KEGG   ORTHOLOGY: K19645
Entry
K19645            Tight     KO                                     

Name
dfrB, dfr2
Definition
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Pathway
ko00670  One carbon pool by folate
ko00790  Folate biosynthesis
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K19645  dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
   00670 One carbon pool by folate
    K19645  dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19645  dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K19645  dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    K19645  dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
Other DBs
RN: R00936 R00939
GO: 0004146
Genes
ECLZ: LI64_22090
AG: AAA72145(dfrB2) AAA82255(dfrB1) AAX46054(dfrB5) ABB72057(dfrB6) ADB54781(dfrB8) CAA51181(dfrB3) CAD22098(dfrB4)
Reference
  Authors
Alonso H, Gready JE
  Title
Integron-sequestered dihydrofolate reductase: a recently redeployed enzyme.
  Journal
Trends Microbiol 14:236-42 (2006)
DOI:10.1016/j.tim.2006.03.003
  Sequence
Reference
  Authors
Howell EE
  Title
Searching sequence space: two different approaches to dihydrofolate reductase catalysis.
  Journal
Chembiochem 6:590-600 (2005)
DOI:10.1002/cbic.200400237
LinkDB

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