KEGG ORTHOLOGY: K16815

ORTHOLOGY: K16815

Entry

K16815                      KO

Symbol

PNPLA8

Name

calcium-independent phospholipase A2-gamma

Disease

H02201

Mitochondrial myopathy with lactic acidosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09190 Not Included in Pathway or Brite
  09191 Unclassified: metabolism
   99983 Lipid metabolism
    K16815  PNPLA8; calcium-independent phospholipase A2-gamma

Genes

HSA:	50640(PNPLA8)

PTR:	472484(PNPLA8)

PPS:	100967394(PNPLA8)

GGO:	101137123(PNPLA8)

PON:	100171809(PNPLA8)

PPYG:

129040180(PNPLA8)

NLE:	100595987(PNPLA8)

HMH:	116814242(PNPLA8)

SSYN:

129484889(PNPLA8)

MCC:	700851(PNPLA8)

MCF:	135970218(PNPLA8)

MTHB:

126951224

MNI:	105475295(PNPLA8)

CSAB:

103226730(PNPLA8)

CATY:

105583127(PNPLA8)

PANU:

100998359(PNPLA8)

TGE:	112620132(PNPLA8)

MLEU:

105544085(PNPLA8)

RRO:	104659970(PNPLA8)

RBB:	108540463(PNPLA8)

TFN:	117073463(PNPLA8)

PTEH:

111520370(PNPLA8)

CANG:

105516112(PNPLA8)

CJC:	100402856(PNPLA8)

SBQ:	101037424 101045416(PNPLA8)

CIMI:

108316768(PNPLA8)

ANAN:

105719579(PNPLA8)

CSYR:

103274021(PNPLA8)

MMUR:

105860792(PNPLA8)

LCAT:

123647706(PNPLA8)

PCOQ:

105815169(PNPLA8)

OGA:	100946142(PNPLA8)

MMU:	67452(Pnpla8)

MCAL:

110307157(Pnpla8)

MPAH:

110324282(Pnpla8)

RNO:	314075(Pnpla8)

MCOC:

116079596(Pnpla8)

ANU:	117716907(Pnpla8)

MUN:	110562987(Pnpla8)

CGE:	100763368(Pnpla8)

MAUA:

101842970(Pnpla8)

PROB:

127214811(Pnpla8)

PLEU:

114702309(Pnpla8)

MORG:

121452192(Pnpla8)

MFOT:

126498609

AAMP:

119818339(Pnpla8)

NGI:	103732165(Pnpla8)

HGL:	101725854(Pnpla8)

CPOC:

100720063(Pnpla8)

CCAN:

109701400(Pnpla8)

DORD:

105991396(Pnpla8)

DSP:	122111814(Pnpla8)

PLOP:

125346876(Pnpla8)

NCAR:

124974394 124991186

MMMA:

107152603(Pnpla8)

OCU:	100328577(PNPLA8)

OPI:	101531480(PNPLA8)

TUP:	102501773(PNPLA8)

GVR:	103591225(PNPLA8)

CFA:	475880(PNPLA8)

CLUD:

112661280(PNPLA8)

VVP:	112908551(PNPLA8)

VLG:	121471374(PNPLA8)

NPO:	129494253(PNPLA8)

AML:	100473082(PNPLA8)

UMR:	103674617(PNPLA8)

UAH:	113258428(PNPLA8)

UAR:	123789412(PNPLA8)

ELK:

111155294

LLV:

125080650

MPUF:

101671357(PNPLA8)

MNP:	132016051(PNPLA8)

MLK:	131829229(PNPLA8)

NVS:	122904692(PNPLA8)

ORO:	101381411(PNPLA8)

EJU:	114201702(PNPLA8)

ZCA:	113911317(PNPLA8)

MLX:	118020606(PNPLA8)

NSU:	110574266(PNPLA8)

LWW:	102730873(PNPLA8)

FCA:	101101296(PNPLA8)

PYU:	121028904(PNPLA8)

PCOO:

112866598(PNPLA8)

PBG:	122487733(PNPLA8)

PVIV:

125159000(PNPLA8)

LRUF:

124523560

PTG:	102952532(PNPLA8)

PPAD:

109268051(PNPLA8)

PUC:

