KEGG   ORTHOLOGY: K19947Help
Entry
K19947                      KO                                     

Name
MICAL
Definition
F-actin monooxygenase [EC:1.14.13.225]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K19947  MICAL; F-actin monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.225  F-actin monooxygenase
     K19947  MICAL; F-actin monooxygenase
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    K19947  MICAL; F-actin monooxygenase
 Protein recycling
  Rab GTPases and associated proteins
   Other Rab GTPase associated proteins
    K19947  MICAL; F-actin monooxygenase
BRITE hierarchy
Genes
HSA: 57553(MICAL3) 64780(MICAL1) 9645(MICAL2)
PTR: 451031(MICAL2) 463145(MICAL1) 745678(MICAL3)
PPS: 100969548(MICAL1) 100987179(MICAL3) 100994154(MICAL2)
GGO: 101127991(MICAL1) 101139251(MICAL2) 101144122 101149053
PON: 100173765(MICAL1) 100438047(MICAL2) 100444220(MICAL3)
NLE: 100581557(MICAL3) 100599627(MICAL2) 100604034(MICAL1)
MCC: 698737(MICAL1) 701439 710292(MICAL3)
MCF: 102124064(MICAL2) 102135771(MICAL3) 102139619(MICAL1)
CSAB: 103222878(MICAL3) 103240067(MICAL2) 103240597(MICAL1)
RRO: 104668570(MICAL2) 104668827(MICAL1) 104676297(MICAL3)
RBB: 108533801(MICAL1) 108535533(MICAL2) 108541715(MICAL3)
CJC: 100394528(MICAL2) 100395442(MICAL1) 100400227(MICAL3)
SBQ: 101027900(MICAL2) 101040006(MICAL3) 101042616(MICAL1)
MMU: 171580(Mical1) 194401(Mical3) 320878(Mical2)
MCAL: 110295772(Mical3) 110299452(Mical2) 110303515(Mical1)
MPAH: 110314399(Mical3) 110318852(Mical2) 110326332(Mical1)
RNO: 294520(Mical1) 362427(Mical3) 365352(Mical2)
MUN: 110541039(Mical2) 110546057(Mical3) 110555442(Mical1)
CGE: 100752579(Mical1) 100754319(Mical3) 100763886(Mical2)
NGI: 103745899(Mical3) 103749557(Mical1) 103750410(Mical2)
HGL: 101701740(Mical1) 101709910(Mical3) 101712859(Mical2)
CCAN: 109684398 109684399 109688102(Mical2) 109694751(Mical1)
OCU: 100347412(MICAL1) 100353897(MICAL2) 100354238(MICAL3)
TUP: 102480907(MICAL3) 102486503(MICAL1) 102494378(MICAL2)
CFA: 476858(MICAL2) 481958(MICAL1) 486761(MICAL3)
VVP: 112917441(MICAL3) 112925126(MICAL1) 112927059(MICAL2)
AML: 100465187(MICAL3) 100465934(MICAL2) 100478759(MICAL1)
UMR: 103675754(MICAL3) 103677024(MICAL1) 103682359(MICAL2)
UAH: 113246261 113258066(MICAL3) 113264746(MICAL1)
ORO: 101366928(MICAL2) 101371709(MICAL3) 101380122(MICAL1)
FCA: 101081558(MICAL3) 101091046 101100722(MICAL1)
PTG: 102951530(MICAL3) 102962220(MICAL1) 102962641(MICAL2)
AJU: 106968456(MICAL3) 106968890(MICAL1) 106971840
BTA: 508306(MICAL1) 532244(MICAL3) 534041(MICAL2)
BOM: 102266509(MICAL2) 102273179(MICAL1) 102286656(MICAL3)
BIU: 109559784(MICAL3) 109563835(MICAL1) 109569548(MICAL2)
BBUB: 102391634(MICAL1) 102395599(MICAL3) 102401601
PHD: 102319362(MICAL2) 102320915(MICAL3) 102342103(MICAL1)
