KEGG   ORTHOLOGY: K16834
Entry
K16834                      KO                                     

Name
SOST
Definition
sclerostin
Pathway
ko04310  Wnt signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
Disease
H00486  Sclerosteosis
H01774  Hyperostosis corticalis generalisata
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K16834  SOST; sclerostin
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K16834  SOST; sclerostin
Genes
HSA: 50964(SOST)
PTR: 740261(SOST)
PPS: 100988982(SOST)
GGO: 101124830(SOST)
PON: 100431718(SOST)
NLE: 100590543(SOST)
MCC: 713617(SOST)
MCF: 102130808(SOST)
CSAB: 103243354(SOST)
RRO: 104672425(SOST)
RBB: 108542701(SOST)
SBQ: 101039901(SOST)
MMU: 74499(Sost)
MCAL: 110305524(Sost)
MPAH: 110332493(Sost)
RNO: 80722(Sost)
MUN: 110551876(Sost)
CGE: 100751279(Sost)
NGI: 103738270(Sost)
HGL: 101719889(Sost)
CCAN: 109697063(Sost)
OCU: 100356489(SOST)
TUP: 102475233(SOST)
CFA: 490948(SOST)
VVP: 112910688(SOST)
AML: 100466486(SOST)
UAH: 113265168(SOST)
ORO: 101378187(SOST)
ELK: 111158020
FCA: 101083725(SOST)
PPAD: 109258243(SOST)
AJU: 113596293(SOST)
BTA: 282880(SOST)
BOM: 102268200(SOST)
BIU: 109573843(SOST)
BBUB: 102409116(SOST)
CHX: 102185686(SOST)
OAS: 101114123(SOST)
SSC: 100513306(SOST)
CFR: 116656778(SOST)
CDK: 116157964(SOST)
BACU: 103010784(SOST)
LVE: 103090222(SOST)
OOR: 101284480(SOST)
DLE: 111170219(SOST)
PCAD: 102979681(SOST)
ECB: 100065060(SOST)
EPZ: 103566127(SOST)
EAI: 106836435(SOST)
MYD: 102764325(SOST)
MNA: 107528840(SOST)
HAI: 109394969(SOST)
DRO: 112298544(SOST)
PALE: 102884991(SOST)
RAY: 107508120(SOST)
MJV: 108387237(SOST)
LAV: 100655563(SOST)
TMU: 101354576
MDO: 100009840(SOST)
SHR: 100929236(SOST)
PCW: 110198451(SOST)
OAA: 100086070(SOST)
GGA: 429784(SOST)
MGP: 100544889(SOST)
CJO: 107325058(SOST)
NMEL: 110388640(SOST)
APLA: 101804474(SOST)
ACYG: 106048800(SOST)
TGU: 100223624(SOST)
LSR: 110471815(SOST)
SCAN: 103821586(SOST)
GFR: 102039959(SOST)
FAB: 101815684(SOST)
PHI: 102106648(SOST)
PMAJ: 107215209(SOST)
CCAE: 111939987(SOST)
CCW: 104697779(SOST)
ETL: 114063652(SOST)
FPG: 101914527(SOST)
FCH: 102051369(SOST)
CLV: 102086936(SOST)
EGZ: 104134660(SOST)
NNI: 104009887(SOST)
ACUN: 113489255(SOST)
PADL: 103919362(SOST)
AAM: 106491778(SOST)
ASN: 102378603(SOST)
AMJ: 102557805(SOST)
PSS: 102447589(SOST)
CMY: 102938301(SOST)
CPIC: 101940157(SOST)
ACS: 100555145(sost)
PVT: 110079124(SOST)
PBI: 103059178(SOST)
PMUR: 107282583(SOST)
TSR: 106538489(SOST)
PMUA: 114582522(SOST)
GJA: 107120473(SOST)
NPR: 108795059(SOST)
DRE: 100000500(sost)
IPU: 108274294(sost)
PHYP: 113527046(sost)
AMEX: 103034637(sost)
EEE: 113574812(sost)
TRU: 101070335(sost)
LCO: 104929202(sost)
NCC: 104962264(sost)
MZE: 101468998(sost)
ONL: 100708173(sost)
OLA: 101173510(sost)
XMA: 102216550(sost)
XCO: 114151902(sost)
PRET: 103481701(sost)
CVG: 107092733(sost)
NFU: 107387626(sost)
KMR: 108247382(sost)
ALIM: 106535778(sost)
AOCE: 111568517(sost)
CSEM: 103381851(sost)
POV: 109644235(sost)
LCF: 108885160(sost)
SDU: 111220454(sost)
SLAL: 111656124(sost)
HCQ: 109512450(sost)
BPEC: 110154305(sost)
MALB: 109969555(sost)
SASA: 106579332(sost) 106589308
ELS: 105007501(sost)
PKI: 111845123(sost)
LCM: 102352324(SOST)
CMK: 103172819
RTP: 109918757
 » show all
Reference
  Authors
Semenov M, Tamai K, He X
  Title
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.
  Journal
J Biol Chem 280:26770-5 (2005)
DOI:10.1074/jbc.M504308200
Reference
  Authors
Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y
  Title
BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.
  Journal
Development 135:3801-11 (2008)
DOI:10.1242/dev.025825
Reference
  Authors
Balemans W, Ebeling M, Patel N, Van Hul E, Olson P, Dioszegi M, Lacza C, Wuyts W, Van Den Ende J, Willems P, Paes-Alves AF, Hill S, Bueno M, Ramos FJ, Tacconi P, Dikkers FG, Stratakis C, Lindpaintner K, Vickery B, Foernzler D, Van Hul W
  Title
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).
  Journal
Hum Mol Genet 10:537-43 (2001)
DOI:10.1093/hmg/10.5.537
  Sequence
[hsa:50964]
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