125929827

AJU:

106980669

HHV:	120241849(PNPLA8)

BTA:	535496(PNPLA8)

BOM:	102279398(PNPLA8)

BIU:	109557395(PNPLA8)

BBUB:

102409221(PNPLA8)

BBIS:

104989715(PNPLA8)

CHX:	102177213(PNPLA8)

OAS:	101106930(PNPLA8)

BTAX:

128046598(PNPLA8)

ODA:	120878196(PNPLA8)

CCAD:

122438326(PNPLA8)

MBEZ:

129552311 129552408(PNPLA8)

SSC:	100521328(PNPLA8)

CFR:	102519956(PNPLA8)

CBAI:

105062910(PNPLA8)

CDK:	105097361(PNPLA8)

VPC:	102541264(PNPLA8)

BACU:

103017583(PNPLA8)

BMUS:

118900593(PNPLA8)

LVE:	103069821(PNPLA8)

OOR:	101277547(PNPLA8)

DLE:	111184475(PNPLA8)

PCAD:

102989481(PNPLA8)

PSIU:

116759246(PNPLA8)

NASI:

112397925(PNPLA8)

ECB:	100060568(PNPLA8)

EPZ:	103552444(PNPLA8)

EAI:	106825230(PNPLA8)

MYB:	102253733(PNPLA8)

MYD:	102772728(PNPLA8)

MMYO:

118665980(PNPLA8)

MLF:	102435390(PNPLA8)

MDT:	132211135(PNPLA8)

PKL:	118714429(PNPLA8)

EFUS:

103293825(PNPLA8)

MNA:	107526622(PNPLA8)

DRO:	112302875(PNPLA8)

SHON:

119003969(PNPLA8)

AJM:	119054729(PNPLA8)

PDIC:

114507513(PNPLA8)

PHAS:

123811862(PNPLA8)

MMF:	118619841(PNPLA8)

PPAM:

129063123(PNPLA8)

RFQ:	117012315(PNPLA8)

PALE:

102895987(PNPLA8)

PGIG:

120591422(PNPLA8)

PVP:	105303196(PNPLA8)

RAY:	107507067(PNPLA8)

MJV:	108396993(PNPLA8)

TOD:	119245669(PNPLA8) 119260197

SARA:

101557668(PNPLA8)

SETR:

126022315(PNPLA8)

LAV:	100676122(PNPLA8)

TMU:

101350217

ETF:	101646459(PNPLA8)

DNM:	101439301(PNPLA8)

MDO:	100010579(PNPLA8)

GAS:	123249586(PNPLA8)

SHR:	100929598(PNPLA8)

AFZ:

127539140

PCW:	110207026(PNPLA8)

TVP:	118852293(PNPLA8)

OAA:	103166639(PNPLA8)

GGA:	417785(PNPLA8)

PCOC:

116226656(PNPLA8)

MGP:	100548419(PNPLA8)

CJO:	107309431(PNPLA8)

TPAI:

128073265(PNPLA8)

LMUT:

125689556(PNPLA8)

NMEL:

110392670(PNPLA8)

APLA:

101796431(PNPLA8)

ACYG:

106047860(PNPLA8)

CATA:

118246711(PNPLA8)

AFUL:

116491059(PNPLA8)

TGU:	100229888(PNPLA8)

LSR:	110478566(PNPLA8)

SCAN:

103820368(PNPLA8)

PMOA:

120510682(PNPLA8)

OTC:	121331546(PNPLA8)

PRUF:

121355797(PNPLA8)

GFR:	102037446(PNPLA8)

FAB:	101819407(PNPLA8)

OMA:	130248547(PNPLA8)

PHI:	102104506(PNPLA8)

PMAJ:

107204526(PNPLA8)

CCAE:

111931859(PNPLA8)

CCW:	104698316(PNPLA8)

CBRC:

103614778(PNPLA8)

ETL:	114062213(PNPLA8)

ZAB:	102065994(PNPLA8)

ZLE:	135442622(PNPLA8)

ACHL:

103799874(PNPLA8)

SVG:	106850096(PNPLA8)

MMEA:

130573597(PNPLA8)

HRT:	120752334(PNPLA8)

SATI:

136361255(PNPLA8)

