KEGG   ORTHOLOGY: K13575
Entry
K13575                      KO                                     

Name
SLC4A4, NBC1
Definition
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Pathway
ko04964  Proximal tubule bicarbonate reclamation
ko04972  Pancreatic secretion
ko04976  Bile secretion
Disease
H00429  Proximal renal tubular acidosis (RTA type 2)
H02310  Renal tubular acidosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09154 Digestive system
   04972 Pancreatic secretion
    K13575  SLC4A4, NBC1; solute carrier family 4 (sodium bicarbonate cotransporter), member 4
   04976 Bile secretion
    K13575  SLC4A4, NBC1; solute carrier family 4 (sodium bicarbonate cotransporter), member 4
  09155 Excretory system
   04964 Proximal tubule bicarbonate reclamation
    K13575  SLC4A4, NBC1; solute carrier family 4 (sodium bicarbonate cotransporter), member 4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K13575  SLC4A4, NBC1; solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Transporters [BR:ko02000]
 Solute carrier family (SLC)
  SLC4: Bicarbonate transporter
   K13575  SLC4A4, NBC1; solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Other DBs
GO: 0008510
TC: 2.A.31.2.2 2.A.31.2.9
Genes
HSA: 8671(SLC4A4)
PTR: 461271(SLC4A4)
PPS: 100989755(SLC4A4)
GGO: 101124071(SLC4A4)
PON: 100461591(SLC4A4)
NLE: 100580725(SLC4A4)
MCC: 705830(SLC4A4)
MCF: 102136348(SLC4A4)
CSAB: 103235765(SLC4A4)
RRO: 104678744(SLC4A4)
RBB: 108534022(SLC4A4)
CJC: 100394336(SLC4A4)
SBQ: 101045802(SLC4A4)
MMU: 54403(Slc4a4)
MCAL: 110294362(Slc4a4)
MPAH: 110330570(Slc4a4)
RNO: 84484(Slc4a4)
MUN: 110560196(Slc4a4)
CGE: 100763623
NGI: 103730941(Slc4a4)
HGL: 101723129(Slc4a4)
CCAN: 109695106(Slc4a4)
OCU: 100008727(SLC4A4)
TUP: 102499824(SLC4A4)
CFA: 475171(SLC4A4)
VVP: 112909252
AML: 100482348(SLC4A4)
UMR: 103665297(SLC4A4)
UAH: 113263295(SLC4A4)
ORO: 101385439(SLC4A4)
ELK: 111148909
FCA: 101083262(SLC4A4)
PTG: 102949720(SLC4A4)
PPAD: 109277963(SLC4A4)
AJU: 106983688(SLC4A4)
BTA: 282360(SLC4A4)
BOM: 102268544(SLC4A4)
BIU: 109560559(SLC4A4)
BBUB: 102405795(SLC4A4)
CHX: 102175283(SLC4A4)
OAS: 494440
SSC: 503546(SLC4A4)
CFR: 102524365(SLC4A4)
CDK: 105091193(SLC4A4)
BACU: 103015733(SLC4A4)
LVE: 103071602(SLC4A4)
OOR: 101281380(SLC4A4)
DLE: 111187679(SLC4A4)
PCAD: 102974122(SLC4A4)
ECB: 100049977(SLC4A4)
EPZ: 103564167
EAI: 106835101(SLC4A4)
MYB: 102262233(SLC4A4)
MYD: 102767230(SLC4A4)
MNA: 107532649(SLC4A4)
HAI: 109393717(SLC4A4)
DRO: 112322038(SLC4A4)
PALE: 102890430(SLC4A4)
RAY: 107504010(SLC4A4)
MJV: 108394226(SLC4A4)
LAV: 100667036(SLC4A4)
TMU: 101360693
MDO: 100014567(SLC4A4)
SHR: 100934284(SLC4A4)
PCW: 110209807(SLC4A4)
OAA: 100078786(SLC4A4)
GGA: 422649(SLC4A4) 769199(SLC4A9)
CJO: 107313345(SLC4A4) 107320477(SLC4A9)
NMEL: 110398811(SLC4A4) 110405495(SLC4A9)
