KEGG ORTHOLOGY: K16857

ORTHOLOGY: K16857

Entry

K16857 KO

Name

THBS1

Definition

thrombospondin 1

Pathway

ko04015

Rap1 signaling pathway

ko04115

p53 signaling pathway

ko04145

Phagosome

ko04151

PI3K-Akt signaling pathway

ko04350

TGF-beta signaling pathway

ko04510

Focal adhesion

ko04512

ECM-receptor interaction

ko05144

Malaria

ko05165

Human papillomavirus infection

ko05205

Proteoglycans in cancer

ko05206

MicroRNAs in cancer

ko05219

Bladder cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K16857  THBS1; thrombospondin 1
   04350 TGF-beta signaling pathway
    K16857  THBS1; thrombospondin 1
   04151 PI3K-Akt signaling pathway
    K16857  THBS1; thrombospondin 1
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K16857  THBS1; thrombospondin 1
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K16857  THBS1; thrombospondin 1
  09143 Cell growth and death
   04115 p53 signaling pathway
    K16857  THBS1; thrombospondin 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K16857  THBS1; thrombospondin 1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K16857  THBS1; thrombospondin 1
   05205 Proteoglycans in cancer
    K16857  THBS1; thrombospondin 1
  09162 Cancer: specific types
   05219 Bladder cancer
    K16857  THBS1; thrombospondin 1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K16857  THBS1; thrombospondin 1
  09174 Infectious disease: parasitic
   05144 Malaria
    K16857  THBS1; thrombospondin 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K16857  THBS1; thrombospondin 1
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K16857  THBS1; thrombospondin 1
   04990 Domain-containing proteins not elsewhere classified
    K16857  THBS1; thrombospondin 1
Membrane trafficking [BR:ko04131]
Endocytosis
  Phagocytosis
   Opsonins
    K16857  THBS1; thrombospondin 1
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Extracellular matrix molecules
   K16857  THBS1; thrombospondin 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
Thrombospondin domain-containing proteins
  Thrombospondins
   K16857  THBS1; thrombospondin 1

Genes

HSA:	7057(THBS1)

PTR:	453319(THBS1)

PPS:	100994890(THBS1)

GGO:	101135507(THBS1)

PON:	100453386(THBS1)

NLE:	100603886(THBS1)

MCC:	705413(THBS1)

MCF:	102130245(THBS1)

CSAB:

103245860(THBS1)

RRO:	104659681(THBS1)

RBB:	108526966(THBS1)

CJC:	100390178(THBS1)

SBQ:	101029602(THBS1)

MMU:	21825(Thbs1)

MCAL:

110310932(Thbs1)

MPAH:

110319023(Thbs1)

RNO:	445442(Thbs1)

MUN:	110564049(Thbs1)

CGE:	100760878(Thbs1)

NGI:	103727450(Thbs1)

HGL:	101701581(Thbs1)

CCAN:

109700113(Thbs1)

OCU:	100350430(THBS1)

TUP:	102497602(THBS1)

CFA:	487486(THBS1)

VVP:	112919933(THBS1)

AML:	100465724(THBS1)

UMR:	103673473(THBS1)

UAH:	113242050(THBS1)

ORO:	101376329(THBS1)

ELK:

111161597

FCA:	101092689(THBS1)

PTG:	102969748(THBS1)

PPAD:

109263182(THBS1)

AJU:	106979757(THBS1)

BTA:	281530(THBS1)

BOM:	102278109(THBS1)

BIU:	109564916(THBS1)

BBUB:

102401160(THBS1)

CHX:	100860971(THBS1)

OAS:	101106433(THBS1)

SSC:	492313(THBS1)

CFR:	102519986(THBS1)

CDK:	105096896(THBS1)

BACU:

103019307(THBS1)

LVE:	103080694(THBS1)

OOR:	101283920(THBS1)

DLE:	111181763(THBS1)

PCAD:

102995420(THBS1)

ECB:	100057478(THBS1)

EPZ:	103556716(THBS1)

EAI:	106835162(THBS1)

MYB:	102250983(THBS1)

MYD:	102758170(THBS1)

MNA:	107543012(THBS1)

HAI:	109384080(THBS1)

DRO:	112311111(THBS1)

PALE:

102898784(THBS1)

RAY:	107514453(THBS1)

MJV:	108400147(THBS1)

LAV:	100667431(THBS1)

TMU:

101344047

MDO:	100031767(THBS1)

SHR:	100926698(THBS1)

PCW:	110202873(THBS1)

OAA:	100092988(THBS1)

GGA:	373987(THBS1)

MGP:	100542373(THBS1)

CJO:	107314919(THBS1)

NMEL:

110401369(THBS1)

APLA:

101793322(THBS1)

ACYG:

106031773(THBS1)

TGU:	100230636(THBS1)

LSR:	110475265(THBS1)

SCAN:

103826589(THBS1)

GFR:	102031762(THBS1)

FAB:	101818592(THBS1)

PHI:	102103663(THBS1)

PMAJ:

107206295(THBS1)

CCAE:

111930312(THBS1)

CCW:	104684025(THBS1)

ETL:	114063733(THBS1)

FPG:	101915773(THBS1)

FCH:	102054866(THBS1)

CLV:	102091738(THBS1)

EGZ:	104122092(THBS1)

NNI:	104020294(THBS1)

ACUN:

113480732(THBS1)

PADL:

103914353(THBS1)

AAM:	106482797(THBS1)

ASN:	102374383(THBS1)

AMJ:	102568233(THBS1)

PSS:	102447926(THBS1)

CMY:	102943153(THBS1)

CPIC:

101940307(THBS1)

ACS:	100552734(thbs1)

PVT:	110080127(THBS1)

PBI:	103054107(THBS1)

PMUR:

107296464(THBS1)

TSR:	106542050(THBS1)

PMUA:

114593635(THBS1)

GJA:	107119648(THBS1)

XLA:	379508(thbs1.S) 779026(thbs2.L)

XTR:	100170153(thbs1)

NPR:	108796832(THBS1)

DRE:	100332237(thbs1a) 561901(thbs1b)

SRX:	107719693 107721311 107743901 107756566

SANH:

107668245 107671781 107678760 107687209

SGH:	107549089 107567351(thbs1) 107568499 107601983

CCAR:

109108576 109108577 109113549

IPU:	108257932(thbs1) 108270370

PHYP:

113530102(thbs1) 113531877

AMEX:

103029184(thbs1) 103031445

EEE:	113570532 113571350

TRU:	101061772(thbs1) 101062487

TNG:	GSTEN00022976G001 GSTEN00032374G001

LCO:	104926707 104934764

NCC:	104957017(thbs1) 104963041

MZE:	101472122 101487021

ONL:	100533981(thbs1a) 100533982(thbs1b)

OLA:	100302438 100302441(thbs1)

XMA:	102222883 102236898(thbs1)

XCO:	114134229 114158629

PRET:

103457638 103458518(thbs1)

CVG:	107084065 107093665

NFU:	107377820 107392441(thbs1)

KMR:	108233501(thbs1b) 108236340

ALIM:

106522431(thbs1) 106535463

AOCE:

111569559 111588169

CSEM:

103381239 103393533

POV:	109627896 109636170

LCF:	108887258 108892515

SDU:	111225391 111236186

SLAL:

111661462 111663195

HCQ:	109516072 109523753(thbs1)

BPEC:

110155241 110172375

MALB:

109962404 109967980(thbs1)

SASA:

106571097 106587655 106608163 106610834

OTW:	112217958 112233141 112261815

SALP:

111968762 111972691 112069670 112080561

ELS:	105015675 105024329

SFM:	108919589(thbs1)

PKI:	111838851(thbs1)

LCM:	102358103(THBS1)

CMK:	103175202(thbs1)

RTP:	109918114(thbs1)

CIN:	100176068 619278

SPU:

APLC:

SKO:

NVE:

AQU:

Reference

PMID:2430973

Authors

Lawler J, Hynes RO

Title

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

Journal

J Cell Biol 103:1635-48 (1986)
DOI:10.1083/jcb.103.5.1635

Sequence

[hsa:7057]

Reference

PMID:15707899

Authors

Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA

Title

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.

Journal

Cell 120:421-33 (2005)
DOI:10.1016/j.cell.2004.12.020

LinkDB

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