FPG:	101915933(PNPLA8)

FCH:	102058569(PNPLA8)

CCRI:

104158193(PNPLA8)

NNT:

104400071

SHAB:

115605043(PNPLA8)

ACUN:

113490012(PNPLA8)

TALA:

104367131(PNPLA8)

ACHC:

115341370(PNPLA8)

HALD:

104323505(PNPLA8)

HLE:	104835837(PNPLA8)

AGEN:

126044600

GCL:

127019878

CSTI:

104553745(PNPLA8)

LDI:	104343954(PNPLA8)

MNB:	103777538(PNPLA8)

DPUB:

104303062(PNPLA8)

AVIT:

104280727(PNPLA8)

BRHI:

104500898(PNPLA8)

EGZ:	104127593(PNPLA8)

NNI:	104013604(PNPLA8)

PCRI:

104032924(PNPLA8)

PCAO:

104039580

PADL:

103920002(PNPLA8)

AFOR:

103905246(PNPLA8)

FGA:	104070610(PNPLA8)

GSTE:

104251625

CLV:	102086355(PNPLA8)

MUI:

104536072

PGUU:

104463914

PLET:

104624592(PNPLA8)

EHS:	104515618(PNPLA8)

CMAC:

104479802(PNPLA8)

CUCA:

104062396(PNPLA8)

TEO:

104376903

BREG:

104631868(PNPLA8)

OHA:	104337484(PNPLA8)

ACAR:

104528392(PNPLA8)

CPEA:

104384759 104396432(PNPLA8)

CVF:	104282739(PNPLA8)

RTD:	128906654(PNPLA8)

AAM:	106488800(PNPLA8)

AROW:

112964649(PNPLA8)

NPD:	112946986(PNPLA8)

TGT:	104574192(PNPLA8)

DNE:	112993781(PNPLA8)

SCAM:

104153339(PNPLA8)

ASN:	102386716(PNPLA8)

AMJ:	102570971(PNPLA8)

CPOO:

109315588(PNPLA8)

GGN:	109295638(PNPLA8)

PSS:	102459639(PNPLA8)

CMY:	102931275(PNPLA8)

CCAY:

125630312(PNPLA8)

DCC:	119857889(PNPLA8)

CPIC:

101945938(PNPLA8)

TST:	117876904(PNPLA8)

CABI:

116832617(PNPLA8)

MRV:	120386742(PNPLA8)

ACS:	100558210(pnpla8)

ASAO:

132776237(PNPLA8)

PVT:	110082132(PNPLA8)

SUND:

121932318(PNPLA8)

PBI:

103064646

PMUR:

107295181(PNPLA8)

CTIG:

120313586(PNPLA8)

TSR:	106545615 106548995(PNPLA8)

PGUT:

117656179 132711041

APRI:

131202666(PNPLA8)

PTEX:

113444372(PNPLA8)

NSS:	113413085(PNPLA8)

VKO:	123019862(PNPLA8)

PMUA:

114605007(PNPLA8)

PRAF:

128421646(PNPLA8)

ZVI:	118091039(PNPLA8)

HCG:	128327335(PNPLA8)

GJA:	107113886(PNPLA8)

STOW:

125434417(PNPLA8)

EMC:	129335956(PNPLA8)

XLA:	108711125(pnpla8.L)

XTR:	100038186(pnpla8)

NPR:	108783859(PNPLA8)

RTEM:

120931902(PNPLA8)

BBUF:

120981411(PNPLA8)

BGAR:

122927963(PNPLA8)

MUO:	115478519(PNPLA8)

GSH:	117366995(PNPLA8)

DRE:	100126812(pnpla8) 101885865

SRX:	107725648 107737657 107748016 107757281

SANH:

107655584(pnpla8) 107671993 107687618 107694266 107695424

SGH:	107560901 107573395 107581761 107587144

CCAR:

109106916

CAUA:

113041178 113047994 113048168 113071159

CGIB:

127956862 127975800 128012186

PTET:

122328437 122331242 122342902(pnpla8)

LROH:

127154935 127157333 127164456(pnpla8)

OMC:	131532671 131534735 131539534(pnpla8)

PPRM:

120463106 120474042 120476889(pnpla8)

