KEGG   ORTHOLOGY: K22274
Entry
K22274            Tight     KO                                     

Symbol
NS4A
Name
HCV non-structural protein 4A
Pathway
map03230  Viral genome structure
map03240  Viral replication
map05160  Hepatitis C
Network
nt06121  TLR signaling (viruses and bacteria)
nt06133  RLR signaling (viruses)
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
  Element
N00271  HCV NS3/4A to RIG-I-like receptor signaling pathway
N00516  HCV NS3/4A to TLR3-IRF3 signaling pathway
N00517  HCV NS3/4A to TLR3-IRF3 signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22274  NS4A; HCV non-structural protein 4A
   03240 Viral replication
    K22274  NS4A; HCV non-structural protein 4A
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22274  NS4A; HCV non-structural protein 4A
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22274  NS4A; HCV non-structural protein 4A
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus
   K22274  NS4A; HCV non-structural protein 4A
Genes
VP: 951475-7(NS4A)
Reference
  Authors
Murayama A, Sugiyama N, Suzuki R, Moriyama M, Nakamura N, Mochizuki H, Wakita T, Kato T
  Title
Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production.
  Journal
J Virol 91:e02124-16 (2017)
DOI:10.1128/JVI.02124-16
  Sequence
Reference
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
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