KEGG   ORTHOLOGY: K11787
Entry
K11787                      KO                                     

Symbol
GART
Name
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]
Pathway
map00230  Purine metabolism
map00670  One carbon pool by folate
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01523  Antifolate resistance
Module
M00048  Inosine monophosphate biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.2  phosphoribosylglycinamide formyltransferase 1
     K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.1  phosphoribosylformylglycinamidine cyclo-ligase
     K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.13  phosphoribosylamine---glycine ligase
     K11787  GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase
Other DBs
RN: R04144 R04208 R04325 R04326
GO: 0004637 0004644 0004641
Genes
HSA: 2618(GART)
PTR: 107970128(GART)
PPS: 100991318(GART)
GGO: 101142154(GART)
PON: 100444934(GART)
NLE: 100585363(GART)
MCC: 704926(GART)
MCF: 101925128(GART)
CSAB: 103216649(GART)
CATY: 105575385(GART)
PANU: 100137547(GART)
RRO: 104658753(GART)
RBB: 108536859(GART)
TFN: 117095719(GART)
PTEH: 111525392(GART)
CJC: 100412337(GART)
SBQ: 101032514(GART)
MMUR: 105861505(GART)
MMU: 14450(Gart)
MCAL: 110311510(Gart)
MPAH: 110329397(Gart)
RNO: 288259(Gart)
MCOC: 116086139(Gart)
MUN: 110541947(Gart)
CGE: 100689446(Gart)
PLEU: 114698431(Gart)
NGI: 103736448(Gart)
HGL: 101697318(Gart)
OCU: 100328811(GART)
TUP: 102487990(GART)
CFA: 100856570(GART)
VVP: 112909277(GART)
VLG: 121479445(GART)
AML: 100479165(GART)
UMR: 103673116(GART)
UAH: 113264297(GART)
ORO: 101384632(GART)
ELK: 111155699
MPUF: 101676521(GART)
EJU: 114218318(GART)
MLX: 118018835(GART)
FCA: 101087772(GART)
PYU: 121035984(GART)
PBG: 122491215(GART)
PTG: 102956979(GART)
PPAD: 109249721(GART)
AJU: 106966453(GART)
HHV: 120229609(GART)
BTA: 281183(GART)
BOM: 102276357(GART)
BIU: 109567366(GART)
BBUB: 102392383(GART)
CHX: 102172194(GART)
OAS: 101121731(GART)
ODA: 120854436(GART)
CCAD: 122428721(GART)
SSC: 100620652(GART)
CFR: 102517474(GART)
CBAI: 105070227(GART)
CDK: 105089861(GART)
BACU: 102999179(GART)
LVE: 103080650(GART)
OOR: 101285238(GART)
DLE: 111163810(GART)
ECB: 100052316(GART)
EPZ: 103549081(GART)
EAI: 106832833(GART)
MYB: 102262953(GART)
MYD: 102772036(GART)
MMYO: 118677255(GART)
MNA: 107537466(GART)
HAI: 109373228(GART)
DRO: 112305577(GART)
SHON: 118983252(GART)
AJM: 119035718(GART)
MMF: 118617075(GART)
PALE: 102893033(GART)
PGIG: 120598631(GART)
RAY: 107519587(GART)
MJV: 108396821(GART)
TOD: 119257226(GART)
LAV: 100672037(GART)
TMU: 101354872
MDO: 100026350(GART)
SHR: 100925249(GART)
PCW: 110214813(GART)
OAA: 100083317(GART) 100083336
GGA: 395315(GART) 427977(GART-B)
PCOC: 116241974 116241995(GART)
MGP: 100539128(GART) 100542357
CJO: 107322963 107322977(GART)
APLA: 101790581 101803101(GART)
ACYG: 106043414(GART) 106043431
TGU: 100217856(GART) 100222702
LSR: 110479223(GART) 110479231
SCAN: 103824404(GART) 103824418
PMOA: 120504004 120504005(GART)
GFR: 102045486(GART) 102045650
FAB: 101816412(GART) 101817498
PMAJ: 107200378(GART) 107200385
CCAE: 111928826(GART) 111928969
CCW: 104698062(GART) 104698091
ETL: 114070711(GART)
FPG: 101917332(GART) 101920107
FCH: 102054569 102058598(GART)
CLV: 102088577 102096509(GART)
NNI: 104020123(GART) 104020174
ACUN: 113479892(GART) 113485589
PADL: 103920259(GART) 103920317
NPD: 112948158(GART) 112948159
ASN: 102378888(GART) 102384374
AMJ: 102567665(GART) 102569060
CPOO: 109305783 109305785(GART)
GGN: 109302469 109302471(GART)
PSS: 102460115(GART) 102461235
CMY: 102929919 102946476(GART)
CABI: 116828284 116828286(GART)
ACS: 100561300(gart) 100565628
PVT: 110080382(GART) 110080394
PBI: 103048917 103067155(GART)
XLA: 100101294(gart.L) 108707418
XTR: 100485140 496927(gart)
NPR: 108787812(GART)
DRE: 58141(gart)
SRX: 107726994(gart)
SANH: 107689944(gart)
SGH: 107572075(gart)
CAUA: 113080559(gart)
IPU: 108258901(gart)
PHYP: 113537379(gart)
AMEX: 103047427(gart)
EEE: 113574576(gart)
TRU: 101075229(gart)
LCO: 104932032(gart)
CGOB: 115018514(gart)
ELY: 117250198(gart)
PLEP: 121962768(gart)
SLUC: 116044481(gart)
ECRA: 117939248(gart)
PFLV: 114550974(gart)
MSAM: 119904058(gart)
CUD: 121506446(gart)
MZE: 101485338(gart)
ONL: 100706422(gart)
OAU: 116318479(gart)
OLA: 100049526(gart)
OML: 112160056(gart)
XMA: 102236613(gart)
XCO: 114140906(gart)
PRET: 103476711(gart)
CVG: 107098796(gart)
CTUL: 119791183(gart)
NFU: 107380853(gart)
KMR: 108245013(gart)
ALIM: 106523921(gart)
AOCE: 111587765(gart) 111587996
CSEM: 103389466(gart)
POV: 109645513
LCF: 108894876(gart)
SDU: 111236692(gart)
SLAL: 111644444(gart) 111652198
XGL: 120797986(gart)
HCQ: 109528647(gart)
BPEC: 110153183(gart)
MALB: 109952606(gart)
SASA: 106575120(gart)
OTW: 112254021
OMY: 110527589(gart)
SNH: 120033148(gart) 120051214
ELS: 105008058(gart)
SFM: 108938543(gart)
PKI: 111855964(gart)
AANG: 118214096(gart)
LOC: 102689420(gart)
LCM: 102366881(GART)
CMK: 103186759(gart)
RTP: 109913465(gart)
BFO: 118423361
BBEL: 109481176
CIN: 100177674
SPU: 580766
APLC: 110974915
SKO: 100370502
DME: Dmel_CG31628(Gart)
DER: 6541431
DSE: 6611485
DSI: Dsimw501_GD22518(Dsim_GD22518)
DAN: 6497761
DSR: 110185553
DPO: Dpse_GA25439(Dpse_ade3)
DPE: 6593684
DMN: 108161417
DWI: 6642061
DGR: 6566505
DAZ: 108611166
DNV: 115562844
DHE: 111593156
DVI: 6627736
CCAT: 101453018
MDE: 101889546
LCQ: 111687291
ACOZ: 120956491
AARA: 120899923
AAG: 5573654
CPII: 120427835
AME: 100577675
ACER: 108001090
BIM: 100745134
BBIF: 117206181
BTER: 100649405
CCAL: 108628546
OBB: 114871746
MGEN: 117224854
NMEA: 116427720
CGIG: 122400933
SOC: 105195432
MPHA: 105833511
AEC: 105151040
ACEP: 105619803
PBAR: 105422190
VEM: 105566543
HST: 105181536
DQU: 106746782
CFO: 105258500
FEX: 115244635
LHU: 105668386
PGC: 109862194
OBO: 105285113
PCF: 106793389
NVI: 100118788
CSOL: 105366517
MDL: 103568662
CCIN: 107268763
TCA: 661737
DPA: 109538289
ATD: 109608770
AGB: 108903471
LDC: 111513014
NVL: 108558768
APLN: 108736128
PPYR: 116179354
OTU: 111426615
BMOR: 101744981
BMAN: 114244943
MSEX: 115447492
BANY: 112045029
PMAC: 106709179
PPOT: 106107617
PXU: 106115479
PRAP: 110993220
ZCE: 119830621
HAW: 110379208
TNL: 113499068
API: 100168774
DNX: 107164822
AGS: 114133025
RMD: 113556016
BTAB: 109040029
DCI: 103512854
CLEC: 106662492
HHAL: 106688074
NLU: 111052553
ZNE: 110836263
CSEC: 111862131
FCD: 110852602
PVM: 113827918
HAME: 121860996
HAZT: 108679322
DSV: 119464398
RSAN: 119401292
RMP: 119163965
VDE: 111253747
VJA: 111271956
TUT: 107360181
DPTE: 113797879
CSCU: 111614698
PTEP: 107443075
SDM: 118193245
CEL: CELE_F38B6.4(F38B6.4)
CBR: CBG10863
PCAN: 112557529
BGT: 106056062
GAE: 121390076
CRG: 105346659
MYI: 110459783
PMAX: 117345237
OBI: 106876245
LAK: 106161237
NVE: 5509911
EPA: 110248354
ATEN: 116296447
ADF: 107343906
AMIL: 114954638
PDAM: 113666788
SPIS: 111328606
DGT: 114532554
HMG: 100199281
AQU: 100632260
SMIN: v1.2.022838.t1(symbB.v1.2.022838.t1) v1.2.024758.t1(symbB.v1.2.024758.t1)
 » show all
Reference
PMID:2183217
  Authors
Schild D, Brake AJ, Kiefer MC, Young D, Barr PJ
  Title
Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.
  Journal
Proc Natl Acad Sci U S A 87:2916-20 (1990)
DOI:10.1073/pnas.87.8.2916
  Sequence
[hsa:2618]
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