RKG:	130072898 130078761(pnpla8)

MAMB:

125261522

CIDE:

127494338 127505030

CERY:

137008879 137015151 137024384(pnpla8)

MASI:

127419135 127434968 127436804 127437160

TROS:

130550599 130552158

TDW:	130408785 130414320 130421241(pnpla8)

MANU:

129432274(pnpla8) 129433201

IPU:	108275274 108275530

IFU:	128618178(pnpla8) 128618906

PHYP:

113529787(pnpla8) 113530663

SMEO:

124392832(pnpla8)

TFD:	113639190(pnpla8) 113641801

TVC:	132857131(pnpla8) 132862338

TRN:	134311353 134322838(pnpla8) 134333897

AMEX:

103026605 103046551(pnpla8)

CMAO:

118811814 118812090(pnpla8) 118821960

EEE:	113571839 113578101

CHAR:

105888491 105902616(pnpla8) 105906859

TRU:	101065054 101067553 101072724(pnpla8)

TFS:	130519401(pnpla8) 130529652 130535814

TNG:	GSTEN00023607G001 GSTEN00023608G001 GSTEN00029710G001 GSTEN00034272G001

LCO:	104925416 104932187 109138875

NCC:	104946809 104955230 104965397

TBEN:

117479444 117483240(pnpla8) 117494995

CGOB:

115009610 115010973 115028178

PGEO:

117439092(pnpla8) 117447871 117448965

GACU:

117543020 117547864 117558235(pnpla8)

EMAC:

134872237 134879551(pnpla8) 134880477

ELY:	117249399(pnpla8) 117257808 117262391

EFO:	125882563(pnpla8) 125887751 125891489

PLEP:

121947008 121950056 121961570(pnpla8)

SLUC:

116038482 116039785(pnpla8) 116043507

ECRA:

117938368(pnpla8) 117948009 117949416

ESP:	116673466 116692839 116694187

PFLV:

114550162 114558257 114559963

GAT:	120809329 120817878(pnpla8) 120828836

PPUG:

119196235 119211162(pnpla8) 119221968 119221973

AFB:	129099494 129108177 129112442(pnpla8)

CLUM:

117725986(pnpla8) 117732235 117733618

PSWI:

130195420 130199517 130200446(pnpla8)

MSAM:

119893392 119905322 119915254 119918240(pnpla8)

SCHU:

122871097(pnpla8) 122874882 122883261

CUD:	121505247(pnpla8) 121515309 121516910

ALAT:

119023317 119024767 119032719(pnpla8)

MZE:	101475781 101478328 101478562

ONL:	100699449 100707296 100708614

OAU:	116310946 116328743(pnpla8) 116332674

OLA:	101156785 101163951 101171662

OML:	112152144 112155910(pnpla8) 112159311

CSAI:

133424063(pnpla8) 133443801 133456843

XMA:	102234498 102236395 102237946

XCO:	114145997 114159113 114160603(pnpla8)

XHE:	116732922 116736085 116736878

PRET:

103459460 103465828 103467668

PFOR:

103134425 103144059 103156690

PLAI:

106934611 106945306 106955440

PMEI:

106905545 106924968 106929213

GAF:	122826714(pnpla8) 122833478 122835587

PPRL:

129361831 129370438 129375576(pnpla8)

CVG:	107098110 107098430

CTUL:

119782046 119795739(pnpla8) 119799133

GMU:	124856631 124883133(pnpla8)

NFU:	107384374 107388486

KMR:	108230210 108241018(pnpla8)

ALIM:

106523522 106525483

NWH:	119415844 119428013(pnpla8)

AOCE:

111564113 111567056 111572110 111580534

MCEP:

125000059(pnpla8) 125015210 125024261

CSEM:

103380114 103382866 103385341

POV:	109623955 109632823 109635157

SSEN:

122765866(pnpla8) 122776025 122777765

HHIP:

117756985(pnpla8) 117763440 117765207

HSP:	118101672(pnpla8) 118109317 118110755

PPLT:

128428891(pnpla8) 128442617 128444387

SMAU:

118285821(pnpla8) 118315014 118317000

LCF:	108882137 108888542 108888937(pnpla8)