CHX: 102172084(MICAL2) 102178522(MICAL3) 102185000(MICAL1)
OAS: 101113940(MICAL1) 101118097(MICAL3) 101121880(MICAL2)
SSC: 100153346(MICAL1) 100157721(MICAL3) 100519075(MICAL2)
CFR: 102507940(MICAL2) 102511399(MICAL1) 102522111(MICAL3)
CDK: 105086699(MICAL2) 105097110(MICAL1) 105100736(MICAL3)
BACU: 103000884(MICAL1) 103012504(MICAL3) 103012861(MICAL2)
LVE: 103069359(MICAL2) 103087508(MICAL1) 103088697(MICAL3)
OOR: 101275370(MICAL2) 101275745(MICAL3) 101285142(MICAL1)
DLE: 111164423(MICAL1) 111165227(MICAL2) 111176586(MICAL3)
ECB: 100054807(MICAL3) 100055978 100066627(MICAL1)
EPZ: 103551111(MICAL1) 103565092(MICAL3) 103566075
EAI: 106829758(MICAL1) 106833091(MICAL2) 106839442(MICAL3)
MYB: 102248958(MICAL2) 102251692(MICAL1) 102258499(MICAL3)
MYD: 102751644(MICAL3) 102759552(MICAL1) 102769793(MICAL2)
MNA: 107535318(MICAL2) 107537711(MICAL3) 107540706(MICAL1)
HAI: 109373294(MICAL3) 109388271 109388272 109391423(MICAL1)
RSS: 109446180 109449085(MICAL1) 109461201(MICAL3)
DRO: 112297007(MICAL1) 112303258 112311619(MICAL3)
PALE: 102887125(MICAL3) 102889705(MICAL2) 102892071(MICAL1)
LAV: 100661909(MICAL3) 100663700 100665365(MICAL1)
MDO: 100022040(MICAL3) 100029104(MICAL1) 100030142(MICAL2)
SHR: 100920737(MICAL1) 100922670(MICAL2) 100929940(MICAL3)
PCW: 110218729(MICAL3) 110218891(MICAL2) 110222901(MICAL1)
OAA: 100073551(MICAL2) 100085361(MICAL1) 100086054(MICAL3)
GGA: 418164(MICAL3) 423031(MICAL2) 429474(MICAL1)
MGP: 100541969 100545712(MICAL1) 100548226(MICAL3) 104911003(MICAL2) 104912086
CJO: 107314574 107314988(MICAL3) 107324612(MICAL1)
APLA: 101794484(MICAL2) 101803780(MICAL1) 101805047(MICAL3)
ACYG: 106030921(MICAL3) 106040898(MICAL2) 106040899(MICALCL) 106046127
TGU: 100219168(MICAL3) 100227450(MICAL2) 100232670(MICAL1)
LSR: 110469104(MICAL2) 110469123(MICALCL) 110473459(MICAL1) 110482582(MICAL3)
SCAN: 103820469(MICAL3) 103823343(MICAL1) 103824313(MICAL2)
GFR: 102032677(MICAL3) 102033849(MICAL2) 102034019(MICALCL) 102043330(MICAL1)
FAB: 101811190(MICAL2) 101819614(MICAL3) 101820098(MICAL1) 101821255(MICALCL)
PHI: 102107564(MICAL3) 102107919(MICAL2) 102108109(MICALCL) 102108714(MICAL1)
PMAJ: 107204329(MICAL3) 107205792(MICAL2) 107214787(MICAL1)
CCAE: 111928083(MICAL3) 111930849(MICAL2) 111939748(MICAL1)
CCW: 104692251(MICAL3) 104692546(MICAL1) 104692969
ETL: 114056527(MICAL2) 114065769(MICAL1) 114068977(MICAL3)
FPG: 101914505(MICAL3) 101922313(MICAL1) 101924713(MICAL2) 101924875(MICALCL)
FCH: 102047357(MICAL3) 102052557(MICAL2) 102060220(MICAL1)
CLV: 102085132(MICAL2) 102093478(MICAL3) 102096460(MICAL1)
EGZ: 104123406(MICAL2) 104123414(MICALCL) 104125757(MICAL1) 104134379(MICAL3)
NNI: 104009445(MICAL2) 104009522(MICALCL) 104013230(MICAL1) 104020203(MICAL3)
ACUN: 113481325(MICAL2) 113489033(MICAL1) 113491284(MICAL3)
