KEGG   ORTHOLOGY: K14370
Entry
K14370                      KO                                     

Name
eryK, CYP113A
Definition
erythromycin 12 hydroxylase [EC:1.14.13.154]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14370  eryK, CYP113A; erythromycin 12 hydroxylase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14370  eryK, CYP113A; erythromycin 12 hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14370  eryK, CYP113A; erythromycin 12 hydroxylase
   00199 Cytochrome P450
    K14370  eryK, CYP113A; erythromycin 12 hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.154  erythromycin 12-hydroxylase
     K14370  eryK, CYP113A; erythromycin 12 hydroxylase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K14370  eryK, CYP113A; erythromycin 12 hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP113 family
   K14370  eryK, CYP113A; erythromycin 12 hydroxylase
Other DBs
RN: R05521 R05522
COG: COG2124
Genes
AER: AERYTH_15860
SEN: SACE_0713(eryK)
AEY: CDG81_13225
Reference
  Authors
Savino C, Montemiglio LC, Sciara G, Miele AE, Kendrew SG, Jemth P, Gianni S, Vallone B
  Title
Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.
  Journal
J Biol Chem 284:29170-9 (2009)
DOI:10.1074/jbc.M109.003590
  Sequence
[sen:SACE_0713]
Reference
PMID:8416893
  Authors
Stassi D, Donadio S, Staver MJ, Katz L
  Title
Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis.
  Journal
J Bacteriol 175:182-9 (1993)
DOI:10.1128/JB.175.1.182-189.1993
  Sequence
[sen:SACE_0713]
LinkDB

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