SDU:	111224513 111229874 111238202

SLAL:

111651515 111654996 111663702

XGL:	120793211 120803236(pnpla8) 120804235

HCQ:	109512992 109523663(pnpla8) 109530870

SSCV:

125970510 125992440

SBIA:

133493664(pnpla8) 133501769 133515011

PEE:	133397352(pnpla8) 133403270 133407588

PTAO:

133471663(pnpla8) 133477947 133478132

BPEC:

110161748 110164487 110169607

MALB:

109968258 109974276

BSPL:

114857414 114862872(pnpla8)

SJO:	128353326(pnpla8) 128357308 128358435

SASA:

106561642 106567269 106576575 106591883 106593409 106596512 106596742 106596764 106596787 106596881

STRU:

115168112 115188454 115197616

OTW:	112218894 112221938 112240703 121838787

OMY:	110490626 110500006 110503752 118939551

OGO:	124019707 124033001 124045896

ONE:	115102335 115115111

OKI:	109867042 109869391 109877490(pnpla8) 109886443

OKE:	118359859 118371671 127926687

SALP:

111962761 111976234 112078651

SNH:	120032048 120066466

CCLU:

121531633 121543906 121545640 121559107

ELS:	105021841 105024875

SFM:	108931591(pnpla8) 108942382

PKI:	111834386(ren) 111846116 111854603

AANG:

118207953 118219265(pnpla8)

LOC:	102691717(pnpla8)

PSPA:

121299495 121318136 121319966

ARUT:

117395743 117416059 117419995(pnpla8) 117429336

PSEX:

120533865(pnpla8)

LCM:	102365519(PNPLA8)

CMK:	103186239(pnpla8)

RTP:	109916684(pnpla8)

CPLA:

122559497(pnpla8)

HOC:	132824773(pnpla8)

LERI:

129706220(pnpla8)

PMRN:

116951306(PNPLA8) 116952663

LRJ:	133356429(PNPLA8) 133356799

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

ARUN:

SKO:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109421047 109429043 115258741

ASUA:

CPII:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:	115237911 115237967

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:	657424 657581

DPA:	109544152 109544193

SOY:	115880746 115880765

AGRG:

126736930 126736931

ATD:

109597301

CSET:

123306772 123307936

AGB:	108913334 108913349

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212919B

BANY:

MJU:

NIQ:

VCD:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110382332 135118610

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

BTAB:

CLEC:

HHAL:

NLU:	111057549 111063064

HVI:

124355267

MQU:	128982426 128996494 129005232

PHU:	Phum_PHUM308670

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DMK:

PJA:

HAME:

PCLA:

CQD:	128694377 128695920

PTRU:

ESN:

MNZ:

HAZT:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

CEL:	CELE_Y73B6BL.4(ipla-6)

CBR:	CBG_05466 CBG_05480

CRQ:	GCK72_013681

NAI:	NECAME_09105

BMY:	BM_BM7094(Bma-ipla-6)

LOA:	LOAG_06364

HRO:	HELRODRAFT_76804

LGI:	LOTGIDRAFT_223198

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105333230 117685665

CANU:

128161639

CVN:	111108175 111109748

OED:

MMER:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

RES:

TAD:	TRIADDRAFT_3592

AQU:

100641114

CCP:	CHC_T00009450001

BSC:	COCSADRAFT_31857

BOR:	COCMIDRAFT_35792

BBIG:

BBBOND_0301870

FCY:	FRACYDRAFT_185101

» show all

Reference

PMID:16973413

Authors

Schaloske RH, Dennis EA

Title

The phospholipase A2 superfamily and its group numbering system.

Journal

Biochim Biophys Acta 1761:1246-59 (2006)
DOI:10.1016/j.bbalip.2006.07.011

Reference

PMID:15695510

Authors

Murakami M, Masuda S, Ueda-Semmyo K, Yoda E, Kuwata H, Takanezawa Y, Aoki J, Arai H, Sumimoto H, Ishikawa Y, Ishii T, Nakatani Y, Kudo I

Title

Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2.

Journal

J Biol Chem 280:14028-41 (2005)
DOI:10.1074/jbc.M413766200

Sequence

[hsa:50640]

LinkDB

DBGET integrated database retrieval system