KEGG   ORTHOLOGY: K14020
Entry
K14020                      KO                                     

Name
WFS1
Definition
wolfamin
Pathway
ko04141  Protein processing in endoplasmic reticulum
Disease
H00409  Type 2 diabetes mellitus
H00604  Deafness, autosomal dominant
H00854  Wolfram syndrome
H01202  Cataract
H01705  Bilateral sudden sensorineural hearing loss
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K14020  WFS1; wolfamin
Genes
HSA: 7466(WFS1)
PTR: 461100(WFS1)
PPS: 100983540(WFS1)
GGO: 101140111(WFS1)
PON: 100174672(WFS1)
NLE: 100582796(WFS1)
MCC: 710948(WFS1)
MCF: 101926576(WFS1)
CSAB: 103246405(WFS1)
RRO: 104667560(WFS1)
RBB: 108538799(WFS1)
CJC: 100386022(WFS1)
SBQ: 101032223(WFS1)
MMU: 22393(Wfs1)
MCAL: 110294183(Wfs1)
MPAH: 110330419(Wfs1)
RNO: 83725(Wfs1)
MUN: 110544856(Wfs1)
CGE: 100770775(Wfs1)
NGI: 103750637(Wfs1)
HGL: 101711151(Wfs1)
CCAN: 109687310(Wfs1)
OCU: 103346422(WFS1)
TUP: 102501003(WFS1)
CFA: 482113(WFS1)
VVP: 112909875(WFS1)
AML: 100469519(WFS1)
UMR: 103658294(WFS1)
UAH: 113266656(WFS1)
ORO: 101378249(WFS1)
ELK: 111149055
FCA: 101092024(WFS1)
PTG: 102969992(WFS1)
PPAD: 109269700(WFS1)
AJU: 106982717(WFS1)
BTA: 100298456(WFS1)
BOM: 102270797(WFS1)
BBUB: 102391511(WFS1)
CHX: 102188574(WFS1)
OAS: 101112732(WFS1)
SSC: 100621070(WFS1)
CFR: 102507025(WFS1)
CDK: 105085108(WFS1)
BACU: 103001171(WFS1)
LVE: 103070663(WFS1)
OOR: 101281370(WFS1)
DLE: 111179115(WFS1)
PCAD: 102985279(WFS1)
ECB: 100070117(WFS1)
EPZ: 103561812(WFS1)
EAI: 106843315(WFS1)
MYB: 102243829(WFS1)
MYD: 102774692(WFS1)
MNA: 107524058(WFS1)
HAI: 109374121(WFS1)
DRO: 112316856(WFS1)
PALE: 102889841(WFS1)
RAY: 107519034(WFS1)
MJV: 108409758(WFS1)
LAV: 100669166(WFS1)
TMU: 101356143
MDO: 100018961(WFS1)
SHR: 100922667(WFS1)
PCW: 110212263(WFS1)
OAA: 100079398(WFS1)
GGA: 422857(WFS1)
MGP: 104910845(WFS1)
CJO: 107314009(WFS1)
NMEL: 110397902(WFS1)
APLA: 101800827(WFS1)
ACYG: 106035101(WFS1)
TGU: 100231376(WFS1)
LSR: 110481862(WFS1)
SCAN: 103824125(WFS1)
GFR: 102032466(WFS1)
FAB: 101818977(WFS1)
PHI: 102105537(WFS1)
PMAJ: 107203219(WFS1)
CCAE: 111928206(WFS1)
CCW: 104690742(WFS1)
ETL: 114065677(WFS1)
FPG: 101922103(WFS1)
FCH: 102050774(WFS1)
CLV: 102090163(WFS1)
EGZ: 104123275(WFS1)
NNI: 104018038(WFS1)
ACUN: 113479339(WFS1)
PADL: 103920952(WFS1)
AAM: 106498757(WFS1)
ASN: 102378020(WFS1)
AMJ: 102558683(WFS1)
PSS: 102460839(WFS1)
CMY: 102947530(WFS1)
CPIC: 101950225(WFS1)
ACS: 100566233(wfs1)
PVT: 110088717(WFS1)
PBI: 103055967(WFS1)
PMUR: 107299172(WFS1)
TSR: 106544483(WFS1)
PMUA: 114604764(WFS1)
GJA: 107121379(WFS1)
XLA: 108706536(wfs1.S) 734911(wfs1.L)
XTR: 100127642(wfs1)