AAM: 106487711(MICAL1) 106488631(MICAL3) 106497117(MICAL2) 106497118(MICALCL)
ASN: 102371980 102375438(MICAL3) 102377820(MICAL2)
AMJ: 102565781(MICAL1) 102574107(MICALCL) 106737063(MICAL3) 109280514
PSS: 102443943(MICAL3) 102447311 102462749(MICAL2)
CMY: 102932362(MICAL2) 102934250(MICALCL) 102935764(MICAL1) 102942117(MICAL3)
CPIC: 101936236(MICAL1) 101936780(MICAL3) 101946730(MICAL2)
ACS: 100552986(mical1) 100554427(mical3) 100564862(mical2) 103279667(micalcl)
PVT: 110076703(MICAL3) 110079674(MICAL1) 110080915(MICAL2) 110080917(MICALCL)
PMUR: 107289040(MICAL1) 107292277(MICAL3) 107293552 107299372 114923034(MICALCL)
XTR: 100486205(mical3) 100487018(mical2)
NPR: 108785688(MICALCL) 108786140(MICAL2) 108791576(MICAL3)
DRE: 402881(mical3a) 566850(mical3b) 568573(mical1) 569564(mical2b) 569607(mical2a)
HCQ: 109512974 109520707(micalcl) 109520720 109525935(mical2) 109530374(mical3) 109532568
LCM: 102345089 102360081(MICAL3) 102366021(MICAL2) 106704417(MICALCL)
CIN: 100175527
SPU: 582210(MICAL3)
APLC: 110989175
DME: Dmel_CG33208(Mical)
DER: 6552049
DPE: 6598648
DSI: Dsimw501_GD20744(Dsim_GD20744)
DWI: 6647152
DAZ: 108615232
DNV: 108658541
MDE: 101887289
AAG: 5568484
AME: 413310
BIM: 100744389
BTER: 100650962
SOC: 105204672
AEC: 105145217
ACEP: 105617147
PBAR: 105423576
DQU: 106741595
CFO: 105257878
LHU: 105675006
PGC: 109854698
OBO: 105283811
PCF: 106785377
NVI: 100120752
MDL: 103579831
TCA: 100141546
NVL: 108557182
BMOR: 101742566(T15.180a)
PMAC: 106717230
PRAP: 111003396
HAW: 110382349
TNL: 113503945
API: 100168266
DNX: 107162729
CLEC: 106674386
ZNE: 110827699
TUT: 107372243
DPTE: 113794869
BMY: Bm1_43575
CRG: 105346067
OBI: 106870794
LAK: 106178150
SHX: MS3_03588
EGL: EGR_02335
ADF: 107332908
SMIN: v1.2.023094.t1(symbB.v1.2.023094.t1) v1.2.023094.t2(symbB.v1.2.023094.t2) v1.2.027574.t1(symbB.v1.2.027574.t1)
SPAR: SPRG_02957
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Giridharan SS, Rohn JL, Naslavsky N, Caplan S
  Title
Differential regulation of actin microfilaments by human MICAL proteins.
  Journal
J Cell Sci 125:614-24 (2012)
DOI:10.1242/jcs.089367
  Sequence
[hsa:64780 9645]
Reference
  Authors
Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, Demmers J, Peranen J, Pasterkamp RJ, van der Sluijs P, Hoogenraad CC, Akhmanova A
  Title
Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers.
  Journal
Curr Biol 21:967-74 (2011)
DOI:10.1016/j.cub.2011.04.030
  Sequence
[hsa:57553]
Reference
  Authors
Hung RJ, Yazdani U, Yoon J, Wu H, Yang T, Gupta N, Huang Z, van Berkel WJ, Terman JR
  Title
Mical links semaphorins to F-actin disassembly.
  Journal
Nature 463:823-7 (2010)
DOI:10.1038/nature08724
  Sequence
LinkDB All DBs

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