KEGG   ORTHOLOGY: K13050
Entry
K13050                      KO                                     

Name
PCSK9
Definition
proprotein convertase subtilisin/kexin type 9 [EC:3.4.21.-]
Pathway
ko04979  Cholesterol metabolism
Disease
H00155  Familial hypercholesterolemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    K13050  PCSK9; proprotein convertase subtilisin/kexin type 9
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K13050  PCSK9; proprotein convertase subtilisin/kexin type 9
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K13050  PCSK9; proprotein convertase subtilisin/kexin type 9
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.-  
     K13050  PCSK9; proprotein convertase subtilisin/kexin type 9
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S8: subtilisin family
   K13050  PCSK9; proprotein convertase subtilisin/kexin type 9
Chaperones and folding catalysts [BR:ko03110]
 Intramolecular chaperones
  Subtilisin family
   K13050  PCSK9; proprotein convertase subtilisin/kexin type 9
Other DBs
GO: 0050750
Genes
HSA: 255738(PCSK9)
PTR: 456880(PCSK9)
PPS: 100971792(PCSK9)
GGO: 101132967(PCSK9)
PON: 100457996(PCSK9)
NLE: 100580053(PCSK9)
MCC: 717147(PCSK9)
MCF: 102142788(PCSK9)
CSAB: 103224756(PCSK9)
RRO: 104669649(PCSK9)
RBB: 108527889(PCSK9)
CJC: 100395116(PCSK9)
SBQ: 101049523(PCSK9)
MMU: 100102(Pcsk9)
MCAL: 110292266(Pcsk9)
MPAH: 110323578(Pcsk9)
RNO: 298296(Pcsk9)
MUN: 110547616(Pcsk9)
CGE: 100769049(Pcsk9)
NGI: 103734098(Pcsk9)
HGL: 101700911(Pcsk9)
CCAN: 109689558(Pcsk9)
OCU: 100338756(PCSK9)
TUP: 102501918(PCSK9)
CFA: 102152231(PCSK9)
SSC: 100620501(PCSK9)
CFR: 102521308(PCSK9)
CDK: 105092855(PCSK9)
BACU: 103020139(PCSK9)
LVE: 103073014(PCSK9)
OOR: 101270390(PCSK9)
DLE: 111175854(PCSK9)
PCAD: 102985433(PCSK9)
ECB: 100147049(PCSK9)
EPZ: 103566202(PCSK9)
EAI: 106833161(PCSK9)
LAV: 100661542(PCSK9)
TMU: 101350117
MDO: 100032437(PCSK9)
SHR: 100927600(PCSK9)
PCW: 110201332(PCSK9)
OAA: 103167403(PCSK9)
GGA: 424664(PCSK9)
MGP: 100544916(PCSK9)
CJO: 107317679(PCSK9)
NMEL: 110402677(PCSK9)
APLA: 101802433(PCSK9)
ACYG: 106032927(PCSK9)
TGU: 100223154(PCSK9)
LSR: 110477287(PCSK9)
SCAN: 103815203(PCSK9)
GFR: 102031452(PCSK9)
FAB: 101810947(PCSK9)
PHI: 102114228(PCSK9)
PMAJ: 107208259(PCSK9)
CCW: 104695511(PCSK9)
ETL: 114055193(PCSK9)
FPG: 101919643(PCSK9)
FCH: 102049014(PCSK9)
CLV: 102087734(PCSK9)
EGZ: 104123891(PCSK9)
NNI: 104009344(PCSK9)
ACUN: 113482804(PCSK9)
PADL: 103913359(PCSK9)
ASN: 102382151(PCSK9)
AMJ: 102564097(PCSK9)
PSS: 102451609(PCSK9)
CMY: 102929839(PCSK9)
CPIC: 101948827(PCSK9)
ACS: 100564252(pcsk9)
PVT: 110082259(PCSK9)
PBI: 103057033(PCSK9)
PMUR: 107286638(PCSK9)
TSR: 106551184(PCSK9)
PMUA: 114598947(PCSK9)
GJA: 107107434(PCSK9)
XLA: 108715614 495509(pcsk9.L)
XTR: 100484989(pcsk9)
NPR: 108793080(PCSK9)
DRE: 100150316(pcsk9)
SRX: 107712881(pcsk9) 107716550
SANH: 107687184 107697372
SGH: 107566146 107578795
CCAR: 109112959(pcsk9)
IPU: 108257816(pcsk9)
PHYP: 113545301(pcsk9)
AMEX: 103029992(pcsk9)
EEE: 113588645(pcsk9)
TRU: 101078715(pcsk9)
TNG: GSTEN00032705G001
LCO: 104919160
NCC: 104953647(pcsk9)
MZE: 101486231(pcsk9)
ONL: 100710647(pcsk9)
OLA: 101168532(pcsk9)
XMA: 102219623(pcsk9)
XCO: 114151502(pcsk9)
PRET: 103463793(pcsk9)
CVG: 107094067(pcsk9)
NFU: 107393434(pcsk9)
KMR: 108243370(pcsk9)
AOCE: 111581127(pcsk9)
CSEM: 103376649(pcsk9)
POV: 109625512(pcsk9)
LCF: 108879077(pcsk9)
SDU: 111226322(pcsk9)
SLAL: 111665197(pcsk9)
HCQ: 109532117(pcsk9)
BPEC: 110154820(pcsk9)
MALB: 109962012(pcsk9)
SFM: 108923497(pcsk9)
PKI: 111833983(pcsk9)
LCM: 102352703(PCSK9)
CMK: 103182738(pcsk9)
RTP: 109928313(pcsk9)
BFO: 118424163 118424319 118427567 118427573
SKO: 100369892
PCAN: 112554562
 » show all
Reference
  Authors
Ding K, McDonough SJ, Kullo IJ
  Title
Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species.
  Journal
PLoS One 2:e1098 (2007)
DOI:10.1371/journal.pone.0001098
  Sequence
[hsa:255738] [ptr:456880] [mcc:717147] [ggo:101132967]
Reference
  Authors
Nassoury N, Blasiole DA, Tebon Oler A, Benjannet S, Hamelin J, Poupon V, McPherson PS, Attie AD, Prat A, Seidah NG
  Title
The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.
  Journal
Traffic 8:718-32 (2007)
DOI:10.1111/j.1600-0854.2007.00562.x
  Sequence
[hsa:255738]
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