NPR: 108791049(WFS1)
DRE: 556580(wfs1b) 566876(wfs1a)
CCAR: 109049829
IPU: 108260676 108269302(wfs1)
PHYP: 113525730 113542876(wfs1)
TRU: 101062334(wfs1) 101064513
LCO: 104922614(wfs1) 104924361
NCC: 104957012 104961175(wfs1)
MZE: 101464362 101479301(wfs1)
ONL: 100690548(wfs1) 100709626
OLA: 101167425 101168126(wfs1)
XMA: 102220803 102236466(wfs1)
XCO: 114139445(wfs1) 114145132
PRET: 103469373 103471345(wfs1)
NFU: 107376626(wfs1) 107382173
KMR: 108241546 108243015(wfs1)
ALIM: 106511061(wfs1) 106531114
AOCE: 111567096 111583655(wfs1)
CSEM: 103383729 103390930(wfs1)
POV: 109628768(wfs1) 109637739
LCF: 108885533(wfs1) 108896423
SDU: 111231387 111232763(wfs1)
SLAL: 111662769(wfs1) 111664506
HCQ: 109511429 109524358(wfs1)
MALB: 109957891(wfs1) 109958469
ELS: 105020812 105025217(wfs1)
SFM: 108924155(wfs1) 108925906
PKI: 111836210(wfs1) 111836784
LCM: 102355317(WFS1)
CMK: 103181324(wfs1)
RTP: 109931417(wfs1)
CIN: 100186442
SKO: 100329063(WFS1)
DME: Dmel_CG4917(wfs1)
DER: 6554917
DSE: 6607474
DSI: Dsimw501_GD18439(Dsim_GD18439)
DAN: 6500780
DSR: 110177302
DPE: 6588008
DMN: 108156896
DWI: 6648098
DAZ: 108613700
DNV: 108651586
DHE: 111597753
DVI: 6632383
MDE: 101897202
LCQ: 111678253
AAG: 5569230
AME: 552818
BIM: 100747318
BTER: 100642820
CCAL: 108632474
OBB: 114873030
SOC: 105206549
MPHA: 105839079
AEC: 105152641
ACEP: 105625597
PBAR: 105432460
VEM: 105568059
HST: 105182738
DQU: 106751128
CFO: 105247880
LHU: 105672435
PGC: 109855029
OBO: 105281759
PCF: 106785301
NVI: 100118973
CSOL: 105361428
MDL: 103570515
TCA: 662278
DPA: 109535223
ATD: 109601931
NVL: 108569416
BMOR: 101737669
BMAN: 114250763
PMAC: 106717359
PRAP: 110998945
HAW: 110380837
TNL: 113494834
API: 100163067
DNX: 107162103
AGS: 114122302
RMD: 113551810
BTAB: 109037666
CLEC: 106662483
ZNE: 110834719
FCD: 110845444
PVM: 113804408
CSCU: 111621063
PTEP: 107452511
PCAN: 112564450
CRG: 105344157
OBI: 106867480
LAK: 106155106
NVE: 5503349
EPA: 110236989
PDAM: 113677062
SPIS: 111326278
AQU: 105316107
 » show all
Reference
  Authors
Takei D, Ishihara H, Yamaguchi S, Yamada T, Tamura A, Katagiri H, Maruyama Y, Oka Y
  Title
WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum.
  Journal
FEBS Lett 580:5635-40 (2006)
DOI:10.1016/j.febslet.2006.09.007
  Sequence
[hsa:7466]
Reference
  Authors
Fonseca SG, Ishigaki S, Oslowski CM, Lu S, Lipson KL, Ghosh R, Hayashi E, Ishihara H, Oka Y, Permutt MA, Urano F
  Title
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.
  Journal
J Clin Invest 120:744-55 (2010)
DOI:10.1172/JCI39678
  Sequence
[hsa:7466] [mmu:22393] [rno:83725]
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