XTR: 100125213(nsd2)
DRE: 100000709(nsd2)
SRX: 107747575
SANH: 107666517
SGH: 107556918
CCAR: 109068361
IPU: 108263739(nsd2)
PHYP: 113545431
AMEX: 103021320(nsd2)
EEE: 113589677(nsd2)
TRU: 101064304(nsd2)
LCO: 104926795(nsd2)
MZE: 101475058(nsd2)
ONL: 100690380(nsd2)
OLA: 101172132(nsd2)
XMA: 102228489(nsd2)
XCO: 114134512(nsd2)
CVG: 107087115(whsc1)
NFU: 107391900
KMR: 108249929(nsd2)
ALIM: 106519948(whsc1)
AOCE: 111580106
CSEM: 103383239(whsc1)
POV: 109641752
LCF: 108889160
SDU: 111225656(nsd2)
SLAL: 111646799
HCQ: 109520165(nsd2)
BPEC: 110171104(nsd2)
MALB: 109962432(nsd2)
SASA: 106607996
OTW: 112222905
ELS: 105015872(nsd2)
SFM: 108920768(nsd2)
PKI: 111844205(nsd2)
LCM: 102363237(NSD2)
BFO: 118413224
CIN: 100184753
SPU: 580047
DME: Dmel_CG4976(NSD)
DER: 6554177
DSE: 6618732
DSI: Dsimw501_GD18047(Dsim_GD18047)
DAN: 6498935
DSR: 110188397
DPE: 6588501
DMN: 108155091
DWI: 6650025
DAZ: 108611016
DNV: 108659461
DHE: 111603264
DVI: 6632940
AAG: 5573316
AME: 102655244
TCA: 662527
API: 100161826
DNX: 107165982
NVE: 5515072
 » show all
Reference
  Authors
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
  Title
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
  Journal
Blood 117:211-20 (2011)
DOI:10.1182/blood-2010-07-298349
  Sequence
[hsa:7468]
Reference
  Authors
Kim JY, Kee HJ, Choe NW, Kim SM, Eom GH, Baek HJ, Kook H, Kook H, Seo SB
  Title
Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.
  Journal
Mol Cell Biol 28:2023-34 (2008)
DOI:10.1128/MCB.02130-07
  Sequence
[hsa:7468] [mmu:107823]
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