KEGG   ORTHOLOGY: K17388Help
Entry
K17388                      KO                                     

Name
ROCK2
Definition
Rho-associated protein kinase 2 [EC:2.7.11.1]
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04071  Sphingolipid signaling pathway
ko04270  Vascular smooth muscle contraction
ko04310  Wnt signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04530  Tight junction
ko04611  Platelet activation
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko04921  Oxytocin signaling pathway
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05135  Yersinia infection
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04071 Sphingolipid signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04024 cAMP signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04022 cGMP-PKG signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17388  ROCK2; Rho-associated protein kinase 2
   04530 Tight junction
    K17388  ROCK2; Rho-associated protein kinase 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K17388  ROCK2; Rho-associated protein kinase 2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K17388  ROCK2; Rho-associated protein kinase 2
   04670 Leukocyte transendothelial migration
    K17388  ROCK2; Rho-associated protein kinase 2
   04062 Chemokine signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K17388  ROCK2; Rho-associated protein kinase 2
  09158 Development and regeneration
   04360 Axon guidance
    K17388  ROCK2; Rho-associated protein kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K17388  ROCK2; Rho-associated protein kinase 2
   05205 Proteoglycans in cancer
    K17388  ROCK2; Rho-associated protein kinase 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K17388  ROCK2; Rho-associated protein kinase 2
   05132 Salmonella infection
    K17388  ROCK2; Rho-associated protein kinase 2
   05131 Shigellosis
    K17388  ROCK2; Rho-associated protein kinase 2
   05135 Yersinia infection
    K17388  ROCK2; Rho-associated protein kinase 2
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K17388  ROCK2; Rho-associated protein kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K17388  ROCK2; Rho-associated protein kinase 2
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K17388  ROCK2; Rho-associated protein kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K17388  ROCK2; Rho-associated protein kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   K17388  ROCK2; Rho-associated protein kinase 2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K17388  ROCK2; Rho-associated protein kinase 2
BRITE hierarchy
Genes
HSA: 9475(ROCK2)
PTR: 470307(ROCK2)
PPS: 100969111(ROCK2)
GGO: 101134988(ROCK2)
PON: 100461801(ROCK2)
NLE: 100585294(ROCK2)
MCC: 708444(ROCK2)
MCF: 102133054(ROCK2)
CSAB: 103220805(ROCK2)
RRO: 104675191(ROCK2)
RBB: 108516461(ROCK2)
CJC: 100408337(ROCK2)
SBQ: 101039371(ROCK2)
MMU: 19878(Rock2)
MCAL: 110306686(Rock2)
MPAH: 110324181(Rock2)
RNO: 25537(Rock2)
MUN: 110541556(Rock2)
CGE: 100767265(Rock2)
NGI: 103747607(Rock2)
HGL: 101724195(Rock2)
CCAN: 109684863(Rock2)
OCU: 100346837(ROCK2)
TUP: 102490242(ROCK2)
CFA: 482970(ROCK2)
VVP: 112927709(ROCK2)
AML: 100466003(ROCK2)
UMR: 103660117(ROCK2)
UAH: 113269955(ROCK2)
ORO: 101372971(ROCK2)
ELK: 111154090
FCA: 101094501(ROCK2)
PTG: 102949986(ROCK2)
PPAD: 109268495(ROCK2)
AJU: 106977263(ROCK2)
BTA: 282041(ROCK2)
BOM: 102267122(ROCK2)
BIU: 109566382(ROCK2)
BBUB: 102409368(ROCK2)
CHX: 102181692(ROCK2)
OAS: 101103800(ROCK2)
SSC: 397445(ROCK2)
CFR: 102512572(ROCK2)
CDK: 105091254(ROCK2)
BACU: 102999355(ROCK2)
LVE: 103081507(ROCK2)
OOR: 101289250(ROCK2)
DLE: 111164467(ROCK2)
PCAD: 102994518(ROCK2)
ECB: 100072339(ROCK2)
EPZ: 103544175 103557393(ROCK2)
EAI: 106846040(ROCK2)
MYB: 102254781(ROCK2)
MYD: 102763604(ROCK2)
MNA: 107542396(ROCK2)
HAI: 109386644(ROCK2)
DRO: 112297718(ROCK2)
PALE: 102897424(ROCK2)
RAY: 107501194(ROCK2)
MJV: 108409101(ROCK2)
LAV: 100658857(ROCK2)
TMU: 101345959
MDO: 100032706(ROCK2)
SHR: 100916865(ROCK2)
PCW: 110207655(ROCK2)
OAA: 100073941(ROCK2)
GGA: 374182(ROCK2)
MGP: 100538826(ROCK2)
CJO: 107312208(ROCK2)
NMEL: 110395385(ROCK2)
APLA: 101792620(ROCK2)
ACYG: 106030727(ROCK2)
TGU: 100221127(ROCK2)
LSR: 110467944(ROCK2)
SCAN: 103820586(ROCK2)
GFR: 102032829(ROCK2)
FAB: 101817597(ROCK2)
PHI: 102103730(ROCK2)
PMAJ: 107201732(ROCK2)
CCAE: 111925960(ROCK2)
CCW: 104685437(ROCK2)
ETL: 114061910(ROCK2)
FPG: 101916990(ROCK2)
FCH: 102053908(ROCK2)
CLV: 102084971(ROCK2)
EGZ: 104127169(ROCK2)
NNI: 104013015(ROCK2)
ACUN: 113477643(ROCK2)
PADL: 103924034(ROCK2)
AAM: 106494758(ROCK2)
ASN: 102371812(ROCK2)
AMJ: 102572451(ROCK2)
PSS: 102457091(ROCK2)
CMY: 102934710(ROCK2)
CPIC: 101952051(ROCK2)
ACS: 100562729(rock2)
PVT: 110083697(ROCK2)
PMUR: 107294640(ROCK2)
TSR: 106548729 106549506(ROCK2)
PMUA: 114593802(ROCK2)
GJA: 107114818(ROCK2) 107125308
XLA: 100301953(rock2.S) 394289(rock2.L)
XTR: 100493965(rock2)
NPR: 108788599(ROCK2)
DRE: 317747(rock2a)
CCAR: 109044970 109101104(rock2)
EEE: 113576241(rock2) 113588491
TRU: 101067715 101068674(rock2)
LCO: 104924772(rock2) 104926776
MZE: 101470679 101475967(rock2)
ONL: 100701417 100709780(rock2)
XMA: 102226221(rock2) 102230495
XCO: 114133879(rock2) 114158490
PRET: 103457451 103458704(rock2)
CVG: 107081643 107094724(rock2)
NFU: 107377468 107396125(rock2)
KMR: 108233468 108241747(rock2)
ALIM: 106518444(rock2) 106522615
AOCE: 111566441 111568806(rock2)
POV: 109628087(rock2) 109636100
SDU: 111225444(rock2) 111239446
BPEC: 110155690(rock2) 110172686
MALB: 109953729 109972800(rock2)
ELS: 105021675 105029946(rock2)
SFM: 108922224(rock2) 108929341
PKI: 111851538 111855542(rock2)
LCM: 102354777(ROCK2)
CMK: 103180944(rock2)
RTP: 109915504
CIN: 100176906
SPU: 579202(ROCK)
APLC: 110985687
AME: 100578506(ROCK2)
NVI: 100119770
API: 100164812
PCAN: 112574232
MYI: 110466108
OBI: 106876226
EGL: EGR_03487
EPA: 110232859
ADF: 107334472
AMIL: 114960351
PDAM: 113681521
SPIS: 111337741
HMG: 100201834
VVI: 104881115
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9933571
  Authors
Takahashi N, Tuiki H, Saya H, Kaibuchi K
  Title
Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24.
  Journal
Genomics 55:235-7 (1999)
DOI:10.1006/geno.1998.5344
  Sequence
[hsa:9475]
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