APLA: 101798600(SLC4A4) 101800095(SLC4A9)
ACYG: 106042745(SLC4A9) 106043968(SLC4A4)
TGU: 100217496(SLC4A4) 100226802(SLC4A9)
LSR: 110470141(SLC4A4) 110471344(SLC4A9)
SCAN: 103817448(SLC4A9) 103823423(SLC4A4)
GFR: 102031624(SLC4A9) 102032408(SLC4A4)
FAB: 101810169(SLC4A4) 101815025(SLC4A9)
PHI: 102106396(SLC4A4) 102108145(SLC4A9)
PMAJ: 107203116(SLC4A4) 107210681(SLC4A9)
CCAE: 111929479(SLC4A4)
CCW: 104693555(SLC4A9) 104696827(SLC4A4)
ETL: 114059800(SLC4A9) 114060049(SLC4A4)
FPG: 101923414(SLC4A9) 101924912(SLC4A4)
FCH: 102050674(SLC4A4) 102052359(SLC4A9)
CLV: 102089304(SLC4A4) 102094587(SLC4A9)
EGZ: 104125168(SLC4A4) 104135804(SLC4A9)
NNI: 104009212(SLC4A9) 104011371(SLC4A4)
ACUN: 113479464(SLC4A4) 113485278(SLC4A9)
PADL: 103915468(SLC4A9) 103916950(SLC4A4)
AAM: 106492027(SLC4A4) 106494292(SLC4A9)
ASN: 102372352(SLC4A9) 102378439(SLC4A4)
AMJ: 102566362(SLC4A9) 102572650(SLC4A4)
PSS: 102455257(SLC4A9) 102461696(SLC4A4)
CMY: 102931226 102946570(SLC4A4)
CPIC: 101934356(SLC4A9) 101948810(SLC4A4)
ACS: 100559398(slc4a4) 100561955(slc4a9)
PVT: 110082101(SLC4A9) 110088679(SLC4A4)
PBI: 103051587(SLC4A9) 103053004(SLC4A4)
PMUR: 107284137(SLC4A9) 107289771(SLC4A4)
PMUA: 114601159(SLC4A9) 114603758(SLC4A4)
GJA: 107117829(SLC4A4) 107119742(SLC4A9)
XLA: 108706771(slc4a4.S) 108710906(slc4a9.L) 108711128(slc4a4.L)
XTR: 100490445(slc4a4) 100498479(slc4a9)
NPR: 108784705(SLC4A4) 108799384
DRE: 561618(slc4a4b) 568631(slc4a4a)
IPU: 108255856(slc4a4) 108278557
PHYP: 113535397 113537135(slc4a4)
EEE: 113589168(slc4a4) 113591315
TRU: 101065651 101078720(slc4a4)
MZE: 101481441 101484802(slc4a4)
ONL: 100702090(slc4a4) 100706137
XMA: 102223229 102235257(slc4a4)
XCO: 114149448 114154134(slc4a4)
PRET: 103470728(slc4a4) 103473356
LCF: 108882871 108891345(slc4a4)
HCQ: 109519570(slc4a4) 109525544
ELS: 105027271 105027424(slc4a4)
LCM: 102358464
CMK: 103177677(slc4a4) 103186491
RTP: 109932964
BMY: Bm1_32765
TSP: Tsp_10583
SMIN: v1.2.036624.t2(symbB.v1.2.036624.t2) v1.2.037242.t1(symbB.v1.2.037242.t1)
 » show all
Reference
PMID:9235899
  Authors
Burnham CE, Amlal H, Wang Z, Shull GE, Soleimani M
  Title
Cloning and functional expression of a human kidney Na+:HCO3- cotransporter.
  Journal
J Biol Chem 272:19111-4 (1997)
DOI:10.1074/jbc.272.31.19111
  Sequence
[hsa:8671]
Reference
  Authors
Aalkjaer C, Frische S, Leipziger J, Nielsen S, Praetorius J
  Title
Sodium coupled bicarbonate transporters in the kidney, an update.
  Journal
Acta Physiol Scand 181:505-12 (2004)
DOI:10.1111/j.1365-201X.2004.01324.x
Reference
  Authors
Becker HM, Deitmer JW
  Title
Carbonic anhydrase II increases the activity of the human electrogenic Na+/HCO3- cotransporter.
  Journal
J Biol Chem 282:13508-21 (2007)
DOI:10.1074/jbc.M700066200
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