KEGG   ORTHOLOGY: K17078
Entry
K17078                      KO                                     
Symbol
neoL
Name
2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase [EC:3.5.1.112 3.5.1.113]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08895  2'-N-acetylparomamine hydrolase (acetate-forming)
R08901  2'''-acetyl-6'''-hydroxyneomycin-C hydrolase (acetate-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K17078  neoL; 2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.112  2'-N-acetylparomamine deacetylase
     K17078  neoL; 2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase
    3.5.1.113  2'''-acetyl-6'''-hydroxyneomycin C deacetylase
     K17078  neoL; 2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase
Genes
PMUY: KSS95_17150
SRN: A4G23_05119(neoL)
SNF: JYK04_00663(neoL)
SFB: CP974_27320
STRY: EQG64_18475
SDD: D9753_07125 D9753_17065
SARG: HKX69_16470
SPIQ: OHA34_16955
DVC: Dvina_05430
AG: BAD95829(neoL) CAE46942(kanN)
Reference
PMID:18802637
  Authors
Fan Q, Huang F, Leadlay PF, Spencer JB
  Title
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase.
  Journal
Org Biomol Chem 6:3306-14 (2008)
DOI:10.1039/b808734b
Reference
PMID:16506694
  Authors
Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K
  Title
Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.
  Journal
J Antibiot (Tokyo) 58:766-74 (2005)
DOI:10.1038/ja.2005.104
  Sequence
[ag:BAD95829]
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