| Entry |
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| Symbol |
dfrB, dfr2
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| Name |
dihydrofolate reductase (trimethoprim resistance protein) [EC: 1.5.1.3]
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| Pathway |
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| Reaction |
| R00936 | 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase |
| R00939 | 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
00670 One carbon pool by folate
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
01504 Antimicrobial resistance genes
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
Enzymes [BR:ko01000]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3 dihydrofolate reductase
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance genes [BR:ko01504]
Gene variants
Trimethoprim resistance genes
Dihydrofolate reductases
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance: KEGG signatures [br01600.html]
Signature KOs for antimicrobial resistance
K19645
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| Other DBs |
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| Genes |
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| Reference |
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| Authors |
Alonso H, Gready JE |
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| Title |
Integron-sequestered dihydrofolate reductase: a recently redeployed enzyme. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Howell EE |
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| Title |
Searching sequence space: two different approaches to dihydrofolate reductase catalysis. |
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| Journal |
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| LinkDB |
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