KEGG   ORTHOLOGY: K13939
Entry
K13939                      KO                                     

Name
FOL1
Definition
dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase [EC:4.1.2.25 2.7.6.3 2.5.1.15]
Pathway
ko00790  Folate biosynthesis
ko01100  Metabolic pathways
ko01240  Biosynthesis of cofactors
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.15  dihydropteroate synthase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
  2.7  Transferring phosphorus-containing groups
   2.7.6  Diphosphotransferases
    2.7.6.3  2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.25  dihydroneopterin aldolase
     K13939  FOL1; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase
Other DBs
RN: R03066 R03067 R03503 R03504
COG: COG1539 COG0801 COG0294
GO: 0004150 0003848 0004156
Genes
SCE: YNL256W(FOL1)
AGO: AGOS_AFR647C
ERC: Ecym_1119
KLA: KLLA0_C02783g
KMX: KLMA_10126(FOL1)
LTH: KLTH0F02882g
VPO: Kpol_2000p42
ZRO: ZYRO0F16170g
CGR: CAGL0J07920g
NCS: NCAS_0A00710(NCAS0A00710)
NDI: NDAI_0F04090(NDAI0F04090)
TPF: TPHA_0B04280(TPHA0B04280)
TBL: TBLA_0A05660(TBLA0A05660)
TDL: TDEL_0C05970(TDEL0C05970)
KAF: KAFR_0D03830(KAFR0D03830)
CAL: CAALFM_C500770CA(FOL1)
SLB: AWJ20_43(FOL1)
CNE: CNC04040
CNB: CNBC3140
TASA: A1Q1_04530
ABP: AGABI1DRAFT115300(AGABI1DRAFT_115300)
ABV: AGABI2DRAFT208226(AGABI2DRAFT_208226)
MRT: MRET_0826
DDI: DDB_G0278283(fol1)
DFA: DFA_08871(fol1)
 » show all
Reference
  Authors
Lawrence MC, Iliades P, Fernley RT, Berglez J, Pilling PA, Macreadie IG
  Title
The three-dimensional structure of the bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase of Saccharomyces cerevisiae.
  Journal
J Mol Biol 348:655-70 (2005)
DOI:10.1016/j.jmb.2005.03.021
Reference
  Authors
Guldener U, Koehler GJ, Haussmann C, Bacher A, Kricke J, Becher D, Hegemann JH
  Title
Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth.
  Journal
Mol Biol Cell 15:3811-28 (2004)
DOI:10.1091/mbc.E03-09-0680
  Sequence
[sce:YNL256W]
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