KEGG   ORTHOLOGY: K18589
Entry
K18589                      KO                                     

Name
dfrA1, dhfr
Definition
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Pathway
ko00670  One carbon pool by folate
ko00790  Folate biosynthesis
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K18589  dfrA1, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
   00670 One carbon pool by folate
    K18589  dfrA1, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18589  dfrA1, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K18589  dfrA1, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    K18589  dfrA1, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
Other DBs
RN: R00936 R00937 R00939 R00940 R02235 R02236
COG: COG0262
GO: 0004146
Genes
ESL: O3K_00505
ESO: O3O_25165
ESM: O3M_00535
ECOS: EC958_A0108(dfrA17)
ECM: EcSMS35_A0121(dhfrV)
ELN: NRG857_30100
STY: HCM1.165c(dhfR)
SALZ: EOS98_23485
SFE: SFxv_4142a
ECLE: ECNIH2_23760
EAR: CCG28764
CIR: C2U53_02605(dfrA)
KAS: KATP_49880(dfrA25)
LEI: C2U54_24275(dfrA) C2U54_25015(dfrA)
LEH: C3F35_23540(dfrA)
PRG: RB151_012120(dhfrI_1) RB151_015860(dhfrI_2) RB151_018130(dhfrI_3)
VCE: Vch1786_I0148(dfrA1)
VSP: VS_1884(dfrA)
ABY: ABAYE3644(dhfrI)
MVS: MVIS_2596(dhfrXV)
RHH: E0Z06_15075(dfrA)
PAND: DRB87_20550(dfrA)
MELA: C6568_16825(dfrA)
DPS: DP0311
AG: AAK60186(dfrA16) ABB71176(dfrA25) ACD56152(dfrA27) ACZ52983(dfrA32) BAD02331(dfrA17) BAD88719(dfrA31) CAA25445(dfrA1) CAA31356(dfrA5) CAA41326(dfrA7) CAA90688(dfrA14) CAB05887(dfrA15) CAB06660(dfrA6) CAQ53849(dfrA30) CAT00035(dfrA28)
 » show all
Reference
  Authors
Agerso Y, Peirano G, Aarestrup FM
  Title
dfrA25, a novel trimethoprim resistance gene from Salmonella Agona isolated from a human urine sample in Brazil.
  Journal
J Antimicrob Chemother 58:1044-7 (2006)
DOI:10.1093/jac/dkl366
Reference
  Authors
Roberts MC, Schwarz S, Aarts HJ
  Title
Erratum: Acquired antibiotic resistance genes: an overview.
  Journal
Front Microbiol 3:384 (2012)
DOI:10.3389/fmicb.2012.00384
Reference
  Authors
Skold O
  Title
Resistance to trimethoprim and sulfonamides.
  Journal
Vet Res 32:261-73 (2001)
DOI:10.1051/vetres:2001123
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