KEGG   ORTHOLOGY: K21164Help
Entry
K21164                      KO                                     

Name
sgcE7, ncsE7, kedE7
Definition
enediyne biosynthesis protein E7
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21164  sgcE7, ncsE7, kedE7; enediyne biosynthesis protein E7
BRITE hierarchy
Other DBs
COG: COG2124
Genes
PRAG: EKN56_15110
CSER: CCO03_03245
PSEB: EOK75_04365
HDH: G5B40_02015 G5B40_06825
MHAD: B586_03880
MRH: MycrhN_0267
MMV: MYCMA_1134
MABB: MASS_2078
MABL: MMASJCM_2102
MSAO: MYCSP_09200
SGR: SGR_611
SBH: SBI_00200(cyp3)
STRM: M444_37990
LMOI: VV02_06570
SRO: Sros_6996
AMD: AMED_6869
AMN: RAM_35245
AMM: AMES_6764
AMZ: B737_6764
AOI: AORI_1836
AMYY: YIM_41005
AMI: Amir_4102
SESP: BN6_39230
ACTI: UA75_19085
ACAD: UA74_18595
ALO: CRK57504
SAQ: Sare_0554
ACTN: L083_3213
CAI: Caci_6371
AG: AAM78009(ncsE7) AFV52138(kedE7)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:12183628 (sgcE7)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33980]
Reference
PMID:15797213 (ncsE7)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE7)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
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