KEGG ORTHOLOGY: K14250

ORTHOLOGY: K14250

Entry

K14250                      KO

Symbol

oxyN, snoaM, dpsY, aknW, mtmY

Name

cyclase

Pathway

map00253

Tetracycline biosynthesis

map01057

Biosynthesis of type II polyketide products

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00778

Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide

Reaction

R09188

R09325

R09326

R09350

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
   00253 Tetracycline biosynthesis
    K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide synthase (PKS)
  Type II PKS
   C7-C14 cyclized polyketide type
    Nonaketide PKS
     K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase
    Decaketide PKS
     K14250  oxyN, snoaM, dpsY, aknW, mtmY; cyclase

Genes

PAKH:

B0X70_21795

PLUI:

CE143_21840

NAH:	F5544_10720 F5544_17035

SHY:

SHJG_1191

SHO:	SHJGH_1026

SFA:

Sfla_5330

SBH:

SBI_06843

STRP:

F750_1293

SCI:	B446_13310

SGS:	AVL59_46195

SGM:	GCM10017557_73870

SPHW:

NFX46_24960

STIR:

DDW44_27835

SKA:	CP970_39875

SGAL:

CP966_29015

SVR:	CP971_24010

SRIM:

SCIN:

STSU:

SCHA:

SGX:	H4W23_11705

SCOE:

CP976_33000

SPLA:

CP981_34465

SHUN:

DWB77_05175(kynB)

SPEU:

SINE:

SNIG:

SSPN:

SJN:	RI060_18330

SHAU:

K9S39_40590

SKG:	KJK29_16130

KAU:	B6264_18585

KIS:	HUT16_23675

TALX:

FOF52_07470

AORI:

SD37_34190

KAL:

KALB_7821

KUT:	JJ691_15750

LED:	BBK82_02440

PMAD:

BAY61_07775

ACTU:

Actkin_02483(kynB_1)

CROS:

N8J89_20415

MAU:	Micau_4023

MIL:

ML5_4398

MFEU:

H1D33_25780

PLK:	CIK06_11115

CATI:

CS0771_73090

DAUR:

Daura_37900

CCAZ:

COUCH_15915

AG:	AAC38443(dpsY) AAF01818(snoaM) AAF73459(aknW) AAZ78337(oxyN) CAK50782(mtmY)

» show all

Reference

PMID:16597959 (oxyN)

Authors

Zhang W, Ames BD, Tsai SC, Tang Y

Title

Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.

Journal

Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006

Sequence

[ag:AAZ78337]

Reference

PMID:20522541

Authors

Pickens LB, Tang Y

Title

Oxytetracycline biosynthesis.

Journal

J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419

Reference

PMID:17631493

Authors

Zhang W, Watanabe K, Wang CC, Tang Y

Title

Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway.

Journal

J Biol Chem 282:25717-25 (2007)
DOI:10.1074/jbc.M703437200

Reference

PMID:11683270 (snoaM)

Authors

Torkkell S, Kunnari T, Palmu K, Mantsala P, Hakala J, Ylihonko K

Title

The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures.

Journal

Mol Genet Genomics 266:276-88 (2001)
DOI:10.1007/s004380100554

Sequence

[ag:AAF01818]

Reference

PMID:9573189 (dpsY)

Authors

Lomovskaya N, Doi-Katayama Y, Filippini S, Nastro C, Fonstein L, Gallo M, Colombo AL, Hutchinson CR

Title

The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis.

Journal

J Bacteriol 180:2379-86 (1998)
DOI:10.1128/JB.180.9.2379-2386.1998

Sequence

[ag:AAC38443]

Reference

PMID:10102355 (mtmY)

Authors

Prado L, Lombo F, Brana AF, Mendez C, Rohr J, Salas JA

Title

Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.

Journal

Mol Gen Genet 261:216-25 (1999)
DOI:10.1007/s004380050960

Sequence

[ag:CAK50782]

LinkDB

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