ORTHOLOGY: K13050
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Entry
K13050 KO
Name
PCSK9
Definition
proprotein convertase subtilisin/kexin type 9 [EC:3.4.21.-]
Pathway
ko04979
Cholesterol metabolism
Disease
H00155
Familial hypercholesterolemia
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09150 Organismal Systems
09154 Digestive system
04979 Cholesterol metabolism
K13050 PCSK9; proprotein convertase subtilisin/kexin type 9
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors
K13050 PCSK9; proprotein convertase subtilisin/kexin type 9
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts
K13050 PCSK9; proprotein convertase subtilisin/kexin type 9
Enzymes [BR:
ko01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.-
K13050 PCSK9; proprotein convertase subtilisin/kexin type 9
Peptidases and inhibitors [BR:
ko01002
]
Serine peptidases
Family S8: subtilisin family
K13050 PCSK9; proprotein convertase subtilisin/kexin type 9
Chaperones and folding catalysts [BR:
ko03110
]
Intramolecular chaperones
Subtilisin family
K13050 PCSK9; proprotein convertase subtilisin/kexin type 9
BRITE hierarchy
Other DBs
GO:
0050750
Genes
HSA:
255738
(PCSK9)
PTR:
456880
(PCSK9)
PPS:
100971792
(PCSK9)
GGO:
101132967
(PCSK9)
PON:
100457996
(PCSK9)
NLE:
100580053
(PCSK9)
MCC:
717147
(PCSK9)
MCF:
102142788
(PCSK9)
CSAB:
103224756
(PCSK9)
RRO:
104669649
(PCSK9)
RBB:
108527889
(PCSK9)
CJC:
100395116
(PCSK9)
SBQ:
101049523
(PCSK9)
MMU:
100102
(Pcsk9)
MCAL:
110292266
(Pcsk9)
MPAH:
110323578
(Pcsk9)
RNO:
298296
(Pcsk9)
MUN:
110547616
(Pcsk9)
CGE:
100769049
(Pcsk9)
NGI:
103734098
(Pcsk9)
HGL:
101700911
(Pcsk9)
CCAN:
109689558
(Pcsk9)
OCU:
100338756
(PCSK9)
TUP:
102501918
(PCSK9)
CFA:
102152231
(PCSK9)
SSC:
100620501
(PCSK9)
CFR:
102521308
(PCSK9)
CDK:
105092855
(PCSK9)
BACU:
103020139
(PCSK9)
LVE:
103073014
(PCSK9)
OOR:
101270390
(PCSK9)
DLE:
111175854
(PCSK9)
PCAD:
102985433
(PCSK9)
ECB:
100147049
(PCSK9)
EPZ:
103566202
(PCSK9)
EAI:
106833161
(PCSK9)
LAV:
100661542
(PCSK9)
TMU:
101350117
MDO:
100032437
(PCSK9)
SHR:
100927600
(PCSK9)
PCW:
110201332
(PCSK9)
OAA:
103167403
(PCSK9)
GGA:
424664
(PCSK9)
MGP:
100544916
(PCSK9)
CJO:
107317679
(PCSK9)
NMEL:
110402677
(PCSK9)
APLA:
101802433
(PCSK9)
ACYG:
106032927
(PCSK9)
TGU:
100223154
(PCSK9)
LSR:
110477287
(PCSK9)
SCAN:
103815203
(PCSK9)
GFR:
102031452
(PCSK9)
FAB:
101810947
(PCSK9)
PHI:
102114228
(PCSK9)
PMAJ:
107208259
(PCSK9)
CCW:
104695511
(PCSK9)
ETL:
114055193
(PCSK9)
FPG:
101919643
(PCSK9)
FCH:
102049014
(PCSK9)
CLV:
102087734
(PCSK9)
EGZ:
104123891
(PCSK9)
NNI:
104009344
(PCSK9)
ACUN:
113482804
(PCSK9)
PADL:
103913359
(PCSK9)
ASN:
102382151
(PCSK9)
AMJ:
102564097
(PCSK9)
PSS:
102451609
(PCSK9)
CMY:
102929839
(PCSK9)
CPIC:
101948827
(PCSK9)
ACS:
100564252
(pcsk9)
PVT:
110082259
(PCSK9)
PBI:
103057033
(PCSK9)
PMUR:
107286638
(PCSK9)
TSR:
106551184
(PCSK9)
PMUA:
114598947
(PCSK9)
GJA:
107107434
(PCSK9)
XLA:
108715614
495509
(pcsk9.L)
XTR:
100484989
(pcsk9)
NPR:
108793080
(PCSK9)
DRE:
100150316
(pcsk9)
SRX:
107712881
(pcsk9)
107716550
SANH:
107687184
107697372
SGH:
107566146
107578795
CCAR:
109112959
(pcsk9)
IPU:
108257816
(pcsk9)
PHYP:
113545301
(pcsk9)
AMEX:
103029992
(pcsk9)
EEE:
113588645
(pcsk9)
TRU:
101078715
(pcsk9)
TNG:
GSTEN00032705G001
LCO:
104919160
NCC:
104953647
(pcsk9)
MZE:
101486231
(pcsk9)
ONL:
100710647
(pcsk9)
OLA:
101168532
(pcsk9)
XMA:
102219623
(pcsk9)
XCO:
114151502
(pcsk9)
PRET:
103463793
(pcsk9)
CVG:
107094067
(pcsk9)
NFU:
107393434
(pcsk9)
KMR:
108243370
(pcsk9)
AOCE:
111581127
(pcsk9)
CSEM:
103376649
(pcsk9)
POV:
109625512
(pcsk9)
LCF:
108879077
(pcsk9)
SDU:
111226322
(pcsk9)
SLAL:
111665197
(pcsk9)
HCQ:
109532117
(pcsk9)
BPEC:
110154820
(pcsk9)
MALB:
109962012
(pcsk9)
SFM:
108923497
(pcsk9)
PKI:
111833983
(pcsk9)
LCM:
102352703
(PCSK9)
CMK:
103182738
(pcsk9)
RTP:
109928313
(pcsk9)
BFO:
118424163
118424319
118427567
118427573
SKO:
100369892
PCAN:
112554562
» show all
Taxonomy
UniProt
Reference
PMID:
17971861
Authors
Ding K, McDonough SJ, Kullo IJ
Title
Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species.
Journal
PLoS One 2:e1098 (2007)
DOI:
10.1371/journal.pone.0001098
Sequence
[hsa:
255738
] [ptr:
456880
] [mcc:
717147
] [ggo:
101132967
]
Reference
PMID:
17461796
Authors
Nassoury N, Blasiole DA, Tebon Oler A, Benjannet S, Hamelin J, Poupon V, McPherson PS, Attie AD, Prat A, Seidah NG
Title
The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.
Journal
Traffic 8:718-32 (2007)
DOI:
10.1111/j.1600-0854.2007.00562.x
Sequence
[hsa:
255738
]
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All DBs
DBGET
integrated